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撰稿者:腫瘤醫學研究中⼼ ⾼詩涵博⼠ 校稿者:癌症基因體研究中⼼ 吳國瑞教授
‣圖表2
DDX17 is polyubiquitinated by HectH9 via K63-linkage,
and K190R reduces tumor stem-like properties.
(A) Schematic representation of the experimental procedure of
immunoprecipitation using Flag-tagged K63-specific tandem ubiquitin-binding
entity (K63-specific TUBEs)
(B) Pie chart showing GO annotation for K63-ubiquitinated targets using
DAVID functional annotation tool.
(C) Representative pictures of tumor sphere formation of DDX17-WT or DDX17-
K190R clones in H1299 and FaDu.
(D) Number of tumor sphere formation activity of WT or K190R clones
measured by primary, secondary, and tertiary spheres. P < 0.05.
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