• 冠狀動脈疾病

• 週邊血管疾病

• 結構性心臟病

1.  自2002年1月起至2008年6月止發表論文第一作者及指導作者共135篇

• SCI期刊之第一作者有76篇
• 國內期刊之第一作者有10篇

2. 本團隊之研究成果榮獲心臟內科學（Heart Disease, A textbook of cardiovascular disease）教科書中引用，收錄於第1,237頁之 「Chapter 48 - Primary Percutaneous Coronary Intervention in the Management of Acute Myocardial Infarction」中。 (Chest 122:1322, 2002)

• International Observational Fellow

-Peter, W.T. Wang               (Walaysia)

-Ali A. Yusuf                          (Egypt)

• International Visiting Staff

-K.W.Lau                                (Singapore)

-Y.T.Lim　　　　　　　　(Singapore)

-Shigeru Saito　　　　　 (Japan)           

-Cheung-Wah Chang    　 (Hong Kong)

-Wai-Kwong Chan               (Hong Kong)

-Zhu Guo Yin                         (China)

1.      Yip HK, Lu CH, Yang CH, Chang HW, Hung WC, Cheng CI, Chen SM, Wu CJ.  Levels and value of platelet activity in patients with severe internal carotid artery stenosis.  Neurology  2006; 66:804-808

2.      Yip HK, Chang LT, Sun CK, Chen MC, Yang CH, Hung WC, Hsieh YK, Fang CY, Hang CL, Wu CJ, Chang HW.   Platelet activity is a biomarker of cardiac necrosis and predictive of untoward clinical outcomes in patients with acute myocardial infarction undergoing primary coronary stenting.  Circ J  2006; 70:31-36 

3.      Wu CJ, Chang HW, Hung WC, Yang CH, Chen YH, Su CY, Yip HK.  N-terminal pro-brain natriuretic peptide is a biomarker of congestive heart failure and predictive of 30-day untoward clinical outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.  Circ J  2006;70:163-168  

4.      Wu CJ, Cheng CI, Hung WC, Fang CY, Yang CH, Chen CJ, Chen YH, Hang CL, Hsieh YK, Chen SM, Yip HK.  Feasibility and safety of transbrachial approach for patients with severe carotid Artery stenosis undergoing stenting.  Cathet Cardiovasc Intervent  2006; 67:967-971    

5.      Yip HK, Chang LT, Sun CK, Yang CH, Hung WC, Cheng CI, Chua S, Yeh KH, Wu CJ, Fu M.  Impact of clopidogrel on suppression of circulating levels of soluble CD40 ligand in patients with unstable angina undergoing coronary stenting.  Am J Cardiol  2006; 97:192-194    

6.      Yip HK, Sun CK, Chang LT, Chen MC, Liou CW.  Time course and prognostic value of plasma levels of N-terminal pro-brain natriuretic peptide in patients after ischemic stroke.  Circ J  2006;70:447-452 

7.      Chen SM, Hsieh YK, Guo BF, Fang CY, Yip HK et al.  Angiographic and clinical outcome in ST-segment elevation myocardial infarction patients receiving an adjunctive double bolus regimen of tirofiban for primary percutaneous coronary intervention.  Circ J  2006; 70:536-541 

8.      Yip HK, Sun CK, Chang LT, Wu CJ.  Strong correlation between serum levels of inflammatory mediators and their distribution in infarct coronary.  Circ J  2006; 70:838-845  

9.      Youssef AA, Wu CJ, Hang CL, Yip HK.  Impact of PercuSurge device conjugative with intracoronary administration of nitroprusside on no-reflow phenomenon following primary percutaneous coronary intervention.  Circ J  2006; 70:1538-1542  

10.   Chen MC, Yip HK, Chen CJ, Yang CH, Wu CJ, Chen YH, Chai HT, Lee CP, Chang HW.  No age-related change in circulating endothelial progenitor cells in healthy subjects.  Jpn Heart J  2006; 47; 95-105   

11.   Chang LT, Sun CK, Chiang CH, Yip HK.  Impact of simvastatin and losartan on anti-inflammatory effect: in vitro study.  J Cardiovasc Pharmacol  2007; 49:20-26    

12.   Yip, HK, Lai SL, Lan MY, Liou, Liou CW, et al.  Time course of platelet activation and von Willebrand Factor in patients with nonvalvular atrial fibrillation after ischemic stroke: evaluation of prognostic determinants.  Circ J  2007; 71: 321-326    

13.    Youssef AA, Change LT, Hang CL, Wu CJ, Cheng CI, Yang CH, Sheu JJ, Chai HT, Chua S, Yeh KH, Yip HK.  Level and value of interleukin-18 in patients with acute myocardial infarction undergoing primary coronary angioplasty.  Circ J  2007; 71:703-708  

14.    Yip HK, Wang PW, Chang LT, Youssef AA, Sheu JJ, Lee FY, Wu CJ.  Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction.  Circ J  2007; 71:1213-1218    

15.    Yip HK, Youssef AA, Chang LT, Yang CH, Sheu JJ, Chua S, Yeh KH, Lee FY, Wu CJ, Hang CL.  Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention.  Circ J  2007; 71:1086-1091

16.   Cheng CI, Wu CJ, Fang CY, Youssef AA, Chen CJ, Chen SM, Yang CH, Hsueh SK, Yip HK, Chen MC, Fu M, Hsieh YK.  Feasibility and safety of transradial stenting for unprotected left main coronary artery stenosis.  Circ J   2007; 71:855-861

17.   Yip HK, Youssef AA, Chang WN, Lu CH, Yang CH, Chen SM, Wu CJ.  Feasibility and safety of transradial arterial approach for simultaneous right and left vertebral artery angiographic studies and stenting.  Cardiovasc Intervent Radiol  2007; 30:840-846

18.   Youssef AA, Chang LT, Sheu JJ, Lee FY, Chua S, Yeh KH, Yang CH, Wu CJ, Yip HK.  Association between circulating level of CD40 ligand and angiographic morphologic features that indicate high-burden thrombus formation in patients with acute myocardial infarction undergoing primary coronary intervention.  Cir J  2007; 71:1857-1861   

19.    Yuen CM, MD, Chiu CA, Chang LT, Liou CW, Lu CW, Youssef AA, Yip HK.  Level and value of interleukin-18 in patients after acute ischemic stroke.  Circ J  2007; 71:1691-1696 

20.    Yip HK, Sun CK, Chang LT, Wu CJ, Chua S, Fu M.  Strong suppression of high-sensitivity C-reactive protein level and its mediated pro-atherosclerotic effects with simvastatin: in vivo and in vitro studies.  Int J Cardiol  2007; 121:253-260  

21.   Chen MC, Chen CJ, Yang CH, Wu CJ, Fang CY, Hseih YK, Chang HW.  Interleukin-18: a strong predictor of the extent of coronary artery disease in patients with unstable angina.  Heart and Vessels  2007; 22:371-375 

22.   Yip HK, Chang LT, Sun CK, Youssef AA, Sheu JJ, Wang CJ.  Shock wave therapy applied to rat bone marrow–derived mononuclear cells enhance formation of cells stained positive for CD31 and vascular endothelial growth factor.  Circ J  2008; 72:150-156 

23.   Yip HK, Chang LT, Chang WN, Lu CH, Liou CW, Lan MY, Liu JS, Youssef AA, Chang HW.  Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke.  Stroke  2008; 39:69-74 

24.   Yip HK, Chang LT, Sun CK, Sheu JJ, Chiang CH, Youssef AA, Lee FY, Wu CJ, Fu M.   Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats.  Critical Care Medicine  2008;36:873-880 

25.   Chang LT, Sun CK, Sheu JJ, Chiang CH, Youssef AA, Lee FY, Wu CJ, Yip HK.  Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat model.  Circ J  2008; 72:825-831  

26.   Yip HK, Chang LT, Wu CJ, Sheu JJ, Youssef AA, Pei SN, Lee FY, Sun CK.  Autologous bone marrow-derived mesenchymal stem cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction.  Circ J  2008;72:1336-1346  

27.    Cheng CI, Hsueh SK, Lee FY, Wu CJ, Fang CY, Sheu JJ, Chen SM, Yang CH, Hsieh YK, Chen MC, Fu M, Yip HK.  Circ J  2008; 72:1598-1604

28.    Chen MC, Chen CJ, Yang CH, Liu WH, Fang CY, Hseih YK, Chang HW.  Relationship of the percentage of circulating endothelial progenitor cell to the severity of coronary artery disease.  Heart and Vessels  2008; 23:47-52

29.   Chen MC, Chang JP, Hwang CC, Chang HW, Chen CJ, Yang CH, WH Liu.  Differentiation of atrial cardiomyocytes in cardiac valve disease.  Cardiovasc Pathology  2008; 17:156-165

30.   Chen MC, Chang JP, Liu WH, Yang CH, Chen YL, Tsai TH Wang YH, Pang KL.  Increased inflammatory cell infiltration in the atrial myocardium of patients with atrial fibrillation.  Am J Cardiol  2008; 102:861-865  

31.    Sun CK, Chang LT, Sheu JJ, Chiang CH, Lee FY, Wu CJ, Chua S, Fu M, Yip KH.  Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat dilated cardiomyopathy.  Crit Care Med  2008 (in press)