Page 58 - @林口醫研部201909電子報
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撰稿者 / 校稿者 : 林⼝⾧庚醫院神經內科 張國軒醫師
‣圖表3
Characterization and neuronal differentiation of AD-iPSCs.
Treatment with indole compound NC009-1 improved AD phenotypes
in AD-iPSC-derived neurons.
(A) Structure, formula, and molecular weight of indole compound
NC009-1. (B) Intracellular and (C) secreted levels of Aβ40 and Aβ42, (D)
GSK3β (serine 9), and (E) tau (threonine 181 and serine 396)
phosphorylation levels. (F) Neurite outgrowth. (G) SYP expression
levels. (H) Caspase 1 activities in AD- (AD1 and AD2) and NC-iPSC-derived
neurons (NC1 and NC2) upon treatment with NC009-1. Data were
normalized to NC1. *p < 0.05 compared to neurons without NC009–1
treatment.
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