Division of Cardiology --- Chang Gung Memorial Hospital of Kaohsiung

| International || Domestic / external || domestic / internal |


Funding	XMPRG860442
Duration of Project	2007 / 1 / November ~ 2009 / 31 / October
Title	Randomized, multinational, multicenter, double-blind, placebo-controlled, two-arm parallel group trial of rimonabant 20 mg OD for reducing the risk of major cardiovascular events in abdominally obese patients with clustering risk factors
Principal Investigator	Dr. Mien-Cheng Chen

Funding	XMPRG860143
Duration of Project	2007 / 20 / May ~ 2010 / 6 / February
Title	A study of platelet inhibition and patient outcomes In ST-elevation and Non–ST-elevation acute coronary syndrome
Principal Investigator	Dr. Mien-Cheng Chen

Funding
Duration of Project	2008 / 24 / September ~ 2014 / 16 / April
Title	Patient Related Outcomes with Endeavor versus Cypher Stenting Trial
Principal Investigator	Dr. Chiung-Jen Wu

Funding
Duration of Project	2007 / 21 / November ~ 2009 / 31 / December
Title	DRI 6624 SEPIA-ACSI TIMI 42 Study
Principal Investigator	Dr. Chiung-Jen Wu

Funding
Duration of Project	2007 / 17 / April ~ 2010 / 16 / April
Title	The e-SELECT Registry A Multicenter Post-Market Surveillance
Principal Investigator	Dr. Chiung-Jen Wu


Funding	NMRPG876182
Duration of Project	2009 / 1 / Augst ~ 2010 / 31 / July
Title	Temporal evolution of dedifferentiation of atrial cardiomyocytes in a pig model of mitral regurgitation: changes in atrial histopathology and signalling mediators
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG876172
Duration of Project	2009 / 1 / Augst ~ 2010 / 31 / July
Title	Serial Changes of Circulating Endothelial Progenitor Cells and Prognostic Outcome after Acute Ischemic Stroke Undergoing Epoetin Therapy: an experimental and clinical observational study
Principal Investigator	Dr.Hon-Kan Yip

Funding	NMRPG876171
Duration of Project	2008 / 1 / Augst ~ 2009 / 31 / July
Title	Serial Changes of Circulating Endothelial Progenitor Cells and Prognostic Outcome after Acute Ischemic Stroke Undergoing Epoetin Therapy: an experimental and clinical observational study
Principal Investigator	Dr.Hon-Kan Yip

Funding	NMRPG876181
Duration of Project	2008 / 1 / Augst ~ 2009 / 31 / July
Title	Temporal evolution of dedifferentiation of atrial cardiomyocytes in a pig model of mitral regurgitation: changes in atrial histopathology and signalling mediators
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG860201
Duration of Project	2007 / 1 / Augst ~ 2008 / 31 / October
Title	Autophagic cell death versus necrosis as a possible mechanism of atrial myocardial cell death in valvular heart disease: role of atrial fibrillation
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG860211
Duration of Project	2007 / 1 / Augst ~ 2008 / 31 / July
Title	Combination of Bone Marrow-Derived Endothelial Progenitor Cell & Cilostazol Therapy for Prevention Monocrotaline-Induced Pulmonary Arterial Hypertension: Phase II study util
Principal Investigator	Dr.Hon-Kan Yip

Funding	NMRPG860221
Duration of Project	2007 / 1 / Augst ~ 2008 / 31 / July
Title	體外震波治療氣球擴張損傷之老鼠總頸動脈內皮細胞：探討震波治療的抗發炎及增強循環原生性內皮細胞至受損頸
Principal Investigator	吳炯仁

Funding	NMRPG850151
Duration of Project	2006 / 1 / Augst ~ 2007 / 31 / October
Title	Role of nuclear and mitochondria transcription factors on cardiac mitochondrial biogenesis and nuclear and mitochondrial genes encoding mitochondrial proteins in patients with valvular heart disease and persistent atrial fibrillation
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG850441
Duration of Project	2006 / 1 / Augst ~ 2007 / 31 / July
Title	Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Post-infarcted Rat Myocardium: comparison of effects between stem cell and losartan therapy on subcellular signal transduction and short- and long-term outcomes
Principal Investigator	Dr.Hon-Kan Yip

Funding	NMRPG850461
Duration of Project	2006 / 1 / Augst ~ 2007 / 31 / July
Title	Effect of angiotensin II on proliferation, apoptosis, cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells
Principal Investigator	Dr. Cheng-I Cheng

Funding	NMRPG840381
Duration of Project	2005 / 1 / Augst ~ 2006 / 31 / July
Title	Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke.
Principal Investigator	Dr.Hon-Kan Yip/ Dr. Mien-Cheng Chen

Funding	NMRPG840521
Duration of Project	2005 / 1 / Augst ~ 2006 / 31 / October
Title	Circulatory endothelial progenitor cells in patients with diabetes mellitus complicated with ischemic lower extremities
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG840391
Duration of Project	2005 / 1 / Augst ~ 2006 / 31 / July
Title	細胞毒殺T淋巴球(CTLA-4)及程式化細胞死亡-1 (PD-1)基因多形性在急性心肌梗塞患者的表現
Principal Investigator	吳炯仁

Funding	NMRPG3139
Duration of Project	2004 / 1 / Augst ~ 2005 / 31 / October
Title	Correlation of structural changes of atrial myocardium and clinical outcomes in patients with permanent atrial fibrillation undergoing radiofrequency maze operation
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG314342
Duration of Project	2004 / 1 / Augst ~ 2005 / 31 / July
Title	探討藥物(Simvastatin及Losartan)對發炎蛋白影響內皮細胞功能的調節作用
Principal Investigator	傅懋洋

Funding	NMRPG3145
Duration of Project	2004 / 1 / Augst ~ 2005 / 31 / July
Title	Time course of platelet activation and von Willebrand Factor in patients with nonvalvular atrial fibrillation after ischemic stroke: evaluation of prognostic determinants
Principal Investigator	Dr.Hon-Kan Yip/ Dr. Mien-Cheng Chen

Funding	NMRPG2174
Duration of Project	2003 / 1 / Augst ~ 2005 / 31 / July
Title	比較冠狀動脈氣球擴張術後無放射治療和加貝他液態錸
Principal Investigator	洪志凌

Funding	NMRPG2186
Duration of Project	2003 / 1 / Augst ~ 2004 / 31 / October
Title	Kinetic changes of circulatory endothelial progenitor cells and plasma interleukin-18 in patients with unstable angina undergoing percutaneous coronary intervention
Principal Investigator	Dr. Mien-Cheng Chen

Funding	NMRPG1099
Duration of Project	2002 / 1 / Augst ~ 2003 / 31 / July
Title	Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation.
Principal Investigator	Dr.Hon-Kan Yip

Funding	NMRPG9049
Duration of Project	2000 / 1 / Augst ~ 2002 / 31 / July
Title	評估施行貝他放射線照射以防止經血管氣球擴張術後之冠狀動脈再狹窄：對擴散性支架放置
Principal Investigator	洪志凌


Funding	CMRPG880401
Duration of Project	2009 / 1 / April ~ 2010 / 31 / March
Title	The role of inflammation in the programmed cell pathway activation in the atria in cardiac valve disease and its mechanisms
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRPG880231
Duration of Project	2009 / 1 / February ~ 2010 / 31 / January
Title	The influence of gender difference in acute myocardial infarction heart breakage, cardiac remodeling, preservation of cardiac function as well as improvement long-term prognosis: mice animal model
Principal Investigator	Dr. Sarah Chua

Funding	CMRPG880321
Duration of Project	2009 / 1 / January ~ 2009 / 31 / December
Title	合併使用Cyclosporine及Labetalol可有效減低迷你豬前壁心肌梗塞的範圍及左心室重塑
Principal Investigator	Dr. Chiung-Jen Wu

Funding	CMRPG880291
Duration of Project	2009 / 1 / January ~ 2009 / 31 / December
Title	Impacts of Angiogenesis,Chemokine/Paracrine mediators and Stem Cell Homing on Preserving Heart Function in Rat Model of Dilated Cardiomyopathy
Principal Investigator	Dr.Hon-Kan Yip

Funding	CMRPG870911
Duration of Project	2008 / 1 / November ~ 2010 / 31 / October
Title	心臟衰竭整合治療計劃
Principal Investigator	劉文浩

Funding	CMRPG870351
Duration of Project	2008 / 1 / May ~ 2009 / 30 / April
Title	Endothelium Dysfunction Predict Cardiovascular Outcomes in Orthotopic Liver Transplantation Patients
Principal Investigator	Dr.Shyh-Ming Chen

Funding	CMRPG870341
Duration of Project	2008 / 1 / April ~ 2009 / 31 / March
Title	合併使用自體骨髓間質幹細胞及體外震波治療於缺血性糖尿病迷你豬:探討血管增生及心臟功能恢復機轉
Principal Investigator	傅懋洋

Funding	CMRPG870211
Duration of Project	2008 / 1 / March ~ 2009 / 28 / February
Title	Combination of Bone Marrow-Derived Endothelial Progenitor Cell & Cilostazol Therapy for Prevention Monocrotaline-Induced Pulmonary Arterial Hypertension: Phase II study utilizing an anim
Principal Investigator	Dr.Hon-Kan Yip

Funding	CMRPG860521
Duration of Project	2007 / 30 / November ~ 2008 / 31 / May
Title	Effect of angiotensin II and angiotensin II type 1 receptor blocker on cell growth and angiogenesis of mice bone marrow mesenchymal stem cells
Principal Investigator	Dr. Cheng-I Cheng

Funding	CMRPG860391
Duration of Project	2007 / 1 / October ~ 2009 / 31 / March
Title	The significance of plasma C-reactive protein and pro-inflammatory cytokines in the perpetuation of atrial fibrillation following radiofrequency maze procedure for persistent atrial fibrillation in patients undergoing concomitant mitral valvular surgery: dynamic changes of plasma concentrations of pro-inflammatory cytokine, adhesion molecules and endothelin-1
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRPG860311
Duration of Project	2007 / 1 / September ~ 2008 / 30 / November
Title	Significance of atrial cardiomyocytes with positive DNA in situ nick end-labeling (TUNEL) and dedifferentiated in patients with mitral valve disease: not apoptosis but living cells with DNA repair
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRPG860151
Duration of Project	2007 / 1 / April ~ 2008 / 30 / June
Title	Evaluation of Coronary Artery Stent Patency by 64-slice Multi-detector Computed Tomography: A Comparison with Conventional Coronary Anglography and Intra vascular ultrasound
Principal Investigator	Dr.Chi-Ling Hang

Funding	CMRPG860041
Duration of Project	2007 / 1 / March ~ 2008 / 28 / February
Title	Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation to Dilated Cardiomyopathy Rats: evaluate molecular and cell biological impact on improving left ventricular function
Principal Investigator	Dr.Hon-Kan Yip

Funding	CMRPG850501
Duration of Project	2006 / 1 / December ~ 2007 / 30 / November
Title	急性心肌梗塞病患血液中循環內皮原生細胞的數目及白血球中TRL4接受體活化的臨床價值
Principal Investigator	吳炯仁

Funding	CMRPG850031
Duration of Project	2006 / 1 / March ~ 2007 / 31 / Augst
Title	Dedifferentiation of atrial myocytes in patients with mitral valve disease and sinus rhythm: role of atrial pressure and volume overload
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRPG840631
Duration of Project	2005 / 1 / December ~ 2006 / 30 / November
Title	Strong suppression of high-sensitivity C-reactive protein level and its mediated pro-atherosclerotic effects with simvastatin: in vivo and in vitro studies.
Principal Investigator	Dr.Hon-Kan Yip

Funding	CMRPG840621
Duration of Project	2005 / 1 / December ~ 2007 / 28 / February
Title	以骨隨內皮原生細胞治療肺動脈壓過高疾病
Principal Investigator	傅懋洋

Funding	CMRPG84016
Duration of Project	2005 / 1 / March ~ 2006 / 31 / Augst
Title	Correlation of apoptotic changes of atrial myocardium and clinical outcomes in patients with permanent atrial fibrillation undergoing radiofrequency maze operation
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRPG83059
Duration of Project	2005 / 1 / January ~ 2005 / 31 / December
Title	Strong suppression of high-sensitivity C-reactive protein level and its mediated pro-atherosclerotic effects with simvastatin: in vivo and in vitro studies
Principal Investigator	Dr.Hon-Kan Yip

Funding	CMRPG83004
Duration of Project	2004 / 1 / January ~ 2004 / 31 / December
Title	Strong correlation between serum levels of inflammatory mediators and their distribution in infarct coronary.
Principal Investigator	Dr.Hon-Kan Yip/ Dr. Mien-Cheng Chen

Funding	CMRPG8037
Duration of Project	2003 / 1 / February ~ 2004 / 31 / January
Title	Effects of Percutaneous Transluminal Mitral Valvulopasty on the Expression of Pro-inflammatory Cytokines and Chemokines in Patients with Rheumatic Mitral Stenosis
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRP1139
Duration of Project	2001 / 1 / April ~ 2003 / 31 / Augst
Title	Effects of Percutaneous Transluminal Mitral Valvulopasty on Platelet and Endothelial Cell Activation
Principal Investigator	Dr. Mien-Cheng Chen

Funding	CMRP984
Duration of Project	2000 / 1 / April ~ 2001 / 31 / July
Title	經皮狀動脈血管成形術後一氧化氮及循環中免疫內皮細胞素的變化:術中冠狀動脈內貝他射
Principal Investigator	洪志凌

Funding	CMRP978
Duration of Project	2000 / 1 / April ~ 2001 / 31 / March
Title	利用血管內都普勒血流導線直接評估風濕性僧帽瓣狹窄病人的肺靜脈血流型態,並評估肺
Principal Investigator	傅懋洋