Wen-I Lee , M.D., Ph.D. 
Intitution: Chang Gung Memorial Hospital and University
Position: Associate professor in Primary Immunodeficiency Care And Research (PICAR) Institute
Mail Address: No. 5, Fu-Shing Street, Kueishan, Taoyuan 333, Taiwan.
Tel: +886-3-328-1200 ext.8255
E-mail: wen2707@hotmail.com
Focus of Interest:- Recurrent infections
- Primary immunodeficiency
- Immune reconstruction after hematopoietic stem cell transplantation
- Allergic diseases (including asthma, allergic rhinitis, atopic dermatitis, urticaria)
Short Biography
Graduate Institute of Clinical Medical Sciences, Chang Gung University, (1999-2005)
Genetic & molecular approach in Primary Immunodeficieny in University of Washington Medical Center, Seattle (2000-2003)
Establish Primary Immunodeficiency Care And Research (PICAR) Institute, since 2003
Referred expert for primary immunodeficiency diseases in Jeffery Modell Foundation
Associate professor of Chang Gung Memorial and Children’s Hospital, since 2009
Consultant expert in Taiwan Foundation For Rare Disorders (TFRD) since 2003
Professional Experience
Post-doctorial research scientist in Genetic & molecular approach in Primary Immunodeficiencies in University of Washington Medical Center (UWMC)
Education:
Graduate Institute of Clinical Medical Sciences, Chang Gung University, (1999-2005)
Genetic & molecular approach in Primary Immunodeficieny in University of Washington Medical Center, Seattle
(2000-2003)
Selected Publications:1.Lee WI, Zhu Q, Gambineri E, et al. Inducible CO-Stimulator molecule (ICOS), a candidate gene for defective isotype switching, is normal in patients with Hyper IgM syndrome of unknown molecular diagnosis. J Allergy Clin Immunol 2003; 112:958-964
2. Imai K, Slupphaug G, Lee WI, et al. Uracil-DNA glycosylase deficiency proundly impairs immunoglobulin class switch recombination, leading to a hyper-IgM syndrome. Nat Immunol 2003; 4:1023-8
3.Lee WI, Torgerson TR, Schumacher MJ, et al. Molecular analysis in a large cohort of patients with hyper immunoglobulin M (IgM) syndrome. Blood 2005; 105:1881-1890
4.Lee WI,* Huang JL, Huang YC, et al. Clinical, Immunological and Genetic Features of Taiwanese Patients with the Phenotype of Hyper-Immunoglobulin E Recurrent Infection Syndromes (HIES). Immunobiology. 2011;216:909-17.
5.Lee WI,* Huang JL, Jaing TH, et al. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985–2010. Immunobiology. 2011; 216:1286-94. 6.Lee WI,* Huang JL, Wu TS, et al. Patients with inhibitory and neutralizing auto-antibodies to interferon-γ resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. Immunobiology. 2013;218:762-71.
7.Lee WI,* Chen SH, Huang JL, et al. Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia. Immunobiology. 2013;218:828-33.
8.Lee WI,* Huang JL, Yeh KW, et al. Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype. Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print]
Honor and Awards:
- The invited honor speaker for primary immunodeficiency in the Asian-Pacific Primary immunodeficiency (Tokoyama, 2008)
- Asian Pacific Congress of Pediatrics (Shanghai, 2009)
- Congress of Asian Society for Pediatric Research (Taipei, 2010)
- International Congress of Tropical Pediatrics (Bangkok, 2011)
- APAPARI 2012 & 16st TAPAAI & 34th TCSI (Taipei, 2012)
- Referred expert for primary immunodeficiency diseases in Jeffery Modell Foundation since 2005 and Invited to Summit Conference in Berlin Jul 17-20, 2013
- Excellent Study Honor in Chinese Immunology Society