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兒童過敏免疫風濕科
兒童腸胃科
兒童感染科
兒童腎臟科
兒童胸腔科
兒童神經科
兒童血液腫瘤科
兒童加護科
兒童心臟科
一般醫學科
次專科簡介
  • 本科自民國75年元旦，由黃嵩雀醫師創立，以促進兒童的健康及神經心智發展為宗旨。
  • 服務的病童包括：
    1. 發展障礙-如腦性麻痺、智障、自閉症、學習障礙、過動症等。
    2. 兒童痙攣-如熱痙攣、兒童良性癲癇、兒童頑固型癲癇。
    3. 神經肌肉病變-如神經炎、肌炎、肌肉營養症、重症肌無力等
    4. 不自主動作症候群-如Tic、妥瑞症、過動症、張力失調症。
    5. 先天性腦部發育異常-如裂腦症、胼胝體發育不全、小頭症、大頭症、水腦症。
    6. 代謝性腦病變-如粒腺體疾病、維他命B6缺乏症等。
    7. 急重症腦炎-如細菌性腦膜炎、病毒性腦炎、重積型癲癇、腦血管拴塞及腦出血。
    8. 腦腫瘤診斷及後續追蹤照顧。
  • 本科的特色為：
    1. 整合兒童復健科、兒童心智科、兒童耳鼻喉科、兒童眼科及兒童內科各次專科，提供兒童全面性的評估與治療。
    2. 多樣的檢測工具-如南台灣唯一的24小時錄影腦波記錄及24小時腦波紀錄專屬病房，可對難治療的癲癇病童做長時間的腦波監測。
    3. 24小時的兒童神經急重症處置，不經照會由專科醫師於加護病房直接處置，以在第一時間將腦傷減至最低。
    4. 重視病童家屬的心理需求，定期舉辦病友會活動。
    5. 針對困難治療頑性癲癇患者，提供客製化生酮飲食治療計劃，由兒童神經科及營養部共同合作回診，目前治療成功率及持續使用率為全國之冠。為本院特色醫療。
    6. 與神經外科合作發展癲癇手術治療，目前已組成兒童癲癇手術團隊及買進高端儀器設備，可以服務南台灣需要癲癇手術之病患。
  • 本科目前共4位主治醫師，黃立同醫師致力於嬰幼兒抽痙的研究；張瑛玿醫師專長於兒童神經認知發展和新生兒缺氧窒息腦病變；洪碧蓮醫師專長神經疾患之生酮飲食治療、兒童癲癇治療及兒童神經罕病整合照護；徐美欣醫師為目前科主任，專長為神經重症及腦炎等治療。
醫師團隊
Apo_horn
團隊大合照
irasutoya_clipborad_hakui_man
徐美欣 主任
現職
高雄長庚兒童神經內科主任
學歷
台大藥學系畢業
高雄醫學大學學士後醫系畢業
經歷
林口長庚兒童內科住院醫師
高雄長庚住院醫師及臨床研究員
高雄長庚兒童急診科主治醫師
高雄長庚兒童神經科主治醫師
高雄長庚兒童加護科主治醫師
高雄長庚兒童神經內科主任
專業證照
兒科專科醫師
兒童神經專科醫師
兒童重症專科醫師
兒童急診專科醫師
兒保專科醫師
教職
部定助理教授
專長
小兒神經重症
兒童腦炎
兒童抽搐重症
論文及研究
  1. An antibody treats almost all refractory autoimmune diseases: fact and beyond.
    Lin LY, Hsu MH, Yang KD.
    J Formos Med Assoc. 2012 Apr;111(4):181-2. doi: 10.1016/j.jfma.2011.05.004. PMID: 22655322.
  2. Paraneoplastic neurological disorders in children with benign ovarian tumors.
    Hsu MH, Huang CC, Hung PL, Huang HM, Huang LT, Huang CC, Sheen JM, Huang SC, Chang YC.
    Brain Dev. 2014 Mar;36(3):248-53. doi: 10.1016/j.braindev.2013.04.009. Epub 2013 May 18. PMID: 23694758.
  3. Effects of melatonin on prenatal dexamethasone-induced epigenetic alterations in hippocampal morphology and reelin and glutamic acid decarboxylase 67 levels.
    Lui CC, Hsu MH, Kuo HC, Chen CC, Sheen JM, Yu HR, Tiao MM, Tain YL, Chang KA, Huang LT.
    Dev Neurosci. 2015;37(2):105-14. doi: 10.1159/000368768. Epub 2015 Feb 25. PMID: 25720733.
  4. Combined Intraperitoneal and Intrathecal Etanercept Reduce Increased Brain Tumor Necrosis Factor-Alpha and Asymmetric Dimethylarginine Levels and Rescues Spatial Deficits in Young Rats after Bile Duct Ligation.
    Sheen JM, Chen YC, Hsu MH, Tain YL, Yu HR, Huang LT.
    Front Cell Neurosci. 2016 Jun 23;10:167. doi: 10.3389/fncel.2016.00167. PMID: 27445694; PMCID: PMC4917524.
  5. Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats.
    Sheen JM, Chen YC, Hsu MH, Tain YL, Huang YH, Tiao MM, Li SW, Huang LT.
    Int J Mol Sci. 2016 Aug 20;17(8):1365. doi: 10.3390/ijms17081365. PMID: 27556445; PMCID: PMC5000760.
  6. Variations of movement disorders in anti-N-methyl-D-aspartate receptor encephalitis: A nationwide study in Taiwan.
    Duan BC, Weng WC, Lin KL, Wong LC, Li ST, Hsu MH, Lin JJ, Fan PC, Lin MI, Chiu NC, Lin YC, Wang HS, Hung KL, Lee WT.
    Medicine (Baltimore). 2016 Sep;95(37):e4365. doi: 10.1097/MD.0000000000004365. PMID: 27631202; PMCID: PMC5402545.
  7. Minocycline restores cognitive-relative altered proteins in young bile duct-ligated rat prefrontal cortex.
    Li SW, Chen YC, Sheen JM, Hsu MH, Tain YL, Chang KA, Huang LT.
    Life Sci. 2017 Jul 1;180:75-82. doi: 10.1016/j.lfs.2017.03.023. Epub 2017 Mar 31. PMID: 28366719.
  8. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease.
    Lin DS, Kao SH, Ho CS, Wei YH, Hung PL, Hsu MH, Wu TY, Wang TJ, Jian YR, Lee TH, Chiang MF.
    Oncotarget. 2017 Sep 1;8(43):73627-73639. doi: 10.18632/oncotarget.20617. PMID: 29088732; PMCID: PMC5650287.
  9. Melatonin prevented spatial deficits and increases in brain asymmetric dimethylarginine in young bile duct ligation rats.
    Hsu MH, Chen YC, Sheen JM, Li SW, Huang LT.
    Neuroreport. 2018 May 2;29(7):541-546. doi: 10.1097/WNR.0000000000000972. PMID: 29384993; PMCID: PMC6023590.
  10. Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague⁻Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways.
    Hung PL, Hsu MH, Yu HR, Wu KLH, Wang FS.
    Int J Mol Sci. 2018 Aug 29;19(9):2573. doi: 10.3390/ijms19092573. PMID: 30158497; PMCID: PMC6164053.
  11. Neurological Complications in Young Infants With Acute Bacterial Meningitis.
    Hsu MH, Hsu JF, Kuo HC, Lai MY, Chiang MC, Lin YJ, Huang HR, Chu SM, Tsai MH.
    Front Neurol. 2018 Oct 24;9:903. doi: 10.3389/fneur.2018.00903. PMID: 30405525; PMCID: PMC6207629.
  12. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.
    Huang YW, Chiang MF, Ho CS, Hung PL, Hsu MH, Lee TH, Chu LJ, Liu H, Tang P, Victor Ng W, Lin DS.
    Aging Dis. 2018 Dec 4;9(6):1043-1057. doi: 10.14336/AD.2018.0222. PMID: 30574417; PMCID: PMC6284769.
  13. Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease.
    Lin DS, Huang YW, Ho CS, Hung PL, Hsu MH, Wang TJ, Wu TY, Lee TH, Huang ZD, Chang PC, Chiang MF.
    Cells. 2019 Jan 17;8(1):65. doi: 10.3390/cells8010065. PMID: 30658448; PMCID: PMC6356288.
  14. PRRT2 missense mutations cluster near C-terminus and frequently lead to protein mislocalization.
    Tsai MH, Nian FS, Hsu MH, Liu WS, Liu YT, Liu C, Lin PH, Hwang DY, Chuang YC, Tsai JW.
    Epilepsia. 2019 May;60(5):807-817. doi: 10.1111/epi.14725. Epub 2019 Apr 13. PMID: 30980674.
  15. Left Ventricle Decompression Strategies in Pediatric Peripheral Extracorporeal Membrane Oxygenation.
    Lin YJ, Liu HY, Kuo HC, Huang CF, Hsu MH, Cheng MC, Chien SJ, Lin IC, Lo MH, Sheu JJ.
    Acta Cardiol Sin. 2019 May;35(3):335-341. doi: 10.6515/ACS.201905_35(3).20181125A. PMID: 31249464; PMCID: PMC6533587.
  16. Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin.
    Sheen JM, Yu HR, Tain YL, Chen YC, Hsu MH, Huang LT.
    Int J Dev Neurosci. 2019 Nov;78:83-89. doi: 10.1016/j.ijdevneu.2019.09.003. Epub 2019 Sep 21. PMID: 31550497.
  17. Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
    Chen YC, Sheen JM, Hsu MH, Hsiao CC, Wang SC, Huang LT.
    Life Sci. 2020 Feb 1;242:116931. doi: 10.1016/j.lfs.2019.116931. Epub 2019 Oct 13. PMID: 31618610.
  18. Early Clinical Predictors of Neurological Outcome in Children With Asphyxial Out-of-Hospital Cardiac Arrest Treated With Therapeutic Hypothermia.
    Lin JJ, Lin YJ, Hsia SH, Kuo HC, Wang HS, Hsu MH, Chiang MC, Lin CY, Lin KL.
    Front Pediatr. 2020 Jan 17;7:534. doi: 10.3389/fped.2019.00534. PMID: 32010648; PMCID: PMC6979260.
  19. Rats with prenatal dexamethasone exposure and postnatal high-fat diet exhibited insulin resistance, and spatial learning and memory impairment: effects of enriched environment.
    Hsu MH, Sheen JM, Chen YC, Yu HR, Tain YL, Huang LT.
    Neuroreport. 2020 Feb 5;31(3):265-273. doi: 10.1097/WNR.0000000000001406. PMID:32032284.
  20. Rats with prenatal dexamethasone exposure and postnatal high-fat diet exhibited insulin resistance, and spatial learning and memory impairment: effects of enriched environment.
    Hsu MH, Sheen JM, Chen YC, Yu HR, Tain YL, Huang LT.
    Neuroreport. 2020 Feb 18. doi: 10.1097/WNR.0000000000001406. Epub ahead of print. PMID: 32073536.
  21. Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity.
    Hsu MH, Chen YC, Sheen JM, Huang LT.
    Int J Environ Res Public Health. 2020 Mar 2;17(5):1610. doi: 10.3390/ijerph17051610. PMID: 32131513; PMCID: PMC7084214.
  22. Outcome analysis of pediatric hemophagocytic lymphohistiocytosis.
    Chen TY, Hsu MH, Kuo HC, Sheen JM, Cheng MC, Lin YJ.
    J Formos Med Assoc. 2020 Apr 16:S0929-6646(20)30119-4. doi: 10.1016/j.jfma.2020.03.025. Epub ahead of print. PMID: 32307323.
  23. Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy.
    Hsu MH, Kuo HC, Lin JJ, Chou MY, Lin YJ, Hung PL.
    Biomed J. 2020 Apr 21:S2319-4170(20)30040-8. doi: 10.1016/j.bj.2020.04.004. Epub ahead of print. PMID: 32330677.
  24. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet.
    Hsu MH, Sheen JM, Lin IC, Yu HR, Tiao MM, Tain YL, Huang LT.
    Int J Mol Sci. 2020 May 12;21(10):3428. doi: 10.3390/ijms21103428. PMID: 32408716; PMCID: PMC7279178.
  25. Epileptiform Discharge and Electrographic Seizures during the Hypothermia Phase as Predictors of Rewarming Seizures in Children after Resuscitation.
    Lin JJ, Hsu MH, Hsia SH, Lin YJ, Wang HS, Kuo HC, Chiang MC, Chan OW, Lee EP, Lin KL, The iCNS Group.
    J Clin Med. 2020 Jul 8;9(7):E2151. doi: 10.3390/jcm9072151. PMID: 32650443.
irasutoya_clipborad_hakui_man
洪碧蓮 醫師
現職
高雄長庚醫院 兒童神經科
長庚醫院 副教授
學歷
中國醫藥大學醫學系
長庚大學臨研所博士班畢業
經歷
高雄長庚醫院兒童神經科 主任
長庚大學 專任助理教授
專業證照
兒科專科醫師
兒童神經科醫師
教職
教育部部定助理教授
論文及研究
  1. Severe complication of catatonia in a young patient with Hashimoto's encephalopathy comorbid with Cornelia de Lange syndrome.
    Chen YW, Hung PL, Wu CK, Tseng PT*.
    Kaohsiung J Med Sci. 2015 Jan;31(1):60-1.
  2. Activating the Wnt/β-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.
    Huang HM, Huang CC, Wang FS, Hung PL, Chang YC*.
    Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4300-8.
  3. Two Cases of Cerebrovascular Accidents in Neonates with Incontinentia Pigmenti.
    Tsai WC, Cheng YW, Chen CC, Hung PL*.
    Pediatr Neurol. 2015 Sep;53 (3):e7-9.
  4. Prenatal Dexamethasone and Postnatal High-Fat Diet Decrease Interferon Gamma Production through an Age-Dependent Histone Modification in Male Sprague-Dawley Rats.
    Yu HR, Tain YL, Sheen JM, Tiao MM, Chen CC, Kuo HC, Hung PL, Hsieh KS, Huang LT*.
    Int J Mol Sci. 2016 Sep 22;17(10). pii: E1610
  5. The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism.
    Fan HC, Lee HS, Chang KP, Lee YY, Lai HC, Hung PL, Lee HF, Chi CS*.
    Int J Mol Sci. 2016 Aug 1;17(8). pii: E1242.
  6. Variations of stereotypies in individuals with Rett syndrome: A nationwide cross-sectional study in Taiwan.
    Chin Wong L, Hung PL(Co-First), Jan TY, Lee WT; Taiwan Rett Syndrome Association.
    Autism Res. 2017 Jul;10(7):1204-1214.
  7. Ictus emeticus presenting as an unusual seizure type in chromosome 22q11.2 deletion syndrome.
    Hung PL, Huang LT, Kwan SY, Chang KP, Chen HH, Lee YY, Fan HC, Chen C.
    Epileptic Disord. 2017 Mar 1;19(1):76-81.
  8. Age-Dependent Effects of Prenatal Dexamethasone Exposure on Immune Responses in Male Rats.
    Chou MY, Huang LT, Tain YL, Kuo HC, Tiao MM, Sheen JM, Chen CC, Hung PL, Hsieh KS, Yu HR.
    Tohoku J Exp Med. 2017 Mar;241(3):225-237
  9. Diagnostic value of bronchoalveolar lavage in children with nonresponding community-acquired pneumonia.
    Tsai CM, Wong KS, Lee WJ, Hsieh KS, Hung PL, Niu CK, Yu HR.
    Pediatr Neonatol. 2017 Oct;58(5):430-436.
  10. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease.
    Dar-Shong Lin, Shu-Huei Kao, Che-Sheng Ho, Yau-Huei Wei, Pi-Lien Hung, Mei-Hsin Hsu, Tsu-Yen Wu, Tuan-Jen Wang, Yuan-Ren Jian, Tsung-Han Lee and Ming-Fu Chiang.
    Oncotarget 2017, 8 (43): 73627-73639
  11. Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants.
    Pi-Lien Hung, Chun-Chung Lui, Chen-Chang Lee, Yin-Hsiu Chien, Feng-Shun Chen, Chih-Cheng Chen,Hong-Ren Yu, Mei-Yung Chung, Li-Tung Huang.
    2018 Jan, 15(1): 1013-1020.
  12. Mutational analysis of CCM1, CCM2 and CCM3 in a Han Chinese cohort with multiple cerebral cavernous malformations in Taiwan.
    Jih KY, Chung CP, Chang YY, Hung PL, Soong BW, Liao YC, Lan MY, Lee YC.
    Clin Genet. 2018 Oct;94(3-4):389-390
  13. Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague⁻Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways.
    Hung PL, Hsu MH, Yu HR, Wu KLH, Wang FS.
    Int J Mol Sci. 2018 Aug 29;19(9). pii: E2573
  14. Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease.
    Lin DS, Huang YW, Ho CS, Hung PL, Hsu MH, Wang TJ, Wu TY, Lee TH, Huang ZD, Chang PC, Chiang MF.
    Cells. 2019 Jan 17;8(1). pii: E65.
  15. A Transcriptome Study of Progeroid Neurocutaneous Syndrome Reveals POSTN As a New Element in Proline Metabolic Disorder.
    Huang YW, Chiang MF, Ho CS, Hung PL, Hsu MH, Lee TH, Chu LJ, Liu H, Tang P, Victor Ng W, Lin DS.
    Aging Dis. 2018 Dec 4;9(6):1043-1057.
  16. The effectiveness of music therapy for individuals with Rett syndrome and their families.
    Chou MY, Chang NW, Chen C, Lee WT, Hsin YJ, Siu KK, Chen CJ, Wang LJ, Hung PL.
    J Formos Med Assoc. 2019 Jan 19. pii: S0929-6646(18)30427-3.
聯繫方式
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irasutoya_clipborad_hakui_man
張瑛玿 醫師
現職
高雄長庚醫院 兒童神經科資深醫師
長庚大學 兼任副教授
學歷
國立台大醫學系
長庚大學臨研所博士班畢業
經歷
高雄長庚醫院 兒童內科 主治醫師
Johns Hopkms 醫院臨床研究員
專業證照
兒科專科醫師
兒童神經專科醫師
教職
教育部部定副教授
論文及研究
  1. Molecular Genetic Characterization of Patients With Focal Epilepsy Using a Customized Targeted Resequencing Gene Panel.
    Meng-Han Tsai1*, Chung-Kin Chan2, Ying-Chao Chang3, Chih-Hsiang Lin1, Chia-Wei Liou1, Wen-Neng Chang1, Ching-Ching Ng2, Kheng-Seang Lim4 and Daw-Yang Hwang5* (2018, Jul).
    Frontiers in Neurology , Volume 9 | Article 515 ,1-9.
  2. Systemic 7,8-dihydroxyflavone treatment protects immature retinas against hypoxic-ischemic injury via müller glia regeneration and MAPK/ERK activation.
    Hsiu-Mei Huang, Chao-Ching Huang, Meng-Han Tsai, Yi-Chieh Poon,Ying-Chao Chang* (2018, Jun).
    Investigative Ophthalmology & Visual Science, 59(7):3124–3135.
  3. Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain.
    Yi-Chao Lee1,2 & Ying-Chao Chang3,4 & Chia-Ching Wu5 & Chao-Ching Huang6,7,8 (2018, Feb).
    Molecular Neurobiology.
  4. Activating the Wnt/β-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.
    Huang HM, Huang CC, Wang FS, Hung PL, Chang YC. (2015, Jul).
    Invest Ophthalmol Vis Sci, 56(8):4300-8.
  5. TNFR1-JNK signaling is the shared pathway of neuroinflammationand neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain.
    Wang LW, Chang YC, Chen SJ, Tseng CH, Tu YF, Liao NS, Huang CC, Ho CJ. (2014, Dec).
    J Neuroinflammation, 24;11:215.
  6. Cerebral microvascular damage occurs early after hypoxia-ischemiavia nNOS activation in the neonatal brain.
    Hsu YC, Chang YC, Lin YC, Sze CI, Huang CC, Ho CJ. (2014, Apr).
    J Cereb Blood Flow Metab, 34(4):668-76.
  7. Paraneoplastic neurological disorders in children with benign ovarian tumors.
    Hsu MH, Huang CC, Hung PL, Huang HM, Huang LT, Huang CC, Sheen JM, Huang SC, Chang YC. (2014, Mar).
    Brain Dev, 36(3):248-53.
  8. Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor.
    Hung PL, Huang CC, Huang HM, Tu DG, Chang YC. (2013, Aug).
    Stroke , 44(8):2275-83.
聯繫方式
----
irasutoya_clipborad_hakui_man
黃立同 醫師
現職
高雄長庚醫院 兒童神經科資深主治醫師
長庚大學 專任教授
學歷
臺北醫學大學醫學系
經歷
高雄長庚醫院 兒童神經科 主任
高雄長庚醫院 兒童內科 部主任
Stanford University Hospital 臨床研究員
Harvard Medical School 基礎醫學研究員
SUNY， Health Science Center at Brooklyn 實習研究員
專業證照
兒科專科醫師
兒童神經科專科醫師
教職
教育部部定教授
論文發表
  1. Tain YL, Huang LT, Hsu CN. Developmental Programming of Adult Disease: Reprogramming by Melatonin? Int J Mol Sci. 2017;18(2). (SCI; IF=3.2).
  2. Hung PL, Huang LT, Kwan SY, Chang KP, Chen HH, Lee YY, Fan HC, Chen C. Ictus emeticus presenting as an unusual seizure type in chromosome 22q11.2 deletion syndrome. Epileptic Disord. 2017; 19:76-81 (SCI; IF=0.9).
  3. Chou MY, Huang LT, Tain YL, Kuo HC, Tiao MM, Sheen JM, Chen CC, Hung PL, Hsieh KS, Yu HR. Age-Dependent Effects of Prenatal Dexamethasone Exposure on Immune Responses in Male Rats. Tohoku J Exp Med. 2017;241:225-237. (SCI; IF=1.5).
  4. Tain YL, Lin YJ, Sheen JM, Yu HR, Tiao MM, Chen CC, Tsai CC, Huang LT, Hsu CN. High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring. Nutrients. 2017;9(4). (SCI; IF=3.7).
  5. Lin YJ, Tsai CC, Huang LT, Sheen JM, Tiao MM, Yu HR, Chen CC, Tain YL. Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock. J Assist Reprod Genet. 2017;34:817-826. (SCI; IF=1.858).
  6. Tain YL, Lin YJ, Sheen JM, Lin IC, Yu HR, Huang LT, Hsu CN. Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring. J Nutr Biochem. 2017 Jun 24;48:120-127. (SCI; IF=4.552).
  7. Chen YC, Huang YH, Sheen JM, Tain YL, Yu HR, Chen CC, Tiao MM, Kuo HC, Huang LTca. Prenatal dexamethasone exposure programs the development of the pancreas and the secretion of insulin in rats. Pediatr Neonatol 2017;58:135-144 (SCI; IF=1.2).
  8. Li SW, Chen YC, Sheen JM, Hsu MH, Tain YL, Chang KA, Huang LTca. Minocycline restores cognitive-relative altered proteins in young bile duct-ligated rat prefrontal cortex. Life Sci. 2017; 180:75-82 (SCI; IF=2.9).
  9. Tsai CC, Tiao MMca, Huang LTca Melatonin alleviates liver steatosis induced by prenatal dexamethasone exposure and postnatal high fat diet. Exp Ther Med 2017 in press (SCI; IF=1.26).
  10. Hu PL, Huang LTca Gestational age, not transient hyperthyotropinemia impcats brain white matter diffuxion tensor imaging in premature infants. Exp Ther Med 2018:15:1013-1020. (SCI; IF=1.26).
  11. Li SW, Yu HR Tai YL, Huang LTca. A maternal high-fat diet during pregnancy and lactation, in addition to a postnatal high-fat diet, leads to metabolic syndrome with spatial learning and memory deficits: beneficial effects of resveratrol. Oncotarget 2017;8(67):111998-112013 (SCI; IF=5.168).
  12. Hsu MS, Chen YC, Sheen JM, Li SW, Huang LTca . Melatonin prevented spatial deficits and increases in brain asymmetric dimethylarginine in young bile duct ligation rats. NeuroReport 2018;29:541-546. (SCI; IF=1.343).
  13. Yu HR, Tain YL, Tiao MM, Chen CC, Sheen JM, Lin IC, Li SW, Tsai CC, Lin YJ, Hsieh KS, Huang LTca. Prenatal dexamethasone and postnatal high-fat diet have a synergistic effect of elevating blood pressure through a distinct programming mechanism of systemic and adipose renin-angiotensin systems. Lipids Health Dis. 2018;17:50. (SCI; IF=2.6).
  14. Sheen JM, Yu HR, Tain YL, Tsai WL, Tiao MM, Lin IC, Tsai CC, Lin YJ, Huang LTca. Combined maternal and postnatal high-fat diet leads to metabolic syndrome and is effectively reversed by resveratrol: a multiple-organ study. Sci Rep. 2018;8:5607. (SCI; IF=4.2).
  15. Lin YJ, Lin IC, Yu HR, Sheen JM, Huang LT, Tain YL. Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring. Oxid Med Cell Longev. 2018;2018:5343462. (SCI; IF=4.9).
  16. Tiao MM, Lin YJ, Yu HR, Sheen JM, Lin IC, Lai YJ, Tain YL, Huang LT, Tsai CC. Resveratrol ameliorates maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease via renin-angiotensin system. Lipids Health Dis. 2018 Jul 28;17(1):178. (SCI; IF=2.6).
  17. Tsai CC, Lin YJ, Yu HR, Sheen JM, Tain YL, Huang LTca, Tiao MM. Melatonin alleviates liver steatosis induced by prenatal dexamethasone exposure and postnatal high-fat diet. Exp Ther Med. 2018;16:917-924. (SCI; IF=1.4).
  18. Tsai CC, Lin YJ, Yu HR, Sheen JM, Lin IC, Lai YJ, Tain YL, Huang LT, Tiao MM. Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis. Int J Mol Sci. 2018;19(11). (SCI; IF=3.6).
  19. Tsai CC, Tiao MM, Sheen JM, Huang LT, Tain YL, Lin IC, Lin YJ, Lai YJ, Chen CC, Chang KA, Yu HR. Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue. Lipids Health Dis. 2019;18:19. (SCI; IF=2.6).
  20. Hou CY, Tain YL, Yu HR, Huang LTca. The Effects of Resveratrol in the Treatment of Metabolic Syndrome. Int J Mol Sci. 2019 Jan 28;20(3). (SCI; IF=3.86).
  21. Lin YJ, Huang LT, Tsai CC, Sheen JM, Tiao MM, Yu HR, Lin IC, Tain YL. Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing. Placenta. 2019;78:44-53. (SCI; IF=2.436).
  22. Yu HR, Sheen JM, Tiao MM, Tain YL, Chen CC, Lin IC, Lai YJ, Tsai CC, Lin YJ, Tsai CC, Chang KA, Huang LTca. Resveratrol Treatment Ameliorates Leptin Resistance and Adiposity Programmed by the Combined Effect of Maternal and Post-Weaning High-Fat Diet. Mol Nutr Food Res. 2019:e1801385. (SCI; IF=5.1).
  23. Chen HE, Lin YJ, Lin IC, Yu HR, Sheen JM, Tsai CC, Huang LT, Tain YL. Resveratrol prevents combined prenatal NG-nitro-L-arginine-methyl ester (L-NAME) treatment plus postnatal high-fat diet induced programmed hypertension in adult rat offspring: interplay between nutrient-sensing signals, oxidative stress and gut microbiota. J Nutr Biochem. 2019 Apr 24;70:28-37. (SCI; IF=4.4).
  24. Hsu CN, Lin YJ, Yu HR, Lin IC, Sheen JM, Huang LT, Tain YL. Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy. Int J Mol Sci. 2019 Aug 14;20(16). (SCI; IF=4.17).
  25. Sheen JM, Yu HR, Tain YL, Chen YC, Hsu MH, Huang LTca. Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin. Int J Dev Neurosci. 2019;78:83-89. (SCI; IF=2.37).
  26. Chen YC, Sheen JM, Hsu MH, Hsiao CC, Wang SC, Huang LTca. Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. Life Sci. 2019 Oct 13:116931. (SCI; IF=3.4).
  27. Huang YC, Huang LT, Sheen JM, Hou CY, Yeh YT, Chiang CP, Lin IC, Tiao MM, Tsai CC, Lin YJ, Chen CC, Tain YL, Yu HR. Resveratrol treatment improves the altered metabolism and related dysbiosis of gut programed by prenatal high-fat diet and postnatal high-fat diet exposure. J Nutr Biochem. 2019;75:108260. (SCI; IF=4.4).
  28. Hsu CN, Huang LT, Tain YL. Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases. Int J Mol Sci. 2019 Nov 13;20(22). (SCI; IF=4.1).
  29. Hsu MS, Chen YC, Sheen JM, Huang LTca. Rats with prenatal dexamethasone exposure and postnatal high-fat diet exhibited insulin resistance, and spatial learning and memory impairment : effects of enriched environment. NeuroReport 2020;31: 265-273. (SCI; IF=1.2).
  30. Hsu MS, Chen YC, Sheen JM, Huang LTca. Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal Obesity.Int J Environ Res Public Health. 2020;17. (SCI; IF=2.468).
  31. Tsai TA, Tsai CK, Huang LT, Sheen JM, Tiao MM, Tain YL, Chen CC, Lin IC, Lai YJ, Tsai CC, Lin YJ, Yu HR. Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring. Int J Environ Res Public Health. 2020;17(8). (SCI; IF=2.468).
  32. Hsu MH, Sheen JM, Lin IC, Yu HR, Tiao MM, Tain YL, Huang LTca. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. Int J Mol Sci. 2020;21(10). (SCI; IF=4.55).
  33. Wang CY, Chen YW, Tain YL, Chang SKC, Huang LT, Hsieh CW, Hou CY. Fast quantification of short-chain fatty acids in rat plasma by gas chromatography. J Food Sci. 2020 May 25. (SCI; IF=1.8).
  34. Tsai CC, Chen YJ, Yu HR, Huang LT, Tain YL, Lin IC, Sheen JM, Wang PW, Tiao MM. Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice. Lipids Health Dis. 2020;19:105. (SCI; IF=2.6).
  35. Hsu CN, Lin IC, Yu HR, Huang LT, Tiao MM, Tain YL. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Int J Mol Sci. 2020;21:E4552. (SCI; IF=4.55).
聯繫方式
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irasutoya_clipborad_hakui_man
蘇亭毓 醫師
Dr. Ting-yu, Su
現職 Current Post
高雄長庚醫院 兒童神經科 總醫師 KCGMH Pediatric Neurology Fellowship
學歷 Medical Training
臺北醫學大學醫學系 Taipei Medical University, Department of Medicine
經歷 Experience
高雄長庚醫院 兒童內科 住院醫師 KCGMH Pediatric Residency
專業證照 Licenses
醫師執照 Taiwan Medical License
兒科專科醫師 Pediatric Board License
論文發表及得獎經歷 Research and Award
  1. 第十四屆新生兒醫學研究發展座談會暨第二十九次學術討論會 中英文口頭發表 Oral presentation in 14th Research Conference of Taiwan Society of Neonatology
  2. 第244屆台灣兒科學術演講會 口頭發表 Oral presentation in The 244th Scientific Meeting of Taiwan Pediatric Association
  3. 歐洲聯合新生兒科聯合學術研討會 口頭發表 獲本特·羅伯遜獎 Bengt Robertson Award in 3rd Congress of joint European Neonatal Societies (jENS 2019)
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