Sebastian D. Fugmann

Sebastian D. Fugmann ,Ph.D.
Institution: Chang Gung University
Department: Biomedical Sciences
Position: Professor
Address : 259 Wen-Hwa 1 st Road, Kweishan, Taoyuan, 33302, Taiwan
Tel: +886-3-211-8800 ext:3478
E-mail: sdfugmann@mail.cgu.edu.tw

Focus of Interest:

• V(D)J recombination
• Class switch recombination
• Somatic hypermutation
• B lymphocytes
• Antibody
• Evolution

Research Summary
All multicellular organisms are constantly challenged by a plethora of potentially lethal
pathogens and thus require protection to survive. These defense mechanisms can be
broadly divided into the "innate" and the "adaptive" immune systems. The former relies
on the recognition of conserved pathogen associated molecular patterns where as the
latter utilizes randomly generated antigen receptors, immunoglobulins (Igs) and T cell
receptors (TCRs), without pre-defined specificities. The central theme of my laboratory is
to understand the molecular mechanisms of programmed gene rearrangements and
mutagenesis that generate the diverse antigen receptor repertoires essential for adaptive
immunity.

Employment Records:
1994 Predoctoral Fellowship, Deutsche Forschungsgemeinschaft (DFG), Graduiertenkolleg fuer Biomolekulare Medizin, University of Ulm, Germany 2001 Postdoctoral Fellowship, Irvington Institute for Immunological Research, USA
2004 - 2013 Investigator, Laboratory of Molecular Biology and Immunology, National Institute on Aging / NIH, Baltimore, USA

Education:
1994 - 1998 PhD, Human Biology, University of Ulm, Germany
1998 - 2004 Postdoc, Section of Immunobiology, HHMI / Yale School of Medicine, New Haven, USA

Selected Publications:
1. Kothapalli, N.K., Fugmann, S.D. (2011) Targeting of AID-mediated sequence diversification to immunoglobulin genes. Curr. Opin. Immunol. 23:184-9.
2. Kothapalli, N.R., Collura, K.M., Norton, D.D., Fugmann, S.D. (2011) Separation of mutational and transcriptional enhancers in Ig genes. J. Immunol. 187:3247-55.
3. Kothapalli, N., Norton, D.D., Fugmann, S.D. (2008) Cutting Edge: A cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. J. Immunol. 180:2019-23.
4. Fugmann, S.D., Messier, C., Novack, L.A., Cameron, R.A., Rast, J.P. (2005) An ancient evolutionary origin of the RAG1/2 gene locus. Proc. Natl Acad. Sci. USA 103:3728-33.

Honor and Awards:

• 1994 Predoctoral Fellowship, Deutsche Forschungsgemeinschaft (DFG), Graduiertenkolleg fuer Biomolekulare Medizin, University of Ulm, Germany
• 2001 Postdoctoral Fellowship, Irvington Institute for Immunological Research, USA

Resource:

Mouse strains: none
Cell lines: DT40, 293T, Ramos
Special technology: none