Assistant Investigator, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital

Education: Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Ph.D.

Speciality: Translational Medicine; Molecular Virology; Biotechnics; Development of Pharmaceuticals; Extracorporeal Shockwave Therapy

EXT: +886-7-7317123 ext. 8522

E-Mail: cjh1106@cgmh.org.tw

PUBLICATIONS:
1. Wang CJ, Huang CY, Hsu SL, Chen JH, Cheng JH. Extracorporeal shockwave therapy in osteoporotic osteoarthritis of the knee in rats: an experiment in animals. Arthritis Res Ther. 2014 Jul 3;16(4):R139. (SCI; Impact Factor: 4.117, RHEUMATOLOGY, Rank: 7/30, 23.3%)
2. SC Sheu*, Y Lyu, MS Lee, JH Cheng*. Immunomodulatory Effects of Polysaccharides Isolated from Hericium erinaceus on Dendritic Cells. Process Biochemistry. Volume 48, Issue 9, September 2013, Pages 1402–1408. (SCI; Impact Factor: 2.524, ENGINEERING and CHEMICAL, Rank: 28/133, 21%)
3. IH Chen , JH Cheng, YW Huang, NS Lin, YH Hsu, CH Tsai*. Characterization of the polyadenylation activity in a replicase complex from Bamboo mosaic virus-infected Nicotiana benthamiana plants. Virology. 2013 Sep;444(1-2):64-70. (SCI; Impact Factor: 3.278, VIROLOGY, Rank: 16/32, 37%)
4. Cheng JH, SY Lee, Y Y Lien, MS Lee*, SC Sheu*. Immunomodulating activity of Nymphaea rubra Roxb. extracts: activation of rat dendritic cells and improvement of the TH1 immune response. International Journal of Molecular Sciences. 2012,13, 10722-10735 (SCI; Impact Factor: 2.339, Chemistry & Multidisciplinary, Rank: 52/148, 35% )
5. Cheng JH, SC Sheu, MS Lee, YY Lien, HJ Chen, WH Su, MS Lee*. Identification of NLS and NES motif of VP2 from Chicken Anemia Virus and Interaction with Mini-Chromosome Maintenance Protein 3. BMC Veterinary Research. 2012, 8:15. (SCI; Impact factor: 1.743, Veterinary Sciences, Rank: 23/129, 18%)
6. Chiu WH, Luo SJ, Chen CL, Cheng JH, Hsieh CY, Wang CY, Huang WC, Su WC, Lin CF*. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochem Pharmacol. 2012 May 1;83(9):1159-71. (SCI; Impact factor: 4.650, Pharmacology & Pharmacy, Rank: 25/254, 9%)
7. Chung KM, Huang CH, Cheng JH, Tsai CH, Suen CS, Hwang MJ, X Chen*. Proline in Transmembrane Domain of Type II Protein DPP-IV Governs Its Translocation Behavior through Endoplasmic Reticulum. Biochemistry 2011 Aug 23. 50: 7909-7918. (SCI; Impact factor: 3.194, Biochemistry & Molecular Biology, Rank: 116/291, 39%)
8. KM Chung, Cheng JH#, C S Suen, Y R Chen, C Y Chou, H P Chang, G G Chang, Andrew H J Wang, M J Hwang, X Chen*. The Dimeric Transmembrane Domain of Prolyl Dipeptidase DPP-IV Contributes to its Quaternary Structure and Enzymatic Activities. Protein Science, 2010, 19: 1627-1638. #Equal contribution (SCI; Impact factor: 2.861, Biochemistry & Molecular Biology, Rank: 146/291, 50%)
9. Yeh TK, Tsai TY, Hsu T, Cheng JH, Chen X, Song JS, Shy HS, Chiou MC, Chien CH, Tseng YJ, Huang CY, Yeh KC, Huang YL, Huang CH, Huang YW, Wang MH, Tang HK, Chao YS, Chen CT, Jiaang WT. (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett 2010 Jun 15;20(12):3596-600. Epub 2010 May 17. (SCI; Impact factor: 2.331, CHEMISTRY, ORGANIC, Rank: 25/58, 43%)
10. Lin CH, Peng YH, Coumar MS, Chittimalla SK, Liao CC, Lyn PC, Huang CC, Lien TW, Lin WH, Hsu JT, Cheng JH, Chen X, Wu JS, Chao YS, Lee HJ, Juo CG, Wu SY, Hsieh HP. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists. J Med Chem 2009 Apr 23;52(8):2618-22. (SCI; Impact factor: 5.480, CHEMISTRY, MEDICINAL, Rank: 3/58, 5%)
11. Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang CH, Huang YW, Wu SH, Wang MH, Chen X, Chao YS and Jiaang WT. Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 2009 Apr 1;19(7):1908-12. (SCI; Impact factor: 2.331, CHEMISTRY, ORGANIC, Rank: 25/58, 43%)
12. Tsai TY, Hsu T, Chen CT ,Cheng JH, Yeh TK, Chen CT, Chen X, Huang CY, Chang CN, Yeh KC , Hsieh SH, Chien CH, Chien CH, Chang YW, , Huang CH, Huang YW, Hung CL, Wu SH, Wang MH, Chao YS, Jiaang WT. Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors. Bioorg Med Chem 2009 Mar 15;17(6):2388-99. Epub 2009 Feb 20. (SCI; Impact factor: 2.951, CHEMISTRY, ORGANIC, Rank: 15/58, 25%)
13. Coumar MS, Chang CN, Chen CT, Chen X, Chien CH, Tsai TY, Cheng JH, Wu HY, Han CH, Wu SH, Huang YW, Hsu T, Hsu LJ, Chao YS, Hsieh HP and Jiaang WT. 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3- methylbutyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes. Bioorganic & Medicinal Chemistry Letters 17 (2007) 1274–1279. (SCI; Impact factor: 2.331, CHEMISTRY, ORGANIC, Rank: 25/58, 43%)
14. Lu IL, Lee SJ, Tsu H, Wu SY, Kao KH, Chien CH, Chang YY, Chen YS, Cheng JH, Chang CN, Chen TW, Chang SP, Chen X, and Jiaang WT. Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors. Bioorganic & Medicinal Chemistry Letters 15 (2005) 3271–3275. (SCI; Impact factor: 2.331, CHEMISTRY, ORGANIC, Rank: 25/58, 43%)
15. Cheng JH, Peng CW, Hsu YH, and Tsai The synthesis of minus-strand RNA of bamboo mosaic potexvirus initiates from multiple sites within the poly (A) tail. J Virol 2002 Jun;76(12):6114-20. (SCI; Impact factor: 4.648, VIROLOGY, Rank: 7/32, 21%)
16. Cheng JH, Ding MP, Hsu YH, and Tsai The partial purified RNA-dependent RNA polymerases from bamboo mosaic potexvirus and potato virus X infected plants containing the template-dependent activities. Virus Res 2001 Nov 28;80(1-2):41-52. (SCI; Impact factor: 2.827, VIROLOGY, Rank: 18/32, 56%)
17. Tsai CH, and Cheng JH. The preparation of RNA-dependent RNA polymerase complex from virus infected plants. Proc Natl Sci Counc Repub China 1998 Apr;22(2):83-90.