John Yu

Alice Lin-Tsing Yu

Jung-Tung Hung

Tan-Chi Fan







洪榮堂Jung-Tung Hung Ph.D.
Office Address:

Institute of Stem Cell and Translational Cancer Research, Research building 6F, Chang Gung Memorial Hospital at Linkou, No.15, Wenhua 1st St., Kuei Shang, Taoyuan 333, Taiwan

Tel: (886-3)328-1200 ext. 7803
  • 1993/9 ~ 1997/7 BS, Department of Medical Sciences and Technology, Chung-Shan Medical University
  • 1997/9 ~ 1999/7 MS, Institute of Microbiology and Immunology, National Defense Medical Center
  • 1999/9 ~ 2005/10 Ph. D, Institute of Life Sciences, National Defense Medical Center
Focus of Interest:
  • Molecular mechanisms of tumor associated carbohydrate antigen during tumorigenesis.
  • Carbohydrate-based cancer vaccine development.
  • Immunotherapeutic effects of iNKT cells on hepatocellular carcinoma.
Employment Records:
  • 2006/1~2013/5  Postdoctoral fellows, Genomics research center, Academia Sinica
  • 2013/6~present  Assistant Research Fellow, Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital
Honor and Awards:
  • 2007 Academia Sinica Regular Postdoctoral Fellow
  • 2009 Travel scholarship for 5th International Symposium on CD1/NKT Cells
  • 2009 Academia Sinica Regular Postdoctoral Fellow
  • 2010 Outstanding Post-Doctor Researchers Conference Travel Grant from Foundation for the Advancement of Outstanding Scholarship
  1. Alpha-galactosyl ceramide analogs and their use as immunotherapies. Application number: 12/218,082. Publication number: US 2010/0008954 A1. Filing date: 11 Jul 2008. Issued patent: US7928077 (Issue date 19 Apr 2011)
  2. Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and antibiral, antibacterial, and anticancer. Publication number, EP2320947 A2. Filing date, Jul 10, 2009.

  1. Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., Mcdevitt, H. &Sytwu, H. K. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model, J Autoimmun, 25, 181-92.
  2. *Hsieh, M. H., *Hung, J.T.,Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L. & Liang, P. H. (2012) Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation, Chembiochem, 13, 1689-97.
  3. *Huang, Y. L., *Hung, J.T., *Cheung, S. K., Lee, H. Y., Chu, K. C., Li, S. T., Lin, Y. C., Ren, C. T., Cheng, T. J., Hsu, T. L., Yu, A. L., Wu, C. Y. & Wong, C. H. (2013) Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer. Proc Natl AcadSci U S A, 110, 2517-22.
  4. Tsai, Y. C., Huang, J. R.,Cheng, J. Y., Lin, J. J., Hung, J. T., Wu, Y. Y., Yeh, K. T. and Yu, A. L. (2013) A Prevalent Cancer Associated Glycan, Globo H Ceramide, InducesImmunosuppression by Reducing Notch1 Signaling. J Cancer SciTher, 5(7), 264-270
  5. Huang, J. R., Tsai, Y. C., Chang, Y. J., Wu, J. C., Hung, J. T., Lin, K. H., Wong, C. H., and Yu, A. L. (2014) α-Galactosylceramide but Not Phenyl-Glycolipids Induced NKT Cell Anergy and IL-33–Mediated Myeloid-Derived Suppressor Cell Accumulation via Upregulation of egr2/3J. Immunol. 192:1972-1981
  6. Hung, J. T., Tsai, Y. C., Lin, W. D., Jan, J. T., Lin, K. H., Huang, J. R., Cheng, J. Y.,Chen, M. W., Wong, C. H., and Yu, A. L. (2014) Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus. Antiviral Research, 107C:110-118.
  7. Hung, J. T., Sawant, R. C., Chen, J. C., Yen, Y. F., Chen, W. S., Yu, A. L., Luo, S. Y. (2014) Design and synthesis of galactose-6-OH-modified a-galactosyl ceramide analogues with Th2-biased immune responses. RSC Adv., 4:47341:47356
  8. Cheng, J. Y., Wang, S. H., Lin, J., Tsai, Y. C., Yu, J., Wu, J. C., Hung, J. T., Lin, J. J., Wu, Y. Y., Yeh, K. T., Yu, A. L. (2014) Globo H Ceramide shed from cancer cells triggers translin-associated factor x-dependent angiogenesis. Cancer Res 74(23): 6856-6866.
  9. Hung J.T., Yeh, C.H., Yang, S.A., Lin, C.Y., Tai, H.J., Shelke, G.B., Reddy, D.M., Yu, A.L., Luo, S.Y. (2016) Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety.ACS ChemNeurosci. Aug 17; 7(8):1107-11.
  10. Kuo, H.H., Lin, R.J., Hung, J.T., Hsieh, C.B., Hung, T.H., Lo, F.Y., Ho, M.Y., Yeh, C.T., Huang, Y.L., Yu, J., Yu, A.L. (2017) High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. Sci Rep 7:10750

* co-first author