Feng-Sheng Wang (王 逢 興)

Department of Medical Research
Kaohsiung Chang Gung Memorial Hospital (KCGMH)
Kaohsiung 83301, Taiwan
Tel: 886-7-7317123, ext. 6406
E-mail: wangfs@ms33.hinet.net

Education and Training
1992-1995       Ph.D. in Animal Science, National Taiwan University, Taipei
1999-01   Postdoctoral Fellow in Stem Cell Biology, KCGMH

Current position and relevant experience
2017-   Deputy Director, Department of Medical Research, KCGMH
2015-   Director, Core Laboratory for Phenomics & Diagnostics, KCGMH
2011-       Full Investigator, Department of Medical Research, KCGMH
2010-       Director, Center for Laboratory Animals, KCGMH
2010-       Professor, Graduate Institute of Clinical Medical Sciences, School of Medicine    Chang Gung University

Professional Activities
2019       Scientific Committee Member, European Orthopaedic Research Society
2017-2018  Deputy Chairman, Committee of Research Review, KCGMH
2016-      Associate Editor, Clinical Orthopaedic Related Research
2014-      Ad hoc specialist, AAALAC International, USA
2010-2016  Council Member, Taiwan Orthopedic Research Society, Taiwan
2008-          Editorial Board Member, Acta Pharmacologicia Sinica (Nature Publishing Group)
2002           Advisor for Juvenile Scientist Education Program, National Science Education Center

 

Honors and Awards
2019    Top Award, 2020 Osteoarthritis Research Society International (OARSI)
2018    Outstanding Reviewer Award, Acta Pharmacologicia Sinica (Nature Publishing Group)

  1. Outstanding Reviewer Award, Acta Pharmacologicia Sinica (Nature Publishing Group)
  2. Outstanding Contribution in Reviewing Award 2017, Bone

2017    Outstanding Contribution in Reviewing Award 2017, Clinical Chemica Acta
2016    Top Reviewer Award of Clinical Orthopedic Related Research
2015    Outstanding Contribution in Reviewing for Bone
2013    Award for Article Competition, Taiwan Orthopedic Research Society, Taiwan
2011       Award for Innovative Research Programs, National Health Research Institutes, Taiwan
2009        Excellent Paper Award for Laser Medicine, Laser Medicine Foundation, R. O. C.
2007        Gold Award of Poster Competition of Taiwan Proteomics Society International Congress
 

Editorial highlight
2016    Editorial highlight by Journal of Molecule Medicine
2016    Selected paper by Annual Meeting of American College of Rheumatology
2015    Selected Paper by Annual Meeting of International Bone and Mineral Research Society
2014    Cover page picked by Journal of the American Society of Nephrology
2012    Editorial highlight by Nature Review Rheumatology
2012    Editorial highlight by Arthritis and Rheumatism

Ad hoc Reviewer for Extramural Institutions
Ministry of Science & Technology; National Taiwan University; National Cheng Kong University; National Defense School of Medicine; Tzu-Chi University; Shown Chwan Memorial Hospital, etc.

Ad hoc Reviewer for SCI Journals
Nat Med; Cell Rep; Stem Cells; Diabetes; Arthritis Rheumatol; Arthritis Res Ther; Osteoarthritis Cartilage; Clin Orthop Relate Res; J Cell Mol Med; Bone; FEBS Letter; Apoptosis; J Biomed Sci; Clin Chim Acta; Acta Pharmacologia Sinica; Int J Mole Med; Mol Med Rev; Neuropeptides; Exp Ther Med; Int J Mol Sci; Bioeletromagnetics; Nutrients; Eviron Toxic Pharma; J Respir Med Lung Dis; Mol Med Report; Diabetes Res Clin Pract, etc.

Bibliography (2015-)
* 98 peer-reviewed articles before 2015

  1. Lian WS, Lo JY, Kuo CW, Chen YS, Hsieh CK, Wu SL, Ke HJ, Wang SY, Yu CP, Jahr Holger, Wang FS*. UTX compromises articular chondrocyte anabolism and aggravates osteoarthritis. (Manuscript in preparation).
  2. Kuo CW, Lian WS, Ko JY, Chen YS, Ke HJ, Hsieh CK, Wang SY, JY Ko, Wang FS*. Bromodomain Protein BRD4 accelerates glucocorticoid excess dysregulation of osteogenesis and adipogenesis by regulating H3K9 and Foxp1. Cells (In submission)
  1. Lian WS, Ko JY, Chen YS, Ke HJ, Hiseh CK, Kuo CW, Wang SY, Huang BW, Tseng JG, Wang FS*. MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12. Cell Death & Disease 2019;10:705
  2. Wu RW, Lian WSm Chen YS, Kuo CW, Ke HC, Hsieh CK, Wang SY, Ko JY, Wang FS*. MicroRNA-29a counteracts glucocorticoid induction of bone loss through repressing TNFSF13b modulation of osteoclastogenesis. International Journal of Molecular Sciences 2019;20:5141.
  3. Lian WS, Ko JY, Wu RW, Sun YC, Chen YS, Wu SL, Weng LH, Jahr H, Wang FS*. MicroRNA-128 repressed chondrocyte autophagy exacerbates knee osteoarthritis by disrupting Atg12. Cell Death & Disease 2018;9:919
  4. Lian WS, Ko JY, Chen YS, Ke HJ, Wu SL, Kuo CW, Wang FS*. Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR. Cell Death & Disease 2018;9:938.
  5. Hung PL, Hsu MH, Yu HR, Wu KLH, Wang FS*. Thyroxin protects white mater from hypoxic-ischemic insult in the immature Sprague-Dwaley rat brain by regulating periventricular white matter and cortex BDNF and CREB pathways. International Journal of Molecular Sciences 2018;19:E2573
  6. Wang FS, Wu RW, Lain WS, Tsai TC, Chen YS, Sun YC, Ke HJ, Li JC, Hwang JL, Ko JY. Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration. Bone 2018;112:24-34.
  7. Lin YC, Wang FS, Yang YL, Chuang YT, Huang YH. MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. Biochemic Biophysic Research Communication 2018;496:880-886 (Equal first coauthor)
  8. Kuo SJ, Wang FS, Ko JY, Tang CH, Siu KK, Hsu YH, Tsai TC. Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness. Journal of Shoulder and Elbow Surgery 2018; 27:333-338.
  9. Huang YH, Yang YL, Huang FC, Tiao MM, Lin YC, Tsai MH, Wang FS*. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts bile duct ligation-induced fibrosis pathogenesis in mice. Experimental Biology and Medicine 2018; 243:13-21
  10. Lian WS, Wu RW, Lee MS, Chen YS, Sun YC, Wu SL, Ko JY, Wang FS*. Subchondral mesenchymal stem cells from osteoarthritic knees display high osteogenic differentiation capacity through microRNA-29a regulation of HDAC4. Journal of Molecular Medicine 2017;95:1327-1340.
  11. Ko JY, Lee MS, Lian WS, Wen WT, Sun YC, Chen YS, Li WC, Wang FS*. MicroRNA-29a counteracts synovitis in knee osteoarthritis pathogenesis by targeting VEGF. Scientific Reports 2017;7:3584.
  1. Yang YL, Wang FS, Li SC, Tiao MM, Huang YH. MicroRNA-29a alleviates bile duct ligation exacerbation of hepatic fibrosis in mice through epigenetic control of methyltransferase. International Journal of Molecular Sciences 2017;18:192 (Equal first author)
  2. Wang FS, Lian WS, Weng WT, Chen YS, Sun YC, Wu SL, Ko JY. Histone Demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and –independent pathways. Journal Molecule Medicine 2017;95:499-512
  3. Wang FS, Lian WS, Weng WT, Sun YC, Ke HJ, Chen YS, Ko JY. Neuropeptide Y mediates glucocorticoid-induced osteoporosis and marrow adiposity in mice. Osteoporosis International 2016;27:2777-2789.
  1. Ko JY, Sun YC, Li WC, Wang FS*. Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis. Journal of Molecular Medicine 2016;94:755-769.
  2. Li SC, Wang FS*, Yang YL, Tiao MM, Chuang JH, Huang YH. Microarray study of pathway analysis expression profile associated with microRNA-29a with regard to murine cholestatic liver injuries. International Journal of Molecular Science 2016;17:E324 (Equal first author).
  3. Ko JY, Chuang PC, Su WH, Ke HC, Chen YS, Sun YC, Wang FS*. MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation. Bone 2015;81:80-88
  4. Huang YH, Tiao MM, Chuang JH, Kuo KC, Yang YL, Huang LT, Wang FS*. Activation of miR-29a in activated hepatic stellate cells modulates its profibrogenic phenotype through inhibition of histone deacetylase 4. PLoS One 2015;10:e0136453

Symposium, Plenary, and Invited speeches

  1. Wang FS. MicroRNA regulation of articular homeostasis and osteoarthritis. Symposium of cartilage microenvironment and OA: impact on treatment options. 27th Annual Meeting European Orthopedic Research Society, 2-4 October, 2019, Masstricht, The Netherlands.
  2. Wang FS. MicroRNA control of chondrocyte fate and osteoarthritis development. ICORS Workshop-emerging molecular therapeutic potentials for treating osteoarthritis. The 2nd Triennial International Combined Orthopaedic Research Societies (ICORS) Meeting, 19-22 June, 2019, Montreal, Canada.
  3. Wang FS. MicroRNA-128 impairs cartilage integrity and deteriorates osteoarthritis pathogenesis through deregulating chondrocyte autophagy. 2018 Annual Meeting of American College of Rheumatology, 20-24 October 2018, Chicago, USA.
  4. Wang FS. MicroRNA and histone assembly regulation of osteoarthritis. The 26th Annual Meeting of European Orthopaedic Research Society, 25-28 September 2018, Galway, Ireland.
  5. Wang FS. Emerging therapeutic potential for osteogenesis imperfecta. Symposium of Cross Strait Pediatric Orthopedic Surgery. 16 June 2018, Xiamen, China
  6. Wang FS. Mitochondrial chaperonin regulation of bone and joint homeostasis. 2017 Annual Meeting of Taiwan Society for Mitochondrial Research and Medicine, 04 November 2017, Kaohsiung, Taiwan
  7. Wang FS. Animal use integrity implementation by Kaohsiung Chang Gung Memorial Hospital: deed not words. Annual Meeting of Chinese Taipei Laboratory Animal Society, 17 November 2017, Taipei, Taiwan.
  8. Wang FS, IACUC function and PAM for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 29 August 2017, Chaiyi, Taiwan.
  1. Wang FS, IACUC function and PAM for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 June 2017, New Taipei City, Taiwan.
  2. Wang FS, Site visit to animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 21 September 2016, New Taipei City, Taiwan.
  3. Wang FS, Layout design for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 August 2015, Tainan, Taiwan.
  4. Wang FS, Post approval monitoring for animal protocols. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 August 2015, Tainan, Taiwan.
  5. Wang FS, Layout design for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 01 October 2015, Taipei, Taiwan.
  6. Wang FS, Post approval monitoring for animal protocols. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 01 October 2015, Taipei, Taiwan.

Conference papers

  1. Wang FS. MicroRNA-29a reduction of marrow adiposity ameliorates aging-induced bone loss. The 25th Annual Meeting of Annual Meeting of European Orthopedic Research Society, 13-15 September 2017, Munich, Germany.
  2. Wang FS. MicroRNA-29a curtails synovitis in the development of knee osteoarthritis by disrupting VEGF. The 2016 Annual Meeting of American College of Rheumatology, 13-16 November 2016, Washington DC, USA.
  3. Wang FS.μCT and μMRI quantification of marrow adiposity within osteoporotic skeletons. The 24th Annual Meeting of European Orthopedic Research Society, 14-16 September 2016, Bologna, Italy.
  4. Wang FS. RPTOR maintenance of osteoblast autophagy mitigates glucocorticoid induction of osteoporosis. The 24th Annual Meeting of European Orthopedic Research Society, 14-16 September 2016, Bologna, Italy.
  5. Wang FS. MicroRNA-128 interference mitigates the progression of knee osteoarthritis by regulating sirtuin-1. The 2015 Annual Meeting of American College of Rheumatology, 7-11 November, San Francisco, USA.
  6. Wang FS. Histone lysine demethylase KDM6A mediates joint destruction in osteoarthritic kness by epigenetic disturbance of SOX9 promoter and histone H3K27. The 2014 Annual Meeting of American College of Rheumatology, 16-19 November, 2014, Boston, USA.
  7. Wang FS MicroRNA-29a repression of Th17 immune reactions ameliorates cartilage destruction and synovial fibrosis in osteoarthritic knees. The 24th Annual Meeting of European Orthopaedic Research Societies. 2-4 July, 2014, Nates, France.

Books and book chapters

  1. Wang FS, Lian SW, Kuo CW 2019 Heat shock protein 60 regulation of skeletal tissue integrity. Asea AAA, Kaur P, Springer Nature
  2. Wang FS, Shu KY, Lin WC, Cheng YK 2018 Laboratory Animal Facility Management (Chinese)

Patent & intellectual property

  1. 王逢興、郭繼陽、黃柏文、曾仲葛、巫瑞文、林政宏、連韋雄、謝進貴。無線攜帶式可調控低頻振波骨細胞增生系統。中華民國專利證書新型第M563251號。
  2. 王逢興、郭繼陽、黃柏文、曾仲葛、陳品任、邱煜憲。可調控低頻振波骨細胞增生儀。中華民國專利證書新型第M487051號
    • Wang FS. 2019. FVB/N-Tg(PGK-miR29a )Wfs/Narl. Rodent Model Resource Center, Taiwan
    • Wang FS. 2018. FVB/N-Tg(PGK-HSPD1)Wfs/Narl. Rodent Model Resource Center No. Taiwan