Objectives This study sought to retrospectively appraise the incidence and management of restenosis after drug-eluting
stent (DES) implantation for unprotected left main (ULM) disease.
Background The promising role of DES for ULM has been reported. However, no detailed data are available on subsequent
restenosis.
Methods From the total sample of patients with ULM treated with DES, we identified those presenting with angiographic
ULM restenosis. The primary end point was the long-term rate of major adverse cardiac events (MACE), that is,
death, myocardial infarction (MI), or target lesion revascularization (TLR). We also adjudicated stent thrombosis
according to the Academic Research Consortium.
Results Post-DES restenosis in ULM occurred in 70 of 718 patients (9.7%). Of these, 59 (84.3%) were treated percutaneously
(34 [48.6%] with additional DES, 22 [31.4%] with standard or cutting balloons, 2 [2.9%] with rotational
atherectomy, and 1 [1.4%] with a bare-metal stent), whereas 7 (10%) patients underwent bypass surgery and 4
(5.7%) were treated medically. In-hospital MACE included no periprocedural MI and only 1 (1.4%) death. After
27.2
15.4 months, MACE occurred cumulatively in 18 (25.7%) patients, with death in 4 (5.7%), MI in 2
(2.9%), and TLR in 15 (21.4%). Patients treated with medical, interventional, and surgical therapy had the following
MACE rates, respectively: 50%, 25.4%, and 14.3%. Definite, probable, and possible stent thrombosis occurred
in 0 (0%), 1 (1.4%), and 1 (1.4%) patient, respectively.
Conclusions DES restenosis in the ULM artery can be managed in most cases with a minimally invasive approach, achieving
favorable early and late results. (J Am Coll Cardiol 2009;54:1131–6) © 2009 by the American College of Cardiology Foundation