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心搏過速誘導CD44 / NOX4訊息參與心房重整的發展
‣期刊及主題
心搏過速誘導CD44 / NOX4訊息參與心房重整的發展
Tachycardia-induced CD44/NOX4 signaling is involved in
the development of atrial remodeling
J Mol Cell Cardiol. 2019 Oct
‣作者 ‣指導者
陳偉踐，張尚宏，詹益欣，葉勇信 陳偉踐 (林口心臟內科)
1 (林口心臟內科)
‣研究目的背景
Atrial fibrillation (AF) is associated with oxidative stress and Ca2+ handling
abnormality in atrial myocytes. Our prior study has demonstrated the
involvement of CD44, a membrane receptor for hyaluronan (HA), in the
pathogenesis of AF. This study further evaluates whether CD44 and its
related signaling mediate atrial tachycardia-induced oxidative stress and
Ca2+ handling abnormality.
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