Figure 4.
Previous English Language Studies Examining Progression and Regression
of Cervical Dysplasia
E.J. Mayeaux, Jr., M.D.
Associate Professor of Family Medicine
Clinical Associate Professor of Obstetrics and Gynecology
Louisiana State University Medical Center Shreveport, Louisiana
% % % % Length of Starting
Study (n) Prog. Reg. Recurr* Persist Follow-up Lesion Note
----------------------------------------------------------------------------------------------------
Peckham (54) 242 16% 51% ~~~ 33% 1-4 years dysplasia** Bx as standard
Figge et al. (55) 46 9% 26% ~~~ 65% 1 year dysplasia** Used Vaginal smears
Koss et al. (56) 26 46% 39% ~~~ 15% 3 years + CIN Bx as standard
Koss et al. (56) 67 13% 25% ~~~ 61% 4 years + CIS Bx as standard
Stern et al. (57) 176 1% 32% 33% 62% 2 years dysplasia** Pap & Bx as standard
Fox (17) 111 60% 31% ~~~ 9% 1-11 years CIN 1-2 Pap as standard
Johnson et al. (58) 141 2% 50% 21% 27% 1-9 years dysplasia** Bx as standard
Hall et al. (59) 97 13% 62% ~~~ 24% 1-14 years CIN1 Pap as standard
Hall et al. (59) 85 18% 33% ~~~ 49% 1-14 years CIN2 Pap as standard
Hall et al. (59) 24 33% 19% ~~~ 48% 1-14 years CIN3 Pap as standard
Sedlis et al. (13) 168 23% 42% ~~~ 35% 0.2-5 years dysplasia** Bx as standard
Gad (60) 30 30% 30% ~~~ 12% 1-15years dysplasia** Patients with no tx
Kinlen (61) 52 55% 32% ~~~ ~~~ 2 years dysplasia** Pap & Bx, no Tx
MacGregor (62) 145 15% 65% ~~~ 20% 0.5-10 years dysplasia** Pap as standard
Nasiell et al. (63) 894 35% 50% ~~~ 15% 6 years CIN2 Pap as standard
Brown et al. (7) 86 2% 58% ~~~ 26% 0.5-1 year CIN1 Pap & Bx as standard
Cotton et al. (16) 41 29% 71% ~~~ 0 3.75 years CIN 1-2 Pap & Bx, no Tx
Nasiell et al. (64) 555 16% 62% ~~~ 22% 0.25-1 year CIN1 Pap as standard
Campion et al. (15) 100 26% 11% 4% 67% 1.5-3 years CIN1 Pap & Bx as standard
Carmichael (12) 235 1% 14% ~~~ 21% 1 year CIN 1-2 Bx - 29% loss to f/u
Oortmarssen(65) ~~~ ~~~ 40-84%*** ~~~ ~~~ ~~~ dysplasia** Statistical Model
----------------------------------------------------------------------------------------------------
Average 22% 40% 19% 32%
* Dysplasia found after a lesion regressed to normal.
** Includes unspecified dysplasia or any level of dysplasia.
*** 84% regression for age <34 years, 40% regression for age >34
years.
~~~ Unknown, not recorded, or not applicable.
Controversies
and Decision Making for Uterine Cervical Disease
Colposcopy
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