Page 45 - @林口醫研部201909電子報
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頂尖論⽂
撰稿者:肝臟研究中⼼ 朱育德博⼠ 校稿者:肝臟研究中⼼ 葉昭廷主任
‣期刊及主題
HEPATOLOGY, 2019 May.
Emergence of Oncogenic-Enhancing Hepatitis B Virus X
Gene Mutants in Patients Receiving Suboptimal
Entecavir Treatment.
(於接受⾮優化⾙樂克治療患者中發現致癌性增強的⼄肝病毒X基因突變)
IF= 14.079
Ranking: 6.25%
‣作者
林志郎醫師 1,2,3,* , 朱育德博⼠ , 葉昭廷醫師 3,4
4,*
(*此⼆作者為共同第⼀作者)
1 基隆⾧庚肝臟研究室
2 基隆⾧庚社區醫學研究中⼼
3 ⾧庚⼤學分⼦醫學研究中⼼
4 林⼝⾧庚肝臟研究中⼼
‣研究⺫的背景
To examine whether oncogenic-enhancing HBx mutants emerged in
entecavir-treated patients having suboptimal response.
‣研究發現與應⽤
Detection of novel hepatocarcinogenesis-promoting HBx mutants in
entecavir-treated patients with suboptimal response could alter our current
clinic practice so as to achieve complete virological response whenever
possible.
Department of Medical Research & Development, Linkou Newsletter 45
