Figure 1.
Previous English Language Studies Examining the False Negative Rate of Pap Smears for Screening the General Population for Cervical Dysplasia.

E.J. Mayeaux, Jr., M.D.
Associate Professor of Family Medicine
Clinical Associate Professor of Obstetrics and Gynecology
Louisiana State University Medical Center Shreveport, Louisiana


False Standard Sampling Reading Study n Negative End Poin Error Error Year Note -------------------------------------------------------------------------------

Prospective Studies

Richart 159 ~~~ f/u Pap 2.8% --- 1964 Eliminated Path error. Selim et 168 22% f/u Biopsy ~~~ ~~~ 1973 Coppleso --- 20%-45% Statistics ~~~ ~~~ 1974 For CIN & CIS. White et 442 16% f/u Biopsy ~~~ ~~~ 1976 Lozowski 153 5% f/u Pap ~~~ ~~~ 1982 Calculated from results. Giles et 200 32% f/u Biopsy ~~~ ~~~ 1988 Soost et 1657 10.5% f/u Biopsy ~~~ ~~~ 1991 Calculated from results. -------------------------------------------------------------------------------

Retrospective Studies (false negative Paps in patients with known disease)

Fritches 37 16.6% CIS & IC ~~~ ~~~ 1977 Jafari ( 307 11.7% ICC ~~~ ~~~ 1978 Berkowit 110 55.5% ICC ~~~ ~~~ 1979 Morell e 85 31% ICC ~~~ ~~~ 1982 Fetherst 26 50% ICC ~~~ ~~~ 1983 Gay et a 339 20% CIS & IC 62% 38% 1985 Attwood 74 30% ICC ~~~ ~~~ 1985 van der 555 29.7% CIN to I ~~~ 17.5% 1985 Bearman 264 37% ICC ~~~ ~~~ 1987 Mitchell 143 ~~~ ICC 48% 52% 1990 Pairwuti 4781 1.5% CIS & IC 38.6% 61.4% 1991 Kristens 376 30.9% ICC ~~~ 27.2% 1991 -------------------------------------------------------------------------------


Controversies and Decision Making for Uterine Cervical Disease

Colposcopy Atlas Table of Contents

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