Page 45 - 2021年 林口醫研部 9月電子報

‣研究目的背景

Neutrophil overactivation is critical in the pathogenesis of acute lung

injury (ALI), or acute respiratory distress syndrome (ARDS) clinically. Bletinib

(3,3'-dihydroxy-2',6'-bis(p-hydroxybenzyl)-5-methoxybibenzyl), a natural

bibenzyl, extracted from the Bletilla plant, exhibits antimitotic, antibacterial,

and anti-inflammatory effects. In this study, we evaluated the therapeutic

effects of bletinib in human neutrophilic inflammation and LPS-mediated ALI

in mice.

‣研究發現與應用

Bletinib modulates neutrophilic inflammation by inhibiting the SFK-Btk-

Vav pathway. Bletinib ameliorates LPS-induced ALI in mice. Further

biochemical optimization of bletinib may be a promising strategy for the

development of novel therapeutic agents for inflammatory diseases.

‣背景

急性肺損傷是一類具有高致死率的發炎性疾病，而其病理機轉則與

嗜中性白血球過度活化所造成的氧化壓力密切相關。傳統中草藥台灣白

及(Bletilla formosana)是蘭科白及屬的植物，其塊莖具有多種臨床治療用

途，包括治療呼吸道、腸胃道與皮膚等多種發炎性疾病。近年來許多研

究也陸續證實其生物活性如抗菌、抗發炎、抗腫瘤與縮短凝血時間等效

果。

Department of Medical Research & Development , Linkou Newsletter 45