Chuang Gung Medical Foundation, Division of Pediatric Allergy, Asthma and Rheumatology - UNREGISTERED VERSION

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Chen LC

About Us > Team Member

Li-Chen Chen, M.D.

1. Attending of Physician of Pediatrics, Chang Gung Memory Hospital
2. Member of Committee of Chinese Society of Immunology

Professional Memberships:
1.  Member of Chinese Taipei Pediatric Association
2.  Member of Chinese Society of Immunology
3.  Member of Chinese Society of Pediatric Asthma, Allergy and Immunology
4.  Member of European Academy of Allergology and Clinical Immunology
5.  International member of the American Academy of Allergy, Asthma and Immunology

Research interest
Clinical and basic research of allergic diseases

Allergy, Immunology, and Pediatric Rheumatology

























◎Shao-Fu Lo, Jing-Long Huang, Li-Chen Chen , Kuo-Wei Yeh, Dah-Chin Yan, Kue-Hsiung Hsieh. Serum osteocalcin levels in normal children in Taiwan . Acta Paed Sin 1997;38:443-7.
◎Jing-Long Huang, Wen-Yi Lee, Li-Chen Chen , Iou-Jih Hung, Cheun Hsueh, Kue-Hsiung Hsieh. Successfully treated sulfasalazine-induced fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia with IVIG. Clinical Rheumatol 1998;17:349-52.
◎Jing-Long Huang, Li-Chen Chen . Sulphasalazine in the treatment of children with chronic arthritis. Clinical Rheumatol 1998;17:359-63.
◎Li-Chen Chen , Jing-Long Huang. CT of splenic infarction in systemic lupus erythematosus. Pediatr Radiol 1998;28 :721.
◎Wen-Yi Lee, Mei-Hui Yang, Li-Chen Chen , Syh-Jae Lin, Jing-Long Huang. Role of serum eosinophil cationic protein in the monitoring of children with brohchial asthma and rhinitis. Pediatr Asthma Allergy Immunol 1998;12 :129-138.
◎Hsiu-Chun Kao, Jing-Long Huang, Li-Chen Chen , Chuen-Hsuen. Pemphigus Vulgaris. Acta Paed Sin 1998; 39: 404-5.
◎Li-Chen Chen , Jing-Long Huang, Chao-Ran Wang. 3D CT diagnosis of anomalous innominate artery syndrome: report of one case. Acta Paed Sin 1999; 40(2) :124-7
◎Mei-Hui Yang, Wen-Yi Lee, Li-Chen Chen , Syh-Jae Lin, Jing-Long Huang. Intraarticular triamcinolone hexacetonide injection in children with juvenile chronic arthritis (JCA): a survey of clinical practice. Acta Paed Sin 1999; 40(3): 182-5
◎Li-Chen Chen , Jing-Long Huang. Intratable wheezing and swallowing problem in an infant: report of one case. Acta Paed Sin 1999;40(5): 341-3
◎Li-Chen Chen , Jing-Long Huang, Chao-Ran Wang, Kuo-Wei Yeh. Use of standard radiography to diagnosis paranasal sinus disease in asthmatic children: comparison with computed tomography. Asian Pacific J of Allergy and Immunology 1999; 17(2): 69-76
◎Wen-Yi Lee, Mei-Hui Yang, KF Lee, Li-Chen Chen , Syh-Jae Lin, KW Yeh, Jing-Long Huang . PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis). Clin Rheumatol 1999; 18(3): 207-13
◎Jing-Long Huang, Wen-Yi Lee, Li-Chen Chen , Ming-Lin Kuo, KH Hsieh. Change of serum level of interleukin-2, intercellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1 and Th1 and Th2 cell in severe atopic dermatitis after intravenous immunoglobin therapy. Ann Allergy Asthma Immunol 2000;84(3):345-52.
◎Lin YL, Huang JL, Chen LC , Wang CR. Correlation of total and specific serum immunoglobulin E levels with the severity of chronic sinusitis in children. Asian Pac J Allergy Immunol 2001 Mar;19(1):1-6
◎Li-Chen Chen , Zhongjian Zhang, Allen C. Myers, Shau-Ku Huang. Altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory protein, CC10. J Immunol 2001; 167:3025-28
◎Hsu SC, Chen LC , Kuo ML, Huang JL, Huang SK. Novel SNPs in candidate gene, CRTH2, for allergic diseases. Genes Immun 2002 Apr;3(2):114-6
◎Kumar M, Behera AK, Lockey RF, Zhang J, Bhullar G, De La Cruz CP, Chen LC , Leong KW, Huang SK, Mohapatra SS. Intranasal Gene Transfer by Chitosan-DNA Nanospheres Protects BALB/c Mice Against Acute Respiratory Syncytial Virus Infection. Hum Gene Ther 2002 Aug;13(12):1415-1425
◎Huang Jing-Long, Liang-Shiou Ou, Ching-Hsiung Tsao, Li-Chen Chen , Ming-Ling Kuo. Reduced expression of CD69 and adhesion molecules of T lymphocytes in asthmatic children receiving immunotherapy. Pediatric allergy and immunology 2002; 13: 426-433
◎Chun-Yi Chen, Hsu-Min Tseng, Li-Chen Chen , Ching-Hsiung Tsao, Ming-Ling Kuo, Liang-Shiou Ou, Jing-Long Huang. Use of a new fluorescence immunoassay to detect anti-ds DNA antibodies is more correlated with disease activity and complement than the ELISA method in SLE patient. LUPUS 2003; 12(4): 266-273
◎Ching-Hsiung Tsao, Li-Chen Chen , Kuo-Wei Yeh, Jing-Long Huang. Concomitant Chronic Sinusitis Treatment in Mild Asthmatic Children – The Effect on Bronchial Hyperresponsiveness. Chest 2003;123: 757-764
◎Jing-Long Huang, Li-Chen Chen , Kuo-Wei Yeh, Kue-Hsiung Hsieh, and Ming-Ling Kuo. Th1 and Th2 Cytokine Production in Asthmatic Children Following Immunotherapy. J Asthma 2003; 40(3): 273-279
◎Yao TC, Kuo ML, See LC, Chen LC , Yan DC , Ou LS, Shaw CK, Huang JL. The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children. J Allergy Clin Immunol. 2003 Jun;111(6):1285-92
◎Wen-Jen Chiu, Ming-Ling Kuo, Li-Chen Chen, Ching-Hsiung Tsao, Kuo-Wei Yeh, and Jing-Long Huang. Evaluation of clinical and immunological effects of inactivated influenza vaccine in children with asthma. Pediatr Allergy Immunol. 2003 Dec;14(6):429-36.
◎Chen CY, Chen LC , Yeh KW, Ou LS, Yang MH, Huang JL. Sequential changes to clinical parameters and adhesion molecules following intravenous pulse cyclophosphamide andmethylprednisolone treatment of refractory juvenile idiopathic arthritis. Clin Exp Rheumatol. 2004 Mar-Apr;22(2):259-64.
◎Jing-Long Huang, MD, Ching-Chuan Yeh, MD, Cheng-Kuang Shaw, Dr.PH, Tsung-Chieh Yao, MD , Li-Chen Chen MD , Tsung-Dao Lee, PhD, Ming-Ling Kuo, PhD HLA-DRB1 Genotyping in Patients with Juvenile Idiopathic Arthritis in Taiwan Eur J Immunogenet. 2004 Aug;31(4):185-8.
◎Shih-Jung Chiu, Ching-Hsing Tsao. Li-Chen Chen , Chun-Chich Kao, Ko-Huang Lue, Jing-Long Huang. Chronic mucocutaneous candidiasis in a 6-year-old boy J Microbiol Immunol Infect. 2004 Jun;37(3):196-9.
◎Huang JL, Gao PS, Mathias RA, Yao TC, Chen LC , Kuo ML, Hsu SC, Plunkett B, Togias A, Barnes KC, Stellato C, Beaty TH, Huang SK. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells. Hum Mol Genet. 2004 Nov 1;13(21):2691-7. Epub 2004 Sep 02.
◎Li-Chen Chen , Chih-Hsing Hung, Zhongjian Zhang, Allen C. Myers, Shau-Ku Huang. Regulation of Th2 responses by the pulmonary Clara cell secretory 10-kDa protein (CC10), J Allergy Clin Immunol. 2004 Sep;114(3):664-70.
◎Kuo-Wei Yeh,Sue-Hsien Chen, Li-Chi Chiang, Li-Chen Chen , Jing-Long Huang. Survey of asthma care in Taiwan : a comparison of asthma specialists and general practioners. Ann Asthma Allergy Immunol.2006; 96:593-599
◎CJ Wu, LC Chen, ML Kuo. Attenuated Salmonella Typhimurium reduces Ovalbumin induced airway inflammation and T-helper type 2 response in mice. Clin ExpImmunol 2006 ; 145:116-122
◎KW Yeh, SY Chao, LC Chiang, HR Lai, SH Chen, LC Chen, JL Huang Increasing asthma care knowledge and competence of public health nurses after anational asthma education program in Taiwan. Asian Pac J Allergy Immunol 2006 Dec;24(4):183-9.
◎ Tsai YC, Hou CL, Yao TC, Chen LC, Jaing TH, Huang JLRisk factors and bacterial profiles of urinary tract infections in patients with systemic lupus erythematosus. Asian Pac J Allergy Immunol. 2007 Jun-Sep;25(2-3):155-61
◎Lee WI, Huang JL, Kuo ML, Lin SJ, Chen LC, Chen MT, Jaing THAnalysis of genetic defects in patients with the common variable immunodeficiency phenotype in a single Taiwanese tertiary care hospital. Ann Allergy Asthma Immunol. 2007 Nov;99(5):433-42.
◎ Yang KD, Ou CY, Chang JC, Chen RF, Liu CA, Liang HM, Hsu TY, Chen LC, Huang SK. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clin Immunol. 2007 Oct;120(4):842-8
◎ Hou CL, Tsai YC, Chen LC, Huang JLTuberculosis infection in patients with systemic lupus erythematosus: pulmonary and extra-pulmonary infection compared. Clin Rheumatol. 2008 May;27(5):557-63. Epub 2007 Oct 17.
◎Liang FC, Wei YC, Jiang TH, Hsiehi MY, Wen YC, Chiou YS, Wu SH, Chen LC, Huang JL, Lee WI. Current classification and status of primary immunodeficiency diseases in Taiwan. Acta Paediatr Taiwan. 2008 Jan-Feb;49(1):3-8.
◎Chan CK, Kuo ML, Yeh KW, Ou LS, Chen LC, Yao TC, Huang JLSequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic stateand acute exacerbation and remission of asthma in children. J Asthma. 2009 Apr;46(3):225-8.
◎Tu YL, Chen LC, Ou LH, Huang JL Mesenteric vasculitis as the initial presentation in children with systemic lupuserythematosus. J Pediatr Gastroenterol Nutr. 2009 Aug;49(2):251-3.
◎Huang YL, Chung HT, Chang CJ, Yeh KW, Chen LC, Huang JL. Lymphopenia is a risk factor in the progression of carotid intima-media thickness iin juvenile-onset systemic lupus erythematosus. Arthritis Rheum. 2009 Nov 30;60(12):3766-3775.
◎Differences in Disease Features Between Childhood-Onset and Adult-Onset Systemic Lupus Erythematosus Patients Presenting with Acute Abdominal Pain. Tu YL, Yeh KW, Chen LC, Yao TC, Ou LS, Lee WI, Huang JLSemin Arthritis Rheum. 2010 Sep 28.
◎Pediatric lupus in Asia. Huang JL, Yeh KW, Yao TC, Huang YL, Chung HT, Ou LS, Lee WI, Chen LC. Lupus. 2010;19(12):1414-8.
◎Lee WI, Huang JL, Lin SJ, Yeh KW, Chen L C, Hsieh MY, Huang YC, Kuo HC, Yang KD, Yu HR, Jaing TH, Yang CH. Clinical aspects and genetic analysis of Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndromes (HIES) J Clin Immunol. 2011 Apr;31(2):272-80.
◎Lee WI, Huang JL, Lin SJ, Yeh KW, Chen L C , Ou LS, Yao TC, Hsieh MY, Huang YC, Yu HR, Kuo HC, Yang KD, Jaing TH. Clinical, immunological and genetic features in Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndromes (HIES). Immunobiology. 2011 Aug;216(8):909-17.
◎Lee WI, Huang JL , Jaing TH, Shyur SD, Yang KD, Chien YH, Chiang BL, Soong WJ, Chiou SS, Shieh CC, Lin SJ, Yeh KW, Chen L C , Ou LS, Yao TC, Lin TY, Chiu CH, Huang YC, Wu KH, Lin CY, Yu HH, Yang YH, Yu HR, Yen HJ, Hsieh MY, Kuo ML, Hwu WL, Tsai YC, Kuo HC, Lin YL, Shih YF, Chang KWDistribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985-2010. Immunobiology. 2011 Jun 21.
◎Yao TC, Lee WI, Ou LS, Chen LC, Yeh KW, Huang JL; Reference values of exhaled nitric oxide in healthy asian children age 5 to 18 years. Eur Respir J. 2011 Jun 30
◎Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL, Associations of age, gender, and BMI with prevalence of allergic diseases in children J Asthma. 2011 Jun;48(5):503-10.
◎Yao TC, Ou LS, Lee WI, Yeh KW, Chen LC, Huang JLExhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study. Clin Exp Allergy. 2011 Apr;41(4):556-64
◎Yeh KW, Ou LS, Yao TC, Chen LC, Lee WI, Huang JL. Prevalence and risk factors for early presentation of asthma among preschool. Asian Pac J Allergy Immunol. 2011 Jun;29(2):120-6.
◎Lee WI, Yao TC, Yeh KW, Chen LC, Ou LS, Huang JL; Stronger Toll-like
receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children. Immunobiology. 2012 May 22. [Epub ahead of print]
◎Shen CC, Yeh KW, Ou LS, Yao TC, Chen LC, Huang JL. Clinical features of children with juvenile idiopathic arthritis using the ILAR classification criteria: A community-based cohort study in Taiwan. J Microbiol Immunol Infect. 2012 Jun 21. [Epub ahead of print]
◎Chen LC, Tseng HM, Wu CJ, Kuo ML, Wu CJ, Gao PS, Yeh KW, Yao TC, Lee WI, Ou LS, Huang JL, Huang SK. Evaluation of a common variant of the gene encoding clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children. J Asthma. 2012 Sep;49(7):665-72.
◎Lee WI, Chen SH, Huang JL, Jaing TH, Chung HT, Yeh KW, Chen LC, Yao TC, Hsieh MY, Lin SJ, Kuo ML. Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiology. 2012 Oct 26. [Epub ahead of print]
◎Wu CJ, Huang WC, Chen LC, Shen CR, Kuo ML. Pseudotyped Adeno-Associated Virus 2/9-Delivered CCL11 shRNA Alleviates Lung Inflammation in an Allergen-Sensitized Mouse Model. Hum Gene Ther. 2012 Nov;23(11):1156-65.
◎Wu CJ, Chen LC, Huang WC, Chuang CL, Kuo ML. Alleviation of Lung Inflammatory Responses by Adeno-Associated Virus 2/9 Vector Carrying CC10 in OVA-Sensitized Mice. Hum Gene Ther. 2012 Nov 14. [Epub ahead of print] (Co-first author)
◎Wu CJ, Yang CY, Chen YH, Chen CM, Chen LC, Kuo ML. The DNA Methylation Inhibitor 5-Azacytidine Increases Regulatory T Cells and Alleviates Airway Inflammation in Ovalbumin-Sensitized Mice. Int Arch Allergy Immunol. 2012 Nov 22;160(4):356-364.

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