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                             研 究 成 果  

雷射掃描共軛焦顯微鏡

  • 2016
  1. Liu, C. H., Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022 (IF=3.289)
  2. Rout, B., Liu, C. H., Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480 (IF=3.902)
  3. Modulation of Staphylococcus aureus spreading by water. Lin MH, Ke WJ, Liu CC and Yang MW. Sci Rep. 2016 Apr 29;6:25233. (Impact factor: 5.228)
  4. Ma DHK*, Chen HC, Ma KSK, Lai JY*, Yang U, Yeh LK, Hsueh YJ, Chu WK, Lai CH and Chen JK. Preservation of human limbal epithelial progenitor cells on carbodiimide cross-linked amniotic membrane via integrin-linked kinase-mediated Wnt activation. Acta Biomater, 2016 Feb;31:144-55. (IF=6.025;R/C= 3/76,Engineering,Biomedical)
  5. Hsiao FC, Yeh YH, Chen WJ, Chan YH, Kuo CT, Wang CL, Chang CJ, Tsai HY, Tsai FC, Hsu LA. MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese. Int J Mol Sci. [International Journal of Molecular Science] 2016 Apr 7;17(4):521 (IF=3.257)
  6. Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk. European Journal of Pharmaceutical Sciences.2016. PAGE:1-10. (IF=3.773)
  7. What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. International Journal of Pharmaceutics.2016 . PAGE: 277–286. (IF=3.994)
  8. Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species. Nanomedicine (Lond.).2016 . PAGE: 657–671. (IF= 4.889)

 

  • 2015
  1. Li-Fu Li, Yi-Ting Lai, Chih-Hao Chang, Meng-Chih Lin, Yung-Yang Liu, Kuo-Chin Kao, Ying-Huang Tsai*. 2014 Neutrophil elastase inhibitor reduces ventilation-induced lung injury via nuclear factor-kB and NF-kB repressing factor in mice. Exp Biol Med Vol 239(8):1045-1057. (IF=2.542)
  2. Li-Fu Li, Yung-Yang Liu, Kuo-Chin Kao, Chen-Te Wu, Chih-Hao Chang, Chen-Yiu Hung, and Cheng-Ta Yang*. 2014 Mechanical ventilation augments bleomycin-induced epithelial-mesenchymal transition through the Src pathway. Lab Invest 94(9):1017-1029. (IF=4.202)
  3. Yung-Yang Liu, Li-Fu Li*, Jui-Ying Fu, Kuo-Chin Kao, Chung-Chi Huang, Yueh Chien, Yi-Wen Liao, Shih-Hwa Chiou, Yuh-Lih Chang. Induced Pluripotent Stem Cell Therapy Ameliorates Hyperoxia-Augmented Ventilator-Induced Lung Injury through Suppressing the Src Pathway. PLoS One 2014,9(10):e109953. Corresponding author (IF=3.057)
  4. Hsueh Y-H, Ke W-J, Hsieh C-T, Lin K-S,Tzou D-Y, Chiang C-L (2015) ZnO Nanoparticles Affect Bacillus subtilis Cell Growth and Biofilm Formation. PLoS ONE 10(6): e0128457. doi:10.1371/journal.pone.0128457 (IF=3.057)
  5. Ke W-J, Hsueh Y-H, Cheng Y-C, Wu C-C and Liu S-T (2015) Water surface tension modulates the swarming mechanics of Bacillus subtilis. Front. Microbiol. 6:1017. doi: 10.3389/fmicb.2015.01017 (IF=4.165)
  6. Hsueh YJ, Chen HC, Wu SE, Wang TK, Chen JK and Ma DHK*. (2015, Apr).
    Lysophosphatidic acid induces YAP-promoted proliferation of human corneal
    endothelial cells via PI3K and ROCK pathways. Molecular Therapy - Methods
    & Clinical Development, 29;2:15014. (IF=6.938)
  7. Hsueh YJ, Chen HC, Lai JY, Chen JK and Ma DHK* (2015, Mar). Corneal
    Neovascularization as a Target for Nucleotide-Based Therapies. Journal of
    Clinical & Experimental Ophthalmology, 6: 409. (IF=2.546)
  8. Lin CW1, Wei KC1, Liao SS, Huang CY, Sun CL, Wu PJ, Lu YJ, Yang HW*, Ma CC*. A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis. Biosensors and Bioelectronics. 2015 May; 67: 431-437. (SCI; IF2013=6.451; Electrochemistry 1/27) (1co-first author)
  9. Lin CY, Hsieh HY, Pitt WG, Huang CY, Tseng IC, Yeh CK, Wei KC*, Liu HL*. Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery. Journal of Control Release. 2015 Aug; 212: 1-9. (SCI; IF2013=7.261; Pharmacology & pharmacy 11/254) (co-corresponding author)
  10. Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen and Mu-Yi Hua, “A sensitive and selective magnetic grapheme composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis”, Biosensors and Bioelectronics, 2015, 66, 198-207 (IF=7.476)
  11. Peng YS, Tsai TT, Niu CC, Chu IM, Liao JC, Lai PL* (corresponding): Bone morphogenetic protein 2 gene delivery via polyethylene imine grafted chondroitin sulfate non-viral gene carrier. Formosan Journal of Musculoskeletal Disorders, 2015; Vol. 6(23-34) (IF=n/a)
  12. Liu, C. H., Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67 (IF=1.228)
  13. YJ Lai, GJ Chang, YH Yeh, JH S. Pang, CC Huang, WJ Chen3*, Propylthiouracil Attenuates ExperimentalPulmonary Hypertension via Suppression of  Pen-2, a Key Component of Gamma-Secretase. 2015 PLoS ONE 10(9): e0137426. (SCI: 3.057)
  14. K.T. Shalumon, G.J Lai, C.H. Chen, J.P. Chen.* 2015. Modulation of bone-specific tissue regeneration by incorporating bone morphogenetic protein and controlling the shell thickness of silk fibroin/chitosan/nanohydroxyapatite core–shell nanofibrous membranes. ACS Applied Materials & Interface, 7: 21170-21181. (IF=7.145)
  15. C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Dual functional core–sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion. Acta Biomaterialia, 26, 225-235. (IF=6.008)
  16. C.H. Chen, S.H. Chen, K.T. Shalumon, J.P. Chen.* 2015. Prevention of peritendinous adhesions with electrospun polyethyleneglycol/polycaprolactone nanofibrous membranes. Colloids and Surfaces B: Biointerfaces, 133, 221-230. (IF=3.902)
  17. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2015. Response of human mesenchymal stem cells to intra-fibrillar nanohydroxyapatite content and extra-fibrillar nanohydroxyapatite in biomimetic chitosan/silk fibroin/nanohydroxyapatite nanofibrous membrane scaffolds. International Journal of Nanomedicine, 10, 567–584. (IF=4.320)
  18. C.Y. Kuo, C.H. Chen, C.Y. Hsiao, J.P. Chen.* 2015. Incorporation of chitosan in biomimeticgelatin/chondroitin-6-sulfate/hyaluronan cryogel for cartilage tissue engineering. Carbohydrate Polymers, 117, 722–730. (IF=4.219)
  • 2014
  1. Hsiao-Chien Chen, Jian-Tai Qiu, Fu-Liang Yang, Yin-Chih Liu, Min-Cheng Chen, Rung-Ywan Tsai, Hung-Wei Yang, Chia-Yi Lin, Chu-Chi Lin, Tzong-Shoon Wu, Yi-Ming Tu, Min-Cong Xiao, Chia-Hua Ho, Chien-Chao Huang, Chao-Sung Lai and Mu-Yi Hua, “Magnetic-Composite-Modified Polycrystalline Silicon Nanowire Field-Effect Transistor for Vascular Endothelial Growth Factor Detection and Cancer Diagnosis”, Anal. Chem., 2014, 86, 9443-9450 (IF=5.886)
  2. Hung-Wei Yang , Chih-Wen Lin , Mu-Yi Hua , Shih-Sheng Liao , Ying-Tzu Chen , Hsiao-Chien Chen , Wen-Hui Weng , Cheng-Keng Chuang , See-Tong Pang and Chen-Chi M. Ma, “Combined Detection of Cancer Cells and a Tumor Biomarker using an Immunomagnetic Sensor for the Improvement of Prostate-Cancer Diagnosis”, Adv. Mater., 2014, 26, 3662-3666 (IF=18.960)
  3. Peng YS, Lai PL (Co-first author), Peng S, Wu HC, Yu S, Tseng TY, Wang LF, Chu IM: Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier. International Journal of Nanomedicine. 2014; Vol.9(1) :3163-3174. ( SCI;IF: 4.383;PHARMACOLOGY & PHARMACY,30/254,Q1) CMRPG3C0101
  4. S.H. Chen, C.H. Chen, Y.T. Fong, J.P. Chen.* 2014. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta Biomaterialia, 10, 4971-4982. (IF=6.008)
  5. S.H. Chen, C.H. Chen, K.T. Shalumon, J.P. Chen.* 2014. Preparation and characterization of anti-adhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion. International Journal of Nanomedicine, 9, 4079-4092. (IF=4.320)
  6. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen.* 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 111, 288-297. (IF=4.219)
  7. Y.J. Lu, C.W. Lin, H.W. Yang, K.J. Lin, S.P. Wey, C.L. Sun, K.C. Wei, T.C. Yen, C.I. Lin, C.C.M. Ma, J.P. Chen.* 2014. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon, 74, 83-95. (IF=6.198)
  8. Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation Cell Death and Disease (2014) 5, e1510; doi:10.1038/cddis.2014.468; published online 6 November 2014 (IF=5.378)
  9. Hsu, Chin-Yuan; Hsieh, Yu-Shan. Oxidative stress decreases in the trophocytes and fat cells of worker honeybees during aging.Biogerontology, 2014 April, 15.2: 129-137(徐錦源) (IF=3.252)
  10. Hsu, Chin-Yuan; Chuang, Yu-Lung; Chan, Yu-Pei.Changes in cellular degradation activity in young and old worker honeybees (Apis mellifera).Exp Gerontol. 2014 Feb;50:128-36) (徐錦源) (IF=3.35)
  11. Chang SH, Wu LS, Chiou MJ, Liu JR, Yu KH, Kuo CF, Wen MS, Chen WJ, Yeh YH. Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies. See LC.Cardiovasc Diabetol. 2014 Aug 10;13(1):123. doi: 10.1186/s12933-014-0123-x.PMID: 25106079[PubMed - in process] Free PMC Article(葉勇信) (IF=4.534)
  12. Lee CH, Chang SH, Lin YH, Liu SJ, Wang CJ, Hsu MY, Hung KC, Yeh YH, Chen WJ, Hsieh IC, Wen MS. Acceleration of re-endothelialization and inhibition of neointimal formation using hybrid biodegradable nanofibrous rosuvastatin-loaded stents. Biomaterials. 2014 May;35(15):4417-27. doi: 10.1016/j.Biomaterials.2014.02.017. Epub 2014 Feb 28. (葉勇信) (IF=8.387)
  13. Chien-Hui Hung, Lee-Wen Chen, Wen-Hung Wang, Pey-Jium Chang, Ya-Fang Chiu, Chen-Chia Hung, Ying-Ju Lin, Jieh-Yuan Liou, Wan-Ju Tsai, Chia-Ling Hung, and Shih-Tung Liu. Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal -Regulated Kinase Pathway J. Virol. 2014, 88(20):12133) (劉世東) (IF=4.606)
  14. Peng YS, Lai PL (Co-first author), Peng S, Wu HC, Yu S, Tseng TY, Wang LF, Chu IM: Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier.International Journal of Nanomedicine. 2014, Jun; Vol.9(1) :3163-3174.(賴伯亮) (IF=4.32)
  15. S.H. Chen, C.H. Chen, K.T. Shalumon, J.P. Chen. 2014. Preparation and characterization of anti-adhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion. International Journal of Nanomedicine, 9, 4079-4092.(陳志平 )(IF=4.32)
  16. G.J. Lai, K.T. Shalumon, S.H. Chen, J.P. Chen. 2014. Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 111, 288–297. (陳志平) (IF=4.219)
  17. C.H. Chen, J.M.J. Liu, C.K. Chua, S.M. Chou, V.B.H. Shyu, J.P. Chen. 2014. Cartilage tissue engineering with silk fibroin scaffolds fabricated by indirect additive manufacturing technology. Materials, 7, 2104-2119. (陳志平) (IF=2.728)
  18. Hsu RM, Hsieh YJ, Yang TH, Chiang YC, Kan CY, Lin YT, Chen JT, Yu JS. Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor β (βPIX) to myosin 18A (MYO18A) is required for epithelial cell migration. Biochim Biophys Acta. 8 July 2014. 2513–2527.(余兆松) (IF=5.34)
  19. Lu YC, Chang JT, Liao CT, Kang CJ, Huang SF, Chen IH, Huang CC, Huang YC, Chen WH, Tsai CY, Wang HM, Yen TC, You GR, Chiang CH, Cheng AJ. OncomiR-196 promotes an invasive phenotype in oral cancer through NME4-JNK-TIMP1-MMP signaling pathway. Molecular Cancer 2014, 13:218(鄭恩加) (IF=5.888)
  20. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY.Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.Hepatology. 2014 Jun; 59 (6): 2238-50(謝森永) (IF=5.888)
  21. Liu, C. H., Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014, Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694. (劉繼賢) (IF=1.463)
  22. Chwan-Fwu Lin & Chih-Jen Wen & Ibrahim A. Aljuffali & Chun-Lin Huang & Jia-You Fang. Quantiosomes as a Multimodal Nanocarrier for IntegratingBioimaging and Carboplatin Delivery. Pharmaceutical Research. 15 March 2014(方嘉祐) (IF=3.26)
  23. Yu-Jen Lu, Chih-Wen Lin, Hung-Wei Yang, Kun-Ju Lin, Shiaw-Pyng Wey, Chia-Liang Sun, Kuo-Chen Wei, Tzu-Chen Yen, Ching-I Lin, Chen-Chi M. Ma, Jyh-Ping Chen. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon 2014; 74:83-95. (神經外科楊閎蔚;盧郁仁;魏國珍;林昆儒;閻紫宸) (IF=6.198)
  24. C.H. Chen, M.Y. Lee, V.B.H. Shyu, Y.C. Chen, C.T. Chen, J.P. Chen. 2014. Surface modification of polycaprolactone scaffolds fabricated via selective laser sintering for cartilage tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 40, 389-397.(長庚大學化材系陳志平老師) (IF=3.42)
  • 2013
  1. Hung-Wei Yang, Mu-Yi Hua, Tsong-Long Hwang, Kun-Ju Lin, Chiung-Yin Huang, Rung-Ywan Tsai, Chen-Chi M. Ma, Po-Hung Hsu, Shiaw-Pyng Wey, Peng-Wei Hsu, Pin-Yuan Chen, Yin-Cheng Huang, Yu-Jen Lu, Tzu-Chen Yen, Li-Ying Feng, Chih-Wen Lin, Hao-Li Liu and Kuo-Chen Wei, "Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide", Advanced Materials, 25(26), 3605–3611 (2013). (IF = 14.829, Filtered by Matericals Science, Multidisciplinary, 6/239) (1 Equal Contribution)
  2. Hung-Wei Yang, Yu-Jen Lu, Kun-Ju Lin, Sheng-Chieh Hsu, Chiung-Yin Huang, Shu-Han She, Hao-Li Liu, Chih-Wen Lin, Min-Cong Xiao, Shiaw-Pyng Wey, Pin-Yuan Chen, Tzu-Chen Yen, Kuo-Chen Wei, Chen-Chi M. Ma,“EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy” Biomaterials ,34(29), 7204-7214(2013). IF=8.557
  3. Woan-Ruoh Lee & Shing-Chuan Shen & Saleh A. Al-Suwayeh & Hung-Hsu Yang & Yi-Ching Li & Jia-You Fang Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles Pharmaceutical research (2013) 30:792–802. IF=3.420
  4. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang HF, Chang CJ, Lin YJ, Yung BY, Hsieh SY. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating death evasion and drug sensitivity in human hepatoma cells. Hepatology. 2013 May;57(5):1893-905. IF=11.055
  5. Li-Fu Li, Pao-Hsien Chu, Cheng-Yiu Hung, Winston W.-Y. Kao, Meng-Chih Lin, Yung-Yang Liu, Cheng-Ta Yang. Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway. Chest 2013,143(5):1252-1260. (SCI; IF=5.854; ; Respiratory system 4/50).
  6. Yung-Yang Liu, Li-Fu Li*, Cheng-Ta Yang, Kai-Hsi Lu, Chung-Chi Huang, Kuo-Chin Kao, Shih-Hwa Chiou. Suppressing NF-kB and NKRF pathways by induced pluripotent stem cell therapy in mice with ventilator-induced lung injury. PLoS One 2013,8(6):e66760 (SCI; IF=3.73; Multidisciplinary Sciences 7/56).
  7. Weng CM, Chen BC, Wang CH, Feng PH, Lee MJ, Huang CD, Kuo HP, Lin CH.,The endothelin a receptor mediates fibrocyte differentiation in chronic obstructive asthma. The involvement of connective tissue growth factor. Am J Respir Crit Care Med, 2013 Aug 1,188(3):298-308. IF=12.996
  8. Transdermal delivery of three vitamin C derivatives by Er: YAG and carbon dioxide laser pretreatment. May. ISSN 0268-8921,Volume 28,Number 3, Lasers Med Sci (2013) 28:807-814, DOI 10.1007/s10103-012-1151-y. IF=2.489
  9. Yin-Ju Chen, Li-Yu Lee, Yin-Ka Chao, Joseph T. Chang, Ya-Ching Lu, Hsiao-Fang Li, Ching-Chi Chiu, Yi-Chen Li, Yan-Liang Li, Jeng-Fong Chiou, Ann-Joy Cheng, DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway PLoS ONE 8(5): e64088. doi:10.1371/journal.pone.0064088 Received: December 7, 2012; Accepted: April 10, 2013; Published: May 30, 2013
  10. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Mediates the Differential Responsiveness of Atrial Versus Ventricular Fibroblasts to Transforming Growth Factor-β.Yeh YH, Kuo CT, Chang GJ, Qi XY, Nattel S, Chen WJ.Circ Arrhythm Electrophysiol. 2013 Aug 1;6(4):790-8. doi: 10.1161/CIRCEP.113.000338. Epub 2013 Jul
  11. Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation.Yeh YH, Kuo CT, Lee YS, Lin YM, Nattel S, Tsai FC, Chen WJ.Heart Rhythm. 2013 Mar;10(3):383-91. doi: 10.1016/j.hrthm.2012.11.013. Epub 2012 Nov 24.
  12. Hwang YS, Chiang PR, Hong WH, Chiao CC, Chu IM, Hsiue GH, Shen CR (correspondence). Study in vivo intraocular biocompatibility of in situ gelation hydrogels: Poly (2-ethyl oxazoline)- block- poly (<epsilon>- caprolactone)- block- poly (2-ethyloxazoline) Copolymer, Matrigel and Pluronic F127. PLoS One 2013 (7): e67495. SCI=3.730 (MULTIDISCIPLINARY SCIENCES, 12.50%)
  13. Lin YH, Chang HM, Chang FP, Shen CR (equal to second), Liu CL, Mao WY, Lin CC, Shen CN. Protoporphyrin IX accumulation disrupts mitochondrial dynamics in ABCG2-deficient hepatocytes. FEBS Letters 2013 (in press)
  14. Yu-Shan Hsieh and Chin-Yuan Hsu.Oxidative Stress and Anti-Oxidant Enzyme Activities in the Trophocytes and Fat Cells of Queen Honeybees (Apis mellifera).REJUVENATION RESEARCH, 16(4):295-303(2013.8)
  15. C.Y. Hsu, Y.P Chan . The use of honeybees reared in a thermostatic chamber for aging studies. Age . ,35:149-158(2013.2)
  16. P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, "Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, " PLoS ONE, Accepted, 2013 (*通訊作者; SCI IF = 4.092, 12/85 in "Biology")
  17. Kao C, Chao A, Tsai CL, Lin CY, Chuang WC, Chen HW, Yen TC, Wang TH, Lai CH, Wang HS. , Phosphorylation of signal transducer and activator of transcription 1 reduces ortezomib-mediatedapoptosis in cancer cells. Citation: Cell Death and Disease (2013) 4, e512; doi:10.1038/cddis.2013.38
  18. Chang YL, Wang CN, Wei PC, Peng HH, Chao AS, Chang SD, Cheng PJ, Wang TH., Mitochondrial activation in the growth-restricted fetus of monochorionic twins. Fertility and Sterility. Vol. 100, No. 1, July 2013 0015-0282/$36.00
  19. Soong YK, Huang SY, Yeh CH, Wang TH, Chang KH, Cheng PJ, Shaw SW.,The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines. J Tissue Eng Regen Med (2013) Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/term.1702
  20. Li-Fu Li, Yung-Yang Liu, Cheng-Ta Yang, Yueh Chien, Mong-Lien Wang, Nae-Fang Twu, Chien-Ying Wang, Chung-Chi Huang, Kuo-Chin Kao, Han-Shui Hsu, Shih-Hwa Chiou. Improvement of ventilator-induced lung injury by IPS cell-derived conditioned medium via Inhibition of PI3K/Akt pathway and IP-10-dependent paracrine regulation. Biomaterials Biomaterials 34 (2013) (SCI; IF=7.404; Engineering, Biomedical, 2/72).
  21. Fang-Hsin Chen, Sheng-Yung Fu, Ying-Chieh Yang, Chun-Chieh Wang, Chi-Shiun Chiang, and Ji-Hong Hong. Combination of Vessel-Targeting Agents and Fractionated
    Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway. Int J Radiation Oncol Biol Phys, Vol. 86, No. 4, pp. 777-784, 2013.
  22. Kuo-Hsuan Chang, Meng Li. Clonal Isolation of an Intermediate Pluripotent Stem Cell State. STEM CELLS 2013; 31:918–927
  23. Kuo-Hsuan Chang, Wan-Ling Chen, Li-Ching Lee, Chih-Hsin Lin, Pin-Jui Kung, Te-Hsien Lin, Yi-CiWu, Yih-Ru Wu, Yi-Chun Chen, Guey-Jen Lee-Chen,2 and Chiung-Mei Chen. Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 471659, 11 pages. http://dx.doi.org/10.1155/2013/471659.
  • 2012
  1. Tsai CL, Tsai CN, Lin CY, Chen HW, Lee YS, Chao A, Wang TH, Wang HS, Lai CH., Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells. Cell Reports 2, 283–293, August 30, 2012.
  2. K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, "A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery", ACS Nano, Accepted, 2012 (IF=10.774, 9/152 in “Chemistry, Multidisciplinary”)
  3. Y.L.Chuang , C.Y. Hsu .Changes in mitochondrial energy utilization in young and old worker honeybees (Apis mellifera). Age. ,DOI 10.1007/s11357-012-9490-y (2012.11)
  4. Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J ALLERGY CLIN IMMUNOL, MAY, 2012
  5. Tsai ZT, Tsai FJ, Yang WC, Wang JF, Liu CL, Shen CR (correspondence), Yen TC. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential MRI T2 contrast agent. Mar Drugs 2012; 10(11), 2403-2414. SCI=3.978 (CHEMISTRY, MEDICINAL, 10.17%)
  6. Han Tsung Liao, Chien Tzung Chen*, Chih Hao Chen, Jyh Ping Chen, Jui Che Tsai. Combination of Guided Osteogenesis with Autologous Platelet-Rich Fibrin Glue (PRFG) and Mesenchymal Stem Cell for Reconstruction of Mandibular Defects in Canine Model. J Trauma , 2011 Jan;70(1):228-37. , (SCI) (corresponding author)
  7. Hung TH, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS One. 2012;7(7):e40957. ( IF = 4.411; 12/86 in Biology )
  8. Hung TH*, Chen SF, Lo LM, Li MJ, Yeh YL, Hsieh TT. Myeloperoxidase in the plasma and placenta of normal pregnant women and women with pregnancies complicated by preeclampsia and intrauterine growth restriction. Placenta 2012;33:294-303. ( IF = 2.985; 11/77 in Obstetrics & Gynecology)
  9. Liu, C. H., Huang H. Y., 2012, Sep, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin 60(9):1118-24 (SCI)
  10. Feng PH, Lee KY, Chang YL, Chan YF, Kuo LW, Lin TY, Chung FT, Kuo CS, Yu CT, Lin SM, Wang CH, Chou CL, Huang CD, Kuo HP. CD14(+)S100A9(+) monocytic myeloid-derived suppressor cells and their clinical relevance in non-small cell lung cancer. Am J Respir Crit Care Med. 2012 Nov 15, 186(10):1025-36
  11. Chia-Lung Tsai,Chi-Neu Tsai,Chiao-Yun Lin,Hsi-Wen Chen,Yun-Shien Lee,Angel Chao,Tzu-Hao Wang,Hsin-Shih Wang,and Chyong-Huey Lai. Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells. Cell Reports 2, 283–293, August 30, 2012)
  12. Hsiao-Chien Chen, Mu-Yi Hua, Yin-Chih Liu, Hong-Wei Yang, Rung-Ywan Tsai, "Preparation of water-dispersible poly[aniline-co-sodium N-(1-one-butyric acid) aniline]-zinc oxide nanocomposite for utilization in an electrochemical sensor", J. Mater. Chem., in press (2012). (IF = 5.101, Filtered by Materials Science, Multidisciplinary, 16/225) (1 Equal Contribution)
  13. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu1, Rung-Ywan Tsai, See-Tong Pang, Po-Hong Hsu, Hsiang-Jun Tang, Tzu-Chen Yen, Cheng-Keng Chuang, "An epirubicin–conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer", Biomaterials, 33(15), 3919-3930 (2012). (IF = 7.883, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  14. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu , Rung-Ywan Tsai, Cheng-Keng Chuang, Po-Chun Chu, Pei-Yi Wu, Ying-Hsu Chang, Heng-Chang Chuang, Kai-Jie Yu, See-Tong Pang, "Cooperative Dual-activity Targeted Nanomedicine for Specific and Effective Prostate Cancer Therapy", ACS Nano, 6(2), 1795-1805 (2012). (IF = 9.865, Filtered by Materials Science, Multidisciplinary, 9/225). (1 Equal Contribution)
  15. A-H Liao, H-L Liu, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, "Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging", Physics in Medicine and Biology, in press (2012). (IF = 3.056, Filtered by Engineering, Biomedical, 11/69)
  16. Yu-Jen Lu, Hung-Wei Yang, Sheng-Che Hung, Chiung-Yin Huang, Shin-Ming Li, Chen-Chi M. Ma, Pin-Yuan Chen, Hong-Chieh Tsai, Kuo-Chen Wei, Jyh-Ping Chen, "Improving thermal stability and treatment efficacy of BCNU to glioma cells using PAA-functionalized graphene oxide", International Journal of Nanomedicine, 7, 1737-1747 (2012). (IF = 3.130, Filtered by Pharmacology & Pharmacy, 70/261) (1 Equal Contribution).
  17. Hung-Wei Yang, Mu-Yi Hua, Kun-Ju Lin, Shiaw-Pyng Wey, Rung-Ywan Tsai, Siao-Yun Wu, Yi-Ching Lu, Hao-Li Liu, Tony Wu, Yunn-Hwa Ma, "Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis", International Journal of Nanomedicine 7, 5159-5173 (2012). (IF = 3.130, Filtered by Pharmacology & Pharmacy, 70/261) (1 Equal Contribution).
  18. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu, Chiung-Yin Huang, Kuo-Chen Wei*, "Potential of magnetic nanoparticles for drug delivery ", Nanotechnology, Science and Applications 5, 73-86 (2012) (invited review).
  19. Liu, C. H., Huang H. Y., 2012, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin 60(9):1118-24
  20. Hung-Chi Jesse Chen, Lung-Kun Yeh, Yueh-Ju Tsai, Chyong-Huey Lai, Chi-Chun Chen, Jui-Yang Lai, Chi-Chin Sun, Grace Chang, Tsann-Long Hwang, Jan-Kan Chen,
    and David Hui-Kang Ma."Expression of Angiogenesis-Related Factors in Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation", IOVS, August 2012, Vol. 53, No. 9, 5615-5623
  21. Kang-Yun Lee, Shu-Chuan Ho, Yao-Fei Chan, Chun-Hua Wang, Chien-Da Huang, Wen-Te Liu, Shu-Min Lin, Yu-Lun Lo, Ya-Ling Chang, Lu-Wei Kuo and Han-Pin Kuo. Reduced nuclear factor-kB repressing factor: a link toward systemic inflammation in COPD, Eur Respir J 2012; 40: 863–873
  22. K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu, "Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine", American Journal of Neuroradiology, in press (2012). (IF=3.464, Filtered by Radiology, 20/111)
  23. Yang C, Chu Y, Wu YC, Hsieh MJ, Lu MS, Liu CY, Yuan HS, Liu YH, KO PJ, Liu HP. The lateral decubitus position improved transoral endoscopic access to the posterior aspects of the thorax. Surgical Endoscopy, 2012 Oct;26(10):2988-92. Epub 2012 May 2. IF=4.013
  • 2011
  1. Tran NT, Wang TH, Lin CY, Tsai YC, Lai CH, Tai Y, Yung BY., Direct Synthesis of Rev Peptide-Conjugated Gold Nanoparticles and Their Application in Cancer Therapeutics. Bioconjugate Chem June 7, 2011
  2. Han-Tsung Liao, Chien-Tzung Chen*, Jyh-Ping Chen*. Osteogenic Differentiation and Ectopic Bone Formation of Canine Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable Thermo-Responsive Polymer Hydrogel. Tissue Engineering, 2011, Nov;17(11):1139-49, (SCI, IF=4.636) (co-corresponding author)
  3. Wang CH, Hwang YS, Chiang PR, Shen CR, Hong, WH, Hsiue GH. Extended release of Bevacizumab by thermosensitive biodegradable and biocompatible hydrogel. Biomacromolecules 2012;13(1):40-8. Epub 2011 Dec 6. dx.doi.org/ 10.1021/ bm 2009558 | SCI=5.371 (POLYMER SCIENCE, 4.82%)
  4. Mu-Yi Hua, Hung-Wei Yang, Hao-Li Liu, Rung-Ywan Tsai, See-Tong Pang, Kun-Lung Chuang, Yu-Sun Chang, Tsong-Long Hwang, Ying-Hsu Chang, Heng-Chang Chuang, Cheng-Keng Chuang. Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy. Biomaterials. 2011 32, 8999-9010IF=7.404
  5. Liu, C.-H., Chang, F.-Y., Hung, D.-K. Terpene Microemulsions for Transdermal Curcumin Delivery: Effects of Terpenes and Cosurfactants. Colloids and Surfaces B: Biointerfaces, Volume 82, Issue 1, 1 January 2011, Pages 63-70. IF=3.456
  6. Yung-Hsin Yeh, Chi-Tai Kuo, Ting-Hsiang Chan, Gwo-Jyh Chang, Xiao-Yan Qi,
    FengChun Tsai, Stanley Nattel, and Wei-Jan Chen.Transforming growth factor-b and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovascular Research. 2011 91, 62–70. IF=6.064
  7. Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH. Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Oncogene. 2011 Jul 4. doi: 10.1038/onc.2011.269. IF=6.373
  8. Hsieh YS, Hsu CY., Honeybee trophocytes and fat cells as target cells for cellular senescence studies.; Exp Gerontol., 2011 Apr,46(4), P233-240. IF=3.741
  9. Hsu CY, Chan YP., Identification and localization of proteins associated with biomineralization in the iron deposition vesicles of honeybees (Apismellifera).; PLoS One.,2011 Apr, 6(4), P1-8. IF=4.092
  10. Chen WJ, Chen YH, Lin KH, Ting CH, Yeh YH. Cilostazol Promotes Vascular Smooth Muscles Cell Differentiation Through the cAMP Response Element-Binding Protein-Dependent Pathway. Arterioscler Thromb Vasc Biol. 2011 Jun 16 p2106-2113. IF=6.368
  11. Chen WJ, Yeh YH, Lin KH, Chang GJ, Kuo CT. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 2011 Mar;106(2):163-74. Epub 2011 Jan 14. IF=7.348
  12. Chi-Yu Hsu, Mei-Hui Lin, Chien-Cheng Chen, Shih-Chin Chien, Yi-Hsiang Cheng, I-Ning Su and Jwu-Ching Shu. Vancomycin promotes the bacterial autolysis, release of extracellular DNA, and biofilm formation in vancomycin-non-susceptible Staphylococcus aureus. (2011). FEMS Immunology & Medical Microbiology. DOI: 10.1111/j.1574- 695X.2011.00846.x. IF=2.441
  13. Liu, C. H., Chang, F.Y., 2011, Development and characterization of eucalyptol microemulsions for topic delivery of curcumin, Chem Pharm Bull., 59 (2):172-8. IF=1.592
  14. Liu YH, Chu Y, Wu YC, Yeh CJ, Liu CY, Chen TP, Yuan HC, Ko PJ. (2011) Single-dose antimicrobial prophylaxis in transoral surgical lung biopsy: a preliminary experience. Surgical Endoscopy. (SCI, 2011 Jul 27. Epub ahead of print). IF=4.013
  15. Ko PJ, Chu Y, Wu YC, Liu CY, Hsieh MJ, Chen TP, Chao YK, Wu CY, Yuan HC, Liu YH, Liu HP. (2011). Feasibility of endoscopic transoral thoracic surgical lung biopsy and pericardial window creation. J Surg Res. (SCI, 2011 Apr 7, Epub ahead of print). IF=2.247
  16. Liu YH, Chu Y, Liu CY, Liu HP, Wu, YC, Hsieh MJ, Liu HP. (2011) Feasibility of the transtracheal approach for the thoracic cavity in a large animal model. Surgical Endoscopy. 25(5): 1652-8. (SCI). IF=4.013
  17. Lin CL, Siu LK, Lin JC, Liu CY, Chian CF, Lee CN, Chang FY. (2011). Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in COPD patients. Chest 139(1):43-51. (SCI). IF=5.250
  18. Lee, W.R., Shen, S.C., Al-Suwayeh, S.A., Yang, H.H., Yuan, C.Y., Fang, J.
    Y. (2011) Laser-assisted topical drug delivery by using a low-fluence fractional laser: imiquimod and macromolecules. J. Control. Release, 153, 240-248. IF=5.732
  19. Mu-Yi Hua, Hao-Li Liu, Hung-Wei Yang, Pin-Yuan Chen, Rung-Ywan Tsai, Chiung-Yin Huang, I-Chou Tseng, Lee-Ang Lyu, Chih-Chun Ma, Hsiang-Jun Tang , Tzu-Chen Yen, Kuo-Chen Wei, "The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas", Biomaterials, 32, 516-527 (2011). (IF = 7.882, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  20. Hung-Wei Yang, Mu-Yi Hua, Hao-Li Liu, Chiung-Yin Huang, Rung-Ywan Tsai, Yu-Jen Lu, Ju-Yu Chen, Hsiang-Jun Tang, Jia-Shin Wu, Han-Yi Hsien, Yu-Sun Chang, Tzu-Chen Yen, Pin-Yuan Chen, Kuo-Chen Wei, "Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas", Biomaterials, 32, 6523-6532 (2011). (IF = 7.882, Filtered by Materials Science, Biomaterials, 2/25) (1 Equal Contribution)
  21. Fang-Hsin Chen, Chi-Shiun Chiang, Chun-Chieh Wang, Sheng-Yung Fu, Chien-Sheng Tsai,Shih-Ming Jung, Chih-Jen Wen, Chung-Chi Lee, and Ji-Hong Hong, Vasculatures in Tumors Growing From Preirradiated Tissues: Formed by Vasculogenesis and Resistant to Radiation and Antiangiogenic Therapy. Int. J. Radiation Oncology Biol. Phys., Vol. 80, No. 5, pp. 1512–1521, 2011. IF=4.105
  22. Hsiao, C.Y., Sindy, Hu., Ko, YS, Sung, H.C., & Huang, S.Y. (2011). Skin pretreatment with lasers promotes the transdermal delivery of vitamin C derivatives. Lasers Med Sci 26, 369-376. IF=2.004
  23. Ma DHK, Lai JY, Yu ST, Liu JY, Yang U, Chen HCJ, Yeh LK, Ho YJ, Grace Chang G, Wang SF, Chen JK, Lin KK. Up-regulation of Heat Shock Protein 70-1 (Hsp70-1) in Human Limbo-corneal Epithelial Cells Cultivated on Amniotic Membrane: A Proteomic Study. Journal of Cellular Physiology, 2011, 226: online publication on 7/12. IF=3.874
  24. Chen WJ, Yeh YH, Lin KH, Chang GJ, Kuo CT. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 2011 Mar;106(2):163-74. Epub 2011 Jan 14.
  25. Tong-Hong Wang, Junn-Liang Chang, Jar-Yi Ho, Hsiao-Chun Wu and Tse-Ching Chen. EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability. FEBS Journal 279 (2012) 251–263
  • 2010
  1. Jeng-Fong Chiou, Yu-Huei Wang, Mei-Jie Jou, Tsan-Zon Liu and Chia-Yang Shiau. (2010)Verteporfin-photoinduced apoptosis in HepG2 cells is mediated by reactive oxygen species intermediate. Free Rad Res. 44(2): 155–170. IF=2.878
  2. Mei-Jie Jou, Tsung-I Peng, Lee-Fen Hsu, Shuo-Bin Jou, Russel J. Reiter, Chuen-Mao Yang, Chuan-Chin Chiao, Yi-Fan Lin and Chun-Chia Chen. (2010)Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes RBA-1. J. Pineal Res. 48:20–38. IF=5.794
  3. Mu-Yi Hua, Hung-Wei Yang, Cheng-Keng Chuang, Rung-Ywan Tsai, Wen-Jauh Chen, Kun-Lung Chuang, Ying-Hsu Chang, Heng-Chang Chuang, See-Tong Pang.(2010) Magnetic-nanoparticle-modified paclitaxel for targeted therapy for prostate cancer. Biomaterials 31(28): 7355-7363. IF=7.404
  4. Hao-Li Liu, Mu-Yi Hua, Hung-Wei Yang, Chiung-Yin Huang, Po-Chun Chu, Jia-Shin Wu, I-Chou Tseng, Jiun-Jie Wang, Tzu-Chen Yen, Pin-Yuan Chen, and Kuo-Chen Wei.(2010) Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain. PNAS 107(34): 15205-15210. IF=9.681
  5. Lai, J.-Y., Ma, D.H.-K., Cheng, H.-Y., Sun, C.-C., Huang, S.-J., Li, Y.-T., Hsiue, G.-H. (2010) “Ocular biocompatibility of carbodiimide cross-linked hyaluronic acid hydrogels for cell sheet delivery carriers”, J. Biomater. Sci.-Polym. Ed., 21(3), 359-376. IF=1.691
  6. Ma, D.H.-K., Lai, J.-Y., Cheng, H.-Y., Tsai, C.-C., Yeh, L.-K. (2010) “Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells”, Biomaterials, 31(25), 6647-6658. IF=7.404
  7. Ming-Hui Sun, Jong-Hwei Su Pang, Show-Li Chen, Wen-Hua Han, Tsung-Chuan Ho, Kuan-Jen Chen, Ling-Yuh Kao, Ken-Kuo Lin, and Yeou-Ping Tsao. (2010) Retinal Protection from Acute Glaucoma-Induced Ischemia-Reperfusion Injury through Pharmacologic Induction of Heme Oxygenase-1. IOVS, September 2010, Vol. 51, No. 9: 4798–4808. IF=3.597
  8. Rae-Mann Hsu, Ming-Hung Tsai, Ya-Ju Hsieh, Ping-Chiang Lyu, and Jau-Song Yu.(2010) Identification of MYO18A as a Novel Interacting Partner of the PAK2/ PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration. Molecular Biology of the Cell, Vol. 21, 287–301, January 15. IF=4.942
  9. Wei-Jan Chen, Jong-Hwei S. Pang, Kwang-Huei Lin, Dany-Young Lee, Lung-An Hsu, Chi-Tai Kuo(2010) Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction. Basic Res Cardiol 105:19–28. IF=7.348
  10. Hung TH, Chen SF, Li MJ, Yeh YL, Hsieh TT. Differential Effects of Concomitant Use of Vitamins C and E on Trophoblast Apoptosis and Autophagy between Normoxia and Hypoxia-Reoxygenation. PLoS One. 2010; 5(8): e12202. IF=4.092
  11. Hsu L-F, Peng T-I, Jou S-B, Reiter RJ., Yang C-M, Chiao C-C and Jou M-J. (2010) Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes RBA-1. J. Pineal Res. 48:20–38. IF=5.794
  12. Ing-Tsung Hsiao, Kun-Ju Lin,, Shi-Ing Chang, Tzu-Chen Yen, Tse-Ching Chen, Ta-Sen Yeh. (2010) Impaired liver regeneration of steatotic rats after portal vein ligation: A particular emphasis on 99mTc-DISIDA scintigraphy and adiponectin signaling. Journal of Hepatology, vol. 52 540–549. IF=9.264
  13. Lin, Y.K., Huang, Z.R., Zhuo, R.Z., Fang, J.Y.* (2010) Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery. Int. J. Nanomed., 5, 117-128. IF=3.13
  14. Fang, J.Y.*, Wu, P.C., Fang, C.L., Chen, C.H. (2010) Intravesical delivery of 5-aminolevulinic acid from water-in-oil nano/submicron-emulsion systems. J. Pharm. Sci., 99, 2375-2385. IF=3.055
  15. Lee, W.R., Shen, S.C., Pai, M.H., Yang, H.H., Yuan, C.Y., Fang, J.Y.
    (2010) Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption: a comparison with conventional erbium:YAG laser. J. Control. Release, 145, 124-133. IF=5.732
  16. Jiunn-Woei Liaw, Shiao-Wen Tsai, Kuan-Lin Chen, and Fu-Yin Hsu (2010) Single-Photon and Two-Photon Cellular Imagings of Gold Nanorods and Dyes. Journal of Nanoscience and Nanotechnology Vol. 10, 467–473. IF=1.563
  • 2009
  1. Fang-Hsin Chen, Chi-Shiun Chiang, Chun-Chieh Wang,Chien-Sheng Tsai, Shih-MingJung, Chung-Chi Lee, William H.McBride, and Ji-Hong Hong. (2009) Radiotherapy Decreases Vascular Density and Causes Hypoxia with MacrophageAggregation in TRAMP-C1Prostate Tumors.Clinical Cancer Research 15(5): 1721-1729. IF=7.742
  2. Chen HCJ , Chen HL ,Lai JY, Chen CC , Tsai YJ, Kuo MT , Chu PH ,Sun CC, Chen JK , Ma DHK Persistence of Transplanted Oral Mucosal Epithelial Cells in Human Cornea. IOVS Volume: 50 Issue:10 Pages: 4660-4668 Published: OCT 2009. IF=3.597
  3. Ching-Yi Cheng,Chi-Chin Sun,Wei-Hsuan Yu,Hsi-Lung Hsieh, David Hui-Kang Ma, Jong-Hwei Su Pang, and Chuen-Mao Yang. Novel Laminin 5 2-chain Fragments Potentiating the Limbal Epithelial Cell Outgrowth on Amniotic Membrane. IOVIS Volume: 50 Issue: 10 Pages: 4631-4639 Published: OCT 2009. IF=3.597
  4. Chang CJ, Chen CC ,Hsu LA, Chang GJ, Ko YH, Chen CF, Chen MY, Yang SH, Pang JHS. Degradation of the Internal ElasticLaminae in Vein Grafts of Ratswith Aortocaval Fistulae PotentialImpact on Graft Vasculopathy. American Journal of Pathology Volume: 174 Issue: 5 Pages: 1837-1846 Published: MAY 2009. IF=4.890
  5. Chen WJ , Pang JHS, Lin KH , Yang SH. Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression. Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression. Basic Research in Cardiology Volume: 104 Issue: 1 Pages: 60-68 Published: JAN 2009. IF=7.348
  6. Jeng-Fong Chiou, Cheng-Jeng Tai, Yu-Huei Wang, Tsan-Zon Liu, Yee-Min Jen and Chia-Yang Shiau. Sorafenib Induces Preferential Apoptotic Killing of Hep G2 Cells Through a Mitochondria-Dependent Oxidative Stress Mechanism. Cancer Biology & Therapy 8:20, 1904-1913; October 15, 2009. IF=2.636
  7. Jeng-Fong Chiou, Cheng-Jia Cheng, Yu-Huei Wang, Tsan-Zon Liu and Yu-Jia Chang. Glucose-regulated Chaperon Protein-78 is a novel contributor to the occurrence of resistance acquisition of sorafenib, a multi-kinase inhibitor, in hepatoma cells. Annual Surg Oncology. October 15, 2009. IF=4.166
  8. Lee, W.R., Shen, S.C., Zhuo, R.Z., Wang, K.C., Fang, J.Y. (2009) Enhancement of topical small interfering RNA delivery and expression by low-fluence erbium:YAG laser pretreatment of skin. Hum. Gene Ther., 20, 580-588. IF=4.218
  9. Wang, J.J., Liu, K.S., Sung, K.C., Tsai, C.Y., Fang, J.Y. (2009) Skin permeation of buprenorphine and its ester prodrugs from lipid nanoparticles: lipid emulsion, nanostructured lipid carriers, and solid lipid nanoparticles. J. Microencapsul. December 2009, Vol. 26, No. 8 , Pages 734-747 (doi:10.3109/02652040902746679). IF=1.553
  10. Hwang, T.L., Fang, C.L., Chen, C.H., Fang, J.Y. (2009) Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm. Res., Vol. 26, No.10, October 2009. IF=4.093
  11. Fang, J.Y., Hung, C.F., Hua , S.C. , Hwang, T.L. (2009) Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells. Ultrasonics 49, 39–46. IF=1.838
  12. Ho SC, Lee KY, Chan YF, Kuo LW, Ito K, Adcock IM, Chen BC, Sheu JR, Lin CH, Kuo HP. (2009) Neutrophil Elastase Represses IL-8/CXCL8 Synthesis in Human Airway Smooth Muscle Cells through Induction of NF-kappa B Repressing Factor. J Immunol. 2009 Jul 1;183(1):411-20. IF=5.788
  13. Ma DHK, Kuo MT, Tsai YJ, Chen HCJ, Hsiao CH, Wang SF, Li L, Lin KK. (2009) Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Eye 23:1442-1450. IF=1.851
  14. Chin-Yuan Hsu and Ya-Chi Chiu. (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii), Aging Cell, Volume 8, Issue 6, pages 726–737, December 2009. IF=6.265
  15. DHK Ma, HCJ Chen, JY Lai, CC Sun, SF Wang, KK Lin, JK Chen. Matrix Revolution: Molecular Mechanism for Inflammatory Corneal Neovascularization and
    Restoration of Corneal Avascularity by Epithelial Stem Cell Transplantation. Ocular Surface 2009, 7(3): 128-144. IF=3.931
  • 2008
  1. Fang, J.Y., Fang, C.L., Liu, C.H., Su, Y.H. (2008) Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur. J. Pharm. Biopharm., 70, 633-640.
  2. Lee, W.R., Shen, S.C., Fang, C.L., Zhuo, R.Z., Fang, J.Y. (2008) Topical delivery of methotrexate via skin pretreated with physical enhancement techniques: low-fluence erbium:YAG laser and electroporation. Lasers Surg. Med., 40, 468-476.
  3. Hung TH, Chen SF, Hsieh CC, Hsu JJ, Li MJ, Yeh YL, Hsieh TT*; Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation- induced apoptosis in human placenta, Placenta 2008;29:565-583.
  4. Wen-Chung Tsai, Chih-Chin Hsu, Fuk-Tan Tang, Alice M. K. Wong, Yen-Ching Chen, and Jong-Hwei S. Pang; Ciprofloxacin-Mediated Cell Proliferation Inhibition and G2/M Cell Cycle Arrest in Rat Tendon Cells,Arthritis & Rheumatism Vol. 58, No. 6, June 2008, pp 1657–1663.
  5. Jou M-J (2008) Pathophysiological and Pharmacological Implications of Mitochondria-Targeted Reactive Oxygen Species Generation in Astrocytes. Advanced Drug Delivery Reviews 60:1512-1526.
  6. Lee, W.R., Pan, T.L., Wang, P.W., Zhuo, R.Z., Huang, C.M., Fang, J.Y. (2008) Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control. Release, 128, 200-208.
  7. Chiu CC, Lin CY, Lee LY, Chen YJ, Kuo TF, Chang JT, Liao CT, Wang HM, Yen TC, Shen CR, Liao SK, Cheng AJ.Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. Mol Cancer Ther. 2008 Sep;7(9):2788-97.
  8. Jyh-Ping Chen, Tze-Feng Yang. Applications of chitosan-based thermo-sensitive copolymers for harvesting living cell sheet. Applied Surface Science 255 (2008) 297–300.
  9. Jyh-Ping Chen, Tai-Hong Cheng. Functionalized temperature-sensitive copolymer for tissue engineering of articular cartilage and meniscus. Colloids and Surfaces A: Physicochem. Eng. Aspects 313–314 (2008) 254–259.
  10. Jyh-Ping Chen, Gwo-Yun Chang, Jan-Kan Chen. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces A: Physicochem. Eng. Aspects 313–314 (2008) 183–188.
  11. Lee, W.R., Pan, T.L., Wang, P.W., Zhuo, R.Z., Huang, C.M., Fang, J.Y. (2008) Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination. J. Control. Release, 128, 200-208.
  12. Chun-Hua Wang, Chien-Da Huang, Horng-Chyuan Lin, Kang-Yun Lee, Shu-Min Lin, Chien-Ying Liu, Kuo-Hsiung Huang, Yu-Shien Ko, Kian Fan Chung and Han-Pin Kuo. (2008) Increased Circulating Fibrocytes in Asthma with Chronic Airflow Obstruction. Am J Respir Crit Care Med Vol 178. pp 583–591.
  13. Ming-Hui Sun, Jong-Hwei Su Pang, Show-Li Chen, Ping-Chang Kuo, Kuan-Jen Chen, Ling-Yuh Kao, Ju-Yun Wu, Ken-Kuo Lin, Yeou-Ping Tsao. Photoreceptor Protection against Light Damage by AAV-mediated Overexpression of Heme Oxygenase-1. IOVS, 2008, 48(12)5699-5707.
  14. Mei-Hui Lin and Shih-Tung Liu (2008) Stabilization of pSW100 from Pantoea stewartii by the F Conjugation System. Journal of Bacteriology, Vol. 190, No. 10,May 2008, p. 3681–3689
  15. C.Y. Hsu (correspondence), Chiu Y.C., Hsu W.L., Chan Y.P. (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 63A:1267-1276.
  • 2007
  1. Liu CY, Lin HC, Yu CT, Lin SM, Lee KY, Chen HC, Chou CL, Huang CD, Chou PC, Liu WT, Wang CH, Kuo HP. The concentration-dependent chemokine release and pro-apoptotic effects of neutrophil-derived a-defensin-1 on human bronchial and alveolar epithelial cells. Life Sci.2007. 80:749-758. (SCI)
  2. Chou CL, Chiang LL, Yu CT, Chen HC, Lin SM, Huang CD, Liu WT, Chou PC, Wang CH, Lin HC, Kuo HP, Liu CY. Apoptosis-dependent and -independent mechanisms mediate the phagocytic recognition/clearance of the HL60-A1 transfectants of prolonged survival. Inflamm Res. 2007. 56:195-203. (SCI)
  3. Jou M-J, Peng T-I, Yu P-Z, Jou S-B, Wu H-Y, and Hsu L-F. Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis. J. Pineal Res. 2007. Nov;43(4):389-403.
  4. Wu T, Hua M-Y, Chen J-P, Wei K-C, Jung S-M, Chang Y-J, Jou M-J, and Ma Y-H. Effects of external magnetic field on biodistribution of nanoparticles: A histological study. J. Magn. Magn. Mater., 2007. 311: 372-375.
  5. Hsieh H-L, Wang H-H, Wu C-Y, Jou M-J, Yen M-H, Parker P, and Yang C-M.BK-induced COX-2 expression via PKC-δ-dependent activation of p42/p44 MAPK and NF-κB in astrocytes. Cell. Signal. 2007. 19(2):330-340.
  6. Ming-Dar Woon, Yu-Huei Wang, Hoi-Wan Lo, David Chung, Tsan-Zon Liu, Jeng-Fong Chiou The effect of hepatoma-derived growth factor, bcl-2, and glutathione on radiation-induced apoptosis in hepatocellular carcinoma cell lines. Therapeut Radiol Oncol. 2007. 4(3)
  7. Chiz-Tzung Chang, Cheng-Chieh Hung, Ya-Chung Tian, Chih-Wei Yang and Mai-Szu Wu. Ciclosporin reduces paracellin-1 expression transport in thick ascending limb cells. Nephrol Dial Transplant. 2007. 22: 1033-1040.
  8. Chin-Yuan Hsu, Fu-Yao Ko, Chia-Wei Li, Kuni Fann, Juh-Tzeng Lue Magnetoreception system in honeybees (Apis mellifera) PLoS ONE. 2007 April. 2(4): e395
  9. J.-W. Liaw, “The quantum yield of a metallic nanoantenna”, Appl. Phys. 2007. A 89, 357- 362 (NSC95-2221-E-182-002)
  10. J.-W. Liaw, “Local field enhancement and quantum yield of metallic dimer”, Jpn J. Appl. Phys. 2007. 46(8A), 5373-5378.. (NSC95-2221-E-182-002)
  11. J.-W. Liaw, “New surface integral equations for the light scattering of multi-metallic nanoscatterers”, Eng. Anal. with Boundary Elements 2007. 31(4), 299-310.
    (NSC95-2221-E-182-002)
  12. Liu HW, Chen CH, Tsai CL, Lin IH, Hsiue GH. Heterobifunctional poly (ethylene glycol)-tethered bone morphogenetic protein-2-stimulated bone marrow mesenchymal stromal cells differentiation and osteogenesis. Tissue Engineering 2007; 13:11131124. (SCI, 2006 IF: 3.725) (selected as cover art)
  13. Y-J Chen, JT Chang, L Lee, H-M Wang, C-T Liao, C-C Chiu, P-J Chen and A-J Cheng; DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis; Oncogene (2007), 26:467-476.
  • 2006
  1. Liu HW, Chen CH, Tsai CL, Hsiue GH. Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2–mediated carrier-protein conjugation. Bone 2006; 39:825-836. (SCI, 2005 IF: 3.939)
  2. Hao-Ping Liu, Chih-Ching Wu and Yu-Sun Chang. PRA1 promotes the intracellular traficking and NF-kB signaling of EBV latent membrane protein 1. EMBO J. 2006. August 17 on line) 25 (17): 4120-4130.
  3. Hsieh SY, Shih TC, Yeh CY, Lin CJ, Chou YY, Lee YS.Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics. 2006. Aug 31;6(19):5322-5331.
  4. Chen HC, Wang CJ, Chou CL, Lin SM, Huang CD, Lin TY, Wang CH, Lin HC, Yu CT, Kuo HP, Liu CY. Tumor necrosis factor-a induces caspase-independent cell death in human neutrophil via reactive oxidants and associated with calpain activity. J Biomed Sci. 2006. 13:261-273. (SCI)
  5. Peng TI, Yu PR, Chen JY, Wang HL Wu HY, Wei YH, and Jou MJ*. Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress. Biochimica et Biophysica Ecta. 1762 (2): 241-255, 2006. Feb.
  6. Tsao ML, Chao CH, Yeh CT. Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization. Biochem Biophys Res Commun. 2006 Sep 15;348(1):271-7. Epub 2006. Jul 24.
  7. Wang TH, Chan YH, Chen CW, Kung WH, Lee YS, Wang ST, Chang TC, Wang HS. Paclitaxel (Taxol) upregulates expression of functional IL-6 in human ovarian cancer cells through multiple signaling pathways Oncogene 2006. 25: 4857-4866.
  8. Yoon Y-S, Yoon D-S, Lim I-K, Yoon S-H, Chung H-Y, Rojo M, Malka F, Jou M-J, Martinou J-C, and Yoon G. Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 2006. 209: 468-480.
  9. Chou A-H, Yeh T-H, Kuo Y-L, Kao Y-C, Jou M-J, Hsu C-Y, Tsai S-R, Kakizuka A, and Wang H-L. Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL. Neurobiol Dis 2006. 21:333-345.
  10. Li-Mei Pai, Pei-Yu Wang, Shu-Ru Chen, Gail Barcelo, Wei-Ling Chang, Laura Nilson, Trudi Schupbach; Differential effects of Cbl isoforms on Egfr signaling in Drosophila; Mechanisms of Development 2006. Jun, 123: 450–462.
  11. Ma DHK, Chen JK, Zhang F, Lin KY, Yao JY, Yu JS. Regulation of corneal angiogenesis in limbal stem cell deficiency. Progress in Retinal and Eye Research 2006, 25(6): 563–590.
  12. Lee KY, Ho SC, Lin HC, Lin SM, Liu CY, Huang CD, Wang CH, Chung KF, Kuo HP. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol. 2006 Oct;35(4):407-14. Epub 2006 May 11.
  • 2005
  1. Peng TI, Chang CJ, Guo MJ, Wang YH, Yu JS, Wu HY, and Jou MJ. Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis. Annals New York Academy of Sciences.1042: 419-428, 2005 June.
  2. Jou MJ, Peng TI, Wu HY and Wei YH. Enhanced generation of mitochondrial reactive oxygen species in cybrids containing 4977-bp mitochondrial DNA deletion. Annals New York Academy of Sciences.1042: 221-228, 2005 June.
  3. Peng TI, Chang CJ, Jou SB, Young CM, and Jou MJ.Photosensitizer Targeting: mitochondrion-targeted photosensitizer enhances mitochondrial reactive oxygen species and mitochondrial calcium-mediated apoptosis. Optical and Quantum Electronics.37 (13-15): 1377 – 1384, 2005 December.
  4. Liu CY, Wang CH, Wan YL, Chou CL, Huang KH, Lin HC, Lin SM, Lin TY, Chung KF, Kuo HP. (2005) Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respiratory Research 2005, 6:42. (SCI)
  5. Chang CJ, Ko YS, Ko PJ, Hsu LA, Chen CF, Yang CW, Hsu TS, Pang JH. Thrombosed arteriovenous fistula for hemodialysis access is characterized by a marked inflammatory activity. Kidney Int 2005 Sep; 68(3):1312-9.
  6. Wei-Chi Wu, Chi-Chun Lai, Show-Li Chen, Ming-Hui Sun, Xiao Xiao, Tun-Lu Chen and Ken-Kuo Lin, Shu-Wen Kuo, Yeou-Ping Tsao; Long-Term Safety of GDNF Gene Delivery in the Retina. Current Eye Research, 30:715–722, 2005.
  • 2004
  1. Hsieh H-L, Yen M-H, Jou M-J and Yang C-M. Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.Cellular Signallings 2004, 16(10): 1163-1176.
  2. Wu C-Y, Hsieh H-L, Jou M-J and Yang C-M. Involvement of p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1β-induced matrix metalloproteinase-9 expression in rat brain astrocytes. J of Neurochemistry 2004, 90(6):1477-1488.
  3. Cheng C-Y, Huang SCM, Hsiao L-D, Sun C-C, Jou M-J, Yang C-M. Bradykinin-stimulated p42/p44 MAPK activation associated with cell proliferation in corneal keratocytes. Cellular Signallings 2004, 16(5):535-549.
  4. Ma DHK, Yao JY, Yeh LK, Liang ST, See LC, Chen HT, Lin KY, Liang CC, Lin KK, Chen JK. In Vitro Anti-angiogenic Activities of Ex Vivo Expanded Human Limbal Epithelial Cells Cultivated on Human Amniotic Membrane. Investigative Ophthalmology & Visual Science 2004; 45: 2586–2595.
  5. Jou MJ, Jou SB, Wu HY, Kuo MJ and Peng TI. Mitochondrial reactive oxygen species generation and mitochondrial calcium increase induced by visible light in astrocytes. Annals of the New York Academy of Sciences.1011:45-56, 2004 Apr.
  6. Peng TI and Jou MJ. Mitochondrial swelling and generation of reactive oxygen species induced by photo-irradiation are heterogeneously distributed. Annals of the New York Academy of Sciences.1011:112-122, 2004 Apr.
  7. Jou MJ, Peng TI, Reiter RJ, Jou SB, Wu HY and Wen ST. Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. Journal of Pineal Research. 37: 55-70, 2004 Aug.
  8. Ko YS, Yeh HI, Ko YL, Hsu YC, Chen CF, Wu S, Lee YS, Severs NJ. (2004 Mar). Three-dimensional reconstruction of the rabbit atrioventricular conduction axis by combining histological, desmin, and connexin mapping data. Circulation;109:1172-9.
  9. Wei-Chi Wu, Chi-Chun Lai, Show-Li Chen, Ming-Hui Sun, Xiao Xiao, Tun-Lu Chen, Ray Jui-Fang Tsai, Shu-Wen Kuo, Yeou-Ping Tsao; GDNF gene therapy attenuates retinal ischemic injuries in rats. Molecular Vision 2004; 10:93-102.

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