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‣圖表2




























                     Increased Aβ accumulation and tau phosphorylation,  as well as
                          impaired neurite outgrowth in AD-iPSC-derived neurons.





















                   Increased Aβ accumulation and tau phosphorylation,  as well as
                        impaired neurite outgrowth in AD-iPSC-derived neurons.



         (A) Increased levels of intracellular and (B) secreted Aβ40 and Aβ42 in AD-

         iPSC-derived neurons (AD1 and AD2) compared to NC-iPSC-derived neurons
         (NC1 and NC2). (C) Expression levels of APP in NC- and AD-iPSC-derived

         neurons. (D) β- and γ-secretase activities in NC- and AD-iPSC-derived neurons.
         (E) Lower levels of GSK3β phosphorylation (P-GSK3β,  serine 9),  and (F)

         higher levels of tau phosphorylation (P-tau,  threonine 181,  and serine 396)
         in AD-iPSC-derived neurons compared to NC-iPSC-derived neurons. (G)

         Reduction of neurite outgrowth. (H) Lower SYP expression levels. (I) Higher
         caspase 1 activities in AD-iPSC-derived neurons compared to NC-iPSC-derived

         neurons. Data were normalized to NC1. *p < 0.05 compared to NC1 and NC2.





          Department of Medical Research & Development,  Linkou Newsletter                                             57
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