Figure 4.
Previous English Language Studies Examining Progression and Regression of Cervical Dysplasia

E.J. Mayeaux, Jr., M.D.
Associate Professor of Family Medicine
Clinical Associate Professor of Obstetrics and Gynecology
Louisiana State University Medical Center Shreveport, Louisiana


% % % % Length of Starting Study (n) Prog. Reg. Recurr* Persist Follow-up Lesion Note ---------------------------------------------------------------------------------------------------- Peckham (54) 242 16% 51% ~~~ 33% 1-4 years dysplasia** Bx as standard Figge et al. (55) 46 9% 26% ~~~ 65% 1 year dysplasia** Used Vaginal smears Koss et al. (56) 26 46% 39% ~~~ 15% 3 years + CIN Bx as standard Koss et al. (56) 67 13% 25% ~~~ 61% 4 years + CIS Bx as standard Stern et al. (57) 176 1% 32% 33% 62% 2 years dysplasia** Pap & Bx as standard Fox (17) 111 60% 31% ~~~ 9% 1-11 years CIN 1-2 Pap as standard Johnson et al. (58) 141 2% 50% 21% 27% 1-9 years dysplasia** Bx as standard Hall et al. (59) 97 13% 62% ~~~ 24% 1-14 years CIN1 Pap as standard Hall et al. (59) 85 18% 33% ~~~ 49% 1-14 years CIN2 Pap as standard Hall et al. (59) 24 33% 19% ~~~ 48% 1-14 years CIN3 Pap as standard Sedlis et al. (13) 168 23% 42% ~~~ 35% 0.2-5 years dysplasia** Bx as standard Gad (60) 30 30% 30% ~~~ 12% 1-15years dysplasia** Patients with no tx Kinlen (61) 52 55% 32% ~~~ ~~~ 2 years dysplasia** Pap & Bx, no Tx MacGregor (62) 145 15% 65% ~~~ 20% 0.5-10 years dysplasia** Pap as standard Nasiell et al. (63) 894 35% 50% ~~~ 15% 6 years CIN2 Pap as standard Brown et al. (7) 86 2% 58% ~~~ 26% 0.5-1 year CIN1 Pap & Bx as standard Cotton et al. (16) 41 29% 71% ~~~ 0 3.75 years CIN 1-2 Pap & Bx, no Tx Nasiell et al. (64) 555 16% 62% ~~~ 22% 0.25-1 year CIN1 Pap as standard Campion et al. (15) 100 26% 11% 4% 67% 1.5-3 years CIN1 Pap & Bx as standard Carmichael (12) 235 1% 14% ~~~ 21% 1 year CIN 1-2 Bx - 29% loss to f/u Oortmarssen(65) ~~~ ~~~ 40-84%*** ~~~ ~~~ ~~~ dysplasia** Statistical Model ---------------------------------------------------------------------------------------------------- Average 22% 40% 19% 32%

* Dysplasia found after a lesion regressed to normal.

** Includes unspecified dysplasia or any level of dysplasia.

*** 84% regression for age <34 years, 40% regression for age >34 years.

~~~ Unknown, not recorded, or not applicable.


Controversies and Decision Making for Uterine Cervical Disease

Colposcopy Atlas Table of Contents

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