Expertise at Chang Gung System

Chao, Chuck C.-K. ,Ph.D.
Institution: Chang Gung University
Position: Chair professor
Department: Department of Biochemistry and Molecular Biology
Address: 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan,Taiwan,333, R.O.C.
Tel: +886-3-2118900 Fax: +886-3-2118700
E-mail: cckchao@mail.cgu.edu.tw

Focus of Interest:
  • Biochemistry and Molecular Biology - Medicine
  • Oncology

Fulltime Employment:
  • Postdoc. Fellow, Southwestern Med. Ctr./ CSHL (Cell & Mol. Biol.), 1985-1987
  • Res. Assoc., Stanford Univ. Med. Ctr. (Cancer Biol.), 1987-1988
  • Assoc. Professor, Chang Gung Univ. - Biochem. & Mol. Biol., 1988-1992
  • Professor, Chang Gung University - Biochem. & Mol. Biol., 1992-

Education:
  • B.S., Nat'l Changhua Univ. Edu. (Biology), 1977
  • M.S., Nat'l Tsing Hua Univ. (Radiat. Biol./Life Sci.), 1981
  • Ph.D., Univ. Texas Southwestern Med. Ctr. (Biomed. Sci.), 1985

Selected Main Publications:
  1. Chao, C.C.-K., Huang, S.-L., Huang, H. and Lin-Chao, S. Cross resistance to UV radiation of a cisplatin-resistant human cell line: Overexpression of cellular factors that recognize UV-modified DNA. Mol. Cell. Biol. 11: 2075-2080, 1991.
  2. Kuo, T.-C., Chang, P.-Y., Huang, S.-F., Chou, C.-K. and Chao, C.C.-K. Knockdown of HURP inhibits the proliferation of hepatocellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochem Pharmacol. 83: 758- 768, 2012
  3. Wu, Z.-Z., Sun, N.-K., Chien, K.-Y. and Chao, C.C.-K. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol. 82: 1630-1640,2011
  4. Sun, N.-K.*, Huang, S.-L.*, Chang, P.-Y., Lu, H.-P. and Chao, C.C.-K. Transcriptomic profiling of taxol-resistant ovarian cancer cells identifies FKBP5 and the androgen receptor as critical markers of chemotherapeutic response. Oncotarget 5: 11939-11956, 2014 (*equal contribution)
  5. Lin, Y.-T., Lu, H.-P. and Chao, C.C.-K. Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. Biochem. Pharmacol. 93: 110-124, 2015 (first online: 3 Nov. 2014, DOI:10.1016/j.bcp.2014.10.012)


All Publications List