Page 26 - 林口長庚醫研部電子報-2019年3月刊

The cumulative sensitivity and specificity of ICT

Of the 156 patients enrolled, 91 (58%), 64 (41%) and 72

(46%) were positive to the ICT kit, viral culture and

RTPCR, respectively. The laboratory-confirmed infection

with either positive EV71 culture or RTPCR was used as

the diagnostic standard. The sensitivity and

specificity of ICT kit were 84% and 77% (Figure 2). In

the study, virus culture and RTPCR gave a relatively

lower sensitivity but higher specificity. The patient

age didn’t affect the performance of ICT, virus

culture and RTPCR. However, a low sensitivity of ICT

kit was noted before the second day of disease onset

(Figure 2).In the instruction of the ICT kit, not only

whole blood but the serum and plasma are acceptable for

running the test. We compared the results of ICT kit

from whole blood and plasma samples in the same

patients, and 100% compatibility was noted.

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