Department of Medical Research
Kaohsiung Chang Gung Memorial Hospital (KCGMH)
Kaohsiung 83301, Taiwan
Tel: 886-7-7317123, ext. 6405
E-mail: lianws@gmail.com

Education and Training
1.Department of Animal Science and Technology, National Taiwan University,Taiwan ,Ph.D.,20052011,Stem cells
engineering

2.Department of Animal Science and Technology, National Taiwan University,Taiwan,Master,19982000,Animal science

Current position and relevant experience
2017-   Deputy Director, Department of Medical Research, KCGMH
2015-   Director, Core Laboratory for Phenomics & Diagnostics, KCGMH
2011-       Full Investigator, Department of Medical Research, KCGMH
2010-       Director, Center for Laboratory Animals, KCGMH
2010-       Professor, Graduate Institute of Clinical Medical Sciences, School of Medicine    Chang Gung University

Research and Professional Positions Held in Chronological Sequence
1.2017~present,Assistant Research Fellow,Department of Medical Research,Kaohsiung Chang Gung Memorial Hospital, Taiwan. 2.2014~2017,Post-doctoral,Department of Medical Research,Kaohsiung Chang Gung Memorial Hospital, Taiwan. 3.2011~2014 ,Post-doctoral,Institute of Biomedical Sciences,Academia Sinica, Taipei, Taiwan.

Honors and Awards
1.October 2019,ON/EORS ORTHOREGENERATION AWARD 2019 by ON Foundation
2.April 2018,Award of Chinese Association for Clinical Biochemistry by oral presentation with 3rd place, The 33th JACBS.
3.April 2017,Award of Chinese Association for Clinical Biochemistry in oral presentation with 3rd place, The 32th JACBS.
4.July 2012,Award of Academic Research Thesis in Doctor, National Taiwan University. 5.Nov 2010,Funding by National Science Council. For participated the 43rd American Society of Nephrology annual meeting in Denver.

Record of Serving as Principal Investigator

1.2017-2019,Ministry of science and technology,Epigenetic Regulation and Prevention of Knee Osteoarthritis: Contribution of H3K27 Methylation to Chondrocyte Metabolism,MOST 107-2314-B-182A012 -MY2,$2,200,000

Publications

1.Lin HY, Weng SW, Shen FC, Chang YH, *Lian WS, Hsieh CH, Chuang JH, Lin TK, Liou CW, Chang CS, Lin CY, Su YJ, Wang PW.,Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue.,Antioxid Redox Signal,2020,

2.Wu RW, *Lian WS, Kuo CW, Chen YS, Ko JY, Wang FS. ,S100 Calcium Binding Protein A9 Represses Angiogenic Activity and Aggravates Osteonecrosis of the Femoral Head.,Int J Mol Sci,2019,20,5786,

3.Wu RW, *Lian WS, Chen YS, Kuo CW, Ke HC, Hsieh CK, Wang SY, Ko JY, Wang FS.,MicroRNA-29a
Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis.,Int J Mol Sci,2019,20,5141,

4.Ko JY, *Lian WS, Tsai TC, Chen YS, Hsieh CK, Kuo CW, Wang FS.,MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness.,Int J Mol Sci,2019,20,5742,

5.*Lian WS, Ko JY, Chen YS, Ke HJ, Hsieh CK, Kuo CW, Wang SY, Huang BW, Tseng JG, Wang FS.,MicroRNA29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12. ,Cell Death Dis,2019,10,705,

6.*Lian WS, Ko JY, Chen YS, Ke HJ, Wu SL, Kuo CW, Wang FS.,Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR.,Cell Death Dis. ,2018,9,938,

7.Wang FS, Wu RW, *Lian WS, Tsai TC, Chen YS, Sub YC, Ke HJ, Li JC, Hwang JL, Ko JY. ,Sclerostin Vaccination Mitigates Estrogen Deficiency Induction of Bone Mass Loss and Microstructure Deterioration Bone.,Bone,2018,12,24,34,

8.*Lian WS, Ko JY, Wu RW, Sun YC, Chen YS, Wu SL, Weng LH, Jahr H, Wang FS.,MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12.,Cell Death Dis.,2018,9,191,

9.Shen FC, Weng SW, Tsao CF, Lin HY, Chang CS, Lin CY, Lian WS, Chuang JH, Lin TK, Liou CW, Wang PW.,Early intervention of N-acetylcysteine better improves insulin resistance in diet-induced obesity mice.,Free Radic Res. ,2018,52,1296,

10.*Lian WS, Wu RW, Lee MS, Chen YS, Sun YC, Wu SL, Ke HJ, Ko JY, Wang FS.,Subchondral mesenchymal stem cells from osteoarthritic knees display high osteogenic differentiation capacity through microRNA29a regulation of HDAC4.,J Mol Med (Berl).,2017,95(12),1327,1340, .

11.Ko JY, Lee MS, *Lian WS, Weng WT, Sun YC, Chen YS, Wang FS.,MicroRNA-29a Counteracts Synovitis in Knee Osteoarthritis Pathogenesis by Targeting VEGF.,Sci Rep.,2017,7,3584, .

12.Wang FS, *Lian WS, Lee MS, Weng WT, Huang YH, Chen YS, Sun YC, Wu SL, Chuang PC, Ko JY.,Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histonedependent and -independent pathways.,J Mol Med (Berl).,2017,95,499, .

13.Wang FS, *Lian WS, Weng WT, Sun YC, Ke HJ, Chen YS, Ko JY.,Neuropeptide Y mediates glucocorticoidinduced osteoporosis and marrow adiposity in mice.,Osteoporos Int.,2016,27,2777,2789, .

14.*Lian WS, Chiou HC, Lin H, Chen JJ, Cheng CF.,The prostaglandin agonist beraprost aggravates doxorubicin-mediated apoptosis by increasing iNOS expression in cardiomyocytes.,Curr Vasc Pharmacol.,2015,13,54, .

15.Cheng CF, *Lian WS.,Prooxidant mechanisms in iron overload cardiomyopathy.,Biomed Res Int.,2013,2013,74057,

16.Lin H, Li HF, *Lian WS, Chen HH, Lan YF, Lai PF, Cheng CF.,Thromboxane A2 mediates iron-overload cardiomyopathy in mice through calcineurin-nuclear factor of activated T cells signaling pathway.,Circ J.,2013,77,258,

17.Lin H, *Lian WS, Chen HH, Lai PF, Cheng CF.,Adiponectin ameliorates iron-overload cardiomyopathy through the PPARα-PGC-1-dependent signaling pathway.,Mol Pharmacol.,2013,84,275, .

18.Cheng CC, *Lian WS, Hsiao FS, Liu IH, Lin SP, Lee YH, Chang CC, Xiao GY, Huang HY, Cheng CF, Cheng WT, Wu SC.,Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells.,PLoS One. ,2012,7,3608, .

19.Hsiao FS, *Lian WS, Lin SP, Lin CJ, Lin YS, Cheng EC, Liu CW, Cheng CC, Cheng PH, Ding ST, Lee KH, Kuo TF, Cheng CF, Cheng WT, Wu SC.,Toward an ideal animal model to trace donor cell fates after stem cell therapy: production of stably labeled multipotent mesenchymal stem cells from bone marrow of transgenic pigs harboring enhanced green fluorescence protein gene.,J Anim Sci.,2011,89,346, .

20.Cheng CF, *Lian WS, Chen SH, Lai PF, Li HF, Lan YF, Cheng WT, Lin H.,Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARα-heme oxygenase-1 signaling pathway.,J Cell Physiol.,2012,227,239, .

21.*Lian WS, Lin H, Cheng WT, Kikuchi T, Cheng CF.,Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.,J Biomed Sci.,2011,18,26, .

22.*Lian WS, Cheng WT, Cheng CC, Hsiao FS, Chen JJ, Cheng CF, Wu SC.,In vivo therapy of myocardial infarction with mesenchymal stem cells modified with prostaglandin I synthase gene improves cardiac performance in mice.,Life Sci.,2011,88,4, .

Patent

1.Wei-Shiung Lian, Chin-Kuei Hsieh, Bo-Wun Huang, Jung-Ge Tseng, Jih-Yang Ko, Feng-Sheng
Wang/Wireless portable and adjustable low-frequency vibration platform for stimulation bone cell proliferation/ Utility model patent M563251/Taiwan,2018,2028

Book

1.Authors: Feng-Sheng Wang, Wei-Shiung Lian, Chung-Wen Kuo, Yu-Shan Chen, and Pei-Rong Chang / Chapter Title: Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity (Chapter 19)/ Editor: Alexzander A. A Asea, Punit Kaur/ Book Title: Heat Shock Protein 60 in Human Diseases and Disorders / Book Company: Springer.Com / Americas.,2019

Conference Paper

1.Lian WS, Wang FS/ Methylated Histone Pathway Modulation of Cartilage Integrity and Osteoarthritis / 27th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS), Maastricht, Netherlands. ,2019

2.Lian WS, Wang FS / Trimethyl H3K27 Assembly Modulation of Cartilage Integrity and Osteoarthritis. / 2nd International Combined Orthopaedic Research Society (ICORS) / Montreal, Canada.,2019

3.Wei-Shiung Lian, Jih-Yang Ko and Feng-Sheng Wang/ Sclerostin Vaccination Prevents Estrogen LossInduced Osteoporosis/ 26th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS)/ Galway, Ireland. ,2018

4.Wei-Shiung Lian, Ren-Wen Wu, Jin-Yang Ko and Feng-Sheng Wang/ Subchondral mesenchymal stem cells from osteoarthritic knees display high osteogenic differentiation capacity through microRNA-29a regulation of HDAC4/ 25th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS)/ Munich, Germany. ,2017 5.Wei-Shiung Lian, Jih-Yang Ko and Feng-Sheng Wang/ Differential Characteristics between Cartilage and Bone-marrow Mesenchymal Stem Cells in Osteoarthritic human Knees/ OARSI World Congress on Osteoarthritis in RAI Amsterdam Convention Center/ Amsterdam, Netherlands.,2016

6.Wei-Shiung Lian, Fen-Hsiao Li, His-Hsien Chen, Ching-Feng Cheng, Heng Lin/ Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPAR-α-HO-1 signaling pathway/ American Society of Nephrology 43rd Annual Meeting/ Denver.,2010

7.Wei-Shiung Lian, Ching-Feng Cheng, Chun-Chun Cheng, Shinn-Chih Wu, Heng Lin, Winston Teng-Kuei Cheng/ Enhanced cardiac therapeutic performance through mesenchymal stem cells engineered with prostacyclin synthase gene in mice myocardium infarction/ The 18rd Symposium on Recent Advances in Cellular and Molecular Biology/ Pingtung, Taiwan.,2010