Chuang Gung Medical Foundation, Division of Pediatric Allergy, Asthma and Rheumatology - UNREGISTERED VERSION

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Yao TC

About Us > Team Member

Tsung-Chieh Yao, M.D., Ph.D.

1. Attending Physician, Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taiwan
2. Associate Professor, Chung Gung University, Taiwan
3. Physician Scientist, Department of Medical Research and Development, Chung Gung Memorial Hospital, Taiwan
4. Committee, Taiwan Academy of Pediatric Allergy, Asthma, Immunology and Rheumatology, Taiwan

Asthma, allergic rhinitis, atopic dermatitis, urticaria, and rheumatic diseases in children.

Teaching or Professional Positions
1. Associate Professor, Chung Gung University, Taiwan, Mar. 2012 – Present
2. Physician Scientist, Department of Medical Research and Development, Chung Gung Memorial Hospital, Taiwan, Jun. 2012 - Present
3. Visiting Scholar, Department of Human Genetics, University of Chicago, Illinois, United States, Jan. 2010 - Dec. 2011
4. Editorial Board, Pediatrics & Therapeutics: Current Research, 2011 – Present
5. Editorial Board, Case Reports in Pediatrics, 2011 – Present
6. Assistant Professor, Department of Pediatrics, Chang Gung University, Taiwan, Feb. 2007 - Jan. 2012
7. Chief of Pediatric Ward (10th Floor, Building L), Chang Gung Memorial Hospital, Taiwan, Dec. 2007 - Jan. 2010
8. Instructor, Department of Pediatrics, Chang Gung University, Taiwan, Feb. 2005 - Feb. 2007

Professional Memberships
1. Member and Committee, Taiwan Academy of Pediatric Allergy, Asthma, Immunology and Rheumatology
2. Member, Taiwan Pediatric Association
3. Member, Chinese Society of Immunology
4. Member, Rheumatology, R.O.C
5. Member, European Academy of Allergy and Clinical Immunology

Research Interest
1. Searching the genetic markers of childhood asthma, allergy and rheumatic diseases.
2. Prospective cohort study of childhood asthma and associated phenotypes.
3. Investigating the significance of exhaled nitric oxide in asthma and allergic diseases




















1. Yao TC, Hung IJ, Su LH, Chiu CH*. Endogenous endophthalmitis and necrotising pneumonia caused by Klebsiella pneumoniae in a child with beta-thalassaemia major. Eur J Pediatr 2001;160(7):449. (SCI ; IF=1.879 ; Pediatrics 39/113)
2. Yao TC, Hung IJ*, Jaing TH, Yang CP. Pitfalls in the diagnosis of idiopathic pulmonary haemosiderosis. Arch Dis Child 2002;86(6):436-8. (SCI ; IF=2.881 ; Pediatrics 16/113)
3. Yao TC, Hung IJ, Wong KS*, Huang JL, Niu CK. Idiopathic pulmonary haemosiderosis: an oriental experience. J Paediatr Child Health 2003;39(1):27-30. (SCI ; IF=1.281 ; Pediatrics 66/113)
4. Yao TC, Kuo ML, See LC, Chen LC, Yan DC, Ou LS, Shaw CK, Huang JL*. RANTES promoter polymorphism: A genetic risk factor for near-fatal asthma in Chinese children. J Allergy Clin Immunol 2003;111(6):1285-92. (SCI ; IF=11.003; Allergy 1/24)
5. Chiu WJ, Kuo ML, Chen LC, Tsao CH, Yeh KW, Yao TC, Huang JL*. Evaluation of clinical and immunological effects of inactivated influenza vaccine in children with asthma. Pediatr Allergy Immunol 2003;14(6):429-36. (SCI ; IF=2.459 ; Pediatrics 23/113)
6. Yao TC, Wu KC, Chung HT, Shaw CK, Kuo ML, Wu CJ, Huang JL*. MCP-1 gene regulatory region polymorphism in Chinese children with mild, moderate and near-fatal asthma. Allergy 2004;59(4):436-41. (SCI ; IF=6.271 ; Allergy 2/24)
7. Wu KC, Yao TC, Yeh KW, Huang JL*. Osteomyelitis amongst patients suffering systemic lupus erythematosus. J Rheumatol 2004;31(7):1340-3. (SCI ; IF=3.659 ; Rheumatology 11/29)
8. Huang JL*, Yeh CC, Shaw CK, Yao TC, Chen LC, Lee TD, Kuo ML. HLA-DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan. Eur J Immunogenet 2004;31(4):185-8. (now renamed as Int J Immunogenet; SCI ; IF=1.290 ; Genetics & Heredity 127/157)
9. Liao CH, Yao TC, Chung HT, Kuo ML, See LC, Huang JL*. Polymorphisms in the promoter region of RANTES and in the regulatory region of MCP-1 among Chinese patients with Systemic Lupus Erythematosus. J Rheumatol 2004;31(10):2062-7. (SCI ; IF=3.659 ; Rheumatology 11/29)
10. Huang JL, Gao PS, Mathias RA, Yao TC, Chen LC, Kuo ML, Hsu SH, Plunkett B, Togias A, Barnes KC, Stellato C, Beaty TH, Huang SK*. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet 2004;13(21):2691-7. (SCI ; IF=7.636 ; Genetics & Heredity 13/157)
11. Yao TC, Chiu CY, Wu KC, Wu LJ, Huang JL*. Failure to thrive caused by the coexistence of vallecular cyst, laryngomalacia and gastroesophageal reflux in an infant. Int J Pediatr Otorhinolaryngol 2004;68(11):1459-64. (SCI ; IF=1.167 ; Otorhinolaryngology 21/41)
12. Liao CH, Yao TC, Chung HT, Lien RI, Huang JL*. Staphylococcal endocarditis and multiple emboli in a patient with systemic lupus erythematosus: a case report. J Rheumatol 2004;31(11):2305-6. (SCI ; IF=3.659 ; Rheumatology 11/29)
13. Huang JL*, Yao TC, See LC. Prevalence of Pediatric Systemic lupus erythematosus and juvenile chronic arthritis in a Chinese population: a nationwide prospective population based study in Taiwan. Clin Exp Rheumatol 2004;22(6):776-80. (SCI ; IF= 2.148 ; Rheumatology 17/29)
14. Chiu CY, Wong KS*, Yao TC, Huang JL. Asthmatic versus non-asthmatic spontaneous pneumomediastinum in children. Asian Pacific J Allergy Immunol 2005;23(1):19-22. (SCI ; IF=0.649 ; Allergy 17/24)
15. Yao TC, Kuo ML, See LC, Ou LS, Lee WI, Chan CK, Huang JL*. RANTES and monocyte chemoattractant protein-1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six-year longitudinal study. Arthritis Rheum 2006;54(8):2585-93. (SCI ; IF=7.866 ; Rheumatology 3/29)
16. Tsai YC, Hou CL, Yao TC, Chen LC, Jaing TH, Huang JL*. Risk factors and bacterial profiles of urinary tract infections in patients with systemic lupus erythematosus. Asian Pacific J Allergy Immunol 2007;25(2-3):155-61. (SCI ; IF=0.649 ; Allergy 17/24)
17. Tsai YC, Lee WI*, Huang JL*, Hung IJ, Jaing TH, Yao TC, Chen MT, Kuo ML. Neutrophil function and molecular analysis in severe leukocyte adhesion deficiency type I without separation delay of the umbilical cord. Pediatr Allergy Immunol 2008:19(1):25-32. (SCI ; IF=2.459 ; Pediatrics 23/113)
18. Tsai YC, Yao TC, Kuo ML, Cheng TT, Huang JL*. Lack of association of mannose-binding lectin gene polymorphisms with development and clinical manifestations of systemic lupus erythematosus in Chinese children. Lupus 2009;18(4):372-6. (SCI ; IF=2.337 ; Rheumatology 15/29)
19. Yao TC, Tsai YC, Huang JL*. Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis. Arthritis Rheum 2009;60(4):1173-8. (SCI ; IF=7.866 ; Rheumatology 3/29)
20. Chan CK, Kuo ML, Yeh KW, Ou LS, Chen LC, Yao TC, Huang JL*. Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state, acute exacerbation and remission in asthmatic children. J Asthma 2009;46(3):225-8. (SCI ; IF=1.525 ; Allergy 15/24)
21. Yao TC*, Tsai YC, Chiu CY, Huang JL. Viridans streptococcal bacteremia in a previously healthy infant. Pediatr Int 2010;52(2):e108-10. (SCI ; IF=0.626 ; Pediatrics 97/113)
22. Yao TC*, Chang CJ, Hsu YH, Huang JL. Probiotics for allergic diseases: realities and myths. Pediatr Allergy Immunol 2010;21(6):900-19. (SCI ; IF=2.459 ; Pediatrics 23/113)
23. Huang JL, Yeh KW, Yao TC, Huang YL, Chung HT, Ou LS, Lee WI, Chen LC. Pediatric Lupus in Asia. Lupus 2010;19(12):1414-18. (SCI ; IF=2.337 ; Rheumatology 15/29)
24. Chan WH, Chang KP, Yang SW, Yao TC, Ko TY, Lee YS, Tsai CL, Tsai CN. Transcriptional repression of DLEC1 associates with the depth of tumor invasion in oral squamous cell carcinoma. Oral Oncol 2010;46(12):874-9. (SCI ; IF=2.857 ; Dentistry, Oral Surgery & Medicine 8/81)
25. Tu YL, Tsai YC, Huang JL, Yao TC*. Occult pulmonary hemorrhage as a rare presentation of propylthiouracil-induced vasculitis. Pediatrics 2011;127(1):e245-9. (SCI ; IF=5.437 ; Pediatrics 2/113)
26. Yao TC*, Ou LS, Lee WI, Yeh KW, Chen LC, Huang JL*. Exhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study. Clin Exp Allergy 2011;41(4):556-64. (SCI ; IF=5.032 ; Allergy 3/24)
27. Hua MC, Lai MW, Kuo ML, Yao TC, Huang JL*, Chen SM. Decreased interleukin-10 secretion in peripheral blood mononuclear cells of children with irritable bowel syndrome. J Pediatr Gastroenterol Nutr 2011;52(4):376-81. (SCI ; IF=2.298 ; Pediatrics 27/113)
28. Tu YL, Yeh KW, Chen LC, Yao TC, Ou LS, Lee WI, Huang JL*. Differences in disease features between childhood-onset and adult-onset system lupus erythematosus patients with acute abdominal pain. Semin Arthritis Rheum 2010;40(5):447-54. (SCI ; IF=4.969 ; Rheumatology 5/29)
29. Wang CH, Yao TC, Huang YL, Ou LS, Yeh KW, Huang JL*. Acute pancreatitis in pediatric- and adult-onset systemic lupus erythematosus: a comparison and review of the literature. Lupus 2011;20(5):443-52. (SCI ; IF=2.337 ; Rheumatology 15/29)
30. Yao TC*, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL*. Association of age, gender, and BMI with prevalence of allergic diseases in children: PATCH Study. J Asthma 2011;48(5):503-10. (SCI ; IF=1.525 ; Allergy 15/24)
31. Yeh KW, Ou LS, Yao TC, Chen LC, Lee WI, Huang JL*. Prevalence and risk factors for early presentation of asthma among preschool children in Taiwan. Asian Pacific J Allergy Immunol 2011;29(2):120-6. (SCI ; IF=0.649 ; Allergy 17/24)
32. Ober C*, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 2011;242(1):10-30. (SCI ; IF=11.148 ; Immunology 6/139) (Invited review)
33. Tsai YC, Yeh KW, Yao TC, Huang YL, Kuo ML, Huang JL*. Mannose-binding lectin expression genotype in pediatric-onset systemic lupus erythematosus: Associations with susceptibility to renal disease and protection against infections. J Rheumatol 2011;38(7):1429-35. (SCI ; IF=3.695 ; Rheumatology 11/29)
34. Lee WI*, Huang JL, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Hsieh MY, Huang YC, Yu HR, Kuo HC, Yang KD, Jaing TH. Clinical, immunological and genetic features in Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndrome (HIES). Immunobiology 2011;216(8):909-17. (SCI ; IF=3.205 ; Immunology 61/139)
35. Wu SA, Yeh KW, Yao TC, Huang JL*. Association of Herpes Zoster Infection with Clinical Characteristics and MBL2 gene Polymorphisms in Chinese children with Systemic Lupus Erythematosus. Pediatr Infect Dis J 2011;30(8):656-60. (SCI ; IF= 3.577; Pediatrics 7/113)
36. Su CY, Chang WH, Huang JL, Yao TC*. Gastric volvulus manifesting as infantile wheezing: a puzzling presentation. Pediatr Emerg Care 2011;27(8):737-9. (SCI ; IF=0.782 ; Emergency Medicine 16/24)
37. Lee WI*, Huang JL*, Jaing TH, Shyur SD, Yang KD, Chien YH, Chiang BL, Soong WJ, Chiou SS, Shieh CC, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Lin TY, Chiu CH, Huang YC, Wu KH, Lin CY, Yu HH, Yang YH, Yu HR, Yen HJ, Hsieh MY, Kuo ML, Hwu WL, Tsai YC, Kuo HC, Lin YL, Shih YF, Chang KW. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010. Immunobiology 2011;216(12):1286-94. (SCI ; IF=3.205 ; Immunology 61/139)
38. Yao TC, Lee WI, Ou LS, Chen LC, Yeh KW, Huang JL*. Reference values of exhaled nitric oxide in healthy Asian children age 5 to 18 years. Eur Respir J 2012;39(2):378-84. (SCI ; IF=5.895 ; Respiration System 3/48)
39. Chen LC, Tseng HM, Wu CJ, Kuo ML, Wu CJ, Gao PS, Yeh KW, Yao TC, Lee WI, Ou LS, Huang JL, Hung SK*. Evaluation of a common variant of the gene encoding clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children. J Asthma 2012;49(7):665-72. (SCI ; IF=1.525 ; Allergy 15/24)
40. Lee WI, Yao TC, Yeh KW, Chen LC, Ou LS, Huang JL*. Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children. Immunobiology 2013;218(2):192-200. (SCI ; IF=3.205 ; Immunology 61/139)
41. Lee WI*, Chen SH, Huang JL, Jaing TH, Chung HT, Yeh KW, Chen LC, Yao TC, Hsieh MY, Lin SJ, Kuo ML. Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiology 2013;218(5):828-33. (SCI ; IF=3.205 ; Immunology 61/139)
42. Wu SA, Yeh KW, Lee WI, Yao TC, Kuo ML, Hung B, Huang JL*. Impaired phagocytosis and susceptibility to infection in pediatric-onset systemic lupus erythematosis. Lupus 2013;22(3):279-88. (SCI ; IF=2.337 ; Rheumatology 15/29)
43. Shen CC, Yeh KW, Ou LS, Yao TC, Chen LC, Huang JL*. Clinical features of children with juvenile idiopathic arthritis using the ILAR classification criteria: A community-based cohort study in Taiwan. J Microbiol Immunol Infect (online published on 2012 June 21) (SCI ; IF=0.987 ; Microbiology 93/112)
44. Shen CC, Yao TC, Yeh KW, Huang JL*. Association of disease activity and anti-rheumatic treatment in juvenile idiopathic arthritis with serum lipid profiles: A prospective study. Semin Arthritis Rheum (online published on 2013 Jan 2) (SCI ; IF=4.969 ; Rheumatology 5/29)
45. Lee WI, Huang J, Yeh KW, Yang MJ, Lai MC, Chen LC, Ou Ls, Yao TC, Lin SJ, Jaing TH, Chen SH, Hsieh MY, Yu HH, Chen YH, Shyur SD. Clinical features and genetic analysis of Taiwanese patients with the hyper IgM syndrome phenotype. Pediatr Infect Dis J (online published on 2013 Mar 27) (SCI ; IF= 3.577; Pediatrics 7/113)
46. Hua MC, Chao HC, Yao TC, Lai MW, Huang JL*. Investigation of Interleukin-10 Promoter Polymorphisms and Interleukin-10 levels in Children with Irritable Bowel Syndrome. Gut Liver (In press) (SCI; IF=0.829 ; Gastroenterology & Hepatology 63/74)
47. Liu YC, Tu YL, Wu RC, Huang JL, Yao TC*. Life-threatening Pneumonitis Complicating Low-Dose Methotrexate Treatment for Juvenile Idiopathic Arthritis in A Child. Pediatr Emerg Care (Accepted) (SCI ; IF=0.782 ; Emergency Medicine 16/24)

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