Page 60 - 林口醫研部 9月電子報
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•Figure 2. The model of DMRT3-OAS3-RNase L complex regulates ESR1
expression. DMRT3 serves as a transcription factor to control ESR1 promoter
activity in the nucleus, and DMRT3A815C induces higher ESR1 promoter
activity than wild-type. In the cytosol, ESR1 mRNA is degraded by interacting
with wild-type DMRT3 and being brought to OAS3-RNase L complex.
However, mutant DMRT3 decreases ESR1 mRNA binding ability and mutant
DMRT3-OAS3 complex reduces to interact with RNase L to prevent ESR1
mRNA degradation. Asterisks indicate mutant proteins.
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