Chuang Gung Medical Foundation, Division of Pediatric Allergy, Asthma and Rheumatology - UNREGISTERED VERSION

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About Us > Team Member

Liang-Shiou Ou, M.D.

1. Attending Physician, Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taiwan
2. Member of Committee of Chinese Society of Pediatric Asthma, Allergy and Immunology
3. Physician educator, Chang Gung Memory Hospital
4. President of Childhood Asthma Association of Taiwan
5. Head of Pediatric Allergy and Asthma Center, Chang Gung Memorial Hospital, Taiwan

Professional Memberships
1.  Member of Chinese Taipei Pediatric Association
2.  Member of Chinese Society of Immunology
3.  Member of Chinese Society of Pediatric Asthma, Allergy and Immunology

Allergy, Immunology, and Pediatric Rheumatology, Medical education

Research interest
Clinical and basic research of allergic diseases and medical education























1. Wu CJ, Huang JL*, Yang MH, Yan DC, Ou LS, Ho HH. Clinical Characteristics of Juvenile Rheumatoid Arthritis in Taiwanese. J Microbiol Immunol Infect 2001;34:211-4. ( SCI ; IF=5.012;Pediatrics 1/68)
2. Kao CC, See LC, Yan DC, Ou LS, Huang JL*. Time trend and seasonal variations in hospital admission for childhood asthma in Taiwan from 1990 to 1998. Asian Pacific J Allergy Immunol 2001;19:63-68. (SCI;IF=5.012;Pediatrics 1/68)
3. Ou LS, Huang JL*, Kuo ML. Anaphylaxis to Riboflavin (vitamin B2). Ann Allergy Asthma Immunol 2001;87:430-3.  (SCI;IF=5.012;Pediatrics 1/68)
4. Chen CY, Tsao CH,  Ou LS, Yang MH, Huang JL*. Comparison of soluble molecules in juvenile idiopathic arthritis between the active and remission stages. Ann Rheum Dis 2001;60:1102-6.(SCI;IF=5.012;Pediatrics 1/68)
5. Ou LS, See LC, Wu CJ, Kao CC, Lin YL, Huang JL*. Association between Serum Inflammatory Cytokines and Disease Activity in Juvenile Idiopathic Arthritis. Clin Rheumatol 2002:21:52-6.(SCI;IF=5.012;Pediatrics 1/68)
6. Tsao CH, Chen CY, Ou LS, Huang JL*. Risk factors of mortality for salmonella infection in systemic lupus erythematosus. J Rheumatol 2002 Jun;29(6):1214-8. (SCI;IF=5.012;Pediatrics 1/68)
7. Kao CC, Ou LS, Huang JL*. Childhood idiopathic hypereosinophilic syndrome:report of a case. Asian Pacific J Allergy Immunol 2002 Jun;20(2):121-6. (SCI;IF=5.012;Pediatrics 1/68)Huang JL, Ou LS, Chen LC, Yan DC, Kuo ML*. Reduced expression of CD69 and adhesion molecules of T lymphocytes in asthmatic children with immunotherapy. Pediatr Allergy Immunol 2002 Dec;13(6):426-33. (SCI;IF=5.012;Pediatrics 1/68)
8. Chen CY, Tseng HM, Chen LC, Tsao CH, Kuo ML, Ou LS, Huang JL*.Use of a new fluorescence immunoassay to detect anti-dsDNA antibodies is more correlated with disease activity and complement than the ELISA method in SLE patients.Lupus. 2003;12(4):266-73. ( SCI ;IF=5.012;Pediatrics 1/68)
9. Yao TC, Kuo ML, See LC, Chen LC, Yan DC, Ou LS, Shaw CK, Huang JL*.The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children. J Allergy Clin Immunol. 2003 Jun;111(6):1285-92.  (SCI;IF=5.012;Pediatrics 1/68)
10. Chao SY, Yan DC, Ou LS, Tsao CH, Chen CY, Lai SL, Chiang LC, Huang JL*. Primary School Nurses’ Knowledge/Competence Pertaining to Childhood Asthma and Its Management Prior to and Following a National Asthma Education Program in Taiwan. J Asthma. 2003 Dec;40(8):927-34. (SCI;IF=5.012;Pediatrics 1/68)
11. Chen CY, Chen LC, Yeh KW, Ou LS, Yang MH, Huang JL*. Sequential changes to clinical parameters and adhesion molecules following intravenous pulse cyclophosphamide and methylprednisolone treatment of refractory juvenile idiopathic arthritis. Clin Exp Rheumatol. 2004 Mar-Apr;22(2):259-64.  (SCI;IF=5.012;Pediatrics 1/68)
12. Ou LS, Goleva E, Hall C, Leung DY*. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol. 2004 Apr;113(4):756-63. (SCI; IF=5.012;Pediatrics 1/68)
13. Xu Q, Goleva E, Ou LS, Li LB, Leung DY*. CD56+ cells induce steroid resistance in B cells exposed to IL-15. J Immunol. 2004 Jun 1;172(11):7110-5. (SCI;IF=5.012;Pediatrics 1/68)
14. Li LB, Goleva E, Hall CF, Ou LS, Leung DY*. Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinasekinase/extrecellular signal-regulated kinase (MEK-ERK) pathway. J Allergy Clin Immunol. 2004 Nov;114(5):1059-69. (SCI;IF=5.012;Pediatrics 1/68)
15. Hung JJ, Ou LS, Lee WI, Huang JL. Central nerve system infections in patients with systemic lupus erythematosus J Rheumatol 2005 Jan; 32(1): 40-3. (SCI;IF=5.012;Pediatrics 1/68)
16. Ou LS, Leung DY*. Advances in atopic dermatitis. Chang Gung Med J 2005 Jan; 28(1): 1-8.(SCI;IF=5.012;Pediatrics 1/68)
17. Kao CC, Huang JL*, Ou LS, See LC. The prevalence, severity and seasonal variation of asthma, rhinitis and eczema in Taiwan schoolchildren. Pediatr Allergy Immunol 2005 Aug; 16(5): 408-15(SCI;IF=5.012;Pediatrics 1/68)
18. Goleva E, Cardona ID, Ou LS, Leung DY*. Factors that regulate naturally occurring T regulatory cell-mediated  suppression.  J  Allergy  Clin  Immunol.  2005  Nov;116(5):1094-100.  ( SCI ; IF=5.012;Pediatrics 1/68)
19. Chiu SJ, Ou LS, Tsai TL, Hung IJ, Huang JL*. Sequential evaluation of clinical and laboratory changes   amongst   children  suffering   from   lupus   nephritis during intermittent  intravenous cyclophosphamide therapy. Clin Rheumatol. 2005 Nov 10;:1-5 (SCI;IF=5.012;Pediatrics 1/68)
20. Yan DC, Ou LS, Tsai TL, Huang JL. Prevalence and severity of symptoms of asthma, rhinitis, and eczema in 13- to 14-year-old children in Taipei, Taiwan. Ann Allergy Asthma Immunol. 2005 Dec;95(6):579-85.  (SCI;IF=5.012;Pediatrics 1/68)
21. Cardona ID, Goleva E, Ou LS, Leung DYM. Staphylococcal Enterotoxin B Inhibits Regulatory T cells by Inducing Glucocorticoid-Induced TNF Receptor-Related Protein Ligand on Monocytes J Allergy Clin Immunol. 2006; 117(3):688-95.  (SCI;IF=5.012;Pediatrics 1/68)
22. Yao TC, Kuo ML, See LC, Ou LS, Lee WI, Huang JL*. RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six-year longitudinal study. Arthritis Rheum. 2006 Aug;54(8):2585-93.(SCI;IF=5.012;Pediatrics 1/68)
23. Hung JJ, Wu KC, Lee WI, Kuo ML, Ou LS, Huang JL*. Septic arthritis in patients with systemic lupus erythematosus: salmonella and nonsalmonella infections compared. Semin Arthritis Rheum.2006 Aug;36(1):61-7. Epub 2006 Jul 3.  (SCI;IF=5.012;Pediatrics 1/68)
24. Ou  LS*,  Huang  JL.  Cellular  aspects  of  atopic  dermatitis.  Clin  Rev  Allergy  Immunol.  2007 Dec;33(3):191-8.  (SCI;IF=5.012;Pediatrics 1/68)
25. Chen JC, Chang ML, Huang SF, Chang PY, Muench MO, Fu RH, Ou LS, Kuo ML. Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance. Cell Transplant. 2008;17(5):495-506.  (SCI;IF=5.012;Pediatrics 1/68)
26. Chan CK, Kuo ML, Ou LS, Chen LC, Yao TC, Huang JL*. Sequential evaluation of serum monocyte chemotatic protein 1 among asymptomatic and acute exacerbation and remission in asthmatic children. J Asthma. 2009 Apr;46(3):225-8.  (SCI;IF=5.012;Pediatrics 1/68)
27. Tu YL, Chen LC, Ou LS, Huang JL. Mesenteric vasculitis as the initial presentation in children with systemic lupus erythematosus. J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):251-3. (SCI; IF=5.012;Pediatrics 1/68)
28. Chen JC, Kuo ML, Ou LS, Chang PY, Muench MO, Shen CR, Chang HL, Yu HY, Fu RH. Characterization of tolerance induction through prenatal marrow transplantation: the requirement for a threshold level of chimerism to establish rather than maintain postnatal skin tolerance. Cell Transplant. 2010;19(12):1609-22. Epub 2010 Aug 17.  (SCI;IF=5.012;Pediatrics 1/68)
29. Tu YL, Yeh KW, Chen LC, Yao TC, Ou LS, Lee WI, Huang JL. Differences in disease features between childhood-onset and adult-onset systemic lupus erythematosus patients presenting with acute  abdominal  pain.  Semin  Arthritis  Rheum.  2011  Apr;40(5):447-54.  Epub  2010  Sep  29.(SCI;IF=5.012;Pediatrics 1/68)
30. Huang JL, Yeh KW, Yao TC, Huang YL, Chung HT, Ou LS, Lee WI, Chen LC. Pediatric lupus in Asia.Lupus. 2010 Oct;19(12):1414-8. Review.  (SCI;IF=5.012;Pediatrics 1/68)
31. Lee WI, Huang JL, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Hsieh MY, Huang YC, Yu HR, Kuo HC, Yang KD, Jaing TH. Clinical, immunological and genetic features in Taiwanese patients with   the   phenotype   of   hyper-immunoglobulin   E   recurrent   infection   syndromes   (HIES). Immunobiology. 2011 Aug;216(8):909-17. Epub 2011 Jan 18. (SCI;IF=5.012;Pediatrics 1/68)
32. Wang CH, Yao TC, Huang YL, Ou LS, Yeh KW, Huang JL. Acute pancreatitis in pediatric and adult-onset systemic lupus erythematosus: a comparison and review of the literature. Lupus. 2011 Apr;20(5):443-52. Epub 2011 Feb 18.  (SCI;IF=2.600;Rheumatology 14/29)
33. Yao TC, Ou LS, Lee WI, Yeh KW, Chen LC, Huang JL; PATCH study group. Exhaled nitric oxide  discriminates  children  with  and  without  allergic  sensitization  in  a  population-based study.Clin Exp Allergy. 2011 Apr;41(4):556-64.  (SCI;IF=4.195;Allergy 3/22)
34. Wu CT, Ou LS, Yeh KW, Lee WI, Huang JL. Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis. Clin Rheumatol. 2011 Jul;30(7):959-65. (SCI;IF=1.687;Rheumatology 20/29)
35. Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL; PATCH Study Group. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study.J Asthma. 2011 Jun;48(5):503-10. (SCI;IF=1.34;Allergy 14/22)
36. Yao TC, Lee WI, Ou LS, Chen LC, Yeh KW, Huang JL; for the PATCH Study Group. Reference values of exhaled nitric oxide in healthy asian children age 5 to 18 years. Eur Respir J. 2011 Jun 30(SCI;IF=5.922;Respiratory 4/46)
37. Chen  SY,  Chang  KC,  Yu  MC,  Asueh  S,  Ou  LS.  Pulmonary  Hemorrhage  Associated  with Henoch-Schönlein Purpura in Pediatric Patients: Case Report and Review of the Literature. Semin Arthritis Rheum. 2011 Jun 2.  (SCI;IF=4.744;Rheumatology 6/29)
38. Lee WI, Huang JL, Jaing TH, Shyur SD, Yang KD, Chien YH, Chiang BL, Soong WJ, Chiou SS, Shieh CC, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Lin TY, Chiu CH, Huang YC, Wu KH, Lin CY, Yu HH, Yang YH, Yu HR, Yen HJ, Hsieh MY, Kuo ML, Hwu WL, Tsai YC, Kuo HC, Lin YL, Shih YF, Chang KW. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010. Immunobiology. 2011 Jun 21.  (SCI;IF=4.114;Immunology 32/134)
39. KW, Ou LS, Yao TC, Chen LC, Lee WI, Huang JL; PATCH Study Group. Prevalence and risk factors for early presentation of asthma among preschool children in Taiwan.Yeh Asian Pac J Allergy Immunol. 2011 Jun;29(2):120-6(SCI;IF=0.762;Allergy 16/22)
40. Chen LC, Tseng HM, Wu CJ, Kuo ML, Wu CJ, Gao PS, Yeh KW, Yao TC, Lee WI, Ou LS, Huang JL, Huang SK. Evaluation of a common variant of the gene encoding clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children. J Asthma. 2012 Sep;49(7):665-72.
41. Shen CC, Yeh KW, Ou LS, Yao TC, Chen LC, Huang JL. Clinical features of children with juvenile idiopathic arthritis using the ILAR classification criteria: A community-based cohort study in Taiwan. J Microbiol Immunol Infect. 2012 Jun 21. [Epub ahead of print]
42. Lee WI, Yao TC, Yeh KW, Chen LC, Ou LS, Huang JL; the PATCH Study Group. Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children. Immunobiology. 2012 May 22. [Epub ahead of print]
43. Jaing TH, Tseng CK, Mun-Ching Wong A, Lo WC, Wu CT, Ou LS. Rescue by hematopoietic progenitor cells derived from engrafted cord blood unit in a child with brain tumor after transplantation for T-cell acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2012 Oct;34(7):573-5.
44. Liou YT, Huang JL, Ou LS, Lin YH, Yu KH, Luo SF, Ho HH, Liou LB, Yeh KW. Comparison of cryoglobulinemia in children and adults.J Microbiol Immunol Infect. 2012 Jan 9. [Epub ahead of print]
45. Chen JC, Ou LS, Yu HY, Chang HL, Chang PY, Kuo ML. Allogeneic lymphocytes exerted graft-versus-host rather than tolerogenic effects on preimmune fetuses. J Surg Res. 2013 Jan 2. doi:pii: S0022-4804(12)01959-2. 10.1016/j.jss.2012.12.015. [Epub ahead of print]
46. Lee WI, Huang JL, Yeh KW, Yang MJ, Lai MC, Chen LC, Ou LS, Yao TC, Lin SJ, Jaing TH, Chen SH, Hsieh MY, Yu HH, Chien YH, Shyur SD. Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype. Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print]

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