林口長庚醫院放射腫瘤科教授級主治醫師
長庚大學部定教授

指導住院醫師發表論文『侵襲性直腸癌接受術前短程放射治療與長程化學與放射治療的結果』榮獲2009年“放射治療與腫瘤學”雜誌優良論文獎。

以「確保強度調控放射治療正確性以降低潛在錯誤風險」的主題，參加由醫策會主辦的2011年第12屆醫療品質獎(HQIC) ，獲得主題改善進階組『銀獎』。

帶領嘉義長庚醫院癌症中心團隊，參加2020年第21屆國家醫療品質，榮獲「系統類特色中心」殊榮。

• Chen WC, Hsu CM, Tsai YT, Lin MH, Tsai MS, Chang GH, Lai CH, Fang F, Chen MF*. Prospective Evaluation of Taste Function in Patients With Head and Neck Cancer Receiving Intensity-Modulated Radiotherapy. JAMA Otolaryngol Head and Neck Surgery. 2022 Jul; 148(7):604-611.
• Huang WS, Kuan FC, Lin MH, Chen MF, Chen WC*. Prognostic Significance of Neoadjuvant Rectal Scores in Preoperative Short-Course Radiotherapy and Long-Course Concurrent Chemoradiotherapy for Patients with Locally Advanced Rectal Cancer. Ann Surg Oncol. 2020 Oct;27(11):4309-4318. (*corresponding author) 
  
• Tsai YT, Chen WC†, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP. Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma. World J Surg Oncol. 2020 May 1;18(1):82. (†co-first author)
  
• Chen WC, Tsai MS, Tsai YT, Lai CH, Lee CP, Chen MF. Long-term taste impairment after intensity-modulated radiotherapy to treat head-and-neck cancer: correlations with glossectomy and the mean radiation dose to the oral cavity. Chemical Senses, 2019 May 29;44(5):319-326.
  
• Tsai MS, Chen WC†, Lai CH, Chen YY, Chen MF. Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer. Oral Oncology 2017 Oct;73: 88-96. (†co-first author) 
  
• Chen MF, Chen PT, Lu MS, Lee CP, Chen WC*. Survival benefit of surgery to patients with esophageal squamous cell carcinoma. Scientific Reports. 2017 Apr 6;7:46139.
  
• Chen WC, Lai CH, Chuang HC, Lin PY, Chen MF. Inflammation-induced myeloid-derived suppressor cells associated with squamous cell carcinoma of the head and neck. Head And Neck-Journal for the Sciences and Specialties of the Head and Neck. 2017 Feb;39(2):347-355.
  
• Tsai MS, Lai CH, Lee CP, Yang YH, Chen PC, Kang CJ, Chang GH, Tsai YT, Lu CH, Chien CY, Young CK, Fang KH, Liu CJ, Yeh RA, Chen WC* Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD. PeerJ. 2016 Dec 15;4:e2794.
  
• Chen WC*, Lai CH, Fang CC, Yang YH, Chen PC, Lee CP, Chen MF. Identification of High-Risk Subgroups of Patients With Oral Cavity Cancer in Need of Postoperative Adjuvant Radiotherapy or Chemo-Radiotherapy. Medicine. 2016, 95(22):e3770.
  
• Wu CT, Yang YH, Chen PC, Chen MF, Chen WC*. Androgen deprivation increases the risk of fracture in prostate cancer patients: a population-based study in Chinese patients. Osteoporosis International. 2015, 26(9):2281-90.
  
• Lai CH, Chen MF, Fang FM, Chen WC*. Estimation of life expectancy and quality-adjusted life expectancy in non-metastatic nasopharyngeal cancer patients treated by intensity-modulated radiotherapy with or without chemotherapy. Oral Oncology. 2014, 50(7):646-50.
  
• Chen WC*, Chen MF, Lin PY. Significance of DNMT3b in oral cancer. PLOS ONE. 2014, 9(3):e89956.
  
• Chen MF, Yang YH, Lia CH, Chen PC, Chen WC*. Outcome of Patients with Esophageal Cancer: A Nationwide Analysis. Annals of Surgical Oncology. 2013, 20(9):3023-30.
  
• Chen WC, Lai CH, Lee TF, Hung CH, Liu KC, Tsai MF, Wang WH, Chen HC, Fang FM, Chen MF*. Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: Correlations with parotid dose and quality of life. Oral Oncology. 2013, 49(1):42-48.
  
• Yeh CH, Chen MF, Lai CH, Huang WS, Lee SP, Chen WC*. Comparison of treatment results between surgery alone, preoperative short-course radiotherapy, or long-course concurrent chemoradiotherapy in locally advanced rectal cancer. International Journal of Clinical Oncology. 2012, 17(5):482-490.
  
• Chen MF, Wang WH, Lin PY, Lee KD, Chen WC*. Significance of the TGF-beta1-IL-6 axis in oral cancer. Clinical Science (Lond). 2012, 11(10): 459-472.
  
• Chen CC, Chen WC†, Wang WH, Lu CH, Lin PY, Lee KD, Chen MF*. Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance. Head And Neck-Journal for the Sciences and Specialties of the Head and Neck, 2011, 33(8):1132-1143 (†co-first author).
  
• Chen CC, Chen WC†, Lu CH, Wang WH, Lin PY, Lee KD, Chen MF*. Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor. International Journal of Radiation Oncology Biology Physics, 2010, 76(4):1214-1224 (†co-first author).
  
• Chen WC, Hwang TZ, Wang WH, Lu CH, C.C. Chen, C.M. Chen, H.H. Weng, C.H. Lai, *M.F. Chen. Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in term of treatment results and toxicities. Oral Oncology, 2009, 45(6):505-510. 
  
• Chen MF, Lee KD, Lu MS, Chen CC, Hsieh MJ, Liu YH, Lin PY, Chen WC*. The predictive role of E2-EPF ubiquitin carrier protein in esophageal squamous cell carcinoma. Journal of Molecular Medicine-JMM, 2009, 87(3):307-320.
  
• Chen MF, Tseng CJ, Tseng CC, Yu CY, Wu CT, Chen WC*. Adjuvant concurrent chemoradiotherapy with intensity-modulated pelvic radiotherapy after surgery for high-risk, early stage cervical cancer patients. Cancer Journal, 2008, 14(3):200-206.
  
• Chen MF, Tseng CJ, Tseng CC, Kuo YC, Yu CY, Chen WC*. Clinical outcome in posthysterectomy cervical cancer patients treated with concurrent Cisplatin and intensity-modulated pelvic radiotherapy: comparison with conventional radiotherapy. International Journal of Radiation Oncology Biology Physics, 2007, 67(5):1438-1444.
  
• Chen MF, Keng PC , Wu CT, Mazzatti DJ, Hu YC, Liao SK and Chen WC*.Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. International Journal of Radiation Oncology Biology Physics, 2006, 64(2):581-591.
  
• Chen MF, Keng PC, Lin PY, Liao SK, Wu CT, Chen WC*.Differential effects of caffeic acid phenethyl ester for normal lung and lung cancer treated with irradiation: in vitro and in vivo study. BMC Cancer, 2005, 9(5):158.
  
• Chen WC, McBride WH, Chen SM, Lee KF, Hwang TZ, Jung SM, Shau H, Liao SK, Hong JH and Chen MF. Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: Clinical and in vitro studies. Head And Neck-Journal for the Sciences and Specialties of the Head and Neck, 2005, 27(6):503-512.
  
• Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC*. Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. Journal of Radiation Research, 2004, 45(2):253-60.
  
• Chen MF, Chang JT, Tsang NM, Chen WC*. The role of radiotherapy in the treatment of early stage glottic cancer. Annals of Otology Rhinology and Laryngology, 2003, 112(10):904-911.
  
• Chen WC, Liaw CC, Chunag CK, Chen MF, Chen CS, Lin PY, Chang PL, Chu SH, Wu CT and Hong JH. Concurrent cisplatin, 5-fluorouracil, leucovorin and radiotherapy for invasive bladder cancer. International Journal of Radiation Oncology Biology Physics, 2003, 56(3):726-733.
  
• Chang CN, Chen WC*, Wei KC, Ng SH, Ho YS, Huang DYC, Lee SPH, Hong JH. High-dose-rate sterotactic brachytherapy for patients with newly diagnosed glioblastoma multiformes Journal of Neuro-Oncology, 2003, 61(1):45-55.
  
• Chen WC, McBride WH, Iwamoto KS, Barber CL, Wang CC, Oh YT, Liao YP, Hong JH, Vellis Jde and Shau H. Induction of Radioprotective peroxiredoxin-I by ionizing irradiation. Journal of Neuroscience Research, 2002, 70(6), 794-798.
  
• Chen WC, Liao CT, Tsai HC, Yeh JY, Wang CC, Tang SG and Hong JH. Radiation-induced hearing impairment in patients treated for malignant parotid tumor. Annals of Otology Rhinology and Laryngology, 1999, 108(12):1159-1164.
  
• Chen WC, Chen LH, Leung WM, Tang SG, Tsai MH, Liao CT and See LC. Comparison of radiotherapy and surgical results of early stage glottic cancer: a retrospective analysis. Journal of the Formosan Medical Association, 1993, 92(12):1076-1083.