• 期刊發表(2012年)

  1. Fang Dean YH, Georges El Fakhria, John A. Beckera, Nathaniel M. Alpert. Parametric imaging with Bayesian priors: A validation study with 11C-Altropane PET. NeuroImage 2012;61:131-138 (SCI=5.932; ??/??; 2.65 %)

  2. Lee JD, Huang CH, Yang ST, Chu YH , Shieh YY, Chen JW, Lin KJ. MRI/SPECT-based Diagnosis and CT-Guided High-Intensity Focused-Ultrasound Treatment System in MPTP mouse model of Parkinson's disease. Medical Engineering & Physics. 2012. Accepted. (SCI=1.623; 38/72; 52%)

  3. Wen CJ, Yen TC, Al-Suwayeh SA, Chang HW, Fang JY. In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios. Nanomedicine (Lond). 2011;6:1545-59 .(SCI=5.055; 19/157; 12%)

  4. Liu KS , Wen CJ, Yen TC, Sung KC, Ku MC, Wang JJ, Fang JY. Combined strategies of apomorphine diester prodrugs and nanostructured lipid carriers for efficient brain targeting. Nanotechnology. 2012;23:095103. ( SCI=3.979; 16/125; 12.8%)

  5. Liao AH, Liu HL, Su CH, Hua MY, Yang HW, Weng YT, Hsu PH, Huang SM, Wu SY, Wang Hel, Yen TC, Li PC. Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for theInduction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening andConcurrent MR and Ultrasound Imaging. PHYS MED BIOL . 2012;57:2787-802. (SCI=2.829; 14/72; 19.4%)

  6. Fan CH, Liu HL, Huang CY, Ma YJ, Yen TC*, Yeh CK*. Detection of Intracerebral Hemorrhage and Transient Blood-Supply Shortage in Focused-Ultrasound-Induced Blood-Brain Barrier Disruption by Ultrasound Imaging. ULTRASOUND MED BIOL . Accepted, 2012. (SCI=2.293; 4/30; 13.3%) Correspondence

  7. Wei KC, Tsai HC, Lu YJ, Yang HW, Hua MY, Wu MF, Chen PY, Huang CY, Yen TC, Liu HL*. Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine. AJNR Am J Neuroradiol. 2012 Jun 21. [Epub ahead of print] (SCI=2.928; 27/116; 23.2%)

  8. Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, Kung MP, Lin KJ. Correlation of early-phase (18)F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol Imaging. 2012;39:613-20. (SCI=4.991; 8/116; 6.8%)

  9. Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, Kung MP, Lin KJ. Correlation of early-phase (18)F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies. Eur J Nucl Med Mol I. 2012;39:613-20. (SCI=4.991; 8/116; 6.8%)

  10. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TC, Hsieh SY. MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hematoma. J. Hepatol. 2012 In press. (SCI=9.264; 4/74; 5.4%)

  11. Zhang LW, Wen CJ, Al-Suwayeh SA, Yen TC, Fang JY. Cisplatin and quantum dots encapsulated in liposomes as multifunctional nanocarriers for theranostic use in brain and skin. J. Nanopart. Res. 2012;14: 882-900. (SCI=3.25; 38/231; 16.4%)

  12. Wen CJ, Zhang LW, Al-Suwayeh SA, Yen TC, Fang JY. Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging. International Journal of Nanomedicine. 2012;7:1599–1611. (SCI=4.976; 18/252; 7.1%.)

  13. Liu KS , Wen CJ, Yen TC, Sung KC, Ku MC, Wang JJ, Fang JY. Combined strategies of apomorphine diester prodrugs and nanostructured lipid carriers for efficient brain targeting. Nanotechnology. 2012;23: 095103. (SCI=3.979; 16/125; 12.8%)

  14. Peng YJ, Lu YT , Liu KS , Liu SJ, Fan Ling, Huang WC. Biodegradable balloon-expandable self-locking polycaprolactone stents as buckling explants for the treatment of retinal detachment: An in vitro and in vivo study. J Biomed Mater Res A. 2012; 00A : 000-000. (SCI=2.625; 17/72; 23.6%)

  15. Liaw JW, Tsai SW, Lin HH, Yen TC, Chen BR. Wavelength-dependent Faraday-Tyndall effect on laser-induced microbubble in gold colloid. Journal of Quantitative Spectroscopy and Radiative Transfer . Aug, 2012 (SCI=3.193; 10/41; 24.3 %)

  16. Lin YC, Chan TH, Chi CY, Ng SH, Liu HL, Wei KC, Wai YY, Wang CC, Wang JJ. Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization. Magnetic Resonance in Medicine . E-Pub Mar.1st, 2012. (SCI=2.964; 26/116; 22.4 %)

  17. Yang HW, Hua MY, Liu HL, Tsai RY, Pang ST, Hsu PH, Tang HJ, Yen TC, Chuang CK. An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer. Biomaterials. 2012; 33: 3919-3930. (SCI=7.404; 2/72; 2.7%)

  18. Hsu PH, Wei KC, Huang CY, Wen CJ, Yen TC, Liu CL, Shen CR, Liu HL. Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound. Revising, PLoS One . (SCI=4.092; 12/84; 14.2%)

  19. Lee WY, Wei HJ, Wang JJ, Lin KJ, Lin WW, Chen DY, Huang CC, Lee TY, Mag HY, Hwang SM, Chang Yen, Sung HW. Vascularization and restoration of heart function in rat myocardial infarction using transplantation of human cbMSC/HUVEC core-shell bodies. Biomaterials. 2012;33:2127-2136. (SCI=7.404; 2/72; 2.7%)

  20. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death and Differentiation . 2012; 1–11. (SCI=8.849; 23/289; 7.9%)

  21. Chao KT, Tsao HH, Weng YH, Hsiao IT, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lin KJ. Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([ 18F ]AV-133) in a MPTP-lesioned PD mouse model. Synapse . 2012;66:823-831. (SCI=2.945; 115/243; 47.3%)

  22. Huang HL, Yeh CN, Chang KW, Chen JT, Lin KJ, Chiang LW, Jeng KC, Wang WT, KH Lim, Chen Caleb Gonshen, Lin KI, Huang YC, Lin WJ, Yen TC, Yu CS. Synthesis and evaluation of [ 18F ]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase. Bioorganic & Medicinal Chemistry Letters . 2012; 22: 3998–4003. (SCI=2.554; 21/56; 37.5%)

  23. Ma YH . Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis. International Journal of Nanomedicine. 2012 in press. (SCI=3.13; 70/261; 26.8%)

  24. Su FY, Lin KJ, Sonaje K., Wey SP, Yen TC, Ho YC, Panda N, Chuang EY., Maiti B, Sung HW. Protease Inhibition and Absorption Enhancement by Functional Nanoparticles for Effective Oral Insulin Delivery. Biomaterials . 2012; 33: 2801-2811. (SCI=7.404; 2/72; 2.7%)

  25. Kiran Sonaje, Chuang EY, Lin KJ, Yen TC, Su FY, Tseng Michael T., Sung HW. Opening of Epithelial Tight Junctions and Enhancement of Paracellular Permeation by Chitosan: Microscopic, Ultrastructural, and Computed-Tomographic Observations. Mol. Pharmaceutics. 2012. (SCI=4.782 ; 27/261; 10.3%)

  26. Lin CY, Chang YH, Kao CY, Lu CH, Sung LY, Yen TC, Lin KJ, Hu YC. Augmented healing of critical-size calvarial defects by baculovirus-engineered MSCs that persistently express growth factors. Biomaterials . 2012;33:3682-3692. (SCI=7.404; 2/72; 2.7%)

  27. Lin CY, Lin KJ, Li KC, Sung LY, Swei Hsueh, Lu CH, Chen GY, Chen CL, Huang SF, Yen TC, Chang YH, Hu YC. Immune responses during healing of massive segmental femoral bone defects mediated by hybrid baculovirus-engineered ASCs. Biomaterials . 2012;33:7422-34. (SCI=7.404; 2/72; 2.7%)

  28. Nathaniel M. Alpert, Yu-Hua Dean Fang*, Georges El Fakhri. Single-scan Rest/Stress Imaging 18F -labeled flow tracers. Medical Physics. 2012 Accepted. (SCI= 2.83, 29/116, 25%)

  29. Liao CT Chen IH ,Kang CJ ,Ng SH, Hsueh C, Lee LY ,Yen TC *. Impact of a second FDG PET scan before adjuvant therapy for the early detection of residual/relapsing tumours in high-risk patients with oral cavity cancer and pathological extracapsular spread. Eur J Nucl Med Mol Imaging. 2012;39:944-55. (SCI=4.991, 8/116,7%)

  30. Liao CT, Hsueh C, Lee LY, Lin CY, Fan KH, Wang HM, Huang SF, Chen IH, Kang CJ, Ng SH, Tsao CK, Huang YC, Yen TC*. Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy. Oral Oncol. 2012;48:329-36. (SCI=2.857,82/194,42%)

  31. Pai PC, Chuang CC, Tseng CK, Tsang NM, Chang KP, Yen TC, Liao CT, Hong JH, Chang JT. Impact of Pretreatment Body Mass Index on Patients With Head-and-Neck Cancer Treated With Radiation. Int J Radiat Oncol Biol Phys. 2012;83:e93-e100. (SCI=4.105,45/194,23%)

  32. Yu C, Wan W, Zhang B, Deng S, Yen TC*, Wu Y*. Evaluation of the relationship between [(18)F]FDG and P-glycoprotein expression: an experimental study. Nucl Med Biol. 2012;39:671-8. (SCI=3.023, 24/116, 21%) correspondence

  33. Wang PH, Liu HL, Hsu PH, Wang C CR, Chen PY, Wei KC, Yen TC, Li ML. Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model. Journal of Biomedical Optics. 2012;17:6. 061222. (SCI= 3.188, 8/78,10.3%).

  34. Yang HW, Hua MY, Liu HL, Tsai RY, Chuang CK, Chu PC , Wu PY, Chang YH, Chuang HC, Yu KJ, Pang ST. Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy. ACS Nano. 2012;6:1795-1805. (SCI= 9.865, 9/225,4%).

  35. Liu HL, Yang HW, Hua MY, Wei KC. Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status. Neurosurgical Focus. 2012;32:1, E4. (SCI= 2.348, 43/187,23%).

  36. Ting CY, Fan CH, Liu HL*, Huang CY, Hsieh HY, Yen TC, Wei KC, Yeh CK *. Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatmen. Biomaterials. 2012;33:704-712, (SCI=7.882, 2/69,2.9%).

  37. Toh CH , Wei KC, Ng SH, Wan YL, Castillo M, Lin CP*. Differentiation of tumefactive demyelinating lesions from high-grade gliomas with use of diffusion tensor imaging. AJNR Am J Neuroradiol. 2012; 33:846-851 (SCI=2.928; 27/116; 23.2%)

  38. Wai YY, Wang JJ, Weng YH, Lin WY, Ma HK, Ng SH, Wan YL, Wang CH. Cortical involvement in a gait-related imagery task: Comparison between Parkinson's disease and normal aging. Parkinsonism and Related Disorders . 2012;18:537-542. (SCI=3.795; 35/191; 18.3%)

  39. Liao AH, Liu HL, Su CH, Hua MY, Yang HW, Weng YT, Hsu PH, Huang SM, Wu SY, Wang HE, Yen TC, Li PC. Paramagnetic per?uorocarbon-?lled albumin-(Gd-DTPA) microbubbles for the induction of focused-ultrasound-induced blood–brain barrier opening and concurrent MR and ultrasound imaging. Physics in Medicine and Biology. 2012;57: 2787-2802. (SCI=2.829; 14/72; 19.4%)

  40. Liao AH, Li YK, Lee WJ, Wu MF, Liu HL, Kuo ML. Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging. Ultrasound in Medicine and Biology . 2012 In press. (SCI=2.293; 4/30; 13.3%)

  • 專利

  1. Kun-Ju Lin, Ing-Tsung Hsiao, Tzu-Chen Yen. Precise functional image spatial normalization using early-phase perfusion-like image template (Provisional), USA 61421369 ， 2011 。

  2. 蔡瑞燦、蔡福源、沈家瑞、王忍妃、吳淑婷、閻紫宸 . 「製作磁性四級銨幾丁聚醣磁振造影對比劑」中華民國專利 ， 申請中 ， 2010 。

  3. K-C Wei, H-L Liu, M-Y Hua, Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain ，美國發明專利，申請中， 2011 。

  4. 劉浩澧、鐘皓宇、黃冠祿，多通道超音波發射接收系統之硬體實現，中華明國發明專利 / 美國發明專利，申請中， 2011 。

  5. 劉浩澧、蔡宏杰、盧郁仁、魏國珍，手術導航系統輔助之聚焦式超音波腦部藥物釋放，中華明國發明專利 / 美國發明專利，申請中， 2011 。

  6. H-L Liu, C-C Lin, and H Chang, Multiple-Frequency Ultrasonic Phased Array Driving System ，美國發明專利，申請中， 2011 。