專業人才 > 癌症 | 醫學之生化及分子生物

紀朗明 , Ph.D.
單位: 林口長庚醫院 醫學研究發展部 研究區
現職: 副研究員
聯絡地址: 桃園市龜山區復興街五號
電話: 03-3281200 轉8961
E-mail: lmchi@mail.cgu.edu.tw

研究領域:
  • 癌症
  • 醫學之生化及分子生物

    • 工作經歷:

    1998-2005 助理教授, 醫事檢驗生物技術系/所，元培醫事科技大學
    2005-2012 助研究員, 醫學研究發展部，長庚醫療財團法人林口長庚紀念醫院
    2012-迄今 副研究員, 醫學研究發展部，長庚醫療財團法人林口長庚紀念醫院


    學歷:

    國立清華大學 生命科學所 博士


    殊榮:
    2007 海報論文銀牌獎，台灣蛋白質體國際研討會, 2007
    2009 海報論文獎, The 2nd CGMH International Symposium on Disease Proteomics, Taiwan
    2010 海報論文獎, 2010 Disease Biomarker and TPS International Conference, Taiwan

    代表論文:
    1. Chung PJ, Chi LM, Chen CL, Liang CL, Lin CT, Chang YX, Chen CH, Chang YS. MicroRNA-205 Targets Tight Junction-related Proteins during Urothelial Cellular Differentiation. Molecular & Cellular Proteomics. 2014 Sep;13(9):2321-36.
    2. Chang KP, Wang CL, Kao HK, Liang Y, Liu SC, Huang LL, Hseuh C, Hsieh YJ, Chien KY, Chang YS, Yu JS, Chi LM*. Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma. Cancer. 2013 Nov 15;119(22):4003-11
    3. Chang KP, Yu JS, Chien KY, Lee CW, Liang Y, Liao CT, Yen TC, Lee LY, Huang LL, Liu SC, Chang YS, Chi LM*. Identification of PRDX4 and P4HA2 as Metastasis-Associated Proteins in Oral Cavity Squamous Cell Carcinoma by Comparative Tissue Proteomics of Microdissected Specimens Using iTRAQ Technology. J. Proteome Res., 2011 Nov 4;10(11):4935-47.
    4. Chi LM, Lee CW, Chang KP, Hao SP, Lee HM, Liang Y, Hsueh C, Yu CJ, Lee IN, Chang YJ, Lee SY, Yeh YM, Chang YS, Chien KY*, Yu JS*. Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated 2DLC-ESI-MALDI tandem MS. Molecular & Cellular Proteomics 2009 Jul;8(7):1453-74
    5. Chien KY, Chang YS, Yu JS, Fan LW, Lee CW, Chi LM*. Identification of a new in vivo phosphorylation site in the cytoplasmic carboxyl terminus of EBV-LMP1 by tandem mass spectrometry. Biochem Biophys Res Commun., 2006 Sep, 15;348(1):47-55. [SCI, Impact Factor: 2.648, 134/275


    所有論文著作一覽表

    學會與認證:
    2005- Member, Human Proteome Organization (HUPO)
    2005-2009 Member, Taiwan Society for Mass Spectrometry (TSMS)
    2007- 至今 Member, Taiwan Proteomics Society (TPS)
    2008-2010 Member, American Society for Biochemistry and Molecular Biology (ASBMB)
    2012- 報告簽署人, 測試領域 2368認證實驗室, 財團法人全國認證基金會Accredited Laboratory of Taiwan Accreditation Foundation (TAF)

    目前進行中研究計畫:
    1) 2014/10/1~2015/9/30 高通量定量蛋白質體驗證體液中潛在口腔癌轉移標幟蛋白
    2) 2014/8/1~2015/7/31 探討CAD為頭頸癌侵犯相關基因之細胞蛋白網絡與訊息調控研究