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   顯微鏡核心實驗室

　

 Confocal Microscope

　

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　                            研 究 成 果 　

雷射掃描共軛焦顯微鏡

  • 2021
  1. Jei-Ming Peng, Sheng-Hsuan Lin, Ming-Chin Yu, and Sen-Yung Hsieh. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis. The Journal of Clinical Investigation. 2021;131(1):e133525.(IF2020=11.864)
  2. Yu-Ling Lu、Shu-Fu Lin Cancers (Basel) . Efficacy and Biomarker Analysis of Adavosertib in Differentiated Thyroid Cancer 2021 Jul 12;13(14):3487. doi: 10.3390/cancers13143487.
  3. Yu-Ling Lu、Shu-Fu Lin. Efficacy of adavosertib therapy against anaplastic thyroid cancer. Endocr Relat Cancer . 2021 Apr 29;28(5):311-324. doi: 10.1530/ERC-21-0001.
  4. Jei-Ming Peng , Sheng-Hsuan Lin , Ming-Chin Yu , Sen-Yung Hsieh. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis. J Clin Invest. 2021 Jan 4;131(1):e133525.
  5. Jei-Ming Peng , Ruo-Han Tseng , Tsung-Chieh Shih , Sen-Yung Hsieh. CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling. Cancer Letters. 497 (2021) 66–76.
  6. YJ Lai, Winston WY Kao, YH Yeh, WJ Chen, PH Chu. Lumican deficiency promotes pulmonary arterial remodeling. Translational research. 2021 Jun 6.237:63-81.
  7. YL Huang, PR Chen, YJ Lai*, and HH Hsu.Sirolimus Suppresses Phosphorylation of Cofilin and Reduces Interstitial Septal Thickness in Sporadic Lymphangioleiomyomatosis. Int. J. Mol. Sci. 2021 August 9, 22, 8564.
  8. Wang HL, Yeh TH, Huang YZ, Weng YH, Chen RS, Lu CS, Wei KC, Liu YC, Chen YL, Chen CL, Chen YJ, Lin YW, Hsu CC, Chiu CH, Chiu CC. Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.Neurobiol Aging. 2021 Jun 19:S0197-4580(21)00205-0. doi: 10.1016/j.neurobiolaging. 2021.06.011. Online ahead of print.PMID: 34275689
  9. Yeh TH, Liu HF, Chiu CC, Cheng ML, Huang GJ, Huang YC, Liu YC, Huang YZ, Lu CS, Chen YC, Chen HY, Cheng YC.PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models.Exp Neurol. 2021 Sep 11;346:113863. doi: 10.1016/j.expneurol.2021.113863. Online ahead of print.PMID: 34520727
  10. Lin, Y.C., Fang, Y.P., Hung, C.F., Yu, H.P., Alalaiwe, A., Wu, Z.Y., Fang, J.Y. (2021) Multifunctional TiO2/SBA-15 mesoporous silica hybrids loaded with organic sunscreens for skin application: the role in photoprotection and pollutant adsorption with reduced sunscreen permeation. Colloids Surf. B, 202, 111658.
  11. Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y. (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567-4584.
  12. Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y.(2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.
  13. Juang J-H, Lin H.-C, Chen CY, Kao C-W, Chen CL, Wu S-T, Lin S-H, Shen C-R, Wang J-J, Tsai Z-T, Chu I-M: Noninvasive tracking of mPEG-poly(Ala) hydrogel-embedded MIN6 cells after subcutaneous transplantation in mice. Polymers 2021;13:885
  14. Juang JH, Wang JJ, Shen CR, Chen CY, Kao CW, Chen CL, Lin SH, Wu ST, Li WC, Tsai ZT. Magnetic Resonance imaging of transplanted porcine neonatal pancreatic cell clusters labeled with chitosan-coated superparamagnetic iron oxide nanoparticles in mice. Polymers 2021;13:1238
  15. Steven W. Shaw, Shao Yu Peng, Ching Chung Liang, Tzu Yi Lin, Po Jen Cheng, T’sang T’ang Hsieh, Hao Yu Chuang, Paolo De Coppi & Anna L. David. Prenatal transplantation of human amniotic fluid stem cell could improve clinical outcome of type III spinal muscular atrophy in mice. Scientific Reports. 2021, Apr; 11(1):9158.
  16. Chang, H.-Y., Chen, Y.-C., Tuan, W.-H., Hwang, S.-P., Chang, L.-K., Wu, C.-J., Chen, C.-Y. and Lai, P.-L. Biphasic bone graft prepared using a gel-foaming technique. Ceramics International. Volume 47, Issue 6, 15 March 2021, Pages 7805-7813
  17. Chiang, Ching-Chien and Hsieh, Ming-Kai and Chi-Yun, Wang and Tuan, Wei-Hsing and Lai, Po-Liang. Cytotoxicity and cell response of preosteoblast in calcium sulfate-augmented PMMA bone cement. Biomedical Materials. 2021 Aug. 55014-55028
  • 2020
  1. Pang HH, Ke YC, Li NS, Chen YT, Huang CY, Wei KC, Yang HW*. A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level. Biosensors & Bioelectronics. 2020, 165: 112325. (SCI; IF2019=10.257; Chemistry, analytical 1/86)
  2. Hsu WL, Huang CY, Hsu YP, Hwang TL, Chang SH, Wang HYJ, Feng LY, Tzou SJ, Wei KC, Yang HW. On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management. Chemical Engineering Journal. 2020, 398: 125536. (SCI; IF2019=10.652; Engineering, chemical 4/143)
  3. Lin HC,ChenCY, KaoCW, Wu SJ, Chen CL, Shen CR,Juang JH, Chu IM: In situ gelling-polypeptide hydrogel systems for the subcutaneous transplantation of MIN6 cells. J Polym Res 2020;27:64.
  4. Yu C-P, Juang J-H, Lin Y-J,Kuo C-W, Hsieh L-H, Huang C-C: Enhancement of Subcutaneously Transplanted β Cell Survival Using 3D Stem Cell Spheroids With Proangiogenic and Prosurvival Potential. Adv Biosyst 2020:e1900254.
  5. Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen, and Yung-Hsin Yeh. Ubiquitin Pathway Is Associated with Worsening Left Ventricle Function after Mitral Valve Repair: A Global Gene Expression Study. Int J Mol Sci. 2020 Jul; 21(14): 5073. Published online 2020 Jul 18. doi: 10.3390/ijms21145073
  6. Chih-Hao Chiu, Tsan-Hsuan Chang, Shih-Sheng Chang, Gwo-Jyh Chang, Alvin Chao-Yu Chen, Chun-Ying Cheng, Su-Ching Chen, Jen-Fen Fu, Chih-Jen Wen, and Yi-Sheng Chan. Application of Bone Marrow–Derived Mesenchymal Stem Cells for Muscle Healing After Contusion Injury in Mice. The American Journal of Sports Medicine. 2020 Apr;48(5):1226-1235.
  7. Wang CY, Kuo ZK, Hsieh MK, Ke LY, Chen CC, Cheng CM, Lai PL: Cell migration of preosteoblast cells on a clinical gelatin sponge for 3D bone tissue engineering. Biomedical Materials. 2020; Vol.15:015005. (SCI；IF:3.44；Engineering, Biomedical 21/80 Q2, 2018) CMRPG3H1271, CRRPG3E0183
  8. Chih-Hsin Lin, Pei-Cih Wei, Chiung-Mei Chen, Yu-Ting Huang, Jia-Lan Lin, Yen-Shi Lo, Jia-Li Lin,Chung-Yin Lin, Yih-Ru Wu, Kuo-Hsuan Chang, and Guey-Jen Lee-Chen. Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy. Front Aging Neurosci. 2020; 12: 226
  9. Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y. (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240-251.
  10. Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.(2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.
  11. Yu, H.P., Liu, F.C., Lin, C.Y., Umoro, A., Trousil, J., Hwang, T.L., Fang, J.Y. (2020) The suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions. Nanomedicine, 15, 773-791.
  12. Fang, J.Y., Tang, K.W., Yang, S.H., Alalaiwe, A., Yang, Y.C., Tseng, C.H., Yang, S.C. (2020) Synthetic naphthofuranquinone derivatives are effective in eliminating drug-resistant Candida albicans in hyphal, biofilm, and intracellular forms: an application for skin-infection treatment. Front. Microbiol., 11, 2053.
  13. Liu YC, Wang HL, Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC. Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models. Biochem Pharmacol. 2020 May;175:113919.
  • 2019
  1. Lung-An Hsu,Yu-Shien Ko,Yung-Hsin Yeh,Chi-Jen Chang,Yi-Hsin Chan,Chi-Tai Kuo,Hsin-Yi Tsai,Gwo-Jyh Chang. A Novel DES L115F Mutation Identified by Whole Exome Sequencing is Associated with Inherited Cardiac Conduction Disease. Int J Mol Sci.2019 Dec 10;20(24):6227. doi: 10.3390/ijms20246227.
  2. Chen, C.Y., Lee, Y.H., Chang, S.H., Tsai, Y.F., Fang, J.Y, Hwang, T.L. (2019) Oleic acid-loaded nanosctructured lipid carrier inhibit neutrophil activities in the presence of albumin and alleviates skin inflammation. Int. J. Nanomed., 14, 6539-6553.
  3. Fang, J.Y., Lin, Y.K., Wang, P.W., Alalaiwe, A., Yang, Y.C., Yang, S.C. (2019) The droplet-size effect of squalene@cetylpyridinium chloride nanoemulsions on antimicrobial potency against planktonic and biofilm MRSA. Int. J. Nanomed., 14, 8133-8147
  4. Chou, W.L., Lee, T.H., Huang, T.H., Wang, P.W., Chen, Y.P., Chen, C.C., Chang, Z.Y.,Fang, J.Y., Yang, S.C. (2019)Coenzyme Q from Antrodia cinnamomeaexhibits drug-resistant bacteria eradication and keratinocyte inflammation mitigation to ameliorate infected atopic dermatitis in mouse. Front. Pharmacol., 10, 1445
  5. Pei-Cih Wei, Guey-Jen Lee-Chen, Chiung-Mei Chen, Yih-Ru Wu, Yi-Jing Chen, Jia-Li Lin, Yen-Shi Lo, Ching-Fa Yao,and Kuo-Hsuan Chang. Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson’s Disease Cell Models. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 5074367, 15 pages.
  6. Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Front Cell Neurosci. 2019 Sep 13;13:399.
  7. Chiu CC, Wang HL, Weng YH, Chen RS, Chen CM, Yeh TH, Lu CS, Chen YJ, Liu YC, Huang YZ, Chang KH. Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations. Stem Cell Res. 2019 Oct;40:101552.
  8. Lin SF, Lin JD, Yeh CN, Huang YT, Chou TC, Wong RJ. as a therapeutic approach to well-differentiated thyroid cancer. Endocr Relat Cancer. 2019;26:727–738 (SCI).
  9. Yi-Jen Hsueh; David Hui-Kang Ma; Kathleen Sheng-Chuan Ma; Tze-Kai Wang; Cheng-Hung Chou; Chien-Cheng Lin; Min-Chang Huang; Li-Jyuan Luo; Jui-Yang Lai; Hung-Chi Chen. Extracellular Matrix Protein Coating of Processed Fish Scales Improves Human Corneal Endothelial Cell Adhesion and Proliferation. Translational Vision Science & Technology. May 2019; 27-27.
  10. Yang, S.C., Tang, K.W., Lin, C.H., Alalaiwe, A., Tseng, C.H., Fang, J.Y.* (2019) Discovery of furanoquinone derivatives as a novel class of DNA polymerase and gyrase inhibitors for MRSA eradication in cutaneous infection. Front. Microbiol., 10, 1197.
  11. Lee, W.R., Hsiao, C.Y., Huang, T.H., Wang, C.L., Alalaiwe, A., Chen, E.L., Fang, J.Y.* (2019) Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption. Int. J. Pharm., 564, 48-58 .
  12. Shih-Heng Chen,Pang-Yun Chou, Zhi-Yu Chen, Feng-Huei Lin. Electrospun Water-Borne Polyurethane Nanofibrous Membrane as a Barrier for Preventing Postoperative Peritendinous Adhesion.J.Mol.Sci.2019,20,1625;(2019 Apr)doi:10.3390/ijms20071625(Biochemitry,46/172=26%,Impact factor 4.183)SCIE
  13. Chia-Jung Lin, Chung-Yin Lin, Ya-Tin Lin, Chiung-Yin Huang, Kuo-Chen Wei, Jin-Chung Chen, Guey-Jen Lee-Chen, Hao-Li Liu. Microbubble-Facilitated Ultrasound Pulsation Promotes Direct α-Synuclein Gene Delivery. Biochemical and Biophysical Research Communications.September 2019; 77-83
  14. CJ Chang, HC Hsu, WJ Ho, GJ Chang, JH S. Pang, WJ Chen, CC Huang, and YJ Lai, Cathepsin S promotes the development of pulmonary arterial hypertension, Am J Physiol Lung Cell Mol Physiol, 317(1): 1-13, 2019, Jun
  15. Chung-Hung Honga , Ming-Ru Tanga , Shen-Hsing Hsub , Ching-Hsu Yangc , Chi-Shin Tsengd , Yi-Ching Kob , Che-Shao Guoa , Chih-Wei Yangb, Si-Chen Lee. Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid-infrared exposure. Journal of Photochemistry & Photobiology, B: Biology 198 (2019) 111560
  16. K.T. Shalumon, H.-T. Liao, C.-Y. Kuo, C.-B. Wong, C.-J. Li, Mini P.A., J.P. Chen. 2019. Rational design of gelatin/nanohydroxyapatite cryogel scaffolds for bone regeneration by introducing chemical and physical cues to enhance osteogenesis of bone marrow mesenchymal stem cells. Materials Science & Engineering C, 104, 109855.
  17. H.H. Kao, C.Y. Kuo, K.S. Chen, J.P. Chen. 2019. Preparation of gelatin and gelatin/hyaluronic acid cryogel scaffolds for the 3D culture of mesothelial cells and mesothelium tissue regeneration. International Journal of Molecular Sciences, 20, 4527.
  18. A. Jayasree, K.T. Shalumon, R. Ramachandran, M.N. Sundaram, C.H. Chen, U. Mony, J.P. Chen, R. Jayakumar. 2019. Bioengineered braided micro−nano (multiscale) fibrous scaffolds for tendon reconstruction. ACS Biomaterials Science and Engineering, 5, 1476-1486.
  19. G. Jose, Y.J. Lu, H.A. Chen, H.L. Hsu, J.T. Hung, Anilkumar T.S., J.P. Chen. 2019. Hyaluronic acid modified bubble-generating magnetic liposomes for targeted delivery of doxorubicin. Journal of Magnetism and Magnetic Materials, 474, 355-364.
  20. Wei-Jan Chen, Shang-Hung Chang, Yi-Hsin Chan, Jia-Lin Lee, Ying-Ju Lai, Gwo-Jyh Chang, Feng-Chun Tsai, Yung-Hsin Yeh. Tachycardia-induced CD44 NOX4 signaling is involved in the development. Journal of Molecular and Cellular Cardiology 135 (2019) 67–78
  21. Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo, Yung-Hsin Yeh. Atrial fbrillation and its arrhythmogenesis associated with insulin resistance. Chan et al. Cardiovasc Diabetol (2019) 18:125
  • 2018
  1. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 Jun;67(6):2226-2243. doi: 10.1002/hep.29678. Epub 2018 Apr 19. (IF2017=14.079)
  2. Lin SF, Lin JD, Hsueh C, Chou TC, Wong RJ. Activity of roniciclib in medullary thyroid cancer. Oncotarget 2018; 9:28030-28041. (IF2017=5.168)
  3. Li WC, Chen CY, Kao CW, Huang PC, Hsieh YT, Kuo TY, Chen TY, Chia HY, Juang JH:  Porcine neonatal pancreatic cell clusters maintain their multipotency in culture and after transplantation. Sci Rep. 2018;8:8212. (IF2017=4.122)
  4. Ahmed Alalaiwe, Pei-Wen Wang, Po-Liang Lu, Ya-Ping Chen, Jia-You Fang, Shih-Chun Yang. Synergistic Anti-MRSA Activity of Cationic Nanostructured Lipid Carriers in Combination With Oxacillin for Cutaneous Application. Front. Microbiol. 2018 June. doi: 10.3389/fmicb.2018.01493. (IF2017=4.019)
  5. Ching-Yun Hsu, PhD, Calvin T. Sung, BS, Ibrahim A. Aljuffali, PhD,Chun-Han Chen, MDd,e, Kai-Yin Hu, MS, Jia-You Fang, PhD. Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomedicine. 2018 Feb. 215-225. (IF2017=5.005)
  6. Fu-Chao Liu, Huang‐Ping Yu, Cheng‐Yu Lin, Ahmed O. Elzoghby, Tsong‐Long Hwang, Jia‐You Fang. Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge. J. Nanobiotechnol. 2018 Mar.   doi: 10.1186/s12951-018-0364-z. (IF2017=5.294)
  7. Woan-Ruoh Lee , Shing-Chuan Shen, Calvin T. Sung, Pei-Ying Liu, Jia-You Fang. Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models. Pharm. Res. 2018 Apr. doi: 10.1007/s11095-018-2413-6. (IF2017=3.335)
  8. Chun-Han Chen, Chih-Jung Chen, Ahmed O Elzoghby, Ta-Sen Yeh, Jia-You Fang. Self-assembly and directed assembly of lipid nanocarriers for prevention of liver fibrosis in obese rats: a comparison with the therapy of bariatric surgery. Nanomedicine. 2018 Jul. 1551-1566. (IF2017=5.005)
  9. Shih-Chun Yang, Tse-Hung Huang, Chun-Hui Chiu, Wei-Ling Chou, Ahmed Alalaiwe, Yuan-Chieh Yeh, Kuan-Wen Su, Jia-You Fang. The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata. J. Dermatol. Sci. 2018 Sep. doi: 10.1016/j.jdermsci. (IF2017=3.675)
  10. Chen WJ, Chen YH, Hsu YJ, Lin KH, Yeh YH. MicroRNA-132 targeting PTEN contributes to cilostazol-promoted vascular smooth muscle cell differentiation. Atherosclerosis. Volume 274, July 2018, Pages 1-7. (IF2017=4.467)
  11. Chang SH, Yeh YH, Lee JL, Hsu YJ, Kuo CT, Chen WJ. Transforming growth factor-β-mediated CD44/STAT3 signaling contributes to the development of atrial fibrosis and fibrillation. Basic Res Cardiol.2017 Sep 4;112(5):58. doi: 10.1007/s00395-017-0647-9. (IF2017=5.723)
  12. Li-Fang Chou, Ting-Wen Chen, Huang-Yu Yang, Ming-Yang Chang, Shen-Hsing Hsu, Chung-Ying Tsai, Yi-Ching Ko, Chiung-Tseng Huang, Ya-Chung Tian, Cheng-Chieh Hung, and Chih-Wei Yang. Murine Renal Transcriptome Profiles Upon Leptospiral Infection: Implications for Chronic Kidney Diseases. J Infect Dis. 2018 Sep 22;218(9):1411-1423. doi: 10.1093/infdis/jiy339. (IF2017=1.014)
  13. YJ Lai, IC Chen, HH Li, CC Huang. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2018, 19, 727; doi:10.3390/ijms19030727. (SCI ;IF2017: 3.687) (116/286, Biochemistry & Molecular Biology)
  14. HH Li, HH Hsu, GJ Chang, IC Chen, WJ Ho, PC Hsu, WJ Chen, JHS. Pang, CC Huang, YJ Lai. Prostanoid EP4 Agonist L-902,688 Activates PPARg and Attenuates Pulmonary Arterial Hypertension. Am J Physiol Lung Cell Mol Physiol 2018, 314: L349–L359, (SCI; IF2017: 4.092) (10/136, pulmonary and respiratory Medicine).
  15. Hsieh MK, Wu CJ, Chen CC, Tsai TT, Niu CC, Wu SC, Lai PL*(co-corresponding). BMP-2 gene transfection of bone marrow stromal cells to induce osteoblastic differentiation in a rat calvarial defect model. Materials Science & Engineering C-Materials for Biological Applications. 2018 Jun; Vol. 91: 806-816. ( SCI；IF2017: 5.08; Materials science, biomaterials 6/33, Q1)
  16. Chang TN, Chen KT, Gorden T, Daniel BW, Hernon C, Shafarenko M, Huang YL, Lu JC, Chuang DC. Vascularized Brachial Plexus Allotransplantation - An Experimental Study in Brown Norway and Lewis Rats. Transplantation. 2018 Jul 25. doi: 10.1097/TP.0000000000002387. [Epub ahead of print] (IF2017=3.96)
  17. Lin, Y.C., Lin, C.F., Alalaiwe, A., Wang, P.W., Fang, Y.P., Fang, J.Y.* (2018) UV filter entrapment in mesoporous silica hydrogel for skin protection against UVA with minimization of percutaneous absorption. Eur. J. Pharm. Sci., 122, 185-194.
  18. Chia-Fang Chen, Han-Tsung Liao. Platelet-rich plasma enhances adipose-derived stem cellmediated angiogenesis in a mouse ischemic hindlimb model. World J Stem Cells 2018 December 26; 10(12): 212-227
  19. H.T. Liao, M.J. Tsai, M. Brahmayya, J.P. Chen.* 2018. Bone regeneration using adipose-derived stem cells in injectable thermo-gelling hydrogel scaffold containing platelet-rich plasma and biphasic calcium phosphate. International Journal of Molecular Sciences, 19: 2537.
  • 2017
  1. Lin JD, Lin SF, Chen ST, Hsueh C, Chao TC. Long-term Follow-up of Papillary and Follicular Thyroid Carcinomas with Bone Metastasis. PLoS One 2017;12:e0173354. (IF2016=2.806)
  2. Lin SF, Lin JD, Hsueh C, Chou TC, Wong RJ. A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer. PLoS One 2017;12:e0172315. (IF2016=2.806)
  3. Li LF, Kao KC, Liu YY, Lin CW, Chen NH, Lee CS, Wang CW, Yang CT. Nintedanib reduces ventilation-augmented bleomycin-induced epithelial-mesenchymal transition and lung fibrosis through suppression of the Src pathway. J Cell Mol Med. 2017 Nov;21(11):2937-2949. doi: 10.1111/jcmm.13206. Epub 2017 Jun 9. (IF=4.302)
  4. Lin SF, Lin JD, Hsueh C, Chou TC, Yeh CN, Chen MH, Wong RJ. Efficacy of a HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models. Oncotarget 2017;8,41294-41304. (IF2016=5.168)
  5. Liu FC, Lin HT, Lin SF, Kuo CF, Chung TT, Yu HP. Nationwide Cohort Study on the Epidemiology and Survival Outcomes of Thyroid Cancer. Oncotarget. 2017; 8:78429-78451. (IF2016=5.168)
  6. Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB; LEADER Steering Committee and Investigators. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med. 2017;377:839-848. (IF2016=72.406)
  7. Lin SF, Kuo CF, Chiou MJ, Chang SH. Maternal and Fetal Outcomes of Pregnant Women with Type 1 Diabetes, a National Population Study. Oncotarget. 2017; 8:80679-80687. (IF2016=5.168)
  9. Lung-An Hsu, Yung-Hsin Yeh, Wei-Jan Chen, Chi-Tai Kuo, Feng-Chun Tsai, Yi-Hsin Chan,Chun-Li Wang, Chi-Jen Chang & Hsin-Yi Tsai. Association evidence of CCTTT repeat polymorphism in the iNOS promoter and the risk of atrial fibrillation in Taiwanese. Sci Rep. 2017 Feb 13;7:42388. (IF2016=4.259)
  10. Lee TH, Yeh JC, Tsai CH, Yang JT, Lou SL, Seak CJ, Wang CY, Wei KC*, Liu HL*. Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. Scientific Reports. 2017 May; 7(1): 1638. (SCI; IF2016=4.259; Multidisciplinary sciences 10/64)
  11. Chang EL, Ting CY, Hsu PH, Lin YC, Liao EC, Huang CY, Chang YC, Chan HL, Chiang CS, Liu HL, Wei KC, Fan CH, Yeh CK*. Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors. Journal of Controlled Release. 2017 Jun; 255: 164-175. (SCI; IF2016=7.786; Pharmacology & pharmacy 10/256)
  12. Lin FW, Chen PY, Wei KC, Huang CY, Wang CK, Yang HW*. Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor. Theranostics. 2017 Jun; 7(9): 2524-2536. (SCI; IF2016=8.712; Medicine, research & experimental 8/128)
  13. Chen PY, Yeh CK, Hsu PH, Lin CY, Huang CY, Wei KC*, Liu HL*. Drug-carrying microbubbles as a theranostic tool in convection-enhanced delivery for brain tumor therapy. Oncotarget. 2017 Jun; 8(26): 42359-42371. (SCI; IF2016=5.168; Oncology 44/217) (co-corresponding author)
  14. Lin FW, Chen PY, Wei KC, Huang CY, Wang CK, Yang HW*. Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor. Theranostics. 2017 Jun; 7(9): 2524-2536. (SCI; IF2016=8.712; Medicine, research & experimental 8/128)
  15. Yang, S.C., Tseng, C.H., Wang, P.W., Lu, P.L., Weng, Y.H., Yen, F.L., Fang, J.Y.* (2017) Pterostilbene, a methoxylated resveratrol derivative, efficiently eradicates planktonic, biofilm, and intracellular MRSA by topical application. Front. Microbiol., 8, 1103. (IF2016=4.076)
  16. Yang, S.C., Yen, F.L., Wang, P.W., Aljuffali, I.A., Weng, Y.H., Tseng, C.H., Fang, J.Y.* (2017) Naphtho[1,2-b]furan-4,5-dione is a potent anti-MRSA agent against planktonic, biofilm, and intracellular bacteria. Future Microbiol., 12, 1059-1073. (IF2016=3.374)
  17. Lin, M.H., Hung, C.F., Aljuffali, I.A., Sung, C.T., Huang, C.T., Fang, J.Y.* (2017) Cationic amphiphile in phospholipid bilayer or oil-water interface of nanocarriers affects planktonic and biofilm bacteria killing. Nanomed.-Nanotechnol. Biol. Med., 13, 353-361. (IF2016=5.720)
  18. Chien HJ, Peng SJ, Hua TE, Kuo CH, Juang JH, Tang SC. 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice. Int J Obes (Lond) 40:685-97, 2016. (IF2016=5.487)
  19. Peng S, Lai ZT, Hong DW, Chu IM*, Lai PL* (corresponding): Controlled release of strontium through neutralization reaction within a methoxy(polyethylene glycol)-polyester hydrogel. Journal of Applied Biomaterials & Functional Materials. 2017; Vol.15(2):e162-e169. (SCI；IF: 1.067；Engineering, Biomedical 57/77, Q3)
  20. Ku KL, Lisbeth Grøndah, Dao H, Ke Du, Simon Puttick, Lai PL, Peng H, Chu IM, Andrew K. Whittaker*: In vitro degradation study of polyanhydride copolymers / surface grafted hydroxyapatite composites for bone tissue application. Polymer Degradation and Stability, 2017; Vol. 140:136-146 (SCI；IF: 3.386；polymer science 15/86, Q1)
  • 2016
  1. Kuo ZK, Lai PL (co-first author), Toh EKW, Weng CH, Tseng HW, Chang PZ, Chen CC, Cheng CM*: Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge. Scientific Reports. 2016(published online: Sep.12, 2016); Vol.6:32884-32895. (SCI；IF: 4.259；Multidisciplinary Sciences 10/64, Q1)
  2. Lin JY, Lai PL (co-first author), Lin YK, Peng S, Lee LY, Chen CN and Chu IM*: A poloxamer-polypeptide thermosensitive hydrogel as a cell scaffold and sustained release depot. Polymer Chemistry. 2016; Vol.7(17):2976-2985. (SCI；IF: 5.375；Polymer Science 6/86, Q1)
  3. Yang HW, Tsai RY, Chen JP, Ju SP, Liao JF, Wei KC, Zou WL, Hua MY*. Fabrication of a Nanogold-Dot Array for Rapid and Sensitive Detection of Vascular Endothelial Growth Factor in Human Serum. ACS Applied Materials & interfaces. 2016 Nov; 8(45): 30845-30852. (SCI; IF2016=7.504; Materials science, multidisciplinary 22/275)
  4. Wei KC, Lin FW, Huang CY, Ma CC, Chen JY, Feng LY, Yang HW*. 1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents. International Journal of Nanomedicine. 2016 Aug; 11: 4065-4075. (SCI; IF2016=4.300; Pharmacology & pharmacy 37/256)
  5. Liu HL, Hsu PH, Lin CY, Huang CW, Chai WY, Chu PC, Huang CY, Chen PY, Yang LY, Kuo JS, Wei KC*. Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment. Radiology. 2016 Oct; 281(1): 99-108. (SCI; IF2016=7.296; Radiology, nuclear medicine & medical imaging 2/126)
  6. Lin CY*, Hsieh HY, Chen CM, Wu SR, Tsai CH, Huang CY, Hua MY, Wei KC, Yeh CK, Liu HL*. Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson's Disease Mouse Model. Journal of Controlled Release. 2016 Aug; 235: 72-81. (SCI; IF2016=7.786; Pharmacology & pharmacy 10/256)
  7. Fu-Chih Hsiao , Yung-Hsin Yeh , Wei-Jan Chen , Yi-Hsin Chan , Chi-Tai Kuo ,
    Chun-Li Wang , Chi-Jen Chang , Hsin-Yi Tsai , Feng-Chun Tsai , and Lung-An Hsu
    MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese. Int J Mol Sci. 2016 Apr 7;17(4):521.
  8. Liu, C. H., Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022 (IF=3.289)
  9. Rout, B., Liu, C. H., Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480 (IF=3.902)
  10. Modulation of Staphylococcus aureus spreading by water. Lin MH, Ke WJ, Liu CC and Yang MW. Sci Rep. 2016 Apr 29;6:25233. (Impact factor: 5.228)
  11. Ma DHK*, Chen HC, Ma KSK, Lai JY*, Yang U, Yeh LK, Hsueh YJ, Chu WK, Lai CH and Chen JK. Preservation of human limbal epithelial progenitor cells on carbodiimide cross-linked amniotic membrane via integrin-linked kinase-mediated Wnt activation. Acta Biomater, 2016 Feb;31:144-55. (IF=6.025；R/C= 3/76，Engineering，Biomedical)
  12. Hsiao FC, Yeh YH, Chen WJ, Chan YH, Kuo CT, Wang CL, Chang CJ, Tsai HY, Tsai FC, Hsu LA. MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese. Int J Mol Sci. [International Journal of Molecular Science] 2016 Apr 7;17(4):521 (IF=3.257)
  13. Lee, W.R., Shen, S.C., Aljuffali, I.A., Lin, Y.K., Huang, C.W., Fang, J.Y.* (2016) Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk. Eur. J. Pharm. Sci., 92, 1-10. (IF=3.773)
  14. What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. International Journal of Pharmaceutics.2016 . PAGE: 277–286. (IF=3.994)
  15. Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species. Nanomedicine (Lond.).2016 . PAGE: 657–671. (IF= 4.889)
  • 2015
  1. Li-Fu Li, Yi-Ting Lai, Chih-Hao Chang, Meng-Chih Lin, Yung-Yang Liu, Kuo-Chin Kao, Ying-Huang Tsai*. 2014 Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-kB and NF-kB repressing factor in mice. Exp Biol Med Vol 239(8):1045-1057. (IF=2.542)
  2. Li-Fu Li, Yung-Yang Liu, Kuo-Chin Kao, Chen-Te Wu, Chih-Hao Chang, Chen-Yiu Hung, and Cheng-Ta Yang*. 2014 Mechanical ventilation augments bleomycin-induced epithelial-mesenchymal transition through the Src pathway. Lab Invest 94(9):1017-1029. (IF=4.202)
  3. Yung-Yang Liu, Li-Fu Li*, Jui-Ying Fu, Kuo-Chin Kao, Chung-Chi Huang, Yueh Chien, Yi-Wen Liao, Shih-Hwa Chiou, Yuh-Lih Chang. Induced Pluripotent Stem Cell Therapy Ameliorates Hyperoxia-Augmented Ventilator-Induced Lung Injury through Suppressing the Src Pathway. PLoS One 2014,9(10):e109953. Corresponding author (IF=3.057)
  4. Hsueh Y-H, Ke W-J, Hsieh C-T, Lin K-S,Tzou D-Y, Chiang C-L (2015) ZnO Nanoparticles Affect Bacillus subtilis Cell Growth and Biofilm Formation. PLoS ONE 10(6): e0128457. doi:10.1371/journal.pone.0128457 (IF=3.057)
  5. Ke W-J, Hsueh Y-H, Cheng Y-C, Wu C-C and Liu S-T (2015) Water surface tension modulates the swarming mechanics of Bacillus subtilis. Front. Microbiol. 6:1017. doi: 10.3389/fmicb.2015.01017 (IF=4.165)
  6. Hsueh YJ, Chen HC, Wu SE, Wang TK, Chen JK and Ma DHK*. (2015, Apr).
    Lysophosphatidic acid induces YAP-promoted proliferation of human corneal
    endothelial cells via PI3K and ROCK pathways. Molecular Therapy - Methods
    & Clinical Development, 29;2:15014. (IF=6.938)
  7. Hsueh YJ, Chen HC, Lai JY, Chen JK and Ma DHK* (2015, Mar). Corneal
    Neovascularization as a Target for Nucleotide-Based Therapies. Journal of
    Clinical & Experimental Ophthalmology, 6: 409. (IF=2.546)
  8. Lin CW1, Wei KC1, Liao SS, Huang CY, Sun CL, Wu PJ, Lu YJ, Yang HW*, Ma CC*. A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis. Biosensors and Bioelectronics. 2015 May; 67: 431-437. (SCI; IF2013=6.451; Electrochemistry 1/27) (1co-first author)
  9. Lin CY, Hsieh HY, Pitt WG, Huang CY, Tseng IC, Yeh CK, Wei KC*, Liu HL*. Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery. Journal of Control Release. 2015 Aug; 212: 1-9. (SCI; IF2013=7.261; Pharmacology & pharmacy 11/254) (co-corresponding author)
  10. Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen and Mu-Yi Hua, “A sensitive and selective magnetic grapheme composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis”, Biosensors and Bioelectronics, 2015, 66, 198-207 (IF=7.476)
  11. Peng YS, Tsai TT, Niu CC, Chu IM, Liao JC, Lai PL* (corresponding): Bone morphogenetic protein 2 gene delivery via polyethylene imine grafted chondroitin sulfate non-viral gene carrier. Formosan Journal of Musculoskeletal Disorders, 2015; Vol. 6(23-34) (IF=n/a)
  12. Liu, C. H., Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67 (IF=1.228)
  13. YJ Lai, GJ Chang, YH Yeh, JH S. Pang, CC Huang, WJ Chen3*, Propylthiouracil Attenuates ExperimentalPulmonary Hypertension via Suppression of  Pen-2, a Key Component of Gamma-Secretase. 2015 PLoS ONE 10(9): e0137426. (SCI: 3.057)
  14. K.T. Shalumon, G.J Lai, C.H. Chen, J.P. Chen.* 2015. Modulation of bone-specific tissue regeneration by incorporating bone morphogenetic protein and controlling the shell thickness of silk fibroin/chitosan/nanohydroxyapatite core–shell nanofibrous membranes. ACS Applied Materials & Interface, 7: 21170-21181. (IF=7.145)
  15. C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Dual functional core–sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion. Acta Biomaterialia, 26, 225-235. (IF=6.008)
  16. C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Prevention of peritendinous adhesions with electrospun polyethyleneglycol/polycaprolactone nanofibrous membranes. Colloids and Surfaces B: Biointerfaces, 133, 221-230. (IF=3.902)
  17. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2015. Response of human mesenchymal stem cells to intra-fibrillar nanohydroxyapatite content and extra-fibrillar nanohydroxyapatite in biomimetic chitosan/silk fibroin/nanohydroxyapatite nanofibrous membrane scaffolds. International Journal of Nanomedicine, 10, 567–584. (IF=4.320)
  18. C.Y. Kuo, C.H. Chen, C.Y. Hsiao, J.P. Chen.* 2015. Incorporation of chitosan in biomimeticgelatin/chondroitin-6-sulfate/hyaluronan cryogel for cartilage tissue engineering. Carbohydrate Polymers, 117, 722–730. (IF=4.219)
  • 2014
  1. Hsiao-Chien Chen, Jian-Tai Qiu, Fu-Liang Yang, Yin-Chih Liu, Min-Cheng Chen, Rung-Ywan Tsai, Hung-Wei Yang, Chia-Yi Lin, Chu-Chi Lin, Tzong-Shoon Wu, Yi-Ming Tu, Min-Cong Xiao, Chia-Hua Ho, Chien-Chao Huang, Chao-Sung Lai and Mu-Yi Hua, “Magnetic-Composite-Modified Polycrystalline Silicon Nanowire Field-Effect Transistor for Vascular Endothelial Growth Factor Detection and Cancer Diagnosis”, Anal. Chem., 2014, 86, 9443-9450 (IF=5.886)
  2. Hung-Wei Yang , Chih-Wen Lin , Mu-Yi Hua , Shih-Sheng Liao , Ying-Tzu Chen , Hsiao-Chien Chen , Wen-Hui Weng , Cheng-Keng Chuang , See-Tong Pang and Chen-Chi M. Ma, “Combined Detection of Cancer Cells and a Tumor Biomarker using an Immunomagnetic Sensor for the Improvement of Prostate-Cancer Diagnosis”, Adv. Mater., 2014, 26, 3662-3666 (IF=18.960)
  3. Peng YS, Lai PL (Co-first author), Peng S, Wu HC, Yu S, Tseng TY, Wang LF, Chu IM: Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier. International Journal of Nanomedicine. 2014; Vol.9(1) :3163-3174. ( SCI；IF: 4.383；PHARMACOLOGY & PHARMACY,30/254,Q1) CMRPG3C0101
  4. S.H. Chen, C.H. Chen, Y.T. Fong, J.P. Chen.* 2014. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta Biomaterialia, 10, 4971-4982. (IF=6.008)
  5. S.H. Chen, C.H. Chen, K.T. Shalumon, J.P. Chen.* 2014. Preparation and characterization of anti-adhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion. International Journal of Nanomedicine, 9, 4079-4092. (IF=4.320)
  6. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 111, 288-297. (IF=4.219)
  7. Y.J. Lu, C.W. Lin, H.W. Yang, K.J. Lin, S.P. Wey, C.L. Sun, K.C. Wei, T.C. Yen, C.I. Lin, C.C.M. Ma, J.P. Chen.* 2014. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon, 74, 83-95. (IF=6.198)
  8. Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation Cell Death and Disease (2014) 5, e1510; doi:10.1038/cddis.2014.468; published online 6 November 2014 (IF=5.378)
  9. Hsu, Chin-Yuan; Hsieh, Yu-Shan. Oxidative stress decreases in the trophocytes and fat cells of worker honeybees during aging.Biogerontology, 2014 April, 15.2: 129-137 (IF=3.252)
  10. Hsu, Chin-Yuan; Chuang, Yu-Lung; Chan, Yu-Pei.Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera).Exp Gerontol. 2014 Feb;50:128-36) (IF=3.35)
  11. Chang SH, Wu LS, Chiou MJ, Liu JR, Yu KH, Kuo CF, Wen MS, Chen WJ, Yeh YH. Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies. See LC.Cardiovasc Diabetol. 2014 Aug 10;13(1):123. doi: 10.1186/s12933-014-0123-x.PMID: 25106079[PubMed - in process] Free PMC Article (IF=4.534)
  12. Lee CH, Chang SH, Lin YH, Liu SJ, Wang CJ, Hsu MY, Hung KC, Yeh YH, Chen WJ, Hsieh IC, Wen MS. Acceleration of re-endothelialization and inhibition of neointimal formation using hybrid biodegradable nanofibrous rosuvastatin-loaded stents. Biomaterials. 2014 May;35(15):4417-27. doi: 10.1016/j.Biomaterials.2014.02.017. Epub 2014 Feb 28. (IF=8.387)
  13. Chien-Hui Hung, Lee-Wen Chen, Wen-Hung Wang, Pey-Jium Chang, Ya-Fang Chiu, Chen-Chia Hung, Ying-Ju Lin, Jieh-Yuan Liou, Wan-Ju Tsai, Chia-Ling Hung, and Shih-Tung Liu. Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal -Regulated Kinase Pathway J. Virol. 2014, 88(20):12133) ((IF=4.606)
  14. Peng YS, Lai PL (Co-first author), Peng S, Wu HC, Yu S, Tseng TY, Wang LF, Chu IM: Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier.International Journal of Nanomedicine. 2014, Jun; Vol.9(1) :3163-3174.(IF=4.32)
  15. S.H. Chen, C.H. Chen, K.T. Shalumon, J.P. Chen. 2014. Preparation and characterization of anti-adhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion. International Journal of Nanomedicine, 9, 4079-4092.(IF=4.32)
  16. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen. 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 111, 288–297. (IF=4.219)
  17. C.H. Chen, J.M.J. Liu, C.K. Chua, S.M. Chou, V.B.H. Shyu, J.P. Chen. 2014. Cartilage tissue engineering with silk fibroin scaffolds fabricated by indirect additive manufacturing technology. Materials, 7, 2104-2119. (IF=2.728)
  18. Hsu RM, Hsieh YJ, Yang TH, Chiang YC, Kan CY, Lin YT, Chen JT, Yu JS. Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor β (βPIX) to myosin 18A (MYO18A) is required for epithelial cell migration. Biochim Biophys Acta. 8 July 2014. 2513–2527. (IF=5.34)
  19. Lu YC, Chang JT, Liao CT, Kang CJ, Huang SF, Chen IH, Huang CC, Huang YC, Chen WH, Tsai CY, Wang HM, Yen TC, You GR, Chiang CH, Cheng AJ. OncomiR-196 promotes an invasive phenotype in oral cancer through NME4-JNK-TIMP1-MMP signaling pathway. Molecular Cancer 2014, 13:218(IF2014=4.257)
  20. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY.Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.Hepatology. 2014 Jun; 59 (6): 2238-50(IF=5.888)
  21. Liu, C. H., Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014, Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694. (IF=1.463)
  22. Chwan-Fwu Lin & Chih-Jen Wen & Ibrahim A. Aljuffali & Chun-Lin Huang & Jia-You Fang. Quantiosomes as a Multimodal Nanocarrier for IntegratingBioimaging and Carboplatin Delivery. Pharmaceutical Research. 15 March 2014 (IF=3.26)
  23. Yu-Jen Lu, Chih-Wen Lin, Hung-Wei Yang, Kun-Ju Lin, Shiaw-Pyng Wey, Chia-Liang Sun, Kuo-Chen Wei, Tzu-Chen Yen, Ching-I Lin, Chen-Chi M. Ma, Jyh-Ping Chen. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon 2014; 74:83-95. (IF=6.198)
  24. C.H. Chen, M.Y. Lee, V.B.H. Shyu, Y.C. Chen, C.T. Chen, J.P. Chen. 2014. Surface modification of polycaprolactone scaffolds fabricated via selective laser sintering for cartilage tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 40, 389-397.(IF=3.42)
  • 2013
  1. H.T.Liao, J.P. Chen, M.Y. Lee. 2013. Bone tissue engineering with adipose-derived stem cells in bioactive composites of laser-sintered porous polycaprolactone scaffolds and platelet-rich plasma. Materials, 6, 4911-4929. (IF2013=1.879)
  2. K.H. Chang, H.T. Liao, J.P. Chen. 2013. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies. Acta Biomaterialia, 9, 9012–9026. (IF2013=5.684)
  3. J.P. Chen, M.J. Tsai, H.T. Liao. 2013. Incorporation of biphasic calcium phosphate microparticles in injectable thermoresponsive hydrogel modulates bone cell proliferation and differentiation. Colloids and Surfaces B: Biointerfaces, 110, 120–129.(IF2013=4.287)
  4. Woan-Ruoh Lee, Shing-Chuan Shen, Wei-Yu Chen, Ibrahim A. Aljuffali, Shih-Yun Suen, Jia-You Fang. Noninvasive delivery of siRNA and plasmid DNAinto skin by fractional ablation: Erbium:YAG laser versus CO2 laser. European Journal of Pharmaceutics and Biopharmaceutics. 5 August 2013. Pages 315–323. (IF2013=4.245)
  5. Nan-Kai Wang, Chi-Chun Lai, Chi-Hsiu Liu, Lung-Kun Yeh, Chai Lin Chou, Jian Kong, Takayuki Nagasaki, Stephen H. Tsang and Chung-Liang Chien. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Disease Models & Mechanisms 2013; 6: 1113-1122. ((IF2013=5.537)
  6. Chiu CC, Lee LY, Li YC, Chen YJ, Lu YC, Li YL, Wang HM, Chang JT and Cheng AJ. Grp78 as a therapeutic target for refractory head–neck cancer with CD24-CD44+ stemness phenotype. Cancer Gene Therapy.2013 Nov;20(11):606-15 ((IF2013=2.553)
  7. Whole-exome sequencing to identify a novel LMNA gene mutationassociated with inherited cardiac conduction disease. Lai CC, Yeh YH, Hsieh WP, Kuo CT, Wang WC, Chu CH, Hung CL, Cheng CY, Tsai HY, Lee JL, Tang CY, Hsu LA.PLoS One. 2013 Dec 12;8 (12):e83322. doi: 10.1371/journal.pone.0083322. eCollection 2013. (IF2013=3.534)
  8. Ng GY, Yeh LK (equal first author), Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial  stratification. Invest Ophthalmol Vis Sci. 2013 Nov 7. pii: iovs.13-12646.(IF2014=3.404)
  9. Yuan Y, Yeh LK (equal first author), Liu H, Yamanaka O, Hardie WD, Kao WW, Liu CY. Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Invest Ophthalmol Vis Sci. 2013 Mar 11;54(3):1829-37. doi:10.1167/iovs. 12-11477. (IF2014=3.404)
  10. Chuang, Yu-Lung;Hsu, Chin-Yuan.Changes in mitochondrial energy utilization in young and old worker honeybees.Age (Dordr). 2013 Oct;35(5):1867-79. (IF2013=3.445)
  11. Hung-Wei Yang, Mu-Yi Hua, Tsong-Long Hwang, Kun-Ju Lin, Chiung-Yin Huang, Rung-Ywan Tsai, Chen-Chi M. Ma, Po-Hung Hsu, Shiaw-Pyng Wey, Peng-Wei Hsu, Pin-Yuan Chen, Yin-Cheng Huang, Yu-Jen Lu, Tzu-Chen Yen, Li-Ying Feng, Chih-Wen Lin, Hao-Li Liu and Kuo-Chen Wei, "Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide", Advanced Materials, 25(26), 3605–3611 (2013). (IF = 14.829, Filtered by Matericals Science, Multidisciplinary, 6/239) (1 Equal Contribution)
  12. Hung-Wei Yang, Yu-Jen Lu, Kun-Ju Lin, Sheng-Chieh Hsu, Chiung-Yin Huang, Shu-Han She, Hao-Li Liu, Chih-Wen Lin, Min-Cong Xiao, Shiaw-Pyng Wey, Pin-Yuan Chen, Tzu-Chen Yen, Kuo-Chen Wei, Chen-Chi M. Ma,“EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy” Biomaterials ,34(29), 7204-7214(2013). IF=8.557
  13. Woan-Ruoh Lee & Shing-Chuan Shen & Saleh A. Al-Suwayeh & Hung-Hsu Yang & Yi-Ching Li & Jia-You Fang Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles Pharmaceutical research (2013) 30:792–802. IF=3.420
  14. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang HF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013 May;57(5):1893-905. IF=11.055
  15. Li-Fu Li, Pao-Hsien Chu, Cheng-Yiu Hung, Winston W.-Y. Kao, Meng-Chih Lin, Yung-Yang Liu, Cheng-Ta Yang. Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway. Chest 2013,143(5):1252-1260. (SCI; IF=5.854; ; Respiratory system 4/50).
  16. Yung-Yang Liu, Li-Fu Li*, Cheng-Ta Yang, Kai-Hsi Lu, Chung-Chi Huang, Kuo-Chin Kao, Shih-Hwa Chiou. Suppressing NF-kB and NKRF pathways by induced pluripotent stem cell therapy in mice with ventilator-induced lung injury. PLoS One 2013,8(6):e66760 (SCI; IF=3.73; Multidisciplinary Sciences 7/56).
  17. Weng CM, Chen BC, Wang CH, Feng PH, Lee MJ, Huang CD, Kuo HP, Lin CH.,The endothelin a receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor. Am J Respir Crit Care Med, 2013 Aug 1,188(3):298-308. IF=12.996
  18. Transdermal delivery of three vitamin C derivatives by Er: YAG and carbon dioxide laser pretreatment. May. ISSN 0268-8921,Volume 28,Number 3, Lasers Med Sci (2013) 28:807-814, DOI 10.1007/s10103-012-1151-y. IF=2.489
  19. Yin-Ju Chen, Li-Yu Lee, Yin-Ka Chao, Joseph T. Chang, Ya-Ching Lu, Hsiao-Fang Li, Ching-Chi Chiu, Yi-Chen Li, Yan-Liang Li, Jeng-Fong Chiou, Ann-Joy Cheng, DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway PLoS ONE 8(5): e64088. doi:10.1371/journal.pone.0064088 Received: December 7, 2012; Accepted: April 10, 2013; Published: May 30, 2013. IF=3.234
  20. Yeh YH, Kuo CT, Chang GJ, Qi XY, Nattel S, Chen WJ. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Mediates the Differential Responsiveness of Atrial Versus Ventricular Fibroblasts to Transforming Growth Factor-β.Circ Arrhythm Electrophysiol. 2013 Aug 1;6(4):790-8. doi: 10.1161/CIRCEP.113.000338. Epub 2013 Jul. IF=4.513
  21. Yeh YH, Kuo CT, Lee YS, Lin YM, Nattel S, Tsai FC, Chen WJ. Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation.Heart Rhythm. 2013 Mar;10(3):383-91. doi: 10.1016/j.hrthm.2012.11.013. Epub 2012 Nov 24. IF=5.076
  22. Lin YH, Chang HM, Chang FP, Shen CR (equal to second), Liu CL, Mao WY, Lin CC, Shen CN. Protoporphyrin IX accumulation disrupts mitochondrial dynamics in ABCG2-deficient hepatocytes. FEBS Letters 2013 3202–3209. IF=4.001
  23. Yu-Shan Hsieh and Chin-Yuan Hsu.Oxidative Stress and Anti-Oxidant Enzyme Activities in the Trophocytes and Fat Cells of Queen Honeybees (Apis mellifera).REJUVENATION RESEARCH, 16(4):295-303(2013.8) IF=3.311
  24. C.Y. Hsu, Y.P Chan . The use of honeybees reared in a thermostatic chamber for aging studies. Age . ,35:149-158(2013.2) IF=3.39
  25. P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, "Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, " PLoS ONE, Accepted, 2013 (*通訊作者; SCI IF = 4.092, 12/85 in "Biology")
  26. Kao C, Chao A, Tsai CL, Lin CY, Chuang WC, Chen HW, Yen TC, Wang TH, Lai CH, Wang HS. , Phosphorylation of signal transducer and activator of transcription 1 reduces ortezomib-mediatedapoptosis in cancer cells. Citation: Cell Death and Disease (2013) 4, e512; doi:10.1038/cddis.2013.38. IF=5.014
  27. Chang YL, Wang CN, Wei PC, Peng HH, Chao AS, Chang SD, Cheng PJ, Wang TH., Mitochondrial activation in the growth-restricted fetus of monochorionic twins. Fertility and Sterility. Vol. 100, No. 1, July 2013 0015-0282/$36.00. IF=4.590
  28. Soong YK, Huang SY, Yeh CH, Wang TH, Chang KH, Cheng PJ, Shaw SW.,The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines. J Tissue Eng Regen Med (2013) Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/term.1702. IF=5.199
  29. Li-Fu Li, Yung-Yang Liu, Cheng-Ta Yang, Yueh Chien, Mong-Lien Wang, Nae-Fang Twu, Chien-Ying Wang, Chung-Chi Huang, Kuo-Chin Kao, Han-Shui Hsu, Shih-Hwa Chiou. Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via Inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation. Biomaterials Biomaterials 34 (2013) (SCI; IF=7.404; Engineering, Biomedical, 2/72).
  30. Fang-Hsin Chen, Sheng-Yung Fu, Ying-Chieh Yang, Chun-Chieh Wang, Chi-Shiun Chiang, and Ji-Hong Hong. Combination of Vessel-Targeting Agents and Fractionated
    Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway. Int J Radiation Oncol Biol Phys, Vol. 86, No. 4, pp. 777-784, 2013. IF=4.258
  31. Kuo-Hsuan Chang, Meng Li. Clonal Isolation of an Intermediate Pluripotent Stem Cell State. STEM CELLS 2013; 31:918–927. IF=22.268
  32. Kuo-Hsuan Chang, Wan-Ling Chen, Li-Ching Lee, Chih-Hsin Lin, Pin-Jui Kung, Te-Hsien Lin, Yi-CiWu, Yih-Ru Wu, Yi-Chun Chen, Guey-Jen Lee-Chen,2 and Chiung-Mei Chen. Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 471659, 11 pages. http://dx.doi.org/10.1155/2013/471659. IF=1.880
  • 2012
  1. Tsai CL, Tsai CN, Lin CY, Chen HW, Lee YS, Chao A, Wang TH, Wang HS, Lai CH., Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells. Cell Reports 2, 283–293, August 30, 2012. IF=8.358
  2. K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, "A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery", ACS Nano, Accepted, 2012 (IF=10.774, 9/152 in “Chemistry, Multidisciplinary”)
  3. Y.L.Chuang , C.Y. Hsu .Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera). Age. ,DOI 10.1007/s11357-012-9490-y (2012.11) IF=3.39
  4. Chun-Hua Wang, Chien-Da Huang, Horng-Chyuan Lin, Tzu-Ting Huang, Kang-Yun Lee, Yu-Lun Lo, Shu-Min Lin, Kian Fan Chung, and Han-Pin Kuo. Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J ALLERGY CLIN IMMUNOL, MAY, 2012. IF=11.476
  5. Tsai ZT, Tsai FJ, Yang WC, Wang JF, Liu CL, Shen CR (correspondence), Yen TC. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential MRI T2 contrast agent. Mar Drugs 2012; 10(11), 2403-2414. SCI=3.978 (CHEMISTRY, MEDICINAL, 10.17%)
  6. Han Tsung Liao, Chien Tzung Chen*, Chih Hao Chen, Jyh Ping Chen, Jui Che Tsai. Combination of Guided Osteogenesis with Autologous Platelet-Rich Fibrin Glue (PRFG) and Mesenchymal Stem Cell for Reconstruction of Mandibular Defects in Canine Model. J Trauma , 2011 Jan;70(1):228-37. , (SCI) (corresponding author) IF=2.961
  7. Hung TH, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS One. 2012;7(7):e40957. ( IF = 4.411; 12/86 in Biology )
  8. Hung TH*, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction. Placenta 2012;33:294-303. ( IF = 2.985; 11/77 in Obstetrics & Gynecology)
  9. Liu, C. H., Huang H. Y., 2012, Sep, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin 60(9):1118-24 (SCI) IF=1.164
  10. Feng PH, Lee KY, Chang YL, Chan YF, Kuo LW, Lin TY, Chung FT, Kuo CS, Yu CT, Lin SM, Wang CH, Chou CL, Huang CD, Kuo HP. CD14(+)S100A9(+) monocytic myeloid-derived suppressor cells and their clinical relevance in non-small cell lung cancer. Am J Respir Crit Care Med. 2012 Nov 15, 186(10):1025-36. IF=12.996
  11. Chia-Lung Tsai,Chi-Neu Tsai,Chiao-Yun Lin,Hsi-Wen Chen,Yun-Shien Lee,Angel Chao,Tzu-Hao Wang,Hsin-Shih Wang,and Chyong-Huey Lai. Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells. Cell Reports 2, 283–293, August 30, 2012. IF=8.358
  12. Hsiao-Chien Chen, Mu-Yi Hua, Yin-Chih Liu, Hong-Wei Yang, Rung-Ywan Tsai, "Preparation of water-dispersible poly[aniline-co-sodium N-(1-one-butyric acid) aniline]-zinc oxide nanocomposite for utilization in an electrochemical sensor", J. Mater. Chem., in press (2012). (IF = 5.101, Filtered by Materials Science, Multidisciplinary, 16/225) (1 Equal Contribution)
  13. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu1, Rung-Ywan Tsai, See-Tong Pang, Po-Hong Hsu, Hsiang-Jun Tang, Tzu-Chen Yen, Cheng-Keng Chuang, "An epirubicin–conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer", Biomaterials, 33(15), 3919-3930 (2012). (IF = 7.883, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  14. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu , Rung-Ywan Tsai, Cheng-Keng Chuang, Po-Chun Chu, Pei-Yi Wu, Ying-Hsu Chang, Heng-Chang Chuang, Kai-Jie Yu, See-Tong Pang, "Cooperative Dual-activity Targeted Nanomedicine for Specific and Effective Prostate Cancer Therapy", ACS Nano, 6(2), 1795-1805 (2012). (IF = 9.865, Filtered by Materials Science, Multidisciplinary, 9/225). (1 Equal Contribution)
  15. A-H Liao, H-L Liu, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, "Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging", Physics in Medicine and Biology, in press (2012). (IF = 3.056, Filtered by Engineering, Biomedical, 11/69)
  16. Yu-Jen Lu, Hung-Wei Yang, Sheng-Che Hung, Chiung-Yin Huang, Shin-Ming Li, Chen-Chi M. Ma, Pin-Yuan Chen, Hong-Chieh Tsai, Kuo-Chen Wei, Jyh-Ping Chen, "Improving thermal stability and treatment efficacy of BCNU to glioma cells using PAA-functionalized graphene oxide", International Journal of Nanomedicine, 7, 1737-1747 (2012). (IF = 3.130, Filtered by Pharmacology & Pharmacy, 70/261) (1 Equal Contribution).
  17. Hung-Wei Yang, Mu-Yi Hua, Kun-Ju Lin, Shiaw-Pyng Wey, Rung-Ywan Tsai, Siao-Yun Wu, Yi-Ching Lu, Hao-Li Liu, Tony Wu, Yunn-Hwa Ma, "Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis", International Journal of Nanomedicine 7, 5159-5173 (2012). (IF = 3.130, Filtered by Pharmacology & Pharmacy, 70/261) (1 Equal Contribution).
  18. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu, Chiung-Yin Huang, Kuo-Chen Wei*, "Potential of magnetic nanoparticles for drug delivery ", Nanotechnology, Science and Applications 5, 73-86 (2012) (invited review). IF=1.644
  19. Liu, C. H., Huang H. Y., 2012, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin 60(9):1118-24. IF=1.164
  20. Hung-Chi Jesse Chen, Lung-Kun Yeh, Yueh-Ju Tsai, Chyong-Huey Lai, Chi-Chun Chen, Jui-Yang Lai, Chi-Chin Sun, Grace Chang, Tsann-Long Hwang, Jan-Kan Chen,
    and David Hui-Kang Ma."Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation", IOVS, August 2012, Vol. 53, No. 9, 5615-5623. IF=3.404
  21. Kang-Yun Lee, Shu-Chuan Ho, Yao-Fei Chan, Chun-Hua Wang, Chien-Da Huang, Wen-Te Liu, Shu-Min Lin, Yu-Lun Lo, Ya-Ling Chang, Lu-Wei Kuo and Han-Pin Kuo. Reduced nuclear factor-kB repressing factor: a link toward systemic inflammation in COPD, Eur Respir J 2012; 40: 863–873. IF=7.636
  22. K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu, "Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine", American Journal of Neuroradiology, in press (2012). (IF=3.464, Filtered by Radiology, 20/111)
  23. Yang C, Chu Y, Wu YC, Hsieh MJ, Lu MS, Liu CY, Yuan HS, Liu YH, KO PJ, Liu HP. The lateral decubitus position improved transoral endoscopic access to the posterior aspects of the thorax. Surgical Endoscopy, 2012 Oct;26(10):2988-92. Epub 2012 May 2. IF=4.013
  • 2011
  1. Tran NT, Wang TH, Lin CY, Tsai YC, Lai CH, Tai Y, Yung BY., Direct Synthesis of Rev Peptide-Conjugated Gold Nanoparticles and Their Application in Cancer Therapeutics. Bioconjugate Chem June 7, 2011. IF=4.513
  2. Han-Tsung Liao, Chien-Tzung Chen*, Jyh-Ping Chen*. Osteogenic Differentiation and Ectopic Bone Formation of Canine Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable Thermo-Responsive Polymer Hydrogel. Tissue Engineering, 2011, Nov;17(11):1139-49, (SCI, IF=4.636) (co-corresponding author)
  3. Wang CH, Hwang YS, Chiang PR, Shen CR, Hong, WH, Hsiue GH. Extended release of Bevacizumab by thermosensitive biodegradable and biocompatible hydrogel. Biomacromolecules 2012;13(1):40-8. Epub 2011 Dec 6. dx.doi.org/ 10.1021/ bm 2009558 | SCI=5.371 (POLYMER SCIENCE, 4.82%)
  4. Mu-Yi Hua, Hung-Wei Yang, Hao-Li Liu, Rung-Ywan Tsai, See-Tong Pang, Kun-Lung Chuang, Yu-Sun Chang, Tsong-Long Hwang, Ying-Hsu Chang, Heng-Chang Chuang, Cheng-Keng Chuang. Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy. Biomaterials. 2011 32, 8999-9010IF=7.404
  5. Liu, C.-H., Chang, F.-Y., Hung, D.-K. Terpene Microemulsions for Transdermal Curcumin Delivery: Effects of Terpenes and Cosurfactants. Colloids and Surfaces B: Biointerfaces, Volume 82, Issue 1, 1 January 2011, Pages 63-70. IF=3.456
  6. Yung-Hsin Yeh, Chi-Tai Kuo, Ting-Hsiang Chan, Gwo-Jyh Chang, Xiao-Yan Qi,
    FengChun Tsai, Stanley Nattel, and Wei-Jan Chen.Transforming growth factor-b and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovascular Research. 2011 91, 62–70. IF=6.064
  7. Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH. Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Oncogene. 2011 Jul 4. doi: 10.1038/onc.2011.269. IF=6.373
  8. Hsieh YS, Hsu CY., Honeybee trophocytes and fat cells as target cells for cellular senescence studies.; Exp Gerontol., 2011 Apr,46(4), P233-240. IF=3.741
  9. Hsu CY, Chan YP., Identification and localization of proteins associated with biomineralization in the iron deposition vesicles of honeybees (Apismellifera).; PLoS One.,2011 Apr, 6(4), P1-8. IF=4.092
  10. Chen WJ, Chen YH, Lin KH, Ting CH, Yeh YH. Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway. Arterioscler Thromb Vasc Biol. 2011 Jun 16 p2106-2113. IF=6.368
  11. Chen WJ, Yeh YH, Lin KH, Chang GJ, Kuo CT. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 2011 Mar;106(2):163-74. Epub 2011 Jan 14. IF=7.348
  12. Chi-Yu Hsu, Mei-Hui Lin, Chien-Cheng Chen, Shih-Chin Chien, Yi-Hsiang Cheng, I-Ning Su and Jwu-Ching Shu. Vancomycin promotes the bacterial autolysis, release of extracellular DNA, and biofilm formation in vancomycin-non-susceptible Staphylococcus aureus. (2011). FEMS Immunology & Medical Microbiology. DOI: 10.1111/j.1574- 695X.2011.00846.x. IF=2.441
  13. Liu, C. H., Chang, F.Y., 2011, Development and characterization of eucalyptol microemulsions for topic delivery of curcumin, Chem Pharm Bull., 59 (2):172-8. IF=1.592
  14. Liu YH, Chu Y, Wu YC, Yeh CJ, Liu CY, Chen TP, Yuan HC, Ko PJ. (2011) Single-dose antimicrobial prophylaxis in transoral surgical lung biopsy: a preliminary experience. Surgical Endoscopy. (SCI, 2011 Jul 27. Epub ahead of print). IF=4.013
  15. Ko PJ, Chu Y, Wu YC, Liu CY, Hsieh MJ, Chen TP, Chao YK, Wu CY, Yuan HC, Liu YH, Liu HP. (2011). Feasibility of endoscopic transoral thoracic surgical lung biopsy and pericardial window creation. J Surg Res. (SCI, 2011 Apr 7, Epub ahead of print). IF=2.247
  16. Liu YH, Chu Y, Liu CY, Liu HP, Wu, YC, Hsieh MJ, Liu HP. (2011) Feasibility of the transtracheal approach for the thoracic cavity in a large animal model. Surgical Endoscopy. 25(5): 1652-8. (SCI). IF=4.013
  17. Lin CL, Siu LK, Lin JC, Liu CY, Chian CF, Lee CN, Chang FY. (2011). Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in COPD patients. Chest 139(1):43-51. (SCI). IF=5.250
  18. Lee, W.R., Shen, S.C., Al-Suwayeh, S.A., Yang, H.H., Yuan, C.Y., Fang, J.
    Y. (2011) Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules. J. Control. Release, 153, 240-248. IF=5.732
  19. Mu-Yi Hua, Hao-Li Liu, Hung-Wei Yang, Pin-Yuan Chen, Rung-Ywan Tsai, Chiung-Yin Huang, I-Chou Tseng, Lee-Ang Lyu, Chih-Chun Ma, Hsiang-Jun Tang , Tzu-Chen Yen, Kuo-Chen Wei, "The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas", Biomaterials, 32, 516-527 (2011). (IF = 7.882, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  20. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu, Chiung-Yin Huang, Rung-Ywan Tsai, Yu-Jen Lu, Ju-Yu Chen, Hsiang-Jun Tang, Jia-Shin Wu, Han-Yi Hsien, Yu-Sun Chang, Tzu-Chen Yen, Pin-Yuan Chen, Kuo-Chen Wei, "Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas", Biomaterials, 32, 6523-6532 (2011). (IF = 7.882, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  21. Fang-Hsin Chen, Chi-Shiun Chiang, Chun-Chieh Wang, Sheng-Yung Fu, Chien-Sheng Tsai,Shih-Ming Jung, Chih-Jen Wen, Chung-Chi Lee, and Ji-Hong Hong, Vasculatures in Tumors Growing From Preirradiated Tissues: Formed by Vasculogenesis and Resistant to Radiation and Antiangiogenic Therapy. Int. J. Radiation Oncology Biol. Phys., Vol. 80, No. 5, pp. 1512–1521, 2011. IF=4.105
  22. Hsiao, C.Y., Sindy, Hu., Ko, YS, Sung, H.C., & Huang, S.Y. (2011). Skin pretreatment with lasers promotes the transdermal delivery of vitamin C derivatives. Lasers Med Sci 26, 369-376. IF=2.004
  23. Ma DHK, Lai JY, Yu ST, Liu JY, Yang U, Chen HCJ, Yeh LK, Ho YJ, Grace Chang G, Wang SF, Chen JK, Lin KK. Up-regulation of Heat Shock Protein 70-1 (Hsp70-1) in Human Limbo-corneal Epithelial Cells Cultivated on Amniotic Membrane: A Proteomic Study. Journal of Cellular Physiology, 2011, 226: online publication on 7/12. IF=3.874
  24. Chen WJ, Yeh YH, Lin KH, Chang GJ, Kuo CT. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 2011 Mar;106(2):163-74. Epub 2011 Jan 14. IF=5.414
  25. Tong-Hong Wang, Junn-Liang Chang, Jar-Yi Ho, Hsiao-Chun Wu and Tse-Ching Chen. EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability. FEBS Journal 279 (2012) 251–263. IF=4.001
  • 2010
  1. Jeng-Fong Chiou, Yu-Huei Wang, Mei-Jie Jou, Tsan-Zon Liu and Chia-Yang Shiau. (2010)Verteporfin-photoinduced apoptosis in HepG2 cells is mediated by reactive oxygen species intermediate. Free Rad Res. 44(2): 155–170. IF=2.878
  2. Mei-Jie Jou, Tsung-I Peng, Lee-Fen Hsu, Shuo-Bin Jou, Russel J. Reiter, Chuen-Mao Yang, Chuan-Chin Chiao, Yi-Fan Lin and Chun-Chia Chen. (2010)Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes RBA-1. J. Pineal Res. 48:20–38. IF=5.794
  3. Mu-Yi Hua, Hung-Wei Yang, Cheng-Keng Chuang, Rung-Ywan Tsai, Wen-Jauh Chen, Kun-Lung Chuang, Ying-Hsu Chang, Heng-Chang Chuang, See-Tong Pang.(2010) Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer. Biomaterials 31(28): 7355-7363. IF=7.404
  4. Hao-Li Liu, Mu-Yi Hua, Hung-Wei Yang, Chiung-Yin Huang, Po-Chun Chu, Jia-Shin Wu, I-Chou Tseng, Jiun-Jie Wang, Tzu-Chen Yen, Pin-Yuan Chen, and Kuo-Chen Wei.(2010) Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain. PNAS 107(34): 15205-15210. IF=9.681
  5. Lai, J.-Y., Ma, D.H.-K., Cheng, H.-Y., Sun, C.-C., Huang, S.-J., Li, Y.-T., Hsiue, G.-H. (2010) “Ocular biocompatibility of carbodiimide cross-linked hyaluronic acid hydrogels for cell sheet delivery carriers”, J. Biomater. Sci.-Polym. Ed., 21(3), 359-376. IF=1.691
  6. Ma, D.H.-K., Lai, J.-Y., Cheng, H.-Y., Tsai, C.-C., Yeh, L.-K. (2010) “Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells”, Biomaterials, 31(25), 6647-6658. IF=7.404
  7. Ming-Hui Sun, Jong-Hwei Su Pang, Show-Li Chen, Wen-Hua Han, Tsung-Chuan Ho, Kuan-Jen Chen, Ling-Yuh Kao, Ken-Kuo Lin, and Yeou-Ping Tsao. (2010) Retinal Protection from Acute Glaucoma-Induced Ischemia-Reperfusion Injury through Pharmacologic Induction of Heme Oxygenase-1. IOVS, September 2010, Vol. 51, No. 9: 4798–4808. IF=3.597
  8. Rae-Mann Hsu, Ming-Hung Tsai, Ya-Ju Hsieh, Ping-Chiang Lyu, and Jau-Song Yu.(2010) Identification of MYO18A as a Novel Interacting Partner of the PAK2/ PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration. Molecular Biology of the Cell, Vol. 21, 287–301, January 15. IF=4.942
  9. Wei-Jan Chen, Jong-Hwei S. Pang, Kwang-Huei Lin, Dany-Young Lee, Lung-An Hsu, Chi-Tai Kuo(2010) Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction. Basic Res Cardiol 105:19–28. IF=7.348
  10. Hung TH, Chen SF, Li MJ, Yeh YL, Hsieh TT. Differential Effects of Concomitant Use of Vitamins C and E on Trophoblast Apoptosis and Autophagy between Normoxia and Hypoxia-Reoxygenation. PLoS One. 2010; 5(8): e12202. IF=4.092
  11. Hsu L-F, Peng T-I, Jou S-B, Reiter RJ., Yang C-M, Chiao C-C and Jou M-J. (2010) Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes RBA-1. J. Pineal Res. 48:20–38. IF=5.794
  12. Ing-Tsung Hsiao, Kun-Ju Lin,, Shi-Ing Chang, Tzu-Chen Yen, Tse-Ching Chen, Ta-Sen Yeh. (2010) Impaired liver regeneration of steatotic rats after portal vein ligation: A particular emphasis on 99mTc-DISIDA scintigraphy and adiponectin signaling. Journal of Hepatology, vol. 52 540–549. IF=9.264
  13. Lin, Y.K., Huang, Z.R., Zhuo, R.Z., Fang, J.Y.* (2010) Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. Int. J. Nanomed., 5, 117-128. IF=3.13
  14. Fang, J.Y.*, Wu, P.C., Fang, C.L., Chen, C.H. (2010) Intravesical delivery of 5-aminolevulinic acid from water-in-oil nano/submicron-emulsion systems. J. Pharm. Sci., 99, 2375-2385. IF=3.055
  15. Lee, W.R., Shen, S.C., Pai, M.H., Yang, H.H., Yuan, C.Y., Fang, J.Y.
    (2010) Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption: a comparison with conventional erbium:YAG laser. J. Control. Release, 145, 124-133. IF=5.732
  16. Jiunn-Woei Liaw, Shiao-Wen Tsai, Kuan-Lin Chen, and Fu-Yin Hsu (2010) Single-Photon and Two-Photon Cellular Imagings of Gold Nanorods and Dyes. Journal of Nanoscience and Nanotechnology Vol. 10, 467–473. IF=1.563
  • 2009
  1. Fang-Hsin Chen, Chi-Shiun Chiang, Chun-Chieh Wang,Chien-Sheng Tsai, Shih-MingJung, Chung-Chi Lee, William H.McBride, and Ji-Hong Hong. (2009) Radiotherapy Decreases Vascular Density and Causes Hypoxia with MacrophageAggregation in TRAMP-C1Prostate Tumors.Clinical Cancer Research 15(5): 1721-1729. IF=7.742
  2. Chen HCJ , Chen HL ,Lai JY, Chen CC , Tsai YJ, Kuo MT , Chu PH ,Sun CC, Chen JK , Ma DHK Persistence of Transplanted Oral Mucosal Epithelial Cells in Human Cornea. IOVS Volume: 50 Issue:10 Pages: 4660-4668 Published: OCT 2009. IF=3.597
  3. Ching-Yi Cheng,Chi-Chin Sun,Wei-Hsuan Yu,Hsi-Lung Hsieh, David Hui-Kang Ma, Jong-Hwei Su Pang, and Chuen-Mao Yang. Novel Laminin 5 2-chain Fragments Potentiating the Limbal Epithelial Cell Outgrowth on Amniotic Membrane. IOVIS Volume: 50 Issue: 10 Pages: 4631-4639 Published: OCT 2009. IF=3.597
  4. Chang CJ, Chen CC ,Hsu LA, Chang GJ, Ko YH, Chen CF, Chen MY, Yang SH, Pang JHS. Degradation of the Internal ElasticLaminae in Vein Grafts of Ratswith Aortocaval Fistulae PotentialImpact on Graft Vasculopathy. American Journal of Pathology Volume: 174 Issue: 5 Pages: 1837-1846 Published: MAY 2009. IF=4.890
  5. Chen WJ , Pang JHS, Lin KH , Yang SH. Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression. Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression. Basic Research in Cardiology Volume: 104 Issue: 1 Pages: 60-68 Published: JAN 2009. IF=7.348
  6. Jeng-Fong Chiou, Cheng-Jeng Tai, Yu-Huei Wang, Tsan-Zon Liu, Yee-Min Jen and Chia-Yang Shiau. Sorafenib Induces Preferential Apoptotic Killing of Hep G2 Cells Through a Mitochondria-Dependent Oxidative Stress Mechanism. Cancer Biology & Therapy 8:20, 1904-1913; October 15, 2009. IF=2.636
  7. Jeng-Fong Chiou, Cheng-Jia Cheng, Yu-Huei Wang, Tsan-Zon Liu and Yu-Jia Chang. Glucose-regulated Chaperon Protein-78 is a novel contributor to the occurrence of resistance acquisition of sorafenib, a multi-kinase inhibitor, in hepatoma cells. Annual Surg Oncology. October 15, 2009. IF=4.166
  8. Lee, W.R., Shen, S.C., Zhuo, R.Z., Wang, K.C., Fang, J.Y. (2009) Enhancement of topical small interfering RNA delivery and expression by low-fluence erbium:YAG laser pretreatment of skin. Hum. Gene Ther., 20, 580-588. IF=4.218
  9. Wang, J.J., Liu, K.S., Sung, K.C., Tsai, C.Y., Fang, J.Y. (2009) Skin permeation of buprenorphine and its ester prodrugs from lipid nanoparticles: lipid emulsion, nanostructured lipid carriers, and solid lipid nanoparticles. J. Microencapsul. December 2009, Vol. 26, No. 8 , Pages 734-747 (doi:10.3109/02652040902746679). IF=1.553
  10. Hwang, T.L., Fang, C.L., Chen, C.H., Fang, J.Y. (2009) Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm. Res., Vol. 26, No.10, October 2009. IF=4.093
  11. Fang, J.Y., Hung, C.F., Hua , S.C. , Hwang, T.L. (2009) Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells. Ultrasonics 49, 39–46. IF=1.838
  12. Ho SC, Lee KY, Chan YF, Kuo LW, Ito K, Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP. (2009) Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-kappa B Repressing Factor. J Immunol. 2009 Jul 1;183(1):411-20. IF=5.788
  13. Ma DHK, Kuo MT, Tsai YJ, Chen HCJ, Hsiao CH, Wang SF, Li L, Lin KK. (2009) Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Eye 23:1442-1450. IF=1.851
  14. Chin-Yuan Hsu and Ya-Chi Chiu. (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii), Aging Cell, Volume 8, Issue 6, pages 726–737, December 2009. IF=6.265
  15. DHK Ma, HCJ Chen, JY Lai, CC Sun, SF Wang, KK Lin, JK Chen. Matrix Revolution: Molecular Mechanism for Inflammatory Corneal Neovascularization and
    Restoration of Corneal Avascularity by Epithelial Stem Cell Transplantation. Ocular Surface 2009, 7(3): 128-144. IF=3.931
  • 2008
  1. Fang, J.Y., Fang, C.L., Liu, C.H., Su, Y.H. (2008) Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur. J. Pharm. Biopharm., 70, 633-640. IF=3.383
  2. Lee, W.R., Shen, S.C., Fang, C.L., Zhuo, R.Z., Fang, J.Y. (2008) Topical delivery of methotrexate via skin pretreated with physical enhancement techniques: low-fluence erbium:YAG laser and electroporation. Lasers Surg. Med., 40, 468-476. IF=2.619
  3. Hung TH, Chen SF, Hsieh CC, Hsu JJ, Li MJ, Yeh YL, Hsieh TT*; Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation- induced apoptosis in human placenta, Placenta 2008;29:565-583. IF=2.71
  4. Wen-Chung Tsai, Chih-Chin Hsu, Fuk-Tan Tang, Alice M. K. Wong, Yen-Ching Chen, and Jong-Hwei S. Pang; Ciprofloxacin-Mediated Cell Proliferation Inhibition and G2/M Cell Cycle Arrest in Rat Tendon Cells,Arthritis & Rheumatism Vol. 58, No. 6, June 2008, pp 1657–1663.
  5. Jou M-J (2008) Pathophysiological and Pharmacological Implications of Mitochondria-Targeted Reactive Oxygen Species Generation in Astrocytes. Advanced Drug Delivery Reviews 60:1512-1526.
  6. Lee, W.R., Pan, T.L., Wang, P.W., Zhuo, R.Z., Huang, C.M., Fang, J.Y. (2008) Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control. Release, 128, 200-208.
  7. Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, Liao CT, Wang HM, Yen TC, Shen CR, Liao SK, Cheng AJ.Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. Mol Cancer Ther. 2008 Sep;7(9):2788-97.
  8. Jyh-Ping Chen, Tze-Feng Yang. Applications of chitosan-based thermo-sensitive copolymers for harvesting living cell sheet. Applied Surface Science 255 (2008) 297–300.
  9. Jyh-Ping Chen, Tai-Hong Cheng. Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus. Colloids and Surfaces A: Physicochem. Eng. Aspects 313–314 (2008) 254–259.
  10. Jyh-Ping Chen, Gwo-Yun Chang, Jan-Kan Chen. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces A: Physicochem. Eng. Aspects 313–314 (2008) 183–188.
  11. Lee, W.R., Pan, T.L., Wang, P.W., Zhuo, R.Z., Huang, C.M., Fang, J.Y. (2008) Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control. Release, 128, 200-208.
  12. Chun-Hua Wang, Chien-Da Huang, Horng-Chyuan Lin, Kang-Yun Lee, Shu-Min Lin, Chien-Ying Liu, Kuo-Hsiung Huang, Yu-Shien Ko, Kian Fan Chung and Han-Pin Kuo. (2008) Increased Circulating Fibrocytes in Asthma with Chronic Airflow Obstruction. Am J Respir Crit Care Med Vol 178. pp 583–591.
  13. Ming-Hui Sun, Jong-Hwei Su Pang, Show-Li Chen, Ping-Chang Kuo, Kuan-Jen Chen, Ling-Yuh Kao, Ju-Yun Wu, Ken-Kuo Lin, Yeou-Ping Tsao. Photoreceptor Protection against Light Damage by AAV-mediated Overexpression of Heme Oxygenase-1. IOVS, 2008, 48(12)5699-5707.
  14. Mei-Hui Lin and Shih-Tung Liu (2008) Stabilization of pSW100 from Pantoea stewartii by the F Conjugation System. Journal of Bacteriology, Vol. 190, No. 10,May 2008, p. 3681–3689
  15. C.Y. Hsu (correspondence), Chiu Y.C., Hsu W.L., Chan Y.P. (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 63A:1267-1276.
  • 2007
  1. Liu CY, Lin HC, Yu CT, Lin SM, Lee KY, Chen HC, Chou CL, Huang CD, Chou PC, Liu WT, Wang CH, Kuo HP. The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derived a-defensin-1 on human bronchial and alveolar epithelial cells. Life Sci.2007. 80:749-758. (SCI)
  2. Chou CL, Chiang LL, Yu CT, Chen HC, Lin SM, Huang CD, Liu WT, Chou PC, Wang CH, Lin HC, Kuo HP, Liu CY. Apoptosis-dependent and -independent mechanisms mediate the phagocytic recognition/clearance of the HL60-A1 transfectants of prolonged survival. Inflamm Res. 2007. 56:195-203. (SCI)
  3. Jou M-J, Peng T-I, Yu P-Z, Jou S-B, Wu H-Y, and Hsu L-F. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J. Pineal Res. 2007. Nov;43(4):389-403.
  4. Wu T, Hua M-Y, Chen J-P, Wei K-C, Jung S-M, Chang Y-J, Jou M-J, and Ma Y-H. Effects of external magnetic field on biodistribution of nanoparticles: A histological study. J. Magn. Magn. Mater., 2007. 311: 372-375.
  5. Hsieh H-L, Wang H-H, Wu C-Y, Jou M-J, Yen M-H, Parker P, and Yang C-M.BK-induced COX-2 expression via PKC-δ-dependent activation of p42/p44 MAPK and NF-κB in astrocytes. Cell. Signal. 2007. 19(2):330-340.
  6. Ming-Dar Woon, Yu-Huei Wang, Hoi-Wan Lo, David Chung, Tsan-Zon Liu, Jeng-Fong Chiou The effect of hepatoma-derived growth factor, bcl-2, and glutathione on radiation-induced apoptosis in hepatocellular carcinoma cell lines. Therapeut Radiol Oncol. 2007. 4(3)
  7. Chiz-Tzung Chang, Cheng-Chieh Hung, Ya-Chung Tian, Chih-Wei Yang and Mai-Szu Wu. Ciclosporin reduces paracellin-1 expression transport in thick ascending limb cells. Nephrol Dial Transplant. 2007. 22: 1033-1040.
  8. Chin-Yuan Hsu, Fu-Yao Ko, Chia-Wei Li, Kuni Fann, Juh-Tzeng Lue Magnetoreception system in honeybees (Apis mellifera) PLoS ONE. 2007 April. 2(4): e395
  9. J.-W. Liaw, “The quantum yield of a metallic nanoantenna”, Appl. Phys. 2007. A 89, 357- 362 (NSC95-2221-E-182-002)
  10. J.-W. Liaw, “Local field enhancement and quantum yield of metallic dimer”, Jpn J. Appl. Phys. 2007. 46(8A), 5373-5378.. (NSC95-2221-E-182-002)
  11. J.-W. Liaw, “New surface integral equations for the light scattering of multi-metallic nanoscatterers”, Eng. Anal. with Boundary Elements 2007. 31(4), 299-310.
    (NSC95-2221-E-182-002)
  12. Liu HW, Chen CH, Tsai CL, Lin IH, Hsiue GH. Heterobifunctional poly (ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cells differentiation and osteogenesis. Tissue Engineering 2007; 13:11131124. (SCI, 2006 IF: 3.725) (selected as cover art)
  13. Y-J Chen, JT Chang, L Lee, H-M Wang, C-T Liao, C-C Chiu, P-J Chen and A-J Cheng; DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis; Oncogene (2007), 26:467-476.
  • 2006
  1. Liu HW, Chen CH, Tsai CL, Hsiue GH. Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2–mediated carrier-protein conjugation. Bone 2006; 39:825-836. (SCI, 2005 IF: 3.939)
  2. Hao-Ping Liu, Chih-Ching Wu and Yu-Sun Chang. PRA1 promotes the intracellular traficking and NF-kB signaling of EBV latent membrane protein 1. EMBO J. 2006. August 17 on line) 25 (17): 4120-4130.
  3. Hsieh SY, Shih TC, Yeh CY, Lin CJ, Chou YY, Lee YS.Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics. 2006. Aug 31;6(19):5322-5331.
  4. Chen HC, Wang CJ, Chou CL, Lin SM, Huang CD, Lin TY, Wang CH, Lin HC, Yu CT, Kuo HP, Liu CY. Tumor necrosis factor-a induces caspase-independent cell death in human neutrophil via reactive oxidants and associated with calpain activity. J Biomed Sci. 2006. 13:261-273. (SCI)
  5. Peng TI, Yu PR, Chen JY, Wang HL Wu HY, Wei YH, and Jou MJ*. Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress. Biochimica et Biophysica Ecta. 1762 (2): 241-255, 2006. Feb.
  6. Tsao ML, Chao CH, Yeh CT. Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization. Biochem Biophys Res Commun. 2006 Sep 15;348(1):271-7. Epub 2006. Jul 24.
  7. Wang TH, Chan YH, Chen CW, Kung WH, Lee YS, Wang ST, Chang TC, Wang HS. Paclitaxel (Taxol) upregulates expression of functional IL-6 in human ovarian cancer cells through multiple signaling pathways Oncogene 2006. 25: 4857-4866.
  8. Yoon Y-S, Yoon D-S, Lim I-K, Yoon S-H, Chung H-Y, Rojo M, Malka F, Jou M-J, Martinou J-C, and Yoon G. Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 2006. 209: 468-480.
  9. Chou A-H, Yeh T-H, Kuo Y-L, Kao Y-C, Jou M-J, Hsu C-Y, Tsai S-R, Kakizuka A, and Wang H-L. Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. Neurobiol Dis 2006. 21:333-345.
  10. Li-Mei Pai, Pei-Yu Wang, Shu-Ru Chen, Gail Barcelo, Wei-Ling Chang, Laura Nilson, Trudi Schupbach; Differential effects of Cbl isoforms on Egfr signaling in Drosophila; Mechanisms of Development 2006. Jun, 123: 450–462.
  11. Ma DHK, Chen JK, Zhang F, Lin KY, Yao JY, Yu JS. Regulation of corneal angiogenesis in limbal stem cell deficiency. Progress in Retinal and Eye Research 2006, 25(6): 563–590.
  12. Lee KY, Ho SC, Lin HC, Lin SM, Liu CY, Huang CD, Wang CH, Chung KF, Kuo HP. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol. 2006 Oct;35(4):407-14. Epub 2006 May 11.
  • 2005
  1. Peng TI, Chang CJ, Guo MJ, Wang YH, Yu JS, Wu HY, and Jou MJ. Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis. Annals New York Academy of Sciences.1042: 419-428, 2005 June.
  2. Jou MJ, Peng TI, Wu HY and Wei YH. Enhanced generation of mitochondrial reactive oxygen species in cybrids containing 4977-bp mitochondrial DNA deletion. Annals New York Academy of Sciences.1042: 221-228, 2005 June.
  3. Peng TI, Chang CJ, Jou SB, Young CM, and Jou MJ.Photosensitizer Targeting: mitochondrion-targeted photosensitizer enhances mitochondrial reactive oxygen species and mitochondrial calcium-mediated apoptosis. Optical and Quantum Electronics.37 (13-15): 1377 – 1384, 2005 December.
  4. Liu CY, Wang CH, Wan YL, Chou CL, Huang KH, Lin HC, Lin SM, Lin TY, Chung KF, Kuo HP. (2005) Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respiratory Research 2005, 6:42. (SCI)
  5. Chang CJ, Ko YS, Ko PJ, Hsu LA, Chen CF, Yang CW, Hsu TS, Pang JH. Thrombosed arteriovenous fistula for hemodialysis access is characterized by a marked inflammatory activity. Kidney Int 2005 Sep; 68(3):1312-9.
  6. Wei-Chi Wu, Chi-Chun Lai, Show-Li Chen, Ming-Hui Sun, Xiao Xiao, Tun-Lu Chen and Ken-Kuo Lin, Shu-Wen Kuo, Yeou-Ping Tsao; Long-Term Safety of GDNF Gene Delivery in the Retina. Current Eye Research, 30:715–722, 2005.
  • 2004
  1. Hsieh H-L, Yen M-H, Jou M-J and Yang C-M. Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.Cellular Signallings 2004, 16(10): 1163-1176.
  2. Wu C-Y, Hsieh H-L, Jou M-J and Yang C-M. Involvement of p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1β-induced matrix metalloproteinase-9 expression in rat brain astrocytes. J of Neurochemistry 2004, 90(6):1477-1488.
  3. Cheng C-Y, Huang SCM, Hsiao L-D, Sun C-C, Jou M-J, Yang C-M. Bradykinin-stimulated p42/p44 MAPK activation associated with cell proliferation in corneal keratocytes. Cellular Signallings 2004, 16(5):535-549.
  4. Ma DHK, Yao JY, Yeh LK, Liang ST, See LC, Chen HT, Lin KY, Liang CC, Lin KK, Chen JK. In Vitro Anti-angiogenic Activities of Ex Vivo Expanded Human Limbal Epithelial Cells Cultivated on Human Amniotic Membrane. Investigative Ophthalmology & Visual Science 2004; 45: 2586–2595.
  5. Jou MJ, Jou SB, Wu HY, Kuo MJ and Peng TI. Mitochondrial reactive oxygen species generation and mitochondrial calcium increase induced by visible light in astrocytes. Annals of the New York Academy of Sciences.1011:45-56, 2004 Apr.
  6. Peng TI and Jou MJ. Mitochondrial swelling and generation of reactive oxygen species induced by photo-irradiation are heterogeneously distributed. Annals of the New York Academy of Sciences.1011:112-122, 2004 Apr.
  7. Jou MJ, Peng TI, Reiter RJ, Jou SB, Wu HY and Wen ST. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. Journal of Pineal Research. 37: 55-70, 2004 Aug.
  8. Ko YS, Yeh HI, Ko YL, Hsu YC, Chen CF, Wu S, Lee YS, Severs NJ. (2004 Mar). Three-dimensional reconstruction of the rabbit atrioventricular conduction axis by combining histological, desmin, and connexin mapping data. Circulation;109:1172-9.
  9. Wei-Chi Wu, Chi-Chun Lai, Show-Li Chen, Ming-Hui Sun, Xiao Xiao, Tun-Lu Chen, Ray Jui-Fang Tsai, Shu-Wen Kuo, Yeou-Ping Tsao; GDNF gene therapy attenuates retinal ischemic injuries in rats. Molecular Vision 2004; 10:93-102.

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