Expertise at Chang Gung System

Sen-Yung Hsieh , M.D.,Ph.D.
Institution: Linkou Chang Gung Memorial Hospital / Chang Gung Uiversity
Position: Director /Physician/Professor
Department: Gastroenterology and Hepatology
Address: Dep. of Gastroenterology and Hepatology,No.5, Fusing St., Gueishan Township, Taoyuan County 333, Taiwan.
Tel: +886-3-3281200 ext.8128 Fax: +886-3-3272236

Focus of Interest:
  • Oncology
  • Molecular and cell biology
  • Biochemistry and Molecular Biology - Medicine
  • Cancer Research
  • Gastroenterology&Hepatology
  • Molecular Biology
  • Microbiology
  • Molecular Biology

Fulltime Employment:
  1. 1982-83, Internship training, Veteran General Hospital, Taipei, Taiwan
  2. 1983-85, Medical officer during military service, Chinese Marine Corps, Kaohsiung, Taiwan
  3. 1985-87, Residency training in internal medicine, Provincial Taoyuan General Hospital, Taoyuan, Taiwan
  4. 1991-1992, Residency training in internal medicine, Chang Gung Memorial Hosp, Taipei, Taiwan
  5. 1992/8 to 1994/7, Research fellow in Hepatogastroenterology, Chang-Gung Mem Hosp, Taipei, Taiwan
  6. 1994/8 to 1996/7, Attneding doctor, Hepatogastroenterology, Chang-Gung Mem Hosp, Taipei, Taiwan
  7. 1996/7 to 1998/7, Associate professor in Internal Medicine, Chang Gung University School of Medicine
  8. 1993/8 to 2005/7, Associate professor in Microbiology and Immunology, Chang Gung University School
  9. 2005/8 to date, Professor, Microbiology and Immunology, Chang Gung University School of Medicine
  10. Molecular Medicine Society of Taiwan, council member (2006/12 – 2011/01)
  11. Taiwan Proteomics Society, council member (2008/01-2011/12)
  12. Director, Clinical Proteomics Center, Chang Gung Memorial Hospital, Linkou, Taoyuan (2003/07-2016/06)
  13. Director, Department of Medical Research, Chang Gung Memorial Hospital, Linkou, Taoyuan (2011/09-2016/06)
  14. Director, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan (since 2016/07- )

  • 1983/6, M.D., National Yang-Ming Medical College, Taipei
  • Post-Graduate Education: 1991/7, Ph.D., Molecular biology/pathology, University of Pennsylvania, PA, U.S.A.

Honor and Awards:
  1. 1987 to 1991, government scholarship for PhD training in the US
  2. 1992, 1993, 1995, 1996, 1997, 1998, 2000 Research Award, National Science Council, Taiwan
  3. 1994, Outstanding Research Award, Professor JL Song’s Academic Foundation
  4. 1999, Outstanding Research Award, Taiwan Medical Association
  5. 2002, Outstanding Research Award, Japanese Society on Liver Study
  6. 2011, Best Paper Award, Japanese-American Association of Cancer Research Combined
  7. Conference: Hepatoma Research from clinical and basic
  8. 2013, Best Teacher Award in Research, Chang Gung University
  9. 2018, Dr. Ta-Cheng Tung 's Basic Cancer Research Award

Selected Publications:
  1. Hsieh SY*, He JR, Hsu CY, Chen WJ, Bera R, Lin KY, Shih TC, Yu MC, Lin YJ, Chang CJ, Weng WH, Huang HF.Neuregulin/Erythroblastic Leukemia Viral Oncogene Homolog 3 Autocrine Loop Contributes to invasion and Early Recurrence of Human Hepatoma. Hepatology. 53(2):504-516. FEB 2011. (* correspondent)
  2. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, Lee YS, Yen TZ, Hsieh SY*. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatology. 57(3):584-591. SEP 2012. (* correspondent)
  3. Lo SL, Fan LC, Tsai YF, Lin KY, Huang HL, Wang TH, Liu H, Chen TC, Huang HF, Chang CJ, Lin YJ, Yung BY, Hsieh SY*. A novel interaction of nucleophosmin with BCL2-Associated X protein regulating deathevasion and drug sensitivity in humanhepatoma cells. Hepatology. 57(5):1893-1905. MAY 2013. (* correspondent)
  4. Rabindranath Bera,* Chih-Yung Chiou,* Ming-Chin Yu, Jei-Ming Peng, Chung-Ru He, Chih-Yun Hsu, Hsiao-Ling Huang, Uda Y. Ho, Shi-Ming Lin, Yu-Jr Lin, and Sen-Yung Hsieh**.Functional Genomics Identified a NovelProtein Tyrosine Phosphatase Receptor Type F-Mediated Growth Inhibition in Hepatocarcinogenesis. Hepatology. 59(6):2238-2250. JUN 2014. (** correspondent)
  5. Peng JM, Bera R, Chiou CY, Ming-Chin Yu, Tse-Chin Chen, Chia-Wei Chen, Tsung-Rui Wang, Wan-Ling Chiang, Shin-Pei Chai, Yongkun Wei, Huamin Wang, Mien-Chie Hung, Hsieh SY*. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis. Hepatology. 2017 Nov 23. doi: 10.1002/hep.29678. [Epub ahead of print] (* correspondent)

Full Publication List





Number Applicant Hospita/ Divisionl Inventor Category Certificate No Patents start time Patent end time
找尋肝癌血清/血漿生物標記分子之方法及該肝癌血清/血漿生物標記分子 PROTEIN MARKERS FOR DETECTING
Taiwan:  I 487913USA: US 8,741,288 B2 US 8,741,288 B2 Sen-Yung Hsieh Chang Gung Memorial Hospital, Linkou Sen-Yung Hsieh Patents Taiwan:  I 487913USA: US 8,741,288 B2 US 8,741,288 B2

Taiwan: 2015


Taiwan: 2035

  A NOVEL PHARMACEUTICAL COMPOSITION AND USES THEREOF US9901594B2 Sen-Yung Hsieh Chang Gung Memorial Hospital, Linkou Sen-Yung Hsieh Patents US9901594B2 USA: 2018 USA: 2038

Board Certification/Professional Affiliations:
  • AACR、GEST、TASL、DEST、Taiwan Society of Ultrasound in Medicine

Ongoing Projects:
  1. Molecular, cellular, genomicsandproteomics research in human hepatoma