專業人才 > 醫學之生化及分子生物 | 感染醫學 | 微生物

柯博元 ,Ph.D.
單位: 長庚大學
現職: 生化暨分子生物學科 助理教授
聯絡地址: 333桃園市龜山區文化一路259號
電話: 03-2118800 轉5115
E-mail: pyke0324@mail.cgu.edu.tw

研究領域:
  • 醫學之生化及分子生物
  • 感染醫學
  • 微生物

工作經歷:
2012~迄今 長庚大學醫學院生物化學暨分子生物學科 助理教授

學歷:
國立台灣大學醫學院生物化學暨分子生物學 博士

殊榮:
1. 2003 Excellent Publication Award for Graduate Student, National Taiwan University, College of Medicine
2. 2003 International Conference Travel Award, The Chinese Society of Cell and Molecular Biology
3. 2004 Dr. Chien-Tien Hsu Award in 12th Symposium on Recent Advances in Cellular and Molecular Biology
4. 2004 Outstanding Student Award in Academy, National Taiwan University
5. 2005 Post-doctoral Fellowship Award, National Health Research Institute
6. 2005 The President Award in Medicine and Technology, Tien-Te Lee Biomedical Foundation, Yung Shin PHARM. IND. CO., LTD
7. 2009 Poster Award, 17th Symposium on Recent Advances in Cellular and Molecular Biology
8. 2010 Poster Award, 18th Symposium on Recent Advances in Cellular and Molecular Biology
9. 2010 Research Article Competition Award for Post-Doctoral Research Fellow, Institution of Biomedical Sciences, Academia Sinica
10. 2010 International Travel Fellowship and Invited Oral Presentation Award, 17th International Meeting on Hepatitis C Virus and Related Viruses
11. 2011 Outstanding Paper Award on hepatitis C virus research of Liver Disease Prevention & Treatment Research Foundation, Taiwan, R.O.C.

代表論文:

1. Autophagy in hepatitis C virus-host interactions: Potential roles and therapeutic targets for liver-associated diseases.
Ke, P.Y. and Chen, S,S.L.
World Journal of Gastroenterology 20: 5773-5793, 2014

2. Active RNA replication of hepatitis C virus downregulates CD81 expression.
Ke, P.Y. and Chen, S.S.L.
PLoS ONE8: e54866, 2013.

3. Autophagy: a new guardian of HCV against innate immune response.
Ke, P.Y. and Chen, S.S.L.
Autophagy 7: 533-535, 2011.

4. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro.
Ke, P.Y. and Chen, S.S.L.
Journal of Clinical Investigation 121: 37-56, 2011.

5. Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.
Ke, P.Y., Kuo, Y.Y., Hu, C.M., and Chang, Z.F.
Genes & Development19: 1920-1933, 2005.


所有論文著作一覽表

學會與認證:
Peer Reviewer: Autophagy; Viruses; Apoptosis

目前進行中研究計畫:
2013/8/1~2016/7/30 Functional study of autophagic response in suppression of type I interferon response
2014/1/1~2016/12/30 Study on the Ffunctional role of selective autophagy in hepatitis C virus life cycle
2014/1/1~2017/12/30 Deciphering HCV-host interactions by identifying substrates of viral-induced selective autophagy