林口長庚紀念醫院國際醫療網站地圖

上次更新:2021/04/06

曾雁明

職稱 主治醫師  
專長
頭頸部腫瘤、鼻咽癌、消化系統癌、肝癌、大腸直腸癌
學歷
1982 畢業於台北醫學院
1994 美國哈佛大學公共衛生學院腫瘤生物學博士
經歷
1982/07~1985/06 林口長庚醫院放射腫瘤科住院醫師
1985/07~1986/06 林口長庚醫院放射腫瘤科總醫師
1986/07~迄今       林口長庚醫院放射腫瘤科主治醫師
2003/06~2013/06    臨床組副教授級主治醫師
2013/07~迄今          臨床組教授級主治醫師

參與學會
美國放射腫瘤學會
台灣放射腫瘤學會
發表論文

Publications:

First or corresponding authorship since 2015: [SCI] (*corresponding author)

  • Hsieh CE, Lin CY*, Lee LY, Yang LY, Wang CC, Wang HM, Chang JT, Fan KH, LiaoCT, Yen TC, Fang KH, Tsang YM*. Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study. Radiation Oncology. 2016 Mar 22;11:47.
  • Ngan Ming Tsang*, Ping Ching Pai, Chi Cheng Chuang, Chen Kan Tseng, Kai Ping Chang, Wen Ching Chuang, Tzu Chen Yen, Jen Der Lin, Joseph Tung Chieh Chang. Overweight and obesity predict better overall survival rates in cancer patients with distant metastases. Cancer Medicine. 2016 Apr;5(4):665-75.
  • Lei KF*, Kao CH, Tsang NM*. High throughput and automatic colony formation assay based on impedance measurement technique. Anal Bioanal Chem. 2017 May.409(12):3271-3277.
  • Kin Fong Lei*, Bo-Yuan Lina, Tsang NM*.Real-time and label-free impedimetric analysis of the formation and drug testing of tumor spheroids formed via the liquid overlay technique. RSC Advances.2017 Feb 7.7.13939-13946.
  • Yung-Chih Chou, Ping-Ching Pai, Chen-Kan Tseng, Chien-Yu Lin, Cheng-En Hsieh, Kai-Ping Chang, Cheng-Lung Hsu, Chun-Ta Liao, Chun-Chieh Wang, Shy-Chyi Chin, Tzu-Chen Yen, Tsung-Ying Ho, Ji-Hong Hong, Kin Fong Lei, Joseph Tung-Chieh Chang, and Ngan-Ming Tsang*. Dose-escalated radiation therapy is associated with better overall survival in patients with bone metastases from solid tumors: a propensity score-matched study. Cancer Medicine. 2017 Sep;6(9):2087-2097.
  • Ping Ching Pai, Chi Cheng Chuang, Wen Ching Chuang, Ngan Ming Tsang*, Chen Kan Tseng,Kuan Hung Chen, Tzu Chen Yen, Chien Yu Lin, Kai Ping Chang & Kin Fong Lei. Pretreatment subcutaneous adipose tissue predicts the outcomes of patients with head and neck cancer receiving definitive radiation and chemoradiation in Taiwan.Cancer Medicine. 2018 Jan;7(5):1630-1641 .
  • Yao-Yu Wu , Kai-Ping Chang , Chien-Yu Lin, Ping-Ching Pai, Hung-Ming Wang, Cheng-Lung Hsu, Chun-Ta Liao, Tzu-Chen Yen, Tuan-Jen Fang, Shiang-Fu Huang, Chung-Jan Kang, Ku-Hao Fang, Wan-Ni Lin, Yu-Chien Wang, Li-Jen Hsin & Ngan Ming Tsang*.Prognostic significance of combined pretreatment lymphocyte counts and body mass index in patients with head and neck cancer treated with radiation therapy.Cancer Medicine. 2018 Mar;7(7):2808-2815 .
  • Kin Fong Lei*, Shao-Chieh Hsieh, Rei-Lin Kuo& Ngan Ming Tsang*. Co-Culturing Cancer Cells and Normal Cells in a Biochip under Electrical Stimulation. BioChip Journal. 2018 Aug;pp1-6.
  • Chun-Hao Huang, Kin Fong Lei* & Ngan Ming Tsang*. Dissociated effect and Chemosensitive enhancement of tumor spheroids influenced by an electric field in a microdevice. Biomedical Microdevices. 2018 Aug;20(70):pp1-10.
  • Shu-Chen Liu, Tien Hsu, Yu-Sun Chang, An-Ko Chung, Shih Sheng Jiang Chun-Nan OuYang, Chiou-Hwa Yuh, Chuen Hsueh, Ya-Ping Liu &Ngan Ming Tsang*,( 2018, Sep). Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.Nature Communications, 2018(9);5101.
  • Kin Fong Lei, Shao-Chieh, Hsieh Andrew, Goh Rei-Lin Ku & Ngan Ming Tsang*, Proliferation arrest, selectivity, andchemosensitivity enhancement of cancer cells treated by a low-intensityalternating electric field. Biomedical Microdevices , 2018 Oct; 20:90.
  • Meng-Tsan Tsai, Bo-Huei Huang, Chun-Chih Yeh, Kin Fong Lei,* and
    Ngan Ming Tsang*, Non-Invasive Quantification of the Growth of Cancer
    Cell Colonies by a Portable Optical Micromachines 2019,Jan;10,35
  • Kuan-Hung Chen, Ngan-Ming Tsang*, Wen-Chi Chou, Shiao Fwu Tai, Shu-Chen Liu, Kin-Fong Lei, Kai-Ping Chang, Wen-Ching Chuang, Ping-Ching Pai. Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer. Journal of Geriatric Oncology. 2019 April; 10:757-762.

Co authorship since  2015: [SCI]

  • Ho TY, Chou PC, Yang CT, Tsang NM, Yen TC. Total Lesion Glycolysis Determined per RECIST 1.1 Criteria Predicts Survival in EGFR Mutation-Negative Patients With Advanced Lung Adenocarcinoma. Clin Nucl Med. 2015 Jun;40(6): e295-9.
  • Lei KF, Huang CH, Kuo RL, Chang CK, Chen KF, Tsao KC, Tsang NM. Paper-based enzyme-free immunoassay for rapid detection and subtyping of influenza A H1N1 and H3N2 viruses. Anal Chim Acta. 2015 Jul 9; 883: 37-44.
  • Adel M, Kao HK, Hsu CL, Huang JJ, Lee LY, Huang Y, Browne T, Tsang NM, Chang YL, Chang KP. Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma. Medicine (Baltimore). 2015 Oct;94(43): e1510.
  • Liao CT, Fan KH, Kang CJ, Lin CY, Chang JT, Tsang NM, Huang BS, Chao YK, Lee LY, Hsueh C, Wang HM, Liau CT, Hsu CL, Hsieh CH, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Yen TC. Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. PLoS One. 2015 Sep 3;10(9): e0136918.
  • Kin Fong Lei, Jun-Liang Liu, Chia-Hao Huang, Rei-Lin Kuo, Ngan-Ming Tsang. A reagent-ready-on-chip microfluidic immunoassay system for rapid detection of influenza a H1N1 and H3N2 viruses. BioChip Journal. 2016 March;10(1):34-41. 
  • Lei KF, Huang CH, Tsang NM. Impedimetric quantification of cells encapsulated in hydrogel cultured in a paper-based microchamber. Talanta. 2016 Jan 15; 147:628-33.
  • Chin SC, Lin CY, Huang BS, Tsang NM, Fan KH, Ku YK, Hsu CL, Chan SC, Huang SF, Li CH, Tseng HJ, Liao CT*, Liu HL, Sung K. Pretreatment Dynamic Contrast-Enhanced MRI Improves Prediction of Early Distant Metastases in Patients With Nasopharyngeal Carcinoma. Medicine (Baltimore). 2016 Feb;95(6):e2567.
  • Liou MJ, Tsang NM, Hsueh C, Chao TC, Lin JD*. Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer. Int J Endocrinol. 2016 Mar 29; Volume 2016, Article ID 9570171, 7 pages.
  • Lei KF*, Tseng HP, Lee CY, Tsang NM. Quantitative Study of Cell Invasion Process under Extracellular Stimulation of Cytokine in a Microfluidic Device. Scientific Reports. 2016 May ;6:25557.
  • Wang HM, Lin TL, Kuo YC, Li HP, Chang KP, Lin CY, Fan HC, Lin AC, Hsieh CH, Tsang NM, Lee LY, Chan SC, Lui KW, Chang YS, Hsu CL*. Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis. Oncotarget. 2016 Aug 16;7(33):53217-53229.
  • Huang CH, Lei KF*, Tsang NM. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016 Aug 7;16(15):2911-20.
  • Hsu PY, Yang SH, Tsang NM, Fan KH, Hsieh CH, Lin JR, Hong JH, Lin YC, Chen HY, Yang CT, Yang CW, Chen JL*. Efficacy of Traditional Chinese Medicine in Xerostomia and Quality of Life during Radiotherapy for Head and Neck Cancer: A Prospective Pilot Study. Evidence-Based Complementary and Alternative Medicine. 2016 Aug 21;Volume 2016, Article ID 8359251, 10 pages.
  • Huang BS, Chen WY, Hsieh CE, Lin CY, Lee LY, Fang KH, Tsang NM, Kang CJ, Wang HM, Chang JT*. Outcomes and prognostic factors for surgery followed by modern radiation therapy in parotid gland carcinomas. Japanese Journal of Clinical Oncology. 2016 Sep;46(9):832-8.
  • Chen MY, Wang YC, Wu TH, Lee CF, Wu TJ, Chou HS, Tsang NM, Chan KM*, Lee WC. Efficacy of External Beam Radiation-Based Treatment plus Locoregional Therapy for Hepatocellular Carcinoma Associated with Portal Vein Tumor Thrombosis. Biomed Res Int. 2016 Nov 24; Volume 2016, Article ID 6017406, 9 pages.
  • Chan SC, Chang KP*, Fang YD, Tsang NM, Ng SH, Hsu CL, Liao CT, Yen TC. Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma. Laryngoscope. 2017 Jan;127(1):E22-E28.
  • Chang KP, Wang CI, Pickering CR, Huang Y, Tsai CN, Tsang NM, Kao HK, Cheng MH, Myers JN*. Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma. Head And Neck-Journal for the Sciences And Specialties of the Head And Neck. 2017 Jun;39(6):1131-1137.
  • Kao HK, Abdelrahman M, Huang Y, Tsai CH, Barrera MJ, Tsang NM, Couves AJ, Cheng MH, Chang KP*. Multiple concomitant oral cavity cancers: Incidence, management, and outcomes. J Surg Oncol. 2017 Jun;115(7):835-841.
  • Kin Fong Lei*, Tai-Kun Liu, Ngan-Ming Tsang. Towards a high throughput impedimetric screening of chemosensitivity of cancer cells suspended in hydrogel and cultured in a paper substrate. Biosensors and Bioelectronics.2017 Sep19; 100 (2018): 355–360.
  • Hsin LJ, Lin WN, Fang TJ*, Lee LA, Kang CJ, Huang BS, Lin CY, Fan KH, Tsang NM, Hsu CL, Chang JT, Liao CT, Yen TC, Chang KP, Chuang HF, Li HY. Life quality improvement in hoarse patients with early glottic cancer after transoral laser microsurgery. Head And Neck-Journal for the Sciences And Specialties of the Head And Neck. 2017 Oct;39(10):2070-2078.
  • Yi-Chan Lee, Ta-Jen Lee, Ngan-Ming Tsang, Yenlin Huang, Cheng-Lung Hsu, Li-Jen Hsin, Yi-Hsuan Lee and Kai-Ping Chang*. Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma.Journal of Otolaryngology-Head & Neck Surgery. 2018;47(12);1-8.
  • Sheng-Chieh Chan, Chih-Hua Yeh, Tzu-Chen Yen, Shu-Hang Ng*, Joseph Tung-Chieh Chang, Chien-Yu Lin, Tsang Yen-Ming, Kang-Hsing Fan, Bing-Shen Huang, Cheng-Lung Hsu, Kai-Ping Chang, Hung-Ming Wang & Chun-Ta Liao. Clinical utility of simultaneous whole-body 18F-FDG PET/MRI as a single-step imaging modality in the staging of primary nasopharyngeal carcinoma.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING.2018 Mar;(Epub).
  • Pei Hsin Chu, Ngan Ming Tsang, Li Ang Lee, Chun Ta Liao, Tuan Jen Fang*. To do or not to do: salvage management for hypopharyngeal cancer after chemoradiation therapy.EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2018 Aug;275(8);2119-2126.
  • Ching-Hsin Lee, Sheng-Ping Hung, Ji-Hong Hong, Joseph Tung-Chieh Chang, Ngan-Ming Tsang, Kun-Ming Chan, Jeng-Hwei Tseng, Shih-Chiang Huang, Shi-Ming Lin³, Jau-Min Lien³, Nai-Jen Liu³, Chen-Chun Lin³, Wei-Ting Chen³, Wan-Yu Chen, Po-Jui Chen, Bing-Shen Huang*.How small is TOO small? New liver constraint is needed-Proton therapy of hepatocellular carcinoma patients with small normal liver. PLoS One. 2018 Sep 11;13(9):1-15.
  • Cheng-Lung Hsu, Kar-Wai Lui, Lang-Ming Chi, Yung-Chia Kuo, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee,Yenlin Huang, Tung-Liang Lin, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin,Yen-Jung Lu, Chia-Hsun Hsieh, Kai-Ping Chang, Ngan-Ming Tsang, Hung-Ming Wang, Alex Y. Chang,Yu-Sun Chang and Hsin-Pai Li*.Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma. Journal of Experimental & Clinical Cancer Research. 2018;37(233) :1-15.
  • Yu-Jen Liu, Ngan-Ming Tsang, Chuen Hsueh, Chi-Ju Yeh, Shir-Hwa Ueng,Tong-Hong Wang and Wen-Yu Chuang. Low PD-L1 Expression Strongly Correlates with Local
    Recurrence in Epstein-Barr Virus-Positive Nasopharyngeal Carcinoma after Radiation-Based Therapy. Cancers. 2018;10(374):1-14.
  • Huang SM, Chen YC, Chen WY, Yang LY, Tsan DL, Tsang NM, Yap WK, Tsai CS, Leung WM, Hong JH, Chang JT, Yeh TS, Wu TH, Chen YC, Lin YH, Huang BS. Optimal Timing for Postsurgical Adjuvant Therapy in Patients with Gastric Cancer: A Propensity Score Matching Study. J Cancer. 2019 Jan 1;10(2):332-340.
  • Chun-Hao, Huang Kin FongLei, Ngan Ming Tsang, Apoptosis and cell cycle arrest of hepatocellular carcinoma spheroids treated by an alternating electric field. Biotechnology Progress. 2019 Feb;e2787.
  • Hsieh CE, Hung CY, Lin CY, Chen JS, Chang KP, Aithala SP, Lee LY, Tsang NM, Lu CH, Chen MF, Cheng YF, Yeh KY, Wang CH, Chou WC. High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma. Head Neck. 2019 Jun;41(6):1572-1582.
  • An-Ko Chung, Chun-Nan OuYang, Hsuan Liu, Mei Chao, Ji-Dung Luo, Cheng-Yang Lee, Yen-Jung Lu, Che Chung, Lih-Chyang Chen, Shao-Min Wu, Ngan-Ming Tsang*, Kai-Ping Chang, Cheng-Lung Hsu, Hsin-Pai Li, Yu-Sun Chang. Targeted sequencing of cancer-related genes in nasopharyngeal carcinoma identifies mutations in the TGF-β pathway. Cancer Medicine. 2019 July; 8:5117-5127.
  • Lee SH, Chang PH, Chen PT, Lu CH, Hung YS, Tsang NM, Hung CY, Chen JS, Hsu HC, Chen YY, Chou WC. Association of time interval between cancer diagnosis and initiation of palliative chemotherapy with overall survival in patients with unresectable pancreatic cancer. Cancer Med. 2019 Jul;8(7):3471-3478.
  • Hsieh CE, Venkatesulu BP, Lee CH, Hung SP, Wong PF, Aithala SP, Kim BK, Rao A, Tung-Chieh Chang J, Tsang NM, Wang CC, Lee CC, Lin CC, Tseng JH, Chou WC, Wang YC, Krishnan S, Hong JH. Predictors of Radiation-Induced Liver Disease in Eastern and Western Patients With Hepatocellular Carcinoma Undergoing Proton Beam Therapy. Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):73-86
  • Liu KH, Hung CY, Hsueh SW, Chang PH, Chen YY, Lu CH, Chen PT, Yeh KY, Huang PW, Tsang NM, Hung YS, Chou WC. Lung Metastases in Patients with Stage IV Pancreatic Cancer: Prevalence, Risk Factors, and Survival Impact. J Clin Med.2019 Sep 6;8(9).
  • Chung AK, Ou Yang CN, Liu H, Chao M, Luo JD, Lee CY, Lu YJ, Chung IC, Chen LC, Wu SM, Tsang NM, Chang KP, Hsu CL, Li HP, Chang YS. Targeted sequencing of cancer-related genes in nasopharyngeal carcinoma identifies mutations in the TGF-β pathway. Cancer Med. 2019 Sep;8(11):5116-5127.
  • Hsueh SW, Liu KH, Hung CY, Kuo YC, Tsai CY, Hsu JT, Hung YS, Tsang NM, Chou WC. Significance of the Glasgow Prognostic Score in Predicting the Postoperative Outcome of Patients with Stage III Gastric Cancer. J Clin Med. 2019 Sep 12;8(9).
  • Chung IC, Chen LC, Tsang NM, Chuang WY, Liao TC, Yuan SN, Ou Yang CN, Ojcius DM, Wu CC, Chang YS. Mitochondrial oxidative phosphorylation complex regulates NLRP3 inflammasome activation and predicts patient survival in nasopharyngeal carcinoma. Mol Cell Proteomics. 2019 Nov 13.
  • Hung SP, Huang BS, Hsieh CE, Lee CH, Tsang NM, Chang JT, Chen JS, Chou WC, Tseng JH, Hong JH. Clinical Outcomes of Patients With Unresectable Cholangiocarcinoma Treated With Proton Beam Therapy. Am J Clin Oncol. 2019 Nov 21.

First or corresponding authorship since 2015: [non-SCI]

  • 吳燿宇、張東杰、林倩伃、范綱行、黃炳勝、洪宗民、謝承恩、
    曾雁明*.(2018) 治療前淋巴球數量為頭頸癌患者的預後因子。放射治療與腫瘤學雜誌 第二十五卷第一期第1-12頁。
  • Wing-Keen Yap, Ming-Chieh Shih, Chin Kuo, Ping-Ching Pai, Wen-Chi Chou, Kai-Ping Chang, Mu-Hung Tsai, Ngan Ming Tsang*, Development and Validation of a Nomogram for Assessing Survival in Patients With Metastatic Lung Cancer Referred for Radiotherapy
    for Bone Metastases JAMA Network Open. 2018 Oct 3242

Co authorship since 2015: [non-SCI]

  • 謝承恩、林倩伃*、李麗玉、王宏銘、張東杰、范綱行、黃炳勝、廖俊達、閻紫宸、方谷豪、曾雁明。(2015)手術後單純放射線治療與同步放化療對唾液腺癌之長期預後比較。放射治療與腫瘤學雜誌 第二十二卷第二期第189-101頁。
  • Wang HM, Lin TL, Kuo YC, Li HP, Chang KP, Lin CY, Fan HC, Lin AC, Hsieh CH, Tsang NM, Lee LY, Chan SC, Lui KW, Chang YS, Hsu CL*. Correlation between overall survival and differential plasma and tissue tumor marker expression in nasopharyngeal carcinoma patients with different sites of organ metastasis. Oncotarget. 2016 Aug 16;7(33):53217-53229. 
  • 廖俊凱、葉建裕*、曾雁明、林耕平、唐瑞平、江支銘、游耀東、謝寶秀、蔡文司、洪欣園、游正府、蔣昇甫、賴正洲、陳進勛。(2017) 手術前長程化學與放射治療較手術前短程放射治療對於第三期直腸癌病患的無病存活率有顯著的改善。中華民國大腸直腸外科醫學會雜誌 第二十八期第18-26頁。

Chapter: 

Hao, S-P & Tsang N-M. (2009) Nasopharyngeal carcinoma. In Petruzzelli G. (Ed.), Practical Head and Neck Oncology. (pp. 175-190). Plural Publishing, San Diego, USA.