王逢興 研究員
簡歷 國立臺灣大學畜產學研究所博士 高雄長庚紀念醫院醫學研究部研究員 高雄長庚紀念醫院實驗動物照護暨使用委員會主席 高雄長庚紀念醫院研究計畫審核評估委員會委員 高雄長庚紀念醫院實驗室生物安全委員委員 高雄長庚紀念醫院實驗動物中心主任 高雄長庚紀念醫院實驗動物型態鑑定暨診斷核心研究室主任 長庚大學臨床醫學研究所兼任教授 臺灣骨科研究學會理事
學術專長 骨關節生理學、間質幹細胞生理學、表觀基因調控、蛋白質後轉譯修飾
國際期刊編輯委員 Acta Pharmacologicia Sinica; International Journal of Molecular Medicine; The Open Orthopaedics Journal SCI期刊審查委員 Nature Review Rheumatology; Diabetes; Arthritis and Rheumatology; Osteoarthritis & Cartilage; Bone; Rheumatology; Osteoporosis International; Arthritis Research and Therapy; Clinical Orthopaedic and Related Research; PLoS One; J Trans Res; Journal of Orthopedic Research; Experimental Cell Research; Acta Pharmacia Sinica; Clinical Chemica Acta; Bioelectromagnetics; Nitric Oxide; American Journal of Physiology-Cell Physiology; BMC Musculoskeletal Disease; Journal of Biomedical Science; Molecular Genetics and Metabolism; Scandia Journal of Rheumatology; Biochemical and Environmental Sciences. 國內外研究及認證機構審查委員 行政院科技部生物司、行政院教育部高教司、國家衛生研究院、國立臺灣大學、國立成功大學、國防醫學院等; Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC Internation) Ad hoc Consultant 個人獲獎 Outstanding Contribution in Reviewing Award 2017 bestowed by Bone, October 2017 Outstanding Contribution in Reviewing Award 2017 bestowed by Clinical Chemica Acta, November 2017. APS Outstanding Reviewer Award 2016 bestowed by Acta Pharmacologica Sinica, 15 Nov 2017 Associate Editor bestowed by Clinical Orthopaedics and Related Research, 2017 Top CORR Reviewers Award bestowed by Clinical Orthopaedics and Related Research®, 5 Dec 2016 Outstanding Contribution in Reviewing Award 2015 bestowed by Bone, September 2015
研究方向 Osteoporosis、osteoarthritis、Genetically-modified mice、Wnt/β-catenin/Dkk1 signaling components、microRNA、histone modification & reading

五年內第一或責任作者論文著述 2013年以前共發表84篇SCI期刊論文 A.期刊論文(Wang FS*: Corresponding author) Wang FS, Wu RW, Sun YC, Chen YS, Wu SL, Ko JY Osteoblastic microRNA-29a inhibits osteoclastogenic differentiation and ameliorates osteoporosis by regulating PCAF-RANKL-CXCL axis. (Manuscript in preparation) Wang FS, Wu RW, Sun YC, Lin WC, Chen YS, Haung CC, Weng LH, Ko JY. Gluococorticoid hypomethylation of H3K9 disturbs adipogenesis and osteogenesis of mesenchymal stem cells through BRD4 interaction with Foxp1. Cell Death Different (In submission). Lian WS, Ko JY, Wu RW, Sun YC, Chen YS, Wu SL, Weng LH, Jahr H, Wang FS*. MicroRNA-128 repressed chondrocyte autophagy exacerbates knee osteoarthrtisis by disrupting Atg12. Cell Death Disease 2018;9:919 Lian WS, Ko JY, Chen YS, Ke HJ, Wu SL, Kuo CW, Wang FS*. Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR. Cell Death Disease 2018; doi 10.1038/s41419-018-0970-6 (In press) Hung PL, Hsu MH, Yu HR, Wu KLH, Wang FS*. Thyroxin protects white mater from hypoxic-ischemic insult in the immature Sprague-Dwaley rat brian by regulating periventricular white matter and cortex BDNF and CREB pathways. Int J Mol Sci 2018;19:E2573 Wang FS, Wu RW, Lain WS, Tsai TC, Chen YS, Sun YC, Ke HJ, Li JC, Hwang JL, Ko JY. Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration. Bone 2018;112:24-34. Lin YC, Wang FS, Yang YL, Chuang YT, Huang YH. MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. Biochem Biophys Res Commun 2018;496:880-886 (Equal first coauthor) Kuo SJ, Wang FS, Ko JY, Tang CH, Siu KK, Hsu YH, Tsai TC. Increased expression of type 1 cannabinoid (CB1) receptor among patients with rotator cuff lesions and shoulder stiffness. J Shoulder Elbow Surg 2018; 27:333-338. Huang YH, Yang YL, Huang FC, Tiao MM, Lin YC, Tsai MH, Wang FS*. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts bile duct ligation-induced fibrosis pathogenesis in mice. Exp Biol Med 2018; 243:13-21. Lian WS, Wu RW, Lee MS, Chen YS, Sun YC, Wu SL, Ko JY, Wang FS*. Subchondral mesenchymal stem cells from osteoarthritic knees display high osteogenic differentiation capacity through microRNA-29a regulation of HDAC4. J Mole Med 2017;95:1327-1340 Ko JY, Lee MS, Lian WS, Wen WT, Sun YC, Chen YS, Li WC, Wang FS*. MicroRNA-29a counteracts synovitis in knee osteoarthritis pathogenesis by targeting VEGF. Sci Rep 2017;7:3584. Wang FS, Lian WS, Weng WT, Chen YS, Sun YC, Wu SL, Ko JY. Histone Demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and –independent pathways. J Mole Med 2017;95:499-512. Wang FS, Lian WS, Weng WT, Sun YC, Ke HJ, Chen YS, Ko JY. Neuropeptide Y mediates glucocorticoid-induced osteoporosis and marrow adiposity in mice. Osteoporosis Int 2016;27:2777-2789. Ko JY, Sun YC, Li WC, Wang FS*. Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of Knee osteoarthritis. J Mole Med 2016;94:755-769. Li SC, Wang FS, Yang YL, Tiao MM, Chuang JH, Huang YH. Microarray study of pathway analysis expression profile associated with microRNA-29a with regard to murine cholestatic liver injuries. Int J Mol Sci 2016;17:E324 (Equal first author) Kuo YR, Chien CM, Kuo MJ, Wang FS, Huang EY, Wang CJ. Endothelial-1 expression associated with lipid peroxidation and nuclear factor-kB activation in type 2 diabetes mellitus patients with angiopathy and limb amputation. Plastic Reconstruct Surg 2016;137:187e-195e Kuo SJ, Wang FS, Sheen JM, Yu HR, Wu SL, Ko JY. Complement component C3: serologic signature for osteogenesis imperfecta. Analysis of a comparative proteomic study. J Formos Med Assoc 2015;114:943-949 Ko JY, Chuang PC, Su WH, Ke HC, Chen YS, Sun YC, Wang FS*. MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation. Bone 2015;81:80-88 Huang YH, Tiao MM, Chuang JH, Kuo KC, Yang YL, Huang LT, Wang FS*. Activation of miR-29a in activated hepatic stellate cells modulates its profibrogenic phenotype through inhibition of histone deacetylase 4. PLoS One 2015;10:e0136453 Huang HM, Huang CC, Wang FS, Hung PL, Chang YC. Activating the Wnt/b-catenin pathway did not protein immature retina from hypoxic-ischemic injury. Invest Ophthalmol Vis Sci 2015;56:4300-4308. Huang EY, Wang FS, Chen YM, Chen YF, Wang CC, Lin IH, Huang YJ, Yang KD. Amifostine alleviates radiation-induced lethal small bowel damage via promotion of14-3-3σ-mediated nuclear p53 accumulation. Oncotarget 2014;5:9756-9769 (Equal first author) Lin CL, Lee PH, Lei CC, Hsu YC, Wang JY, Huang YT, Wang SY, Wang FS*. Cannabinoid receptor 1 disturbance of PPARγ2 augments hyperglycermia induction of mesangial inflammation and fibrosis in renal glomeruli. J Mole Med 2014;92:779-792 Lin CL, Lee PH, Hsu YC, Lei CC, Ko JY, Chuang PC, Huang YT, Wang SY, Chen YS, Chiang WC, Reiser J, Wang FS*. MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. J Am Soc Nephrol 2014;25:1698-1709 Yang MY, Chiang YC, Huang YT, Chen CC, Wang FS, Wang CJ, Kuo YR. Serum Proteomic Analysis of Extracorporeal Shock-Wave Therapy Enhanced Diabetic Wound Healing in a STZ-Induced Diabetes Model. Plastic Reconstruct Surg 2014;133:59-68. Tiao MM, Wang FS, Huang LT, Chuang JH, Ko HC, Yang YL, Huang YH. MicroRN-29a protects against acute liver injury in a mouse model of obstructive jaundice via inhibition of the extrinsic apoptosis pathway. Apoptosis 2014;19:30-41 (Equal first author) Ko JY, Chuang PC, Chen MW, Ke HC, Wu SL, Chang YH, Chen YS, Wang FS*. MicroRNA-29a ameliorates glucocorticoid-induced suppression of osteoblast differentiation by regulating β-catenin acetylation. Bone 2013;57:468-475. Cheng CI, Hisao CC, Wu SC, Yip HK, Fu M, Wang FS*. Valsartan impairs angiogenesis of mesenchymal stem cells through Akt pathway. Int J Cardiol 2013;167:2765-2774. Tapeköylü C, Wang FS, Kozaryn R, Albercht-Schgoer K, Theurl M, Schaden W, Ke HJ, Yang Y, Kirchmair R, Grimm M, Wang CJ, Holfeld J. Shock wave treatment induces angiogenesis and mobilizes endogenous CD31/CD34-positive endothelial cells in a hindlimb ischemia model: Implication for angiogenesis and vasculogenesis. J Throac Cardiac Surg 2013;146:971-978. Siu KK, Zheng LB, Ko JY, Wang FS, Wang CJ, Wong T, Chou WY. Increased interleukin 1β levels in the subcromial fluid in diabetic patients with rotator cuff lesions compared with nondiabetic patients. J Shoulder Elbow Surg 2013;22:1547-1551. Chou WY, Siu KK, Ko JY, Chen JM, Wang CJ, Wang FS, Wong T. Preoperative templating and computer-assisted total knee arthroplasty for arthritic valgus knee. J Arthroplasty 2013;28:1781-1787. Wang FS, Chuang PC, Lin CL, Chen MW, Ke, HC, Chang YH, Chen YS, Wu SL, Ko JY. MicroRNA miR-29a protects from glucocorticoid-induced bone loss and fragility by orchestrating bone acquisition and resorption. Arthritis Rheum 2013;65:1530-1540. Wang CJ, Hsu SL, Weng LH, Sun YC, Wang FS. Extracorporeal shock wave therapy shows a number of treatment related chondroprotective effect in osteoarthritis of the knee in rats. BMC Musculo Disord2013;14:44. B. Patent & intellectual property Wang FS, Ko JY, Huang BW, Zheng CH, Wu RW, Lin CH, Lian WS, Hsien CK. 中華民國專利證書新型第M563251號 Wang FS, Ko JY, Huang BW, Zheng CG, Chen PR, Chiu YS. 中華民國專利證書新型第M487051號 Wang FS. 2017. Rodent Model Resource Center No. RMRC-DE-1-17005, Taiwan C. Plenary, keynoted and invited speeches Wang FS. Mitochondrial chaperonin regulation of bone and joint homeostasis. 2017 Annunal Meeting of Taiwan Society for Mitochondrial Research and Medicine, 04 November 2017, Kaohsiung, Taiwan Wang FS. Animal use integrity implementation by Kaohsiung Chang Gung Memorial Hospital: Deed not words. Annual Meeting of Chinese Taipei Laboratory Animal Society, 17 November 2017, Taipei, Taiwan. Wang FS, IACUC function and PAM for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 29 August 2017, Chaiyi, Taiwan. Wang FS, IACUC function and PAM for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 June 2017, New Taipei City, Taiwan. Wang FS, Site visit to animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 21 September 2016, New Taipei City, Taiwan. Wang FS, Layout design for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 August 2015, Tainan, Taiwan. Wang FS, Post approval monitoring for animal protocols. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 06 August 2015, Tainan, Taiwan. Wang FS, Layout design for animal facility. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 01 October 2015, Taipei, Taiwan. Wang FS, Post approval monitoring for animal protocols. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 01 October 2015, Taipei, Taiwan. Wang FS MicroRNA regulation of immune reactions in bone and joint microenvironments. Annual Meeting of Taiwan Rheumatology Association, 06 December 2014, Taichung, Taiwan Wang FS. Highlight of humane and friendly use of laboratory animals: Kaohsiung Chang Gung Memorial Hospital’s commitments, Annual Meeting of Chinese Taipei Laboratory Animal Society, 10 December 2014, Taipei, Taiwan. Wang FS. Multifaceted protection of microRNA-29a against bone joint disorders. Biomedical Research Symposium of NHRI and Dr. Monto Ho Memorial Symposium, 7-8 July 2014, Chiunan, Taiwan. Wang FS, Management and care of laboratory rodents. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 10-11 July 2014, Kaohsiung, Taiwan. Wang FS. MicroRNA insights into osteoarthritic knees. Symposium of Cross Strait Orthopedic Surgery. 23-25 August 2014, Xiamen, China Wang FS. Osteoporosis: a new insight into microRNA actions. Symposium of Taiwan Osteoporosis Association, 1 November 2014, Kaohsiung, Taiwan Wang FS. MicroRNA-29a acts as a master regulator of osteogenic and chondrogenic potency in mesenchymal stem cells, osteoporosis and osteoarthritis. 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine, 10-12 Oct, 2013; Crete, Greece. (Session Chairperson and Invited Speaker ) Wang FS. Dickkopf-1 blockade protects from cartilage and synovial deterioration in osteoarthritic knees: a pre-clinical trial perspective. 8th Combined Meeting of Orthopaedic Research Societies, 13-16 Oct, 2013; Venice, Italy. (Invited Speaker of Symposium) Wang FS. MicroRNA regulation of skeletal disorders. BIT’s 3rd World Congress of Molecule Medicine. 13-16 Nov, 2013; Haikou, China (Session Chairperson and Invited Speaker) Wang FS, Management and care of laboratory rodents. Annual Workshop of Laboratory Animal Management and Care, Agriculture Technology Research Institute, 03-04 Ocober 2012, Kaohsiung, Taiwan Wang FS. Glucocorticoid-induced osteoporosis: crosstalk of osteoblasts and adipocytes. Annual Meeting of Taiwan Osteoporosis Association, 2011, Taipei, Taiwan Wang FS. Wnt inhibitor Dickkopf-1 is a master deleterious factor in bone and cartilage remodeling: from experimental animals to clinical vignettes. Translation Research in Orthopedics, 2011, Kaohsiung, Taiwan (Keynote Speaker). Wang FS, Wu RW, Ko JY, Wu SL, Wu YW. Proteomic approach to search serum biomarkers for osteogenesis imperfecta. 2010 Disease Biomarker and TPS International Conference, Tao-Yuen, Taiwan D. 研討會論文 Wang FS. MicroRNA-29a reduction of marrow adiposity ameliorates aging-induced bone loss. The 25th Annual Meeting of Annual Meeting of European Orthopedic Research Society, 13-15 September 2017, Munich, Germany. Wang FS. MicroRNA-29a curtails synovitis in the development of knee osteoarthritis by disrupting VEGF. The 2016 Annual Meeting of American College of Rheumatology, 13-16 November 2016, Washington DC, USA. Wang FS. μCT and μMRI quantification of marrow adiposity within osteoporotic skeletons. The 24th Annual Meeting of European Orthopedic Research Society, 14-16 September 2016, Bologna, Italy. Wang FS. RPTOR maintenance of osteoblast autophagy mitigates glucocorticoid induction of osteoporosis. The 24th Annual Meeting of European Orthopedic Research Society, 14-16 September 2016, Bologna, Italy. Wang FS. MicroRNA-128 interference mitigates the progression of knee osteoarthritis by regulating sirtuin-1. The 2015 Annual Meeting of American College of Rheumatology, 7-11 November, San Francisco, USA. Wang FS. Histone lysine demethylase KDM6A mediates joint destruction in osteoarthritic kness by epigenetic disturbance of SOX9 promoter and histone H3K27. The 2014 Annual Meeting of American College of Rheumatology, 16-19 November, 2014, Boston, USA. Wang FS MicroRNA-29a repression of Th17 immune reactions ameliorates cartilage destruction and synovial fibrosis in osteoarthritic knees. The 24th Annual Meeting of European Orthopaedic Research Societies. 2-4 July, 2014, Nates, France. Wang FS Neuropeptide Y mediates glucocorticoid excess induction of fatty marrow and bone loss. The 24th Annual Meeting of European Orthopaedic Research Societies. 2-4 July, 2014, Nates, France. Wang FS Heat shock protein 60 stabilizes cartilage integrity in osteoarthritic knees. The 24th Annual Meeting of European Orthopaedic Research Societies. 2-4 July, 2014, Nates, France Wang FS, Ko JY, Ye DW, Ke HJ, Wu SL. MicroRNA-29a mediates glucocorticoid-induction of Dickkopf-1 expression and bone tissue deterioration. The 7th Combined Meeting of the Orthopaedic Research Societies, 2010, Kyoto, Japan. Wang FS Ko JY, Wu SL, Wu YW. Emerging serum biomarkers for osteogenesis imperfecta. The 7th Combined Meeting of the Orthopaedic Research Societies, 2010, Kyoto, Japan. Wang FS, Ko JY, Wu RW, Chen MW, Ke HC. Modulation of type 1 cannabinoid receptor signaling alleviates glucocorticoid-induced osteoblast apoptosis, marrow adipogenesis and bone loss. The Meeting of Asia Pacific Orthopaedic Association. 2010, Taipei, Taiwan. Wang FS, Ko JY, Wu RW, Chen MW, Ke HC. Heat shock protein 60 (HSP60) protects bone tissue against the deleterious action of supraphysiological glucocorticoid. The Meeting of Asia Pacific Orthopaedic Association. 2010, Taipei, Taiwan. Wang FS, Kuo YR, Chang NK. Total quality management improves laboratory animal health, use and facility environment in a medical center. The 4th Asia Federal Laboratory Animal Society Congress Meeting, 2010, Taipei, Taiwan Wang FS, Wu SL, Ke HC. Serum proteomic signatures of laboratory rats housed in individual ventilation cages vs. general diluting ventilation cages. The 4th Asia Federal Laboratory Animal Society Congress Meeting, 2010, Taipei, Taiwan. E. Awards Award for SCI Article Competition bestowed by Taiwan Orthopedic Research Society 26 Oct 2013.