莊蕙青 頭頸外科

現職：

高雄長庚醫院 耳鼻喉部 部主任
高雄長庚耳鼻喉部 副教授級 主治醫師
長庚大學中醫系專任 副教授
教育部 部定副教授
高雄長庚癌症中心頭頸癌團隊成員
 

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學經歷：

中山醫學大學醫學系畢業
長庚大學臨床醫學研究所博士班畢業
美國德州MD Anderson Cancer Center 進修 (2012-9 – 2013-8)
 

學會及期刊：

台灣頭頸癌醫學會 理事
台灣耳鼻喉頭頸外科 專科醫師
美國外科學院院士
美國頭頸外科學院院士
美國耳鼻喉頭頸部外科學會 會員

獲獎:
2008第一屆默克青年生技獎 榮譽獎 

論文及著作：

研究計畫:

1. Principal Investigator
2. The clinicopathological significance of MMP7 expression in buccal cancer

( CMRPG 860341, 2007/10/01-2008/9/30)

1. Identification of genes expression signatures and molecular pathways between

leukoplakia and early oral cancer

(NSC 97-2314-B-182A-068-MY2, 2008/08/01 - 2010/10/31)

1. The regulation of matrix metalloproteinases and cancer cell growth in head and neck

cancer through toll-like receptor 3 signaling pathway.

(CMRPG881301, 2009/12/01-2011/11/30)

1. Co- Principal Investigator
2. To investigate synergistic carcinogenesis mechanisms and potential therapeutic applications of osteopontin and Aurora A in human oral cancer  

(NSC97-2314-B-182A-065, 2008/8/1-2009/7/31)

1. To investigate the polymorphism of Aurora-A gene in OCSCC and unravel the molecular mechanisms of Aurora-A induced by osteopontin that promotes cell metastasis in human oral cancer cell lines.

(NSC98-2314-B-182A-042-MY3, 2009/8/1- 2012/7/31)

研究成果
(A)著作發表
 

First Author

1. Chuang HC, Su CY, Lui CC, Hwang CF, Chien CY. Lingual Nerve Neurilemmoma: A Case Report. J Otolaryngol. 2004 Apr;33(2):132-134.
2. Chuang HC, Su CY, Huang HY, Chien CY, Chen CM, Huang CC. High Expression of CD105 as a Prognostic Predictor of Early Tongue Cancer. Laryngoscope. 2006 Jul; 116(7):1175-1179.
3. Chuang HC, Su CY, Jeng SF, Chien CY. Anterior lateral thigh flap for buccal mucosal defect after resection of buccal cancer. Otolaryngol Head Neck Surg. 2007; 137(4):632-635.
4. Chuang HC, Su CY, Huang HY, Huang CC, Chien CY, Du YY, Chuang JH. Active

Matrix metalloproteinase-7 is associated with invasion in buccal squamous cell carcinoma. Mod Pathol 2008 Dec;21(12):1444-1450.

1. Chuang HC, Chen CH, Huang CC, Fang FM, Tsai HT,Chien CY.Reduced expression of TRF1 and TRF2 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma. Experimental and Therapeutic Medicine 2011;(2):63-67.
2. Chuang HC, Fang FM, Huang CC, Huang HY, Chen HK, Chen CH, Chien CY. The Clinical and Pathological Determinantsin Tonsil Cancer. Head Neck 2011 Dec; 33:1703-1707.
3. Chuang HC, Huang CC, Chien CY, Chuang JH. Toll-Like Receptor 3-Mediated Tumor Invasion in Head and Neck Cancer. Oral Oncol 2012 Mar;48(3):226-232.

 

Co-author

1. Su CY, Chuang HC, Tsai SS, Chiu JF. Bipedical Strap Muscle Transposition for Vocal Fold Deficit after Laser Cordectomy in Early Glottic Cancer Patients. Laryngoscope. 2005 Mar；115(3)：528-533.
2. Chien CY, Hwang CF, Chuang HC, Jeng SF, Su CY. Comparsion of Radial Forearm Free Flap, Pedicled Buccal Fat Pad Flap and Split-thickness Skin Graft in Reconstruction of Buccal Mucosal Defect. Oral Oncology. 2005 Aug；41(7)：694-697
3. Su CY, Tsai SS,Chuang HC, Chiu JF. Funtional Significance of Arytenoid Adduction with the Suture Attaching to Cricoid Cartilage versus to Thyroid Cartilage for Unilateral Paralytic Dysphonia. Laryngoscope. 2005 Oct；115：1752-1759.
4. Yuan CH, Chuang HC, Chien CY. Multiple extramedullary plasmacytomas in head and neck. J Taiwan Otolaryngol Head Neck Surg2005 40(2): 86-91.
5. Chien CY, Su CY, Hwang CF, Chuang HC, Hsiao YC, Wu SL, Huang CC. Clinicopathologic Significance of CD105 Expression in Squamous Cell Carcinoma of the Hypopharynx. Head Neck. 2006 May；28(5)：441-446
6. Chien CY, Su CY, Hwang CF, Chuang HC, Chen CM, Huang CC. High expressions of CD105 and VEGF in Early Oral Cancer Predict Potential Cervical Metastasis.

J Surg Oncol. 2006 Oct；94(5)：413-417

1. Su CY, Chuang HC, Tsai SS, Chiu JF. Transoral approach to laser thyroarytenoid myoneurectomy for treatment of adductor spasmodic dysphonia: short –term results.

Ann Otol Rhinol Laryngol. 2007 Jan ; 116(1)：11-8.

1. Chien CY, Su CY, Fang FM, Huang HY, Chuang HC, Chen CM, Huang CC.

Lower Prevalence but favorable survival for human papillomavirus – related squamous cell carcinoma of tonsil in Taiwan. Oral Oncol. 2008 Feb ; 44(2):174-179.

1. Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, Chen CM, Chen CH, Huang CC. Angiopoietin-1 and -2 Expression in Recurrent Squamous Cell Carcinoma of the Oral Cavity. J Surg Oncol. 2008 Mar ; 97(3): 273-277.
2. Chen TH, Chen CC, Hwang KP, Chung MY, Chuang HC. Retropharyngeal abscess with extensive mediastinitis in a 2-day-old neonate. J Paediatr Child Health. 2008 Mar; 44(3): 154-155.
3. Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, Chen CM, Chen CH, Huang

CC. Clinical significance of osteopontin expression in T1 and T2 tongue cancers.

Head Neck.2008 Jun ; 30(6): 776-781.

1. Chen CH, Su CY, Chien CY, Huang CC, Chuang HC, Fang FM, Huang HY, Chen CM, Chiou SJ. Overexpression of β2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion. Br J Cancer. 2008 Nov 4;99(9):1453-61.
2. Chen CH, Chien CY, Huang CC, Hwang CF, Chuang HC, Fang FM, Huang HY, Chen CM, Liu HL, Huang CY F. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion via increased FOXM1 and MMP-2 activity. Oncogene. 2009 Jul 30;28(30):2723-37.
3. Luo SD, Su CY, Chuang HC, Huang CC, Chen CM, Chien CY. Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract. Otolaryngol Head Neck Surg. 2009 Jul;141(1):108-13.
4. Chien CY, Su CY, Chuang HC, Fang FM, Huang HY, Chen CM, Chen CH, Huang CC. Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma. Oral Oncol 2009 Sep;45(9):798-802.
5. Su YY, Fang FM, Chuang HC, Luo SD, Chien CY. Detection of Metachronous Esophageal Squamous Carcinoma in Patients with Head and Neck Cancer Using Transnasal Esophagoscopy. Head Neck 2010 Jun;32(6):780-5.
6. Al-Swiahb JN, Huang CC, Fang FM, Chuang HC, Huang HY, Luo SD, Chen CH, Chen CM, Chien CY. Prognostic Impact of p16, p53, EGFR, and HPV in Oropharyngeal Cancer in an Area of Betel Nut Chewing. Arch Otolaryngol Head Neck Surg 2010;136(5):502-508.
7. Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Chien CY. Clinical, Pathological, and Molecular Determinants in Squamous Cell Carcinoma of the Oral Cavity. Future Oncol 2010;6(5):837-850.
8. Chuang JH, Chunag HC, Huang CC, Wu CL, Du YY, Kung ML, Chen CH, Chen SC, Tai MH. Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells. J Biomed Sci. 2011 Aug 23;18: 65.
9. Guo CS, Chuang HC, Chien CY. Topical sucralfate for pain after oral CO2 laser surgery: a prospective, randomized, controlled trial. Am J Otolaryngol. 2012 Jan;33(1):109-112.
10. Lin YT, Chuang HC, Chen CH, Armas GL, Chen HK, Fang FM, Huang CC, Chien CY.Clincial significance of erythropoietin receptor expression in oral squamous cell carcinoma. BMC Cancer. 2012 May; 12:94 (Epub ahead of print)
11. Chien CY, Chuang HC, Huang SH, Lin WC, Huang HY. A pilot study of segmental mandibulectomy with surgical navigation using fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography. Laryngoscope. 2012 Jun. (Epub ahead of print)
12. Chien CY, Chuang HC, Chen CH. The side population of cancer stem-like cells in human oral cancer. Oral Oncol. 2012 Jun. (Epub ahead of print)

Presentations at Local Conferences

1. Sinusitis Combine Concomitantly with Orbital and Intracranial Complications 2000/11/04, Taipei
2. Lingual Nerve Neurilemmoma – Case Report 2001/11/10, Taipei
3. Post-pharyngeal wall and laryngeal extramedullary plasmacytoma – Case Report 2002/11/10, Taipei
4. Laryngoplasty with Strap Muscle Transposition for Vocal Atrophy Patients After Failed Fat Injection. 2004/11/13, Taipei  
5. Prevention and Management of False Cord Bulging After Strap Muscle Transposition Laryngoplasty – Video Demostration. 2005/11/6, Kaohsiung
6. The clinical significanceof Toll-like receptor 3 and its crucial role in tumor invasion in oral cancer. 2011/11/12, Kaohsiung

 

Presentations at International Conferences

1. Anterior lateral thigh flap for buccal mucosal defect after resection of buccal cancer. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting, 16-19 Sep 2007, Washington DC, USA
2. Active matrix metalloproteinase-7 is associated with invasion in buccal squamous cell carcinoma. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting, 21-24 Sep 2008, Chicago, Illinois, USA
3. Synovial sarcoma of the head and neck. Asian Society of Head and Neck Oncology Annual Meeting, 18-19 Sep, 2009, Taipei, Taiwan
4. Polymorphisms of Aurora-A gene is associated with increased oral cancer risk. American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting, 26-29 Sep 2010, Boston, MA, USA