PROFESSIONAL POST

Postdoctoral research fellow

Education

B.Sc. in Department of Chemistry, National Chung Cheng University, Taiwan

M.Sc. in Department of Life Science, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Taiwan.

Ph.D. in Department of Life Science, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Taiwan.

RESEARCH INTEREST

My research interest is focus on the structural and functional Leptospiral outer membrane proteins. The outer membrane is the first line to interact with host and induces the inflammatory responses through host cell membrane receptors. The interaction between ligand and receptor provides direct evidence to explain the molecular mechanism of the pathogen and host interaction.

MAJOR BIBLIOGRAPHY

1.       Lo, Y. Y.*, Hsu, S. H.*, Ko, Y. C., Hung, C. C., Chang, M. Y., Hsu, H. H., Pan, M. J., Chen, Y. W., Lee, C. H., Tseng, F. G., Sun, Y. J., Yang, C. W., Pan, R. L. (2013) Essential calcium binding cluster of Leptospira LipL32 for inflammatory responses through the Toll-like receptor 2 pathway, J. Biol. Chem. (Accept; *equal contribution)

2.       Pan, Y. J., Lee, C. H., Hsu, S. H., Huang, Y. T., Liu, T. H., Chen, Y. W., Lin, S. M., and Pan, R. L. (2011) The transmembrane domain 6 of vacuolar H⁺-pyrophosphatase mediates protein targeting and proton transport, Biochim. Biophys. Acta. 1807, 59-67. (SCI IF = 3.688)

3.       Lee, C. H., Pan, Y. J., Huang, Y. T., Liu, T. H., Hsu, S. H., Chen, Y. W., Lin, S. M., Huang, L. K., and Pan, R. L. (2011) Identification of essential lysines involved in substrate binding of vacuolar H⁺-pyrophosphatase, J. Biol. Chem. 286, 11970-11976. (SCI IF =5.328)

4.       Huang, Y. T., Liu, T. H., Chen, Y. W., Lee, C. H., Chen, H. H., Huang, T. W., Hsu, S. H., Lin, S. M., Pan, Y. J., Hsu, I. C., Tseng, F. G., Fu, C. C., and Pan, R. L. (2010) Distance variations between active sites of H⁺-pyrophosphatase determined by fluorescence resonance energy transfer, J. Biol. Chem. 285, 23655-23664.(SCI IF =5.328)

5.        Hsu, S. H., Lo, Y. Y., Tung, J. Y., Ko, Y. C., Sun, Y. J., Hung, C. C., Yang, C. W., Tseng, F. G., Fu, C. C., and Pan, R. L. (2010) Leptospiral outer membrane lipoprotein LipL32 binding on toll-like receptor 2 of renal cells as determined with an atomic force microscope, Biochemistry 49, 5408-5417. (SCI IF = 3.226)

6.        Liu, T. H., Hsu, S. H., Huang, Y. T., Lin, S. M., Huang, T. W., Chuang, T. H., Fan, S. K., Fu, C. C., Tseng, F. G., and Pan, R. L. (2009) The proximity between C-termini of dimeric vacuolar H⁺-pyrophosphatase determined using atomic force microscopy and a gold nanoparticle technique, FEBS J. 276, 4381-4394. (SCI IF = 3.042)

7.        Hsu, S. H., Hsiao, Y. Y., Liu, P. F., Lin, S. M., Luo, Y. Y., and Pan, R. L. (2009) Purification, characterization, and spectral analyses of histidine-tagged vacuolar H⁺-pyrophosphatase expressed in yeast, Bot. Stud. 50, 291-301. (SCI IF = 0.781)

8.        Liu, P. F., Chang, W. C., Wang, Y. K., Munisamy, S. B., Hsu, S. H., Chang, H. Y., Wu, S. H., and Pan, R. L. (2007) Differential regulation of Ku gene expression in etiolated mung bean hypocotyls by auxins, Biochim. Biophys. Acta. 1769, 443-454. (SCI IF = 3.475)

9.        Hsiao, Y. Y., Pan, Y. J., Hsu, S. H., Huang, Y. T., Liu, T. H., Lee, C. H., Liu, P. F., Chang, W. C., Wang, Y. K., Chien, L. F., and Pan, R. L. (2007) Functional roles of arginine residues in mung bean vacuolar H⁺-pyrophosphatase, Biochim. Biophys. Acta. 1767, 965-973. (SCI IF = 3.688)