Lee WI

Lee, Wen-I MD,Ph.D.
Institution:Chang Gung Memorial Hospital and University
Position: Associate professor in Primary Immunodeficiency Care And Research (PICAR) Institute
Department: Department of Pediatric Allergy Immunology Asthma Rheumatology
Address: 5 Fu Shin Street, Kweishan Shiang, Taoyuan Hsien, Taiwan Department of Pediatrics, Chang Gung Memory Hospital
Tel: +886-3-3281200ext 8255
E-mail: wen2707@hotmail.com

Focus of Interest:

• Recurrent infections,
• primary immunodeficiency,
• immune reconstruction after hematopoietic stem cell transplantation, and allergic diseases (including asthma, allergic rhinitis, atopic dermatitis, urticaria)

Education:
Graduate Institute of Medical Clinics, Chang Gung University College of Medicine
Professional Experience
Post-doctorial research scientist in Genetic & molecular approach in Primary Immunodeficiencies in University of Washington Medical Center (UWMC)

Honors & Awards:

• The invited honor speaker for primary immunodeficiency in the Asian-Pacific Primary immunodeficiency (Tokoyama, 2008)
• Asian Pacific Congress of Pediatrics (Shanghai, 2009)
• Congress of Asian Society for Pediatric Research (Taipei, 2010)
• International Congress of Tropical Pediatrics (Bangkok, 2011)
• APAPARI 2012 & 16st TAPAAI & 34th TCSI (Taipei, 2012)
• Referred expert for primary immunodeficiency diseases in Jeffery Modell Foundation since 2005 and Invited to Summit Conference in Berlin Jul 17-20, 2013
• Excellent Study Honor in Chinese Immunology Society

Short Bio:
Graduate Institute of Clinical Medical Sciences, Chang Gung University, (1999-2005)
Genetic & molecular approach in Primary Immunodeficieny in University of Washington Medical Center, Seattle (2000-2003)
Establish Primary Immunodeficiency Care And Research (PICAR) Institute, since 2003
Referred expert for primary immunodeficiency diseases in Jeffery Modell Foundation
Associate professor of Chang Gung Memorial and Children’s Hospital, since 2009
Consultant expert in Taiwan Foundation For Rare Disorders (TFRD) since 2003

Representative and recent publications:
1.Lee WI, Zhu Q, Gambineri E, et al. Inducible CO-Stimulator molecule (ICOS), a candidate gene for defective isotype switching, is normal in patients with Hyper IgM syndrome of unknown Inducible CO-Stimulator molecule.J Allergy Clin Immunol 2003; 112:958-964

2. Imai K, Slupphaug G, Lee WI, et al. Uracil-DNA glycosylase deficiency proundly impairs immunoglobulin class switch recombination, leading to a hyper-IgM syndrome. Nat Immunol 2003; 4:1023-8

3.Lee WI, Torgerson TR, Schumacher MJ, et al. Molecular analysis in a large cohort of patients with hyper immunoglobulin M (IgM) syndrome. Blood 2005; 105:1881-1890

4.Lee WI,* Huang JL, Huang YC, et al. Clinical, Immunological and Genetic Features of Taiwanese Patients with the Phenotype of Hyper-Immunoglobulin E Recurrent Infection Syndromes (HIES).Immunobiology. 2011;216:909-17.

5.Lee WI,* Huang JL, Jaing TH, et al. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985–2010. Immunobiology. 2011; 216:1286-94.

6.Lee WI,* Huang JL, Wu TS, et al. Patients with inhibitory and neutralizing auto-antibodies to interferon-γ resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. Immunobiology. 2013;218:762-71.

7.Lee WI,* Chen SH, Huang JL, et al. Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiology. 2013;218:828-33.

8.Lee WI,* Huang JL, Yeh KW, et al. Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype. Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print]