Renal Fibrosis
The
members of this group include Dr Ya-Chung Tian, Dr I-Jung Li, Dr
Cheng-Hao Weng, and Dr Hsin-Hsu Wu.
In the past
year, we have examined the role of toll-like receptors in the
Leptospira santorosai serovar Shermani outer membrane protein
(OMP)-induced increase of fibronectin in renal proximal tubular
cells. In addition, we have also investigated the impact of
immunosuppressants on polyomavirus BK (BKV) replication.
Finally, we have also discovered that BKV replication can be
regulated by its micro-RNA, miR-B1.
The
achievements of our group in the past year include three
published articles:
1. Leptospira santorosai serovar Shermani
detergent extract induced an increases in
fibronectin production through a toll-like
receptor2-mediated pathway
Tian YC, Hung CC, Li IJ, Chen YC, Chang
MY, Yen TH, Hsu HH, Wu MS, Phillips AO, Yang CW
Infect Immun. 2011 Mar;79(3):1134-42
2. Comparable
10-year outcome in hemodialysis patients with hepatitis C virus and hepatitis B
virus coinfection and single hepatitis B virus infection
Lee CC, Li IJ, Chen YC, Cheng JW, Wu HH, Weng CH,
Fang JT, Tian YC
Blood Purif, 2011 Mar 2;32(2):89-95
3. Cyclophilin and nuclear factor of activated T cells are essential in
cyclosporine-mediated suppression of polyomavirus BK replication
Li IJ, Wu HH, Weng CH, Chen YC, Hung CC, Yang CW, Wang YL, Sakamoto N, Tian YC Am J Transplant (2012 May 29.
doi: 10.1111/j.1600-6143.2012.04116.x.
