Expertise at Chang Gung System

Ming-Ling Chang , M.D.
Institution: Linkou Chang Gung Memorial Hospital / Chang Gung Uiversity
Position: Physician/ Professor
Department: Hepatology and Gastroenterology
Address: No. 5, Fu-Shing Street, Kueishan, Taoyuan 333, Taiwan.
Tel: +886-3-3281200 Fax: +886-3-3285056
E-mail: mlchang8210@gmail.com

Focus of Interest:
  • Basic and clinical researches of chronic hepatitis B, chronic heoatitis C and fatty liver diseases

Fulltime Employment:
  • Professor of Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan
  • Associate Professor of Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan
  • Associate Professor of Department of Medicine, Chang Gung University, Taoyuan, Taiwan

Education:
Taipei Medical School, Department of Medicine.

Honor and Awards:
Young investigator award
  1. For the abstract of Fibrosing steatohepatitis in the conditional liver-specific HCV core transgenics in 1st congress, ASPR, 2005 (Assessed by the reviewers as the best in the presentation field of Hepatology.)
  2. For the Abstract of Hepatic steatosis is the sequel of oxidative stress elicited by HCV core protein: studies in vitro and in a conditionally transgenic mouse line (Asia Pacific Association for the Study of Liver, 2006)
  3. For the abstract of Hepatic inflammation mediated by hepatitis C virus core protein: studies in conditionally transgenic mice (Asia Pacific Association for the Study of Liver, 2008)

Selected Publications:

1. Chang ML,Chen JC, Alonso CR, Kornblihtt AR, Bissell DM. Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci U S A. 2004Dec 28; 101 (52): 18093-8
2. Chang ML, Chien RN, Yeh CT, Liaw YF. Virus and transaminase levels determine the emergence of drug resistance during long-term lamivudine therapy in chronic hepatitis B. J Hepatol. 2005 Jul;43(1):72-7.
3. Chang ML*, Yeh CT, Chen JC, Huang CC, Sheen IS, Lin WP, Tai DI, Chang MY, Chiu CT, Lin DY, Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis. BMC Genomics 2008 Feb 29;9(1):109
4. Chang ML*, Chen JC, Yeh CT, Chang MY, Liang CK, Chiu CT, Lin DY, Liaw YF. Gene Gun Bombardment of DNA-Coated Gold Particles is a Potential Alternative to Hydrodynamic-Based Transfection for Delivering Genes into Superficial Hepatocytes. Hum gene ther, 2008. 19(4): 391-5

5. Chang ML*, Yeh HC, Tsou YK, Wang CJ, Cheng HY, Sung CM, Ho YP, Chen TH, Yeh CT. HCV Core-Induced Nonobese Hepatic Steatosis Is Associated With Hypoadiponectinemia and Is Ameliorated by Adiponectin Administration. Obesity 2012 Feb 23. doi: 10.1038/oby.2012.45

Full Publication List

Board Certification/Professional Affiliations:
  1. Member of Taiwan Society of Internal Medicine
  2. Member of The Gastroenterological Society of Taiwan
  3. Member of The Gastroenterological Panendoscopical Society of Taiwan