張東杰

職稱 主治醫師  
專長
鼻咽癌治療及研究
頭頸部腫瘤治療及研究
上消化道腫瘤治療及研究
顱外放射手術
臨床放射腫瘤學
癌症病患生活品質之研究
醫療經濟及醫療成本效益之研究
放射腫瘤近接治療
腫瘤生物學
自由基和癌症生成與預後之關係
乳癌腫瘤治療及研究
學歷
台北醫學院醫學系畢業
長庚大學醫務管理研究所畢業
經歷
長庚醫院林口醫學中心 教授、主治醫師
長庚大學醫學院 兼任教授
林口長庚醫院放射腫瘤科主任
參與學會
中華民國放射腫瘤學會
中華民國放射線醫學會
中華民國臨床腫瘤學會
中華民國癌症醫學會
中華民國放射物理學會
台灣醫學會
美國放射腫瘤學會
美國癌症研究學會
歐洲放射腫瘤學會
發表論文

Publications(*Corresponding author)

  • Chiang CH, Wu CC, Lee LY, Li YC, Liu HP, Hsu CW, Lu YC, Chang JT*, Cheng AJ*. (2016, 9) Proteomics Analysis Reveals Involvement of Krt17 in Areca Nut-Induced Oral Carcinogenesis. J Proteome Res. 15(9):2981-97. doi: 10.1021/acs.jproteome.6b00138. Epub 2016 Aug 4. (共同指導作者)
  • Huang BS, Chen WY, Hsieh CE, Lin CY, Lee LY, Fang KH, Tsang NM, Kang CJ, Wang HM, Chang JT*. (2016, 9) Outcomes and prognostic factors for surgery followed by modern radiation therapy in parotid gland carcinomas. Jpn J Clin Oncol. 46(9):832-8. doi: 10.1093/jjco/hyw067. Epub 2016 Jun 17.
  •  Li YC, Chang JT, Chiu C, Lu YC, Li YL, Chiang CH, You GR, Lee LY, Cheng AJ*. (2016, 5) Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells. Mol Carcinog. 55(5):1012-23. doi: 10.1002/mc.22344. Epub 2015 Jun 18. (共同第一作者)
  •  Wang HM, Lin CY, Hsieh CH, Hsu CL, Fan KH, Chang JT, Huang SF, Kang CJ, Liao CT, Ng SH, Yen TC. (2016, 4) Induction chemotherapy with dose-modified docetaxel, cisplatin, and 5-fluorouracil in Asian patients with borderline resectable or unresectable head and neck cancer. J Formos Med Assoc. 2016 Apr 25. pii: S0929-6646(16)30015-8. doi: 10.1016/j.jfma.2016.03.005. [Epub ahead of print]
  •  Adel M, Tsao CK, Wei FC, Chien HT, Lai CH, Liao CT, Wang HM, Fan KH, Kang CJ, Chang JT, Huang SF. (2016, 4) Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma. Medicine (Baltimore). 2016 Apr;95(14):e3149.doi: 10.1097/MD.0000000000003149.
  • Lu YC, Chang JT, Chan EC, Chao YK, Yeh TS, Chen JS, Cheng AJ*. (2016, 3) miR-196, an emerging cancer biomarker for digestive tract cancers. J Cancer. 7(6):650-5. doi: 10.7150/jca.13460. eCollection 2016. (共同第一作者)
  • Hsieh CE, Lin CY, Lee LY, Yang LY, Wang CC, Wang HM, Chang JT, Fan KH, Liao CT, Yen TC, Fang KH, Tsang YM*. (2016, 3) Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study. Radiat Oncol. 2016 Mar 22;11(1):47. doi: 10.1186/s13014-016-0617-7.
  • Chen SH, Wang HM, Lin CY, Chang JT, Hsieh CH, Liao CT, Kang CJ, Yang LY, Yen TC. (2016, 2) RGD-K5 PET/CT in patients with advanced head and neck cancer treated with concurrent chemoradiotherapy: Results from a pilot study. Eur J Nucl Med Mol Imaging. 2016 Feb 27. [Epub ahead of print]
  • Ng SH, Liao CT, Lin CY, Chan SC, Lin YC, Yen TC, Chang JT, Ko SF, Fan KH, Wang HM, Yang LY, Wang JJ. (2016, 2) Dynamic contrast-enhanced MRI, diffusion-weighted MRI and 18F-FDG PET/CT for the prediction of survival in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiation. Eur Radiol. 2016 Feb 24. [Epub ahead of print]
  • Tsang NM, Pai PC*, Chuang CC, Chuang WC, Tseng CK, Chang KP, Yen TC, Lin J, Chang JT. (2016, 1) Overweight and obesity predict better overall survival rates in cancer patients with distant metastases. Cancer Med. 2016 Jan 26. doi: 10.1002/cam4.634. [Epub ahead of print]
  • Wang HM, Cheng NM, Lee LY, Fang YH, Chang JT, Tsan DL, Ng SH, Liao CT, Yang LY, Yen TC. (2016, 2) Heterogeneity of (18) F-FDG PET combined with expression of EGFR may improve the prognostic stratification of advanced oropharyngeal carcinoma. Int J Cancer. 138(3):731-8. doi: 10.1002/ijc.29811. Epub 2015 Sep 1.
  • 12. Lee LA, Huang CG, Tsao KC, Liao CT, Kang CJ, Chang KP, Huang SF, Chen IH, Fang TJ, Li HY, Yang SL, Lee LY, Hsueh C, Lin CY, Fan KH, Chang TC, Wang HM, Ng SH, Yen TC. (2015, 11) Human Papillomavirus Infections are Common and Predict Mortality in a Retrospective Cohort Study of Taiwanese Patients With Oral Cavity Cancer. Medicine (Baltimore). 94(47):e2069. doi: 10.1097/MD.0000000000002069.
  • Liao CT, Fan KH, Kang CJ, Lin CY, Chang JT, Tsang NM, Huang BS, Chao YK, Lee LY, Hsueh C, Wang HM, Liau CT, Hsu CL, Hsieh CH, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Yen TC. (2015, 9) Clinical Outcomes of Patients with Resected Oral Cavity Cancer and Simultaneous Second Primary Malignancies. PLoS One. 10(9): e0136918.
  • Lee LY, Chen YJ, Lu YC, Liao CT, Chen IH, Chang JT*, Huang YC, Chen WH, Huang CC, Tsai CY, Cheng AJ*. (2015, 9) Fascin is a circulating tumor marker for head and neck cancer as determined by a proteomic analysis of interstitial fluid from the tumor microenvironment. Clin Chem Lab Med. 2015 Mar 10. Clin Chem Lab Med. 53(10):1631-41. doi: 10.1515/cclm-2014-1016.
  •  Hsu YP, Hsieh CH, Chien HT, Lai CH, Tsao CK, Liao CT, Kang CJ, Wang HM, Chang JT, Huang SF. (2015, 8) Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma. World J Surg Oncol. 21;13:253. doi: 10.1186/s12957-015-0656-9.
  • Chen SC*, Lai YH, Huang BS, Lin CY, Fan KH, Chang JT. (2015, 6) Changes and predictors of radiation-induced oral mucositis in patients with oral cavity cancer during active treatment. Eur J Oncol Nurs. 19(3):214-9.
  • Cheng NM*, Fang YH, Lee LY, Chang JT, Tsan DL, Ng SH, Wang HM, Liao CT, Yang LY, Hsu CH, Yen TC. (2015, 3) Zone-size nonuniformity of 18F-FDG PET regional textural features predicts survival in patients with oropharyngeal cancer. Eur J Nucl Med Mol Imaging. 42(3):419-28.
  • Lu YC, Chang JT, Huang YC, Huang CC, Chen WH, Lee LY, Huang BS, Chen YJ, Li HF, Cheng AJ*. (2015, 2) Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. Clin Biochem. 48(3):115-21. (共同第一作者)
  • Huang SF, Chang JT, Liao CT, Kang CJ, Lin CY, Fan KH, Wang HM, Chen IH. (2015, 1) The role of elective neck dissection in early stage buccal cancer. Laryngoscope. 125(1):128-33.
  • Ng SH, Lin CY, Chan SC, Lin YC, Yen TC, Liao CT, Chang JT, Ko SF, Wang HM, Chang CJ, Wang JJ. (2014, 12) Clinical Utility of Multimodality Imaging with Dynamic Contrast-Enhanced MRI, Diffusion-Weighted MRI, and 18F-FDG PET/CT for the Prediction of Neck Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiation. PLoS One. 9(12):e115933.
  •  Huang CG, Lee LA, Tsao KC, Liao CT, Yang LY, Kang CJ, Chang KP, Huang SF, Chen IH, Yang SL, Lee LY, Hsueh C, Chen TC, Lin CY, Fan KH, Chang TC, Wang HM, Ng SH, Yen TC. (2014, 10) Human papillomavirus 16/18 E7 viral loads predict distant metastasis in oral cavity squamous cell carcinoma. J Clin Virol. 61(2):230-6.
  •  Lu YC, Chang JT, Liao CT, Kang CJ, Huang SF, Chen IH, Huang CC, Huang YC, Chen WH, Tsai CY, Wang HM, Yen TC, You GR, Chiang CH, Cheng AJ*. (2014, 9) OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Mol Cancer. 19;13:218. (共同第一作者)
  • Wang HM, Hsu CL, Hsieh CH, Fan KH, Lin CY, Chang JT, Huang SF, Chen IH, Liao CT, Ng SK. (2014, 5-6) Concurrent chemoradiotherapy using cisplatin, tegafur, and leucovorin for advanced squamous cell carcinoma of the hypopharynx and oropharynx. Biomed J. 37(3):133-40.
  • Chen SC*, Lai YH, Liao CT, Huang BS, Lin CY, Fan KH, Chang JT. (2014, 5) Unmet supportive care needs and characteristics of family caregivers of patients with oral cancer after surgery. Psychooncology. 23(5):569-77.
  • Hung TM, Chen CC, Lin CY, Ng SH, Kang CJ, Huang SF, Liao CT, Fan KH, Wang HM*, Chang JT*. (2014, 3) Prognostic value of prepontine cistern invasion in nasopharyngeal carcinoma treated by intensity-modulated radiotherapy. Oral Oncol. 50(3):228-33.
  • Fan KH, Lin CY, Kang CJ, Lee LY, Huang SF, Liao CT, Chen IH, Ng SH, Wang HM, Chang JT*. (2014, 2) Postoperative concomitant chemoradiotherapy improved treatment outcomes of patients with oral cavity cancer with multiple-node metastases but no other major risk factors. PLoS One. 9(2):e86922.
  •  Fang HY, Huang XY, Chien HT, Chang JT, Liao CT, Huang JJ, Wei FC, Wang HM, Chen IH, Kang CJ, Huang SF*. (2013, 11) Refining the role of preoperative C-reactive protein by neutrophil/lymphocyte ratio in oral cavity squamous cell carcinoma. Laryngoscope. 123(11):2690-9.
  • Chiu CC, Lee LY, Li YC, Chen YJ, Lu YC, Li YL, Wang HM, Chang JT*, Cheng AJ*. (2013, 11) Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype. Cancer Gene Ther. 20(11):606-15.
  • Chan SC, Kuo WH, Wang HM, Chang JT, Lin CY, Ng SH, Hsu CL, Chang KP, Liao CT, Lin YJ, Yen TC. (2013, 10) Prognostic implications of post-therapy 18F-FDG PET in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. Ann Nucl Med. 27(8):710-9.
  • Cheng NM, Fang YH, Chang JT, Huang CG, Tsan DL, Ng SH, Wang HM, Lin CY, Liao CT, Yen TC*. (2013, 10) Textural features of pretreatment 18F-FDG PET/CT images: prognostic significance in patients with advanced T-stage oropharyngeal squamous cell carcinoma. J Nucl Med. 54(10):1703-9.
  • Hsieh CH, Hsu CL, Wang CH, Liaw CC, Chen JS, Chang HK, Yang TS, Chang JW, Lin YC, Liau CT, Tsang NM, Chang JT, Ng SH, Wang HM. (2013, 9~10) Cisplatin, tegafur-uracil and leucovorin plus mitomycin C: an acceptably effective and toxic regimen for patients with recurrent or metastatic nasopharyngeal carcinoma. Biomed J. 36(5):229-36. (非SCI)
  • Ng SH, Lin CY, Chan SC, Yen TC, Liao CT, Chang JT, Ko SF, Wang HM, Huang SF, Lin YC, Wang JJ. (2013, 8) Dynamic Contrast-Enhanced MR Imaging Predicts Local Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiotherapy. PLoS One. 8(8):e72230.
  • Chen SC, Lai YH, Liao CT, Chang JT, Lin CY, Fan KH, Huang BS. (2013, 6) Supportive care needs in newly diagnosed oral cavity cancer patients receiving radiation therapy. Psychooncology. 22(6):1220-8.
  • Chen YJ, Lee LY, Chao YK, Chang JT, Lu YC, Li HF, Chiu CC, Li YC, Li YL, Chiou JF, Cheng AJ. PLoS One. (2013, 5). DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway. PLoS One. 30;8(5):e64088.
  • Le QT, Zhang Q, Cao H, Cheng AJ, Pinsky BA, Hong RL, Chang JT, Wang CW, Tsao KC, Lo YD, Lee NY, Ang KK, Chan AT, Chan KA. (2013.04) An International Collaboration to Harmonize the Quantitative Plasma Epstein-Barr Virus (EBV) DNA Assay for Future Biomarker-Guided Trials in Nasopharyngeal Carcinoma. Clin Cancer Res 2013, 19: 2208-2015. doi: 10.1158/1078-0432.CCR-12-3702. pMID: 23459720.
  • Hung TM, Wang HM, Kang CJ, Huang SF, Liao CT, Chan SC, Ng SH, Chen IH, Lin CY, Fan KH, Chang JT*. (2013, 2) Pretreatment (18)F-FDG PET standardized uptake value of primary tumor and neck lymph nodes as a predictor of distant metastasis for patients with nasopharyngeal carcinoma. Oral Oncol. 2012 Oct 11. 49(2):169-74.
  • Tsan DL, Lin CY, Kang CJ, Huang SF, Fan KH, Liao CT, Chen IH, Lee LY, Wang HM, Chang JT*. (2012,12) The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity. Radiat Oncol. 18;7(1):215.
  • Cheng NM, Chang JT, Huang CG, Tsan DL, Ng SH, Wang HM, Liao CT, Lin CY, Hsu CL, Yen TC. (2012, 11) Prognostic value of pretreatment (18)F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma. Eur J Nucl Med Mol Imaging. 39(11):1673-84.(共同第一作者)
  • Huang SF, Li HF, Liao CT, Wang HM, Chen IH, Chang JT, Chen YJ, Cheng AJ. (2012, 11) Association of HPV infections with second primary tumors in early-staged oral cavity cancer. Oral Dis. 18(8):809-15.
  • Luo CM, Fang TJ, Lin CY, Chang JT, Liao CT, Chen IH, Li HY, Chiang HC. (2012, 9) Transoral Laser Microsurgery Elevates Fundamental Frequency in Early Glottic Cancer. J Voice. 26(5):596-601.
  • Tsai JP, Lee MH, Hsu SC, Chen MY, Liu SJ, Chang JT, Liao CT, Cheng AJ, Chong P, Chu CL, Shen CR, Chen HW. (2012, 08) CD4+ T Cells Disarm or Delete Cytotoxic T Lymphocytes under IL-17-Polarizing Conditions. J Immunol. 15;189(4):1671-9.
  • Pai PC, Chuang CC, Tseng CK, Tsang NM*, Chang KP, Yen TC, Liao CT, Hong JH, Chang JT. (2012, 05) Impact of Pretreatment Body Mass Index on Patients With Head-and-Neck Cancer Treated With Radiation. Int J Radiat Oncol Biol Phys. 1;83(1):e93-e100.
  • Lu YC, Chen YJ, Wang HM, Tsai CY, Chen WH, Huang YC, Fan KH, Tsai CN, Huang SF, Kang CJ, Chang JT*, Cheng AJ*. (2012, 04) Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling. Cancer Prev Res. 5(4):665-74.
  • Chan SC, Chang JT, Lin CY, Ng SH, Wang HM, Liao CT, Chang CJ, Lin SY, Yen TC. (2011, 11) Clinical utility of 18F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification. Nucl Med Commun. 32(11):989-96.
  •  Lin CY, Lin TY, Wang HM, Huang SF, Fan KH, Liao CT, Chen IH, Lee LY, Li YL, Chen YJ, Cheng AJ*, Chang JT*. (2011, 10) GP96 is over-expressed in oral cavity cancer and is a poor prognostic indicator for patients receiving radiotherapy. Radiat Oncol. 12;6(1):136.
  •  Chiu CC, Lin CY, Lee LY, Chen YJ, Lu YC, Wang HM, Liao CT, Chang JT*, Cheng AJ*. (2011, 7) Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer. Clin Cancer Res. 17(14):4629-41.
  • Ng SH, Chan SC, Yen TC, Liao CT, Lin CY, Tung-Chieh Chang J, Ko SF, Wang HM, Chang KP, Fan KH. (2011, 6) PET/CT and 3-T whole-body MRI in the detection of malignancy in treated oropharyngeal and hypopharyngeal carcinoma. Eur J Nucl Med Mol Imaging. 38(6):996-1008.
  • Chen SC, Lai YH*, Cheng SY, Liao CT, Chang JT. (2011, 5) Psychometric testing of the Chinese-version cancer needs questionnaire short form head and neck cancer-specific version in oral cavity cancer patients. Support Care Cancer. 19(5):647-56.
  • Chen SC*, Liao CT, Chang JT. (2011, 2) Orofacial pain and predictors in oral squamous cell carcinoma patients receiving treatment. Oral Oncol. 47(2):131-5.
  • Chen YJ, Liao CT, Chen PJ, Lee LY, Li YC, Chen IH, Wang HM, Chang JT, Chen LJ, Yen TC, Tang CY, Cheng AJ. (2011, 2) Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract. Head Neck, 33(2):257-66.

  Oral and poster presentations

  • Joseph JT (2014, 04) The Health Related Quality of Life For Hypopharyngeal And Laryngeal Cancer Patients Received Organ Preservation Treatment, 33th ESTRO. Vienna, Austria.
  • Joseph JT (2012, 10) The Health Related Quality of Life For Hypopharyngeal And Laryngeal Cancer Patients Received Organ Preservation Treatment, ASTRO. Boston, USA.
  • Joseph JT (2012, 02) Hypopharyngeal cancer management – non surgical approach. Head and Neck Cancer Combined Conference among Taipei Medical University Hospital, Wan-Fang Hospital, Koo Foundation Sun-Yat-Sen Cancer Center, Mackay Memorial Hospital and Shuang Ho Hospital.
  • Joseph JT (2011, 11) IMRT experience for H&N cancer. The First Annual Meeting of the Taiwan Society therapeutic Radiology and Oncology (TASTRO) and Taiwan-American Radiation Oncology Society (TAROS).
  • Joseph JT (2011, 9) The Treatment Result of Advanced Stage Oropharyngeal Cancer by Radiotherapy with or without Chemotherapy – The impact intensity modulation radiotherapy and FDG-PET. ECCO, Stockholm, Sweden.
  • Joseph JT (2011, 7) Radiotherapy for oral cavity cancer – The Taiwan experience. The 3rd World Congress of the IAOO. Singapore.
  • Joseph JT (2011, 5) The treatment result of advanced stage oropharyngeal cancer by radiotherapy with or without chemotherapy – the impact intensity modulation radiotherapy and FDG-PET. 第十六屆台灣癌症聯合學術年會,台北。
  • Joseph JT (2010, 10) Development of a computerized outcome assessment tool for head and neck cancer patients. The 17th Annual Conference of the International Society for Quality of Life Research. London, UK.
  • Joseph JT (2010, 5) The Benefit of Eicosapentaenoic Acid in Nasopharyngeal Cancer Patients Receiving Concurrent Chemoradiotherapy in Outpatient Clinic – an Open Label Prospective Randomized Trial. 第十五屆台灣癌症聯合學術年會,台北。
  • Joseph JT (2010, 4) The Benefit of Eicosapentaenoic Acid in Nasopharyngeal Cancer Patients Receiving Concurrent Chemoradiotherapy in Outpatient Clinic – an Open Label Prospective Randomized Trial. Istanbul, Turkey.
  • Joseph JT (2010, 1) Radiotherapy for NPC-Past, Present, and Future. What we can do more? 放射腫瘤醫學會月會,台中。