1. HLA-DQB1*0602屬於HLA中的常見基因型 (Frequency≧1/10000, Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0.)，在族群中約12~25% 帶有DQB1*0602，漢人約8.5~21.1% (Allele frequency net database 2020 update)。

2. 在台灣漢人族群DQB1*0602與猝睡症有高度相關性 (有猝倒症狀: Narcolepsy + cataplexy，OR = 321.4，95% CI: 70.7 - 1461.4)；不具猝倒症狀: Narcolepsy – cataplexy，OR = 6.9，95% CI: 2.4 - 20.1)，因此國際睡眠障礙分類標準 (ICSD-3)建議，HLA-DQB1*0602基因型可用來協助診斷猝睡症類型。

3. 猝睡症 (Narcolepsy) 為睡眠障礙疾病，中樞神經在清醒與睡眠的控制出現問題，出現白天不可擋的嗜睡症狀1。盛行率約0.05%。依照國際睡眠障礙分類標準 (ICSD-3)，經由猝倒、多次入睡睡眠檢查與多頻睡眠檢查，猝睡症可分為第一型及第二型。第一型猝睡症必須有猝倒症狀，腦部脊髓液中Hypocretin-1濃度偏低 (<110 pg/Ml或小於正常人1/3濃度)，而第二型猝睡症Hypocretin-1濃度大於110 pg/Ml (或大於正常人1/3濃度) 或無法檢測。

4. 猝睡症的致病機轉仍不清楚，疾病風險也受到許多遺傳基因與環境因子共同影響，HLA-DQB1*0602非唯一致病因子，因此本檢驗結果僅供臨床醫師參考。

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