Figure 1.
Previous English Language Studies Examining the False Negative Rate
of Pap Smears for Screening the General Population for Cervical Dysplasia.
E.J. Mayeaux, Jr., M.D.
Associate Professor of Family Medicine
Clinical Associate Professor of Obstetrics and Gynecology
Louisiana State University Medical Center Shreveport, Louisiana
False Standard Sampling Reading
Study n Negative End Poin Error Error Year Note
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Prospective Studies
Richart 159 ~~~ f/u Pap 2.8% --- 1964 Eliminated Path error.
Selim et 168 22% f/u Biopsy ~~~ ~~~ 1973
Coppleso --- 20%-45% Statistics ~~~ ~~~ 1974 For CIN & CIS.
White et 442 16% f/u Biopsy ~~~ ~~~ 1976
Lozowski 153 5% f/u Pap ~~~ ~~~ 1982 Calculated from results.
Giles et 200 32% f/u Biopsy ~~~ ~~~ 1988
Soost et 1657 10.5% f/u Biopsy ~~~ ~~~ 1991 Calculated from results.
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Retrospective Studies (false negative Paps in patients with known disease)
Fritches 37 16.6% CIS & IC ~~~ ~~~ 1977
Jafari ( 307 11.7% ICC ~~~ ~~~ 1978
Berkowit 110 55.5% ICC ~~~ ~~~ 1979
Morell e 85 31% ICC ~~~ ~~~ 1982
Fetherst 26 50% ICC ~~~ ~~~ 1983
Gay et a 339 20% CIS & IC 62% 38% 1985
Attwood 74 30% ICC ~~~ ~~~ 1985
van der 555 29.7% CIN to I ~~~ 17.5% 1985
Bearman 264 37% ICC ~~~ ~~~ 1987
Mitchell 143 ~~~ ICC 48% 52% 1990
Pairwuti 4781 1.5% CIS & IC 38.6% 61.4% 1991
Kristens 376 30.9% ICC ~~~ 27.2% 1991
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Controversies
and Decision Making for Uterine Cervical Disease
Colposcopy
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