Chuang Gung Medical Foundation, Division of Pediatric Allergy, Asthma and Rheumatology - UNREGISTERED VERSION

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Lin SJ

About Us > Team Member

Syh-Jae Lin, M.D.

Associate professor, Pediatrics Chang Gung Children’s Hospital.
Editorial Board
Open Journal of allergy, World Journal of Transplantation.

Specialty
Pediatric allergy and Immunology.

Research interest
Stem cell transplantation Neonatal Immunology

Teaching or Professional Positions:
Rotating Intern, National Taiwan University Hospital (NTUH), 1987-1988
Chinese Army Medical Officer, 1988-1990
Pediatric Residency training, Department of Pediatrics, NTUH, 1990-1993
Chief Resident in Department of Pediatrics, Chang Gung Children’s Hospital, 1993-1994
Fellowship training in Division of Allergy/Immunology, Department of Pediatrics, NTUH, 1993-1994
Post-doctoral fellow in Division of Allergy/Immunology, Department of Pediatrics, UCLA Medical Center, Jan. 1995-Dec. 1996
Attending physician , Division of Allergy, Asthma, Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, 1994-present
Lecturer of Pediatrics, Chang Gung University, 1999
Chief, Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, 2000-present
Assistant professor of Pediatrics, Chang Gung University, 2002
Academic Associate Professor, Chan Gung Memorial Hospital, 2004



Professional Memberships
National Medical Board of the Republic of China, #19754, 1988
National Medical Officer certificate of the Republic of China, #(77)1446, 1988
National Pediatrics Board of the Republic of China, 1993
ECFMG(USMLE), certified, 0-520-672-7,1994
National Board of Rheumatologist of the Republic of China, #206, 1997
National Board of Clinical Immunologist Republic of China, #221, 1997
Board of Pediatric Allergy, Asthma and Immunology, R.O.C.0035, 1998

Member, Taiwan Pediatric Association, 1990
Member, Formosan Medical Association, 1997
Member, Chinese Society of Immunology, R.O.C., 1997
Member, Rheumatism Association of the Republic of China, R.O.C., 1997

 

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ON-LINE REGISTRATION:    https://www.cgmh.org.tw/register_en/rms_lnk.htm

Publication:

1. Lin SJ, Wang PJ, Lin MY and Shen YZ: Rigid spine syndrome presenting with respiratory failure.  Acta Paediatrica Sinica 33: 215-222, 1993.
2. Lin SJ, Tsai WY*, Hsieh HC, Li YW and Yu SC: Insulinoma in childhood.  Acta Paediatrica Sinica 34: 417-424, 1993.
3. Lin SJ*, Lai YC, Wang PJ, Wang LC and Wang SS: Bilateral internal carotid aneurysms with diffuse intracranial calcification- Report of a case.  Acta Paediatrica Sinica 35: 136-143, 1994.
4. Wang LC*, Chiu IS, Wang PJ, Wu MH, Wang JK, Hung YB, Lin SJ: Kabuki make-up syndrome associated with congenital heart disease.  Acta Paediatrica Sinica 35: 63-69, 1994.
5. Lin SJ, Lin TY*, Chiu CH and Huang YC: Experience of intravenous immunoglobulin and acyclovir in neonates at risk for servere varicella infection.  Acta Paediatrica Sinica 36: 53-57, 1995.
6. Lin SJ, Roberts RL, Ank BJ, Nguyen QH, Stiehm ER* Human Immunodeficiency Virus (HIV) Type-1 gp120-specific cell-mediated cytotoxicity(CHC) and natural killer (NK) activity in HIV-infected subjects: Enhancement with IL-2, IL-12, IL-15, Clinical Immunology and Immunopathology, ( currently Clinical Immunology) 82: 163-173, 1997.
7. Huang JL*, Lin SJ, Hsieh KH. The relationship between sinusitis and bronchial asthma. Acta Paediatrica Sinica 38:S13-16,1997
8. Lin SJ*, Chao HC, Huang JL, Lin ZY, Hsieh KH.  Acetaminophen overdose in Children and Adolescents.  Acta Paediatrica Sinica 38:448-453,1997
9. Nguyen QH, Roberts RL, Ank BJ, Lin SJ, Lau CK, Stiehm ER*. Enhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2(IL-2) and IL-12. Clin Diag Lab Immunol 5: 98-104, 1998
10. Lin SJ*, Huang JL, Hsieh KH.  Clinical and laboratory correlation of acute Henoch-Schönlein Purpura in children.  Acta Paediatrica Sinica  39:94-8,1998
11. Chu SM, Huang JL*, Lin SJ, Hsueh C. Successful treatment of Sjogren syndrome by cyclophosphomide pulse therapy: report of one case. Acta Paediatrica Sinica 1998; 39:268-70
12. Lin SJ*, Huang JL, Hsieh KH.  Orthopedic manifestation in a child with hyper immunoglobulin E syndrome.  Acta Paediatrica Sinica 1998;39:330-3
13. Lin SJ*, Chao HC, Huang JL.  Gastrointestinal involvement as the initial manifestation in children with Henoch-Schönlein purpura.  Acta Paediatrica Sinica 1998;39:186-90
14. Lin SJ*, Huang JL. Henoch-Schönlein purpura in children and adults.  Asian Pacific Journal of Allergy and Immunology 1998;16:21-5
15. Lin SJ*, Huang JL, Hsieh KH.  Hodgkin’s disease in a child with Hyperimmunoglobulin E syndrome. Pediatric Hematology and Oncology 1998; 15: 451-454.  
16. Lin SJ*, Huang JL. Circulating interleukin(IL)-1beta, IL-6, and tumor necrosis factor-alpha in children with febrile infection-a comparison with C-reactive protein. Asian Pacific Journal of Allergy and Immunology 1998;16:105-109
17. Lin SJ, Roberts RL, Ank BJ, Nguyen QH, Thomas EK, Stiehm ER*. Effect of IL-12 and IL-15 on activated natural killer (ANK) and antibody-dependent cellular activity (ADCC) in HIV infection. Journal of Clinical Immunology 1998; 18:335-345.  
18. Nguyen QH, Roberts RL, Ank BJ, Lin SJ, Thomas EK, Stiehm ER*, Interleukin (IL)-15 enhances natural killer (NK) activity and antibody dependent cellular cytotoxicity (ADCC) in neonatal cells. Cellular Immunology 1998;185: 83-92   
19. Lee WY, Yang MH, Chen LC, Lin SJ, Huang JL*. Role of serum eosinophil cationic protein in the monitoring of children with bronchial asthma and allergic rhinitis. Pediatric Asthma, Allergy and Immunology 1998; 12: 129-38.
20. Lee WY, Yang MH, Lee KF, Chen LC, Lin SJ, Yeh KW, Huang JL*. PFAPA syndrome. Clinical Rheumatology,1999; 18:207-13.  
21. Jaing TH*, Lu CS, Lin SJ.  The role of heparin in treatment of purpura fulminans: experience in four cases. Tzu Chi Med J 1999;11:97-101.
22. Chao HC*, Wong KS, Lin SJ, Kong MS, Lin TY. Ultrasonographic diagnosis and color flow doppler sonography of internal jugular venous ectasia in children. Journal of Ultrasound in Medicine.1999;18:411-6.  
23. Lin SJ*, Jaing TH. Thrombocytopenia in systemic-onset juvenile chronic arthritis- report of two cases with unusual bone marrow features. Clinical Rheumatology 1999;18:241-43
24. Lin SJ*, Huang JL, Chao HC, Lee WY, Yang MH. A follow-up study of systemic-onset juvenile rheumatoid arthritis in children. Acta Paediatrica Sinica 1999;40:176-81.
25. Lin SJ*, Hsueh C Chao HC. Hyaline-vascular type of Castleman’s disease mimicking adult-onset-Still’s disease. Clinical Rheumatology 1999; 485-487.  
26. Lin SJ*, Chao HC, Yang MH, Lee WY, Huang JL. Effect of heparinization and overnight storage of blood samples on concentration of eosinophil cationic protein in asthmatic children and controls. Pediatric Asthma, Allergy and Immunology 1999; 13, 25-31
27. Lin SJ*, Chao HC, Yan DC, Huang JL. Serum eosinophil cationic protein determination in asthmatic children-effect of different collecting tubes used for blood sampling. Asian Pacific Journal of Allergy and Immunology,1999,17:269-273.  
28. Chao HC*, Chiu CH, Lin SJ. Lin TY.  Colour doppler ultrasonography of retropharyngeal abscess. J Otolarygology 28: 138-41,1999.  
29. Chao HC*, Lin SJ, Huang YC, Lin TY.  Color doppler ultrasonographic evaluation of osteomyelitis in children. Journal of Ultrasound in Medicine.1999,18:729-34.  
30. Yang MH, Lee WI, Chen LL, Lin SJ, Huang JL*. Intraarticular Triamcinolone hexacetonide injection in children with chronic arthritis: a survey of clinical practice. Acta Paediatrica Sinica 1999,40:182-5.
31. Chen LL, Huang JL*, Wang CR, Yeh KW,  Lin SJ. Use of standard radiography to diagnose paranasal sinus disease of asthmatic children in Taiwan: comparison with computed tomography. 1999, Asian Pacific Journal of Allergy and Immunology,17:69-76.
32. Lin SJ*, Yan DC, Huang JL. Conversion to systemic lupus erythromatosus in a child with systemic-onset juvenile rheumatoid arthritis. J Rheumatology R.O.C. 2000; 15: 15-20.
33. Lin SJ*, Chao HC, Yan DC. Different articular outcome of Still’s disease in Chinese children and adults. Clinical Rheumatology 2000, 19: 127-130
34. Chao HC, Kong MS, Lin SJ, Lou CC, Lin PY.  Papillary cystic neoplasm of the pancreas in children: report of three cases and review of the literature. Acta Paediatrica Taiwanica 2000;41:101-5.
35. Chao HC, Kong MS,  Lin SJ*, , Huang JL. Gastrointestinal manifestation and its outcome of Henoch-Schönlein purpura in children. Chang Gung Medical J 2000,23:135-41
36. Chao HC, Kong MS, Lin SJ*. Hepatobiliary involvement of Henoch-Schönlein purpura in children. Acta Paediatrica Taiwanica 2000;41:63-8
37. Lin SJ*, Yang MH, Chao HC, Kuo ML Huang JL. Effect of IL-15 and Flt3-L ligand on natural killer cell expansion and activation-umbilical cord vs. adult peripheral blood mononuclear cells. Pediatric Allergy and Immunology 2000;11:168-174.  
38. Lin SJ*, Chao HC, Kuo ML. Effect of interleukin(IL)-15 and IL-12 on CD69 expression of T-lymphocytes and natural killer cells from umbilical cord blood Biology of Neonate,2000;78:181-185.  
39. Lin SJ*, Chao HC, Yan DC, Huang JL. Serum eosinophil cationic protein determination in asthmatic children-Influence of atopy and concomitant sinusitis. Pediatr Allergy, Asthma, Immunology 2000;14:197-203
40. Chang Kw, Lin SJ, Hseuh C, Kong MS. Menetrier's Disease Associated with Cytomegalovirus Infection in a Child. Acta Paediatrica Taiwanica 2000;41:339-340
41. Chao HC, Kong MS, Chen RY, Lin SJ*, Lin JN. Sonographic evaluation of neonatal intestinal malrotation and the features related to volvulus. Journal of Ultrasound in Medicine.2000;19:371-376  
42. Chao HC*, Lin SJ, et al. Sonographic evaluation of pancreatic duct in children with pancreatitis and normal children Journal of Ultrasound in Medicine.2000; 743-749.
43. Chao HC, Lin SJ, et al. Sonographic evaluation of cellulitis in children. Journal of Ultrasound in Medicine.2000;757-763.
44. Chang KW, How JW, Lin SJ, Kong MS. Alstrom syndrome with hepatic dysfunction. Report of one case. Acta Paediatrica Taiwanica 2000;41:270-72.
45. Lin SJ*, Kuo ML, Yan DC. Idiopathic CD4 lymphopenia in two siblings. A immunological study. Ped Hematology and Oncology 2001: 12:153-156
46. Yang MH, Lin SJ*.. Effect of two-rounds Ficoll-Hypaque density separation on cord blood composition and NK activity. Ped Hematology and Oncology 2001: 12: 57-63.
47. Lin SJ*, Chao HC, Yan DC. Phenotypic changes of T-lymphocyte subsets induced by interleukin(IL)-12 and IL-15-umbilical cord versus adult peripheral blood mononuclear cells. Pediatric Allergy and Immunology 2001;12:21-26
48. Lin SJ*, Yan DC. ICAM-1(CD54) expression on T-lymphocytes and natural killer cells from umbilical cord blood--regulation with interleukin(IL)-12 and IL-15. Cytokines, Cellular & Molecular therapy (now Cytothearpy) 2000 Dec;6(4):161-4.  
49. Lin SJ*, Chao HC. IL-15 enhances CD4+/CD45RA+ expression of umbilical cord mononuclear cell. Pediatric Allergy and Immunology 2001 Aug;12(4):188-93.  
50. Lin SJ*, Wang LY, Huang YJ, Kuo ML. Effect of interleukin (IL)-12 and IL-15 on apoptosis and proliferation of umbilical cord blood mononuclear cells. Bone Marrow Transplant. 2001 Sep;28(5):439-45.  
51. Kao CC, Ou LS, Lin SJ, Huang JL. Childhood idiopathic hypereosinophilic syndrome: report of a case. Asian Pac J Allergy Immunol. 2002 Jun;20(2):121-6.  
52. Lin SJ*, Chang LY, Yan DC, Huang YJ, Lin TJ, Lin TY. Decreased intercellular adhesion molecule-1 (CD54) and L-selectin (CD62L) expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation. Allergy. 2003 Jan;58(1):67-71.  
53. Lin SJ*, Chao HC, Yan DC, Huang YJ. Expression of adhesion molecules on T lymphocytes in young children and infants - a comparative study using whole blood lysis or density gradient separation. Clin Lab Haematol. 2002 Dec;24(6):353-9.  
54. Lin SJ*, Chao HC, Chang KW, Yan DC. Effect of Interleukin (IL)-15 and IL-2 on anti-CD3-induced T cell activation and apoptosis in children with common variable immunodeficiency. Annals of Allergy, asthma, and Immunology 2003,91;65-70.
55. Lin SJ*, Yu RC, Cheng PJ, Hsiao SS, Kuo ML. Effect of Interleukin -15 on anti-CD3/anti-CD28 induced apoptosis in Umbilical cord blood CD4+ T cells. European Journal of Haematology.2003,71:425-432  
56. Huang JL*, Chen LC, Yeh KW, Lin SJ, Hsieh KH, Kuo ML. Th1 and Th2 production among asthmatic children after immunotherapy. Journal of Asthma 2003, 40; 273-9.  
57. Hung JJ, Wen HY, Yen MH, Chen HW, Yan DC, Lin KL, Lin SJ, Lin TY, Hsu CY. Rotavirus gastroenteritis associated with afebrile convulsion in children: clinical analysis of 40 cases. Chang Gung Med J. 2003;26:654-9.
58. Wang IJ, Wang SJ, Yan DC, Lin SJ, Chiang BL. Hyper-IgM syndrome: a case report. J Microbiol Immunol Infect. 2003;36:215-7.
59. Lin SJ*. Allergic Rhinitis and bronchial asthma in children: New treatment options. Acta Pediatrica Taiwanica, 2003,44:S23-24.  
60. Lin SJ*, Cheng PJ. Effect of Interleukin (IL)-7 and IL-15 on activation of purified umbilical cord blood and adult peripheral blood CD4+ cells. Biology of Neonate,2004,85;3-10  
61. Lin SJ, Cheng PJ, Huang YJ, Kuo ML*. Evaluation of interleukin(IL)-12 / IL-15 activated umbilical cord blood natural killer cell cytotoxic function by a propidium-iodide based flow cytometry. Pediatric Allergy and Immunology, 2004 15:79-85  
62. Lee WI, Kuo ML*, Huang JL, Lin SJ, Wu CJ. Distribution and clinical aspects of primary immunodeficiencies in a Taiwan pediatric tertiary hospital during a 20-year period. J Clin Immunol. 2005 Mar;25(2):162-73  
63. Lin SJ*, Yan DC, Kuo ML, Cheng PJ, Hsiao SS, Tsai TL. Effect of FK506 on interleukin-15 driven proliferation and apoptosis of anti-CD3 activated umbilical cord blood T cells   Annals of Allergy, Asthma, and Immunology,2005,95: 586-592
64. Tsai MH, Hsu CY, Yen MH,Yan DC, Chiu CH, Huang YC, Lin SJ, Lin TY. Epstein-Barr virus-associated infectious mononucleosis and risk factor analysis for complications in hospitalized children. J Microbiol Immunol Infect. 2005 Aug;38(4):255-61.
65. Lin SJ, Cheng PJ, Hsiao SS, Lin HH, Hung PF, Kuo ML*. Differential effect of IL-15 and IL-2 on survival of phytohemagglutinin-activated umbilical cord blood T cells. American Journal of Hematology,2005;80:106-12  
66. Lin SJ*, Cheng PJ, Hsiao SS. Effect of interleukin-15 on effector and regulatory function of anti-CD3/anti-CD28 stimulated CD4+T cells. Bone Marrow Transplantation 2006, 37:881-7  
67. Lin SJ , Kuo ML, Cheng PJ, Hsiao SS. Effect of interleukin-15 on alloreactivity in umbilical cord blood. Transplant Immunology 2006;16:112-6
68. Lee WI, Jaing TH, Hsieh MY, Kuo Ml, Lin SJ, Huang JL. Distribution, infections, treatments and molecular analysis in a large cohort of patients with primary immunodeficiency diseases (PIDs) in Taiwan. J Clin Immunol. 2006 May;26:274-83.  
69. Lin SJ, Kuo ML, Cheng PJ, Hsiao SS. Differential cyclosporin sensitivity of umbilical cord  and adult peripheral blood CD4+ T cells- regulation with Interleukin-15. Transplant immunology.2007 18:172-178
70. Lin SJ, Kuo ML. Effect of cyclosporin-A on interleukin-15 activated umbilical cord blood natural killer cell function. Cytotherapy 2008;10(4):397-405  
71. Lin SJ, Yan DC, Lee YJ, Kuo ML. Role of interleukin-15 in umbilical cord blood transplantation. International Review of Immunology 2008;27(6):518-31.
72. Lin SJ, Li JJ, Cheng PJ, Kuo ML. Susceptibility to Fas and tumor necrosis factor-a receptor mediated apoptosis of anti-CD3/anti-CD28-activated umbilical cord blood T cells. Pediatric Allergy and Immunology. 2009:20(4):392-8
73. Lin SJ, Li JJ, Cheng PJ, Kuo ML . The regulatory function of umbilical cord    blood CD4+CD25+ T cells stimulated with anti-CD3/anti-CD28 and exogenous IL-2 or IL-15. Pediatric Allergy and Immunology 2009: 20(7):624-32.
74. Lee WI, Huang JL, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Hsieh MY, Huang YC, Yu HR, Kuo HC, Yang KD, Jaing TH. Clinical, immunological and genetic features in Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndromes (HIES).Immunobiology. 2011 Jan 18.e-pub
75. Lee WI, Huang JL, Lin SJ, Yeh KW, Chen LC, Hsieh MY, Huang YC, Kuo HC, Yang KD, Yu HR, Jaing TH, Yang CH. Clinical Aspects and Genetic Analysis of Taiwanese Patients with the Phenotype of Hyper-Immunoglobulin E Recurrent Infection Syndromes (HIES). J Clin Immunol. 2010 Dec 1.
76. Lin SJ, Lee WJ, Liang YW, Yan DC, Cheng PJ, Kuo ML.. Azithromycin inhibits IL-5 production of T helper type 2 cells from asthmatic children. International Archives of Allergy and Immunology.2011 May 18;156(2):179-186
77. Lin SJ. , Kuo ML.Cytotoxic function of umbilical cord blood natural killer cells: relevance to adoptive immunotherapy. Pediatric Hematology and Oncology 28:640-646, 2011
78. Lin SJ, Yan DC, Kuo ML, Hsiao HS, Lee PT. Umbilical cord blood immunology-relevance to stem cell transplantation Clinical Review of Allergy and Imunology 2011 Dec 3. [Epub ahead of print]
79. Chen YH, Kuo ML,Cheng PJ, Hsiao HS, Lee PT, Lin SJ*. Interleukin(IL)-15 /IL-21 regulation of CD28 expression in umbilical cord blood and adult peripheral blood CD8+ T Cells. Cytokine 2012 Apr;58(1):40-6. (*corresponding author)
80. Lin SJ. Cheng PJ, Lin TY, Lee PT, Hsiao HS, Kuo ML. Effect of influenza A infection on umbilical cord blood natural killer function-regulation with interleukin-15. Journal of Infectious Disease 2012 Mar 1;205(5):745-56
81. Lin SJ, Yan DC, Lee WI, Kuo ML, Hsiao HS, Lee PT. Effect of azithromycin on natural killer function. International Immunopharmocology. 2012 May;13(1):8-14.
82. Lee WI, Chen SH, Huang JL, Jaing TH, Chung HT, Yeh KW, Chen LC, Yao TC, Hsieh MY, Lin SJ, Kuo ML.Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiology. 2013 May;218(5):828-33
83. Lee WI, Huang JL, Yeh KW, Yang MJ, Lai MC, Chen LC, Ou LS, Yao TC, Lin SJ, Jaing TH, Chen SH, Hsieh MY, Yu HH, Chien YH, Shyur SD.Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype. Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print]


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