John Yu

Alice Lin-Tsing Yu

Jung-Tung Hung

Tan-Chi Fan

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Institute of Stem Cell and Translational Cancer Research, Research building 6F, Chang Gung Memorial Hospital at Linkou, No.15, Wenhua 1st St., Kuei Shang, Taoyuan 333, Taiwan

• 1993/09 ~ 1997/07 BS, Life Science, Tsing Hua University
• 1997/09 ~ 1999/07 MS, Life Science, Tsing Hua University
• 2003/09 ~ 2008/02 Ph. D, Institute of Molecular and Cellular Biology, Tsing Hua University

• Molecular functions of glycoproteins in tumor progression and immune checkpoint
• Protein-carbohydrate interactions
• Glycoimmunology

• 2008/03~2013/05 Postdoctoral fellow, Genomics research center, Academia Sinica
• 2013/06~2019/08 Postdoctoral fellow, Chang Gung Memorial Hospital
• 2019/09~ present Assistant research fellow, Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital

• Postdoctoral fellowship, Academia Sinica 2009-2011
• Outstanding poster award, 2015 Glycoscience Symposium (Dec 7-9, 2015) Taipei, Taiwan
• Outstanding paper award, Chang Gung Memorial Hospital at Linkou, Nov 2018

1. Heparin Binding Motif And Use Thereof, US 7595374
2. Methods of using heparin binding motif for treating asthma, US 8399416

1. Chang HT, Pai TW, Fan TC, Su BH, Wu PC, Tang CY, Chang CT, Liu SH, Chang MD. (2006) A reinforced merging methodology for identification of unique peptide motifs in members of protein families. BMC Bioinformatics 7:38.
2. Pai TW, Su BH, Wu PC, Chang MD, Chang HT, Fan TC, Liu SH. (2006) Unique peptide identification of RNase family sequences based on reinforced merging algorithms. Journal of Bioinformatics and Computational Biology 4, 75-92.
3. Chang HT, Kao YL, Wu CM, Fan TC, Lai YK, Huang KL, Chang YS, Tsai JJ, Chang MD. (2007) Signal peptide of eosinophil cationic protein up-regulates TGF-α expression in human cells. J. Cell. Biochem. 100: 1266-1275.
4. Fan TC, Chang HT, Chen IW, Wang HY, Chang MD. (2007) A heparan sulfate facilitated pathway for the internalization of eosinophil cationic protein through lipid raft-dependent macropinocytosis. Traffic 8: 1778-1795.
5. Fan TC, Fang SL, Hwang CS, Hsu CY, Lu XA, Hung SC, Lin SC, Chang MD. (2008) Characterization of molecular interactions between eosinophil cationic protein and heparin. J. Biol. Chem. 283:25468-25474
6. Chang KC, Lo CW, Fan TC, Chang MD, Shu CW, Chang CH, Chung CT, Fang SL, Chao CC, Tsai JJ, Lai YK. (2010) TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells. BMC Cell Biol. 11:6.
7. Chang HT, Tseng LJ, Hung TJ, Kao BT, Lin WY, Fan TC, Chang MD, Pai TW. (2010) Inhibition of the interactions between eosinophil cationic protein and airway epithelial cells by traditional Chinese herbs. BMC Syst Biol. 4 Suppl 2:S8.
8. Liu YS, Tsai PW, Wang Y, Fan TC, Hsieh CH, Chang MD, Pai TW, Huang CF, Lan CY, Chang HT. (2012) Chemoattraction of macrophages by secretory molecules derived from cells expressing the signal peptide of eosinophil cationic protein. BMC Syst Biol. 6:105.
9. Fang SL, Fan TC, Fu HW, Chen CJ, Hwang CS, Hung TJ, Lin LY, Chang MD. (2013) A novel cell-penetrating peptide derived from human eosinophil cationic protein. PLoS One. 8(3):e57318.
10. Hung TJ, Chang WT, Tomiya N, Lee YC, Chang HT, Chen CJ, Kuo PH, Fan TC, Chang MD. (2013) Basic amino acid residues of human eosinophil derived neurotoxin essential for glycosaminoglycan binding. Int J Mol Sci. 14(9):19067-85. doi: 10.3390/ijms140919067.
11. Chang CH, Fan TC, Yu JC, Liao GS, Lin YC, Shih AC, Li WH, Yu AL. (2014) The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. J Transl Med. 12:257.
12. Huang YF, Chen YJ, Fan TC, Chang NC, Chen YJ, Midha MK, Chen TH, Yang HH, Wang YT, Yu AL, Chiu KP. (2018) Analysis of microbial sequences in plasma cell-free DNA for early-onset breast cancer patients and healthy females. BMC Med Genomics. 11(Suppl 1):16.
13. Fan TC, Yeo HL, Hsu HM, Yu JC, Ho MY, Lin WD, Chang NC, Yu J, Yu AL. (2018) Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells. Cancer Lett. 434:184-195.
14. Yeo HL, Fan TC, Lin RJ, Yu JC, Liao GS, Chen ES, Ho MY, Lin WD, Chen K, Chen CH, Hung JT, Wu JC, Chang NC, Chang MD, Yu J, Yu AL. (2019) Sialylation of vasorin by ST3Gal1 facilitates TGF-β1 mediated tumor angiogenesis and progression. Int J Cancer. 144:1996-2007.
15. Midha MK, Huang YF, Yang HH, Fan TC, Chang NC, Chen TH, Wang YT, Kuo WH, Chang KJ, Shen CY, Yu AL, Chiu KP, Chen CJ. (2020) Comprehensive cohort analysis of mutational spectrum in early onset breast cancer patients Cancers (Basel).12(8):E2089.
16. Lin WD, Fan TC, Hung JT, Yeo HL, Wang SH, Kuo CW, Khoo KH, Pai LM, Yu J, Yu AL. (2020) Sialylation of CD55 by ST3GAL1 facilitates immune evasion in cancer. Cancer Immunol Res:canimm.0203.2020.

* co-first author