Chuang Gung Medical Foundation, Division of Pediatric Allergy, Asthma and Rheumatology - UNREGISTERED VERSION

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Lee WI

About Us > Team Member

Wen-I Lee, M.D., Ph.D.

Attending doctor, Chang Gung Children’s Hospital.

Referred Experts in Jeffrey Modell Function for primary Immunodeficiency diseases

Teaching or Professional positions
Division of Allergy, Asthma, Rheumatology, Department of Pediatrics, Hsin-Chu Hospital
Division of Allergy, Asthma, Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital
Visiting scientist in University of Washington Medical Center

Professional Memberships
Chinese Medicine License No: 024693
Board Certification on Pediatrics Society No.002086. Taiwan. ROC.
National Board of Rheumatologist of the Republic of China, #217, 1999
National Board of Clinical Immunologist Republic of China, #248, 1999

Basic research Interests:  
The overall emphasis of research is in human T,B and NK cell development and in aberrations in their development and regulation. The work involves three particular areas of investigation:
1) the cellular and molecular bases of genetically-determined human immunodeficiency diseases,
2) the use of hematopoietic stem cells to cure genetically-determined immunodeficiency diseases and
3) the use of hematopoietic stem cell chimeras to study human thymic education, T and B cell reconstruction.

Primary immunodeficiency disorders, recurrent infections, pediatrics

Clinical research interests:

Recurrent infections, primary immunodeficiency, immune reconstruction after hematopoietic stem cell transplantation, and allergic diseases (including asthma, allergic rhinitis, atopic dermatitis, urticaria)






















Representative publications:

  • Lee WI,* Yao TC, Yeh KW, Chen LC, Ou LS, Huang JL*; the PATCH Study Group. Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children. Immunobiology. 2013;218:192-200.

  • Lee WI,* Huang JL, Wu TS, Lee MH, Chen IJ, Yu KH, Liu CY, Yang CH, Hsieh MY, Lin YL, Shih YF, Jaing TH, Huang SC, Kuo TT, Ku CL. Patients with inhibitory and neutralizing auto-antibodies to interferon-γ resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. Immunobiology. 2013;218:762-71

  • Lee WI,* Huang JL, Jaing TH, Shyur SD, Yang KD, Chien YH, Chiang BL, Soong WJ, Chiou SS, Shieh CC, Lin SJ, Yeh KW, Chen LC, Ou LS, Yao TC, Lin TY, Chiu CH, Huang YC, Wu KH, Lin CY, Yu HH, Yang YH, Yu HR, Yen HJ, Hsieh MY, Kuo ML, Hwu WL, Tsai YC, Kuo HC, Lin YL, Shih YF, Chang KW. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985–2010. Immunobiology. 2011;216:1286-94.

  • Lee WI, Zhu Q, Gambineri E, Jin Y, Walcher AA, Ochs HD*: Inducible CO-Stimulator molecule (ICOS), a candidate gene for defective isotype switching, is normal in patients with Hyper IgM syndrome of unknown molecular diagnosis. J Allergy Clin Immunol 2003; 112:958-964

  • Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD*. Molecular analysis in a large cohort of patients with hyper immunoglobulin M (IgM) syndrome. Blood 2005; 105:1881-1890

  • Imai K, Slupphaug G, Lee WI, Revy P, Nonoyama S, Catalan N, Yel L, Forveille M, Krokan HE, Ochs HD, Alain Fischer, Anne Durandy*: Uracil-DNA glycosylase deficiency proundly impairs immunoglobulin class switch recombination, leading to a hyper-IgM syndrome. Nat Immunol 2003; 4:1023-8 (* correspondence)

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