The Karnofsky performance index and WHO (Zubrod) scale are included here because they are commonly used as proxy measures for quality of life. Because they measure only one dimension of the construct, they would not be considered quality-of-life measures by todayˇ¦s standards. However, given their historical relevance and current high frequency of usage as proxy measures, we have included them here.
This scale is used to measure performance of which the patient is capable. For example, a patient in the hospital for metabolic studies may be fully capable of performing normal activities, but will remain in bed through his or her own choice. Such a patient should be coded 0, ˇ§normal.ˇ¨
0 Normal activity
1 Symptoms, but nearly fully ambulatory
2 Some bed time, but needs to be in bed < 50% of normal daytime
3 Needs to be in bed > 50% of normal daytime
4 Unable to get out of bed
From Zubrod CG, Schneiderman M, Frei E III, et al: Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11:7ˇV33, 1960.