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醫療團隊

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頭頸外科 回耳鼻喉部首頁 > 醫療團隊 > 頭頸外科
Head and Neck Surgery

張凱評醫師

現職：

長庚醫院林口總院 耳鼻喉部 副部主任

長庚大學醫學系 教授

學歷：

長庚大學醫學系醫學士 　　 　
長庚大學醫學博士 　　　
美國醫師資格ECFMG證書

 

 

經歷：

 
  • 國科會生命科學司感官醫學門(耳鼻喉、整形外科、乳房外科) 召集人
  • 長庚醫療體系林口總院醫學研究發展部　副部主任
  • 長庚醫院林口總院耳鼻喉部-頭頸外科 科主任
  • 美國德州休士頓安德生癌症中心 (M.D. Anderson Cancer Center) 臨床研究員、訪問學者
  • 台灣耳鼻喉頭頸外科醫學會監事
  • 台灣頭頸部腫瘤醫學會理事
  • 台灣顱底外科醫學會創始會員
  • 台灣臨床腫瘤專科醫師

主治專長：

  • 專長

頭頸部外科手術、 顱底腫瘤手術、唾液腺腫瘤手術、口腔癌手術、復發型鼻咽癌手術。

  • 治療案例數

顱底癌、鼻咽癌、鼻竇癌、唾液腺腫瘤、口腔癌等各式頭頸部腫瘤手術個案超過3000例。

衛教文章：

個人著作

論文著作

第一或指導作者SCI論文如下

1.  Schuyler SC, Chen HY, Chang KP*. Suppressing Anaphase-Promoting Complex/Cyclosome-Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles. Int J Mol Sci. 2024 Jun 7;25(12):6329. PMID: 38928036 (SCI, IF=4.9; Biochemistry & Molecular biology 66/313) (Correspondence Author)

2.  Tsai TY, Chiang PC, Yap WK, Huang Y, See A, Hung SY, Lu CY, Chang TJ, Kao HK, Chang KP*. Postoperative radiotherapy versus surgery alone in pN1 oral cavity cancer patients: a meta-analysis. Laryngoscope Investig Otolaryngology. 2024 May 15;9(3): e1260. PMID: 38751691(SCI, IF:1.9; OTORHINOLARYNGOLOGY 26/64) (Correspondence Author)

3.  Lee YC, Lee LY, Huang Y, Kao HK, Chang YT, Hung SY, Lu CY, Chang YS, Yu JS, Chang KP*. Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer. Laryngoscope Investig Otolaryngology. 2023 Oct 12;8(6):1547-1556. PMID: 38130271 (SCI, IF:1.9; OTORHINOLARYNGOLOGY 26/64) (Correspondence Author)

4.  Yen WC, Chang KP, Chen CY, Huang Y, Chen TW, Cheng HW, Yi JS, Cheng CC, Wu CC, Wang CI. MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma. Cancer Cell Int. 2023 Jun 12;23(1):112. PMID: 37309001 (SCI, IF:6.435; ONCOLOGY 63/245) (Equal contribution)

5.  Chu HW, Chang KP, Yen WC, Liu HP, Chan XY, Liu CR, Hung CM, Wu CC. Identification of salivary autoantibodies as biomarkers of oral cancer with immunoglobulin A enrichment combined with affinity mass spectrometry. Proteomics. 2023 Jan 10:e2200321. PMID: 36625099 (SCI, IF=5.393; Biochemical research methods 15/79) (Equal contribution)

6.  Yeh CC, Kao HK, Huang Y, Tsai TY, Young CK, Hung SY, Lu CY, Chang KP*. Discovering the Clinical and Prognostic Role of Pan-Immune-Inflammation Values on Oral Cavity Squamous Cell Carcinoma. Cancers (Basel). 2023 Jan 3;15(1):322. PMID: 36612318. (SCI, IF=6.639; ONCOLOGY 51/242) (Correspondence Author)

7.  Tsai TY, Kao HK, Huang Y, Yang CK, Hung SY, Chang YS, Yu JS, Chang KP*. Plasma Matrix Metalloproteinase-1 as a Prognostic Biomarker in Oral Cavity Squamous Cell Carcinoma. Cancer Manag. Res. 022 Dec 15;14: 3459-3468. PMID: 236545225. (SCI, IF=3.989; ONCOLOGY 198/340) (Correspondence Author)

8.  Lee PJ, Sui YH, Liu TT, Tsang NM, Huang CH, Lin TY, Chang KP*, Liu SC. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts. J Exp Clin Cancer Res. 2022 Aug 20;41(1):254. PMID: 35986369 (SCI, IF=12.658; ONCOLOGY 24/245) (Correspondence Author)

9.  Yen WC, Chang IY, Chang KP, Ouyang CN, Liu CR, Tsai TL, Zhang YC, Wang CI, Wang YH, Yu AL, Liu H, Wu CC, Chang YS, Yu JS, Yang CY. Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma. Front Oncol. 2022 Apr 4; 12:792297. PMID: 35444950. (SCI, IF=6.244; ONCOLOGY 62/242) (Equal contribution)

10.      Chen TW, Chang KP, Cheng CC, Chen CY, Hong SW, Sie ZL, Cheng HW, Yen WC, Huang Y, Liu SC, Wang CI. Characterization of Recurrent Relevant Genes Reveals a Novel Role of RPL36A in Radioresistant Oral Squamous Cell Carcinoma. Cancers (Basel). 2021 Nov 10;13(22):5623. PMID: 34830778 (SCI, IF=6.639; ONCOLOGY 51/242) (Equal contribution)

11.      Tsai TY, Huang Y, Iandelli A, Tai SF, Hung SY, Kao HK, Chang KP*. The role of postoperative radiotherapy in pN1 oral cavity cancer without extranodal extension. World J Surg Oncol. 2021 Sep 17;19(1):279. PMID: 34535149 (SCI, IF=2.754; SURGERY 86/212) (Correspondence Author)

12.      Tsai TY, Chou YC, Lu YA, Kang CJ, Huang SF, Liao CT, Chang KP*. The prognostic value of radiologic extranodal extension in nasopharyngeal carcinoma: Systematic review and meta-analysis. Oral Oncol. 2021 Sep 8; 122:105518. PMID: 34507205 (SCI, IF=5.337; ONCOLOGY 82/242) (Correspondence Author)

13.      Lorenzatti Hiles G, Chang KP, Bellile EL, Wang CI, Yen WC, Goudsmit CM, Briggs HL, Thomas TB, Peters L, Afsari MA, Pinatti LM, Morris AC, Jawad N, Carey TE, Walline HM.Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study. PLoS One. 2021 Apr 23;16(4): e0250530. PMID: 33891627(SCI, IF=3.240; MULTIDISCIPLINARY SCIENCES 26/73) (Equal contribution; Correspondence Author)

14.      Tsai TY, Iandelli A, Marchi F, Huang Y, Tai SF, Hung SY, Kao HK, Chang KP*. The Prognostic Value of Lymph Node Burden in Oral Cavity Cancer: Systematic Review and Meta-Analysis. Laryngoscope. 2022 Jan;132(1):88-95. PMID: 34089539 (SCI, IF=3.325; OTORHINOLARYNGOLOGY 9/44) (Correspondence Author)

15.      Tay ZY, Kao HK, Lien KH, Hung SY, Huang Y, Tsang NM, Chang KP*. The impact of preoperative glycated hemoglobin levels on outcomes in oral squamous cell carcinoma. Oral Dis. 2020 Oct; 26(7):1449-1458. PMID: 32426892 (SCI, IF=3.511; DENTISTRY, ORAL SURGERY & MEDICINE 23/91) (Correspondence Author)

16.      Huang Y, Lin C, Kao HK, Hung SY, Ko HJ, Huang YC, Chang YL, Chang KP*. Digital Image Analysis of CD8+ and CD3+ Tumor-Infiltrating Lymphocytes in Tongue Squamous Cell Carcinoma. Cancer Manag Res. 2020;12: 8275-8285. PMID: 32982423(SCI, IF=3.989; ONCOLOGY 128/242) (Correspondence Author)

17.      Yang CY, Liu CR, Chang IY, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL, Liu H, Tseng CP, Chang YS, Wu CC, Chang KP*. Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts. Cancers (Basel). 2020 Jun 29; 12(7):1726. PMID: 32610557. (SCI, IF=6.639; ONCOLOGY 51/242) (Correspondence Author)

18.      Yang WF, Qin N, Song X, Jiang C, Li T, Ji P, Li Y, Ding D, Wang C, Dai J, Jin G, Chen TW, Chang YS, Ouyang DQ, Liao GQ, Hu Z, Su YX, Ma H, Chang KP*. Genomic Signature of Mismatch Repair Deficiency in Areca Nut-Related Oral Cancer. J Dent Res. 2020 Oct; 99(11): 1252-1261. PMID: 32527169. (SCI, IF=6.116; DENTISTRY, ORAL SURGERY & MEDICINE 5/91) (Correspondence Author)

19.      Lee YC, Lee LY, Tsang NM, Hsu CL, Hsin LJ, Kuo TT, Chang KP*. Prognostic Significance of Granuloma and Amyloid Deposition in Nasopharyngeal Carcinoma. Head Neck Pathol. 2020 Jun 19. PMID: 32562216. (SCI, IF=3.2; PATHOLOGY 28/90) (Correspondence Author)

20.      Tsai YT, Chen WC, Chien CY, Hsu CM, Lee YC, Tsai MS, Lin MH, Lai CH, Chang KP*. Treatment patterns and survival outcomes of advanced hypopharyngeal squamous cell carcinoma. World J Surg Oncol. 2020; 18(1):82. PMID: 32357934. (SCI, IF=2.754; SURGERY 86/212) (Correspondence Author)

21.      Lien KH, Padua PFC, Tay ZY, Kao HK, Hung SY, Huang Y, Tsang NM, Chang KP*. Influence of Hyperglycemia on Treatment Outcomes of Oral Cavity Squamous Cell Carcinoma. J Oral Maxillofac Surg. 2020; 78(6): 935-942. (Correspondence Author)

22.      Tay ZY, Padua PFC, Tai SF, Huang YL, Hsu CL, Tsang NM, Chang KP*. Long-term treatment and survival outcome of salivary adenoid cystic carcinoma. Int J Head Neck Science. 2019; 3(4): 208-218. (Correspondence Author)

23.      Renda L, Tsai TY, Huang JJ, Ito R, Hsieh WC, Kao HK, Hung SY, Huang Y, Huang YC, Chang YL, Cheng MH, Chang KP*. A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy. Laryngoscope. 2020 Jan; 130(1):101-107. PMID: 30786034. (SCI, IF=3.325; OTORHINOLARYNGOLOGY 9/44) (Correspondence Author)

24.      Chi LM, Hsiao YC, Chien KY, Chen SF, Chuang YN, Lin SY, Wang WS, Chang IY, Yang C, Chu LJ, Chiang WF, Chien CY, Chang YS, Chang KP*, Yu JS. Assessment of candidate biomarkers in paired saliva and plasma samples from oral cancer patients by targeted mass spectrometry. J Proteomics. 2020; 211: 103571. PMID: 31689561. (SCI, IF=4.044; BIOCHEMICAL RESEARCH METHODS 21/77) (Correspondence Author)

25.      Chu HW, Chang KP, Hsu CW, Chang IY, Liu HP, Chen YT, Wu CC. Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Mol Cell Proteomics. 2019; 18(9):1796-1806. (SCI, IF=5.911; BIOCHEMICAL RESEARCH METHODS 8/77) (Equal contribution)

26.      Hsu CW, Chang KP, Huang Y, Liu HP, Hsueh PC, Gu PW, Yen WC, Wu CC. Proteomic profiling of paired interstitial fluids reveals dysregulated pathways and salivary NID1 as a biomarker of oral cavity squamous cell carcinoma. Mol Cell Proteomics. 2019; 18(10):1939-1949. (SCI, IF=5.911; BIOCHEMICAL RESEARCH METHODS 8/77) (Equal contribution)

27.      Wang CI, Kao HK, Chen TW, Huang Y, Cheng HW, Yi JS, Hung SY, Wu CS, Lee YS, Chang KP*. Characterization of copy number variations in oral cavity squamous cell carcinoma reveals a novel role for MLLT3 in cell invasiveness. Oncologist. 2019; 24(12): e1388-e1400. PMID: 31273053. (SCI, IF=5.025; ONCOLOGY 63/244) (Correspondence Author)

28.      Tsai CN, Tsai CL, Yi JS, Kao HK, Huang YL, Wang CI, Lee YS, Chang KP*. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019 Mar 26; 9(1): 5197. (SCI, IF=4.122; Multidisciplinary Sciences 12/64) (Correspondence Author)

29.      Kao HK, Löfstrand J, Loh CY, Lao WW, Yi JS, Chang YL, Chang KP*. Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma. Sci Rep. 2018; 8(1):13081. (SCI, IF=4.122; Multidisciplinary Sciences 12/64) (Correspondence Author)

30.      Yang CY, Yeh YM, Yu HY, Chin CY, Hsu CW, Liu H, Huang PJ, Hu SN, Liao CT, Chang KP*, Chang YL. Oral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging. Front Microbiol. 2018; 9: 862. (SCI, IF=5.640; MICROBIOLOGY 28/137) (Correspondence Author)

31.      Wang CI, Yu CJ, Huang Y, Yi JS, Cheng HW, Kao HK, Lao WW, Chang KP*. Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer. Head Neck. 2018 Mar 15. doi: 10.1002/hed.25145. (SCI, IF=3.3; Otorhinolaryngology 1/42) (Correspondence Author)

32.      Eltohami YI, Kao HK, Lao WW, Huang Y, Abdelrahman M, Liao CT, Yen TC, Chang KP*. The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2018 Jan 1:194599817751678. doi: 10.1177/0194599817751678. (SCI, IF=2.021; Otorhinolaryngology 11/43) (Correspondence Author) 

33.      Ito R, Huang JJ, Hsieh WC, Kao HK, Lao WW, Fang KH, Huang Y, Chang YL, Cheng MH, Chang KP*. Identification of predisposing factors for osteonecrosis of the jaw after marginal mandibulectomy in the surgical management of oral squamous cell carcinoma. J Surg Oncol. 2018; 117(4): 781-787. doi: 10.1002/jso.24913 (SCI, IF=2.993; Surgery 43/197) (Correspondence Author)

34.      Liao YC, Adel M, Lee LY, Chang KP*. Branchial cleft cyst: An unusual site for the cervical metastasis of nasopharyngeal carcinoma. Auris, nasus, larynx. 2018; 45(2):328-331. (Correspondence Author)

35.      Lee YC, Lee TJ, Tsang NM, Huang Y, Hsu CL, Hsin LJ, Lee YH, Chang KP*. Cavernous sinus involvement is not a risk factor for the primary tumor site treatment outcome of Sinonasal adenoid cystic carcinoma. J Otolaryngol Head Neck Surg. 2018 Feb 5; 47(1):12. doi: 10.1186/s40463-018-0257-z. (Correspondence Author)

36.      Löfstrand J, Chang KP, Lin JA, Loh CYY, Chou HY, Kao HK. Third Repeat Microvascular Reconstruction in Head and Neck Cancer Patients Aged 65 Years and Older: A Longitudinal and Sequential Analysis. Sci Rep. 2017 Nov 16; 7(1):15740. doi: 10.1038/s41598-017-15948-8. PubMed PMID: 29146958. (SCI, IF:=4.259; Multidisciplinary Sciences 10/64) (Equal Contribution)

37.      Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IY, Yeh YM, Chen CD, Li HP, Luo JD, Tan BC, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP*, Chang YS. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nat Commun. 2017 Sep 6; 8(1):465. doi: 10.1038/s41467-017-00493-9. PubMed PMID: 28878238; PubMed Central PMCID: PMC5587710. (SCI, IF:=12.124; Multidisciplinary Sciences 3/64) (Correspondence Author)

38.      Kuo IC, Kao HK, Huang Y, Wang CI, Yi JS, Liang Y, Liao CT, Wu CC, Chang KP*. Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells. Oncotarget. 2017; Jun 27. doi: 10.18632/oncotarget.18680. (SCI, IF=5.168; Oncology 44/217) (Correspondence Author)

39.      Liao YC, Adel M, Lee LY, Chang KP*. Branchial cleft cyst: An unusual site for the cervical metastasis of nasopharyngeal carcinoma. Auris Nasus Larynx.2017; Apr 13. doi: 10.1016/j.anl.2017.03.021. (SCI, IF=1.128; Otorhinolaryngology 27/42) (Correspondence Author)

40.      Kao HK, Abdelrahman M, Huang Y, Tsai CH, Barrera MJ, Tsang NM, Couves AJ, Cheng MH, Chang KP*. Multiple concomitant oral cavity cancers: Incidence, management, and outcomes. J Surg Oncol. 2017; Mar 20. doi: 10.1002/jso.24600. (SCI, IF=2.993; Surgery 43/197) (Correspondence Author)

41.      Chang KP, Wang CI, Pickering CR, Huang Y, Tsai CN, Tsang NM, Kao HK, Cheng MH, Myers JN. Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma. Head Neck. 2017; Feb 23. doi: 10.1002/hed.24728. (SCI, IF=3.3; Otorhinolaryngology 1/42)

42.      Chan SC, Chang KP*, Fang YD, Tsang NM, Ng SH, Hsu CL, Liao CT, Yen TC. Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma. Laryngoscope. 2017; l 127(1): E22-E28. (SCI, IF=2.272; Otorhinolaryngology 9/43) (Correspondence Author)

43.      Offodile AC 2nd, Chang KP, Chen HH, Loesch E, Hung SY, Kao HK. Feasibility and Outcomes of the Third or More Episodes of Sequential Microvascular Reconstruction for Recurrent or Second Primary Oral Cancer. Ann Surg Oncol. 2016; 23(11): 3765-72. (SCI, IF=3.655; Surgery 16/199) (Equal contribution)

44.      Liao CT, Wen YW, Lee SR, Liu TW, Tsai ST, Tsai MH, Lin JC, Lou PJ, Chu PY, Leu YS, Tsai KY, Terng SD, Chen TM, Wang CH, Chien CY, Chen WC, Lee LY, Lin CY, Wang HM, Ng SH, Lin CH, Fang TJ, Huang SF, Kang CJ, Chang KP, Yang LY, Yen TC; Taiwan Oral Cancer Advisory Group. Clinical Outcomes of Taiwanese Patients with cT4 Oral Cavity Squamous Cell Carcinoma: Toward the Identification of the Optimal Initial Treatment Approach for cT4b Patients. Ann Surg Oncol. 2016; November; doi:10.1245/s10434-016-5629-x. (SCI, IF=3.655; Surgery 16/199)

45.      Wu CS, Chang KP*, OuYang CN, Kao HK, Hsueh C, Chen LC, Cheng HY, Liang Y, Liou W, Liang CL, Chang YS. ASC contributes to metastasis of oral cavity squamous cell carcinoma. Oncotarget. 2016; Jun; 2; 7(31):50074-50085. (SCI, IF=5.168; Oncology 44/217) (Correspondence Author)

46.      Adel M, Chang KP*. Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: a case report. J Otolaryngol Head Neck Surg. 2016; April 27; 45:27. (SCI, IF=1.585; Otorhinolaryngology 20/43) (Correspondence Author)

47.      Gleber-Netto FO, Yakob M, Li F, Feng Z, Dai J, Kao HK, Chang YL, Chang KP*, Wong DT. Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population. Clin Cancer Res. 2016; 22(13): 3340-7. (SCI, IF=8.738; Oncology 12/211) (MOST102-2628-B-182A-012- MY3) (Correspondence Author)

48.      Adel M, Kao HK, Hsu CL, Huang JJ, Lee LY, Huang YL, Browne T, Tsang NM, Chang YL, Chang KP*. Evaluation of Lymphatic and Vascular Invasion in Relation to Clinicopathological Factors and Treatment Outcome in Oral Cavity Squamous Cell Carcinoma. Medicine (Baltimore). 2015; October; 94(43): e1510. (SCI, IF=1.206; Medicine, general & internal 77/151)

49.      Wu CC, Chu HW, Hsu CW, Chang KP*, Liu HP*. Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma. Proteomics. 2015; October; 15(19): 3394-404. (IF=4.079; Biochemical research methods 13/77) (MOST102-2628-B-182-015- MY3) (Correspondence Author)

50.      Chang KP, Lin SJ, Liu SC, Yi JS, Chien KY, Chi LM, Kao HK, Liang Y, Lin YT, Chang YS, Yu JS*. Low-molecular-mass secretome profiling identifies HMGA2 and MIF as prognostic biomarkers for oral cavity squamous cell carcinomas. Sci Rep. 2015; July 3; 5: 11689. (SCI, IF:=4.259; Multidisciplinary Sciences 10/64) (MOST102-2628-B-182-015- MY3)

51.      Fanzio P, Chang KP, Chen HH, Hsu HH, Vijay G, Solari M, Kao HK*. Plate exposure after anterolateral thigh free flap reconstruction in head and neck patients with composite mandibular defects. Ann Surg Oncol. 2015; September; 22(9): 3055-60. (SCI, IF=3.655; Surgery 16/199) (Equal contribution)

52.      Hsu CW, Yu JS, Peng PH, Liu SC; Chang YS, Chang KP*, Wu CC*. Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma. J Proteome Res. 2014; November 7; 13(11): 4796-807. (SCI, IF=4.173; Biochemical research methods 12/77) (NSC102-2628-B-182-015-MY3) (Correspondence Author)

53.      Fang KH, Kao HK, Chi LM, Liang Y, Liu SC, Hseuh C, Liao CT, Yen CT, Yu JS, Chang KP*. Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. Laryngoscope. 2014; September; 124(9):E354-60. (SCI, IF=2.272; Otorhinolaryngology 9/43) (NSC102-2628-B-182-015-MY3) (Correspondence Author)

54.      Lin CK, Hsu HH, Lee LY, Chang KP*. Nasopharyngeal hemartoma. J Taiwan Otolaryngol Head Neck Surg. 2013; 48:319-324. (Correspondence Author)

55.      Hsin LJ, Kao HK, Chen IH, Tsang NM, Hsu CL, Liu SC, Chang YS, Chang KP*. Serum CXCL9 levels are associated with tumor progression and treatment outcome in patients with nasopharyngeal carcinoma. PLoS One. 2013; November; 8(11): e80052. (SCI, IF=3.057; Multidisciplinary Sciences 11/63) (Correspondence Author)

56.      Chang KP, Wang CA, Kao HK, Ying L, Liu SC, Huang LL, Hseuh C, Hsieh YJ, Chien KY, Chang YS, Yu JS, Chi LM*. Overexpression of caldesmon is associated with nodal metastasis and poorer prognosis in oral cavity squamous cell carcinomas. Cancer. 2013; November 15; 119(22): 4003-11. (SCI, IF=5.649; Oncology 26/213) (NSC99-2314-B-182A-051-MY3)

56.      Chang KP, Wu CC, Fang KH, Tsai CY, Chang YL, Liu SC, Kao HK*. Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity squamous cell carcinoma. Oral Oncol. 2013; August; 49(8): 802-807. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89) (NSC99-2314-B-182A-051-MY3)

58.      Chang KP, Kao HK, Wu CC, Fang KH, Chang YL, Huang YC, Liu SC, Cheng MH*. Pretreatment of interleukin-6 serum levels are associated with patient survival for oral cavity squamous cell carcinoma. Otolaryngol Head Neck Surg. 2013; May; 148(5): 786-791. (SCI, IF=2.021; Otorhinolaryngology 11/43) (NSC99-2314-B-182A-051-MY3)

59.      Tam YY, Chen CK, Chang KP*. Sphenoethmoidal inverted papilloma causing ipsilateral abducens nerve palsy. Otolaryngol Head Neck Surg. 2013; April; 148(4):703-4. (SCI, IF=2.021; Otorhinolaryngology 11/43) (Correspondence Author)

60.      Kao HK, Chen WF, Chen CH, Shyu VB, Cheng MH, Chang KP*. The Roles of Albumin Levels in Head and Neck Cancer Patients with Liver Cirrhosis Undergoing Tumor Ablation and Microsurgical Free Tissue Transfer. PLoS One. 2012; December; 7(12): e52678. (SCI, IF=3.057; Multidisciplinary Sciences 11/63) (Correspondence Author)

61.      Wu CS, Chang KP*, Chen LC, Chen CC, Liang Y, Hseuh C, Chang YS*. Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Oral Squamous Cell Carcinoma. Oral Oncol. 2012; June; 48(6): 516-22.(SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89) (NSC99-2314-B-182A-051-MY3) (Equal Contribution as First and Correspondence Author)

62.      Du CJ, Fu CH, Ng SH, Chang KP*. Tuberculous arthritis of the temporomandibular joint. Arch Otolaryngol Head Neck Surg. 2012; February; 138(2):197-198. (SCI, IF=2.327; Otorhinolaryngology 6/43) (Correspondence Author)

63.      Hsu HH, Lee LY, Chang KP*. Pathology Quiz: Osteolipoma of the buccal space. Arch Otolaryngol Head Neck Surg. 2012; January; 138(1):97-98. (SCI, IF=2.327; Otorhinolaryngology 6/43) (Correspondence Author)

64.      Chang KP*, Tsang NM, Liao CT, Hsu CL, Chang MJ, Lo CW, Chang SC, Ng SH, Wang HM, Yen TC. Prognostic significant of 18F-FDG PET parameters and plasma EBV DNA load in patients with nasopharyngeal carcinoma. J Nucl Med. 2012; January; 53(1): 21-28. (SCI, IF=5.849; Radiology, Nuclear Medicine & Medical Imaging 3/124) (NSC99-2314-B-182A-051-MY3) (Correspondence Author)

65.      Chang KP, Yu JS, Chien KY, Lee CW, Liang Y, Liao CT, Yen TC, Lee LY, Huang LL, Liu SC, Chang YS, Chi LM*. Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J Proteome Res. 2011; November; 10(11):4935-47. (SCI, IF=4.173; Biochemical research methods 12/77) (NSC99-2314-B-182A-051-MY3)

66.      Yu CJ, Chang KP, Chang YJ, Hsu CW, Liang Y, Yu JS, Chi LM, Chang YS, Wu CC*. Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J Proteome Res. 2011; August; 10(8):3778-88. (SCI, IF=4.173; Biochemical research methods 12/77) (NSC99-2314-B-182A-051-MY3) (Equal contribution)

67.      Chang KP, Chang YT, Wu CC, Liu YL, Chen MC, Tsang NM, Hsu CL, Chang YS, Yu JS*. Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. Head Neck. 2011; June; 33(6): 886-697. (SCI, IF=2.276; Otorhinolaryngology 11/42) (NSC96-2314-B-182A-109-MY3)

68.      Chang KP, Chang YT, Liao CT, Yen TC, Chen IH, Chang YL, Liu YL, Chang YS, Wu CC*, Yu JS*. Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling. Clin Chim Acta. 2011; May; 412(11-12): 184-191. (SCI, IF=2.799; Medical Laboratory Technology 7/30) (NSC99-2314-B-182A-051-MY3)

69.      Kao HK, Guo LF, Cheng MH, Chen IH, Liao CT, Fang KH, Yu JS, Chang KP*. Predicting Postoperative Morbidity and Mortality by MELD Score for Patients with Head and Neck Cancer and Liver Cirrhosis. Head Neck. 2011; April; 33(4): 529-534. (SCI, IF=2.76 ; Otorhinolaryngology 3/43) (Correspondence Author)

70.      hang KP, Kao HK, Yen TC, Chang YL, Liang Y, Liu SC, Lee LY, Chang YL, Kang CJ, Chen IH,  Liao CT*, Yu JS*. Overexpression of macrophage inflammatory protein-3alpha in oral cavity squamous cell carcinoma is associated with nodal metastasis. Oral Oncol. 2011; February; 47(2): 108-113. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89) (NSC99-2314-B-182A-051-MY3)

71.      Chang KP, Wu CC, Chen HC, Chen SJ, Peng PH, Tsang NM, Lee LY, Liu SC, Liang Y, Lee YS, Hao SP, Chang YS, Yu JS*. Identification of Candidate Nasopharyngeal Carcinoma Serum Biomarkers by Cancer Cell Secretome and Tissue Transcriptome Analysis: Potential Usage of Cystatin A for Predicting Nodal Stage and Poor Prognosis. Proteomics. 2010; July; 10(14): 2644-2660. (SCI, IF=4.079; Biochemical research methods 13/77) (NSC96-2314-B-182A-109-MY3)

72.      Chang KP, Kao HK, Liang Y, Cheng MH, Chang YL, Liu SC, Lin YC, Ko TY, Lee YS, Tsai CL, Wang TH, Hao SP*, Tsai CN*. Overexpression of activin A in oral squamous cell carcinoma:  association with poor prognosis and tumor progression. Ann Surg Oncol 2010; July; 17(7):1945-56. (SCI, IF=3.655; Surgery 16/199) (NSC96-2314–B -182A-109-MY3)

73.      am YY, Li LY, Chang KP*.Lymphoepithelial Carcinoma of the Nasolacrimal Duct.  Otolaryngol Head Neck Surg. 2010; January; 142(1): 144-145. (SCI, IF=2.021; Otorhinolaryngology 11/43) (Correspondence Author)

74.      Fang KH, Kao HK, Cheng MH, Chang YL, Tsang NM, Huang YC, Lee LY, Yu JS, Hao SP, Chang KP*. Histological differentiation of primary oral squamous cell carcinomas in betel quid prevalent area. Otolaryngol Head Neck Surg. 2009; December; 141(6): 743-749. (SCI, IF=2.021; Otorhinolaryngology 11/43) (Correspondence Author)

75.      Hsin LJ, Fang TJ, Chang KP*, Fang KH, Tsang NM, Chen YL, Jung SM, Yeh AR, Hao SP. Transoral Endoscopic CO2 Laser Microsurgery for Early Laryngeal Cancers. Chang Gung Med J. 2009; October; 32(5): 517-25. (Correspondence Author)

76.      Chang KP, Hao SP, Chang JH, Wu CC, Tsang NM, Lee YS, Hsu CL, Ueng SH, Liau SC, Liu YL, Wei PC, Liang Y, Chang YS, Yu JS*. Macrophage Inflammatory Protein-3α Is a Novel Serum Marker for Nasopharyngeal Carcinoma Detection and Prediction of Treatment Outcomes. Clin Cancer Res. 2008; November; 14(21): 6979-6987. (SCI, IF=8.738; Oncology 12/211) (NSC94-2314-B-182A-188 & NSC96-2314-B-182A-109-MY3)

77.      Fu CH, Chang KP*, Ueng SH, Wu CC, Hao SP. Primary Thyroid-Like Papillary Adenocarcinoma of the Nasopharynx. Auris Nasus Larynx. 2008; December; 35(4): 579-582. (SCI, IF=1.038;Otorhinolaryngology 30/43) (Correspondence Author)

78.      Chang KP, Hsu CL, Chang YL, Tsang NM, Chen CK, Lee TJ, Huang CG, Tsao KC, Chang YS, Yu JS, Hao SP*. Complementary Serum Test of Antibodies to Epstein-Barr Virus Nuclear Antigen-1 and Early Antigen: A Possible Alternative for Primary Screening of Nasopharyngeal Carcinoma. Oral Oncol. 2008; 44:784-792. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89)  (NSC92-2314-B-182A-207)

79.      Fu CH, Ueng SH, Shao PY, Chang KP*. Pathology Quiz: Solitary fibrous tumor (SFT) of the submandibular gland. Arch Otolaryngol Head Neck Surg. 2008; February; 134(2): 214-216 (SCI, IF=2.327; Otorhinolaryngology 6/43) (Correspondence Author)

80.      Chang KP, Hao SP, Tsang NM, Chang YL, Cheng MH, Liu CT, Lee YS, Tsai CL, Lee TJ, Wang TH, Tsai CN*. Gene Expression and Promoter Polymorphisms of DNMT3B in Nasopharyngeal Carcinomas for Taiwanese people: A Case-Control Study. Oncol Rep. 2008; January; 19: 217-222 (SCI, IF=2.486; Oncology 130/211) (NSC 95-2314-B-182A -105)

81.      Chang KP, Hao SP, Chiu CT, Cheng MH, Chang YL, Lee YS, Wang TH, Tsai CN*. Promoter Polymorphisms of DNMT3B and the Risk of Head and Neck Squamous Cell Carcinoma in Taiwan: A Case-Control Study. Oral Oncol. 2007; April; 43(4): 345-351. (SCI, IF=4.286; Dentistry, oral surgery & medicine 3/89)

82.      Chen MF, Ueng SH, Jung SM, Chen YL, Chang KP*. A Type II First Branchial Cleft Cyst Masquerading as an Infected Parotid Warthin’s Tumor. Chang Gung Med J. 2006; August; 29(4):434-8. (Correspondence Author)

83.      Cheng TY, Ueng SH, Chen YL, Chen TM, Chang KP*. Oncocytic Schineiderian Papilloma Found in a Recurrent Chronic Paranasal Sinusitis - a Case Report. Chang Gung Med J. 2006; June;  29(3):336-41. (Correspondence Author)

84.      Chang KP, Hao SP, Lin SY, Ueng SH, Pai PC, Tsao KC, Tseng CK, Hseuh C, Hsiesh MS, Yu JS, Tsang NM. The 30-bp Deletion of EBV LMP-1 Gene Has No Effect in Nasopharyngeal Carcinoma. Laryngoscope. 2006; April; 116(4): 541-546. (SCI, IF=2.272; Otorhinolaryngology 9/43)(NSC92-2314-B- 182A-207)

85.      Chang KP, Lee LY, Yeh AR, Dai TS, Hao SP. Endoscopic CO2 Laser Surgery for an Atypical Carcinoid Tumor of the Epiglottis Masquerading as a Supraglottic Cyst. Head Neck. 2005; November; 27(11):1004-1007. (SCI, IF=2.276; Otorhinolaryngology 11/42)

86.      Chang KP, Chen YL, Hao SP, Chen SM. Echo-guided closed drainage for abscesses of the head and neck. Otolaryngol Head Neck Surg. 2005; January; 132(1):119-124. (SCI, IF=2.021; Otorhinolaryngology 11/43)

87.      Chang KP, Hao SP, Tsang NM, Ueng SH. Salvage surgery for locally recurrent nasopharyngeal carcinomas -A 10-year experience. Otolaryngol Head Neck Surg. 2004; October; 131(4): 497-502. (SCI, IF=2.76 ; Otorhinolaryngology 3/43)

88.      Chang KP, Huang TS, Hsu HC, Su SY. Cochlear implantation in a post-irradiated patient for nasopharyngeal carcinoma. Cochlear Implants International. 2004: S1(5): 227

89.      Chang KP, Hao SP, Lin SY, Tsao KC, Kuo Tt, Tsai MS, Tsang NM. A lack of association of p53 mutations and recurrent nasopharyngeal carcinoma refractory to radiotherapy. Laryngoscope. 2002; November; 112: 2015-2019. (SCI, IF=2.272; Otorhinolaryngology 9/43) (NSC 87-2314-B182A-003)

90.      Chang KP, Li HY. Treatment results of snoring and sleep apnea in children. J Taiwan Otolaryngol Head Neck Surg. 2001; March; 36(3): 148-154.

91.      Chang KP, Tsang NM, Chen CY, Su JL, Hao SP. Endoscopic management of skull base osteoradionecrosis. Laryngoscope. 2000; July; 110: 1162-1165. (SCI, IF=2.272; Otorhinolaryngology 9/43)

92.      Chang KP, Huang CC, Li HY. Embedded retropharyngeal foreign body- report of two cases. J Taiwan Otolaryngol Head Neck Surg. 2000; January; 35(1): 71-74.