教職：副教授

現職：長庚大學臨床醫學研究所副教授

學歷：美國明尼蘇達大學生物醫學工程學系

專長：組織工程與再生醫學、體外震波與治療應用、基因體醫學、基因甲基化、癌症科學

聯絡電話：(07)731-7123，分機8856

近年發表之論文：

1. Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao*, Li-Hsueh Shih, Su-Wei Chen & Shau-Hsuan Li (2018, Oct). Neck Lymph Node Metastasis as A Poor Prognostic Factor in Thoracic Esophageal Squamous Cell Carcinoma Patients Receiving Concurrent Chemoradiotherapy: A Propensity Score-Matched Analysis. SCIENTIFIC REPORTS, 8(1): 1-10. (SCI, 12/64 (19%), Multidisciplinary Sciences).

2. Keng-Liang Wu, Chung-Mou Kuo, Eng-Yen Huang, Hui-Mei Pan, Chao-Cheng Huang, Yi-Fan Chen, Chang-Chun Hsiao*, Kuender D Yang (2018, Aug). Extracellular galectin-3 facilitates colon cancer cell migration and is related to the epidermal growth factor receptor. Am J Transl Res, 10(8):2402-2412. (SCI, 59/133, Medicine, Research & Experimental).

3. Keng-Liang Wu, Yi-Chun Chiu, Chih-Chien Yao, Cheng-En Tsai, Ming-Luen Hu, Chung-Mou Kuo, Wei-Chen Tai, Seng-Kee Chuah, Chang-Chun Hsiao* (2018, Jul). Effect of extracorporeal low-energy shockwave on diabetic gastroparesis in a rat model. Journal of Gastroenterology and Hepatology, doi: 10.1111/jgh.14368. (SCI, 27/80, Gastroenterology and Hepatology).

4. Chin-Chou Wang, Chia-Cheng Tseng, Huang-Chih Chang, Kuo-Tung Huang,Wen-Feng Fang, Yu-Mu Chen, Cheng-Ta Yang, Chang-Chun Hsiao*, Meng-Chih Lin, Chi-Kung Ho and Hon-Kan Yip (2017, Nov). Circulating Microparticles are Prognostic Biomarkers in Advanced Non-Small Cell Lung Cancer Patients. Oncotarget, 8(44):75952-75967. (SCI, IF 5.168 , Rank 44/217 = 20%， Oncology).

5. Keng-Liang Wu, Eng-Yen Huang, Wen-Ling Yeh, Chang-Chun Hsiao*, Chung-Mou Kuo (2017, Sep). Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis. Oncotarget, 8 (37): 61935-61943. (SCI, IF 5.168 , Rank 44/217 = 20% , Oncology).

6. Yung-Che Chen, Meng-Chih Lin, Chang-Chun Hsiao*, Yi-Xin Zheng, Kuang-Den Chen, Ming-Tse Sung, Chung-Jen Chen, Ting-Ya Wang, Yong-Yong Lin, Huang-Chih Chang, Yu-Mu Chen, Jen-Chieh Chang (2017, Jul). Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma. Oncotarget, 8(28):45710-45724. (SCI, IF 5.168, Rank 44/217 = 20% ， Oncology).

7. Yung-Che Chen, Tung-Ying Chao, Sum-Yee Leung, Chung-Jen Chen, Chao-Chien Wu, Wen-Feng Fang, Yi-Hsi Wang, Huang-Chih Chang, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Meng-Chih Lin, Chang-Chun Hsiao*(2017 Apr). Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease. Am J Transl Res; 9(4): 1943-1955. (SCI, IF 3.146, Rank 41/ 124 = 33%，Medicine, research & Experimental).

8. Yung-Che Chen, Kuang-Den Chen , Chung-Jen Chen, Mao-Chang Su, Chien-Hung Chin, Chia-Wei Liou, Ting-Wen Chen, Ya-Chun Chang, Chin-Chou Wang, Ting-Ya Wang, Jen-Chieh Chang , Yong-Yong Lin, Yi-Xin Zheng , Meng-Chih Lin, Chang-Chun Hsiao*(2017 May). Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea. PLOS ONE; 12(5):e0176575:1-16 (SCI, IF 3.057 , Rank 11/ 63 = 17%，Multidisciplinary Sciences).

9. Yung-Che Chen, Ting-Wen Chen, Mao-Chang Su, Chung-Jen Chen, Kuang-Den Chen, Chia-Wei Liou, Petrus Tang, Ting-Ya Wang, Jen-Chieh Chang, Chin-Chou Wang, Hsin-Ching Lin, Chien-Hung Chin, Kuo-Tung Huang, Meng-Chih Lin, Chang-Chun Hsiao*(2016 Apr). Whole genome DNA methylation analysis of obstructive sleep apnea: IL1R2, NPR2, AR, SP140 methylation and clinical phenotype. Sleep, 39(4):743-755. (SCI, IF 4.923, Rank 25/194=12%, Clinical Neurology).

10. Ming-Tse Kuo, Po-Chiung Fang, Hun-Ju Yu, Tsae-Ling Chao, Chun-Chih Chien, Shin-Ling Tseng, Yu-Hsuan Lai, Chang-Chun Hsiao*, Tsung C. Chang (2016 Apr). A Multiplex Dot Hybridization Assay for Detection and Differentiation of Acanthamoeba and Herpes Keratitis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57 (4): 2158-2163. (SCI, IF 3.427 , Rank 6/56= 10%, OPHTHALMOLOGY).