李秋美
林靖麒
林科名
王文科
謝清川
陳肇寅
郭昶甫
曾啟權
江博暉
林宜君
楊昭輝
林坤成
洪裕強
林志哲
莊文郁
莊蕙青
林素珍
張中明
舒竹青
黃幸宜
郭敏玲
王永樑
羅時成
中野敏明
陳芳馨
周百謙
張國軒
黃冠穎
陳品元
韓仕聰
楊皇煜
賴彬卿
羅淑芬
塗昆樺
許瑞旭
賴振宏
李威震
詹昆明
林承弘
林柏宏
黃璟隆
陳力振
林思偕
劉錦棠
林意旋
沈建忠
吳黃平
胡瀞之
吳宗翰
葉光揚
吳詹永嬌
曾文逸
蔡文彬
廖穗綾
蘇冠文
林胤谷
張心寧
黃澤宏
葉沅杰
李志宏
郭和昌
黃聰龍
楊賢鴻
賴信志
林政道
李文益
陳基益
黃毓惠
沈家瑞
方嘉佑
林怡廷
顧正崙
林錫賢
邱健泰
黃景泰
張文震
邱志勇
傅崇安
林俊彥
周開平
吳承宇
吳庭榕
林展宇
楊智偉
李立夫
陳濘宏
Rajendra Prasad Janapatla
陳奇良
王燕玲
魏福全
陳澤卿
鐘文宏
鍾福財
單位: 長庚大學
現職: 醫學生物技術暨檢驗學系主任/教授
聯絡地址: 33302 桃園市龜山區文化一路259號
電話: 03-2118800 分機:3585 傳真: 03-2118800
E-mail: hclai@mail.cgu.edu.tw
研究領域:
- 微生物學
- 醫學之生化及分子生物
- 免疫
研究成果
Gut microbiota plays an essential role in modulation of host immunity and homeostasis. Dysbiosis results in chronic inflammation and many important diseases such as insulin resistance, diabetes, fatty liver, NASH, colitis and lung immunity dysregulation. Our main research interests focus on interaction between microbiota, pathogens, herbs and host immunity. Besides characterizing the underlying mechanism of chronic inflammation related diseases, we also hope to identify important probiotics and efficient prebiotics for amelioration of the diseases through modulation of host immunity.
工作經歷:
1994-2006 Associate Professor, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taiwan
2006–2007 Professor, Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taiwan
2007–Present Professor and Director, Graduate Institute of Medical Biotechnology and Laboratory Sciences, Chang Gung University, Taiwan
學歷:
1982-1986 B.S, Department of Medical Technology, National Taiwan University, Taiwan.
1986-1988 M.S, Institute of Microbiology & Immunology, National Yang-Ming University, Taiwan
1990-1994 PhD, Department of Pathology, University of Cambridge, UK
殊榮:
1990-1993 Oversea Research Scholarship (ORS) from the University of Cambridge, UK
2006 Ching-Sing Medical Researcher Award from the National Taiwan University
代表論文:
1. Hsin-Chih Lai, Chih-Jung Chang, Chun-Hung Yang, Ya-Jing Hsu, Chang-Chieh Chen,Chuan-Sheng Lin, Yu-Huan Tsai, Tsung-Teng Huang,, David M. Ojcius, Ying-Huang Tsai and Chia-Chen Lu*. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. Journal of Leukocyte Biology. 2012 Oct;92(4):807-14.
2. Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius1,, Yi-Hui Wu, Yun-Fei Ko, Cheng-Yeu Wu, Jan Martel1,, Chia-Chen Lu, Hsin-Chih Lai *& John D. Young*. Hirsutella sinensis mycelium suppresses interleukin-1b and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. SCIENTIFIC REPORTS. 2013;3:1374.
3. Chih-Jung Chang, Yi-Yuan Margaret Chen, Chia-Chen Lu, Chuan-Sheng Lin, Jan Martel, Sheng-Hui Tsai, Yun-Fei Ko, Tsung-Teng Huang, David M. Ojcius, Hsin-Chih Lai* & John D. Young*. Ganoderma lucidum Stimulates NK Cell Cytotoxicity by Inducing NKG2D/NCR Activation and Secretion of Perforin and Granulysin. Innate Immunity. 2014;20(3):301-11. Epub 2013 Jun 26.
4. Huang TT, Wu SP, Chong KY, Ojcius DM, Ko YF, Wu YH, Wu CY, Lu CC, Martel J, Young JD*, Hsin-Chih Lai*. The medicinal fungus Antrodia cinnamomea suppresses inflammation by inhibiting the NLRP3 inflammasome. J Ethnopharmacol. 2014 Aug 8;155(1):154-64.
5. Chia-Chen Lu, Ting-Shu Wu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Ju-Hsin Chia, Tsu-Lan Wu, Tsung-Teng Huang, Jan Martel, David M. Ojcius, John D. Young*, and Hsin-Chih Lai*. NK cells kill mycobacteria directly by releasing perforin and granulysin. J Leukoc Biol.2014 Dec;96(6):1119-29.
所有論文著作一覽表