Page 54 - @林口醫研部201912電子報
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‣圖表A


















































                      PLA2G6     D331Y/D331Y  knockin mice exhibit early-onset and progressive
                                                parkinsonism phenotypes.



                    (A) PLA2G6   D331Y/D331Y  KI mice display neuronal death of SNpc dopaminergic

                    cells.
                    (B) Lewy body pathology is found in the substantia nigra o PLA2G6           D331Y/D331Y

                    KI mice at the age of 9 months.
                    (C) PLA2G6   D331Y/D331Y  KI mice display early-onset motor deficits of

                    parkinsonism.
                    (D) Homozygous (D331Y) PLA2G6 mutation leads to mitochondrial

                    dysfunction.













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