內科部

陳武福副院長

1963出生於台南縣
　

教育訓練

國防醫學院醫學科學研究所醫學博士(Ph.D.)

國防醫學院醫學系醫學士 (M.D.)

現職

高雄長庚醫院副院長

高雄長庚醫院神經外科教授

長庚大學醫學院外科教授

經歷　

2020-2021高雄市立鳳山醫院副院長

2019-2021台灣立體定位功能性神經外科及放射手術學會理事長

2015-2020高雄長庚醫院國際醫療中心主任

2009-2015高雄長庚醫院神經外科主任

專長

巴金森氏症(Parkinson’s disease)

深腦部刺激術(Deep Brain Stimulation)

腦瘤(Brain Tumor)

脊椎手術(Spine Surgery)

論文及研究
　

迄今共發表論文113篇，代表論文：

1. Chen YF, Chang YP, Chen WF, Lin WC, Chang YY, Lin HC, Shih FY. Effect of Intraoperative Computed Tomography in Microelectrode Recording during Frameless Stereotactic Deep Brain Stimulation for Parkinson's Disease. World Neurosurg. 2021 Oct;154:e1-e6.

2. Wen ZH, Huang SY, Kuo HM, Chen CT, Chen NF, Chen WF, Tsui KH. Liu HT, Sung CS. Fumagillin attenuates spinal angiogenesis, neuroinflammation, and pain in neuropathic rats after chronic constriction injury. Biomedicines 2021 Sep 10;9(9):1187. (IF=6.081; Pharmacology & Pharmacy ; Biochemistry & Molecular Biology 65/297)

3. Hung SY, Chen WF, Lee YC, Su JH, Juan YS, Lin IP, Zhang YH, Chang MK, Lin MY, Chen CY, Lee CH. Rhopaloic acid A induces apoptosis, autophagy and MAPK activation through ROS-mediated signaling in bladder cancer. Phytomedicine. 2021 Aug 17;92:153720.

4. Wen ZH, Huang JS, Lin YY, Yao ZK, Lai YC, Chen WF, Liu HT, Lin SC, Tsai YC, Tsai TC, Jean YH. Chondroprotective Effects of a Histone Deacetylase Inhibitor, Panobinostat, on Pain Behavior and Cartilage Degradation in Anterior Cruciate Ligament Transection-Induced Experimental Osteoarthritic Rats. Int J Mol Sci. 2021 Jul 7;22(14):7290.

5. Cheng SY, Chen NF, Wen ZH, Yao ZK, Tsui KH, Kuo HM, Chen WF*. Glutathione S-transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. International Journal of Molecular Science 2021; 22(13):7080. (IF=5.923; Biochemistry & Molecular Biology 67/298. (*corresponding author)

6. Feng CW, Chen NF, Chan TF, Chen WF*. Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo. Parkinsons Dis. 2020 Dec 29;2020:8814236 (*corresponding author)

7. Chen YF, Shih PC, Kuo HM, Yang SN, Lin YY, Chen WF, Tzou SJ, Liu HT, Chen NF. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment. Cancer Med. 2020 Jun;9(11):3918-3931.

8. Wang HC, Chen KY, Lin YT, Chen WF, Liaw MY, Lin YJ, Shih FY, Hsu SY, Tsai NW, Lin MC, Lu CH. Factors Associated With Prolonged Mechanical Ventilation and Reventilation in Acute Cervical Spinal Cord Injury Patients. Spine (Phila Pa 1976). 2020 May 1; 45(9): E515-E524.

9. Cheng MH, Pan CY, Chen NF, Yang SN, Hsieh S, Wen ZH, Chen WF, Wang JW, Lu WH, Kuo HM. Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells. Sci Rep. 2020 Mar 19;10(1):5045.

10. Cheng MH, Pan CY, Chen NF, Yang SN, Hsieh S, Wen ZH, Chen WF, Wang JW, Lu WH, Kuo HM. Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells. Sci Rep. 2020 Mar 19;10(1):5045.

11. Chen KH, Shao PL, Li YC, Chiang JY, Sung PH, Chien HW, Shih FY, Lee MS, Chen WF, Yip HK. Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Effectively Protected the Brain Architecture and Neurological Function in Rat After Acute Traumatic Brain Injury. Cell Transplant. 2020 Jan-Dec;29:963689720929313.

12. Wen ZH, Lin YY, Chang YC, Tang CC, Hsieh SP, Lee HP, Sung CS, Chen WF, Lee CH, Hsuan Jean Y. The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-β1 and NGF expressions in chondrocytes. Eur J Pain. 2020 Jan;24(1):209-222.

13. Feng CW, Chen NF, Sung CS, Kuo HM, Yang SN, Chen CL, Hung HC, Chen BH, Wen ZH, Chen WF*. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci. 2019 Aug 2;13:769. (*corresponding author)

14. Lin CC, Su JH, Chen WF, Wen ZH, Peng BR, Huang LC, Hwang TL, Sung PJ. New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae). Molecules. 2019 Jul 7;24(13):2487.

15. Feng CW, Chen NF, Wen ZH, Yang WY, Kuo HM, Sung PJ, Su JH, Cheng SY, Chen WF*. In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway. Mar Drugs. 2019 May 29;17(6):315. (*corresponding author)

16. Shih FY, Lin CC, Wang HC, Ho JT, Lin CH, Lu YT, Chen WF, Tsai MH. Risk factors for seizures after cranioplasty. Seizure. 2019 Mar;66: 15-21.

17. Cheng SY, Chen NF, Lin PY, Su JH, Chen BH, Kuo HM, Sung CS, Sung PJ, Wen ZH*, Chen WF*. Anti-invasion and antiangiogenic effects of stellettin B through inhibition of the Akt/Girdin signaling pathway and VEGF in glioblastoma cells. Cancers (Basel). 2019 Feb 14;11(2). (IF=5.326; Oncology 45/223) (* co-corresponding author)

18. Chen NF, Sung CS, Wen ZH, Chen CH, Feng CW, Hung HC, Yang SN, Tsui KH, Chen WF*. Therapeutic Effect of Platelet-Rich Plasma in Rat Spinal Cord Injuries. Front Neurosci. 2018 Apr 23;12:252. (SCI;IF= 3.566, Neuroscience, 83/259=32%)

19. Cheng SY, Chen NF, Kuo HM, Yang SN, Sung CS, Sung PJ, Wen ZH*, Chen WF*. Prodigiosin stimulates endoplasmic reticulum stress and induces autophagic cell death in glioblastoma cells. Apoptosis. 2018 Jun;23(5-6):314-328. (SCI;IF=3.967, Pharmaceutical Science 11/205=5.4%)

20. Kao CJ#, Chen WF#, Guo BL, Feng CW, Huang HC, Yang WY, Sung CS, Tsui KH, Chu H, Chen NF*, Wen ZH*. The 1-tosylpentan-3-one protects against 6-hydroxydopamine-induced neurotoxicity. International Journal of Molecular Sciences 2017 May;18: 1096 (SCI; IF=3.226; Chemistry, Multidisciplinary 54/166)

21. Feng CW, Hung HC, Huang SY, Chen CH, Chen YR, Chen CY, Yang SN, Wang HM, Sung PJ, Sheu JH, Tsui KH, Chen WF*, and Wen ZH*. Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway In Vitro and In Vivo Models of Parkinson’s Disease. Marine Drugs 2016 Oct; 14 (10). pii: E187. (SCI; IF=3.503; Chemistry, Medicinal 13/60)

22. Chen CH, Chen NF, Feng CW, Chen SY, Hung HC, Tsui KH, Hsu CH, Sung PJ, Chen WF*, Wen ZH*. A coral-derived compound improves functional recovery after spinal cord injury through its antiapoptotic and anti-inflammatory effects. Marine Drugs 2016 Sep 2; 14(9). pii: E160 (IF=3.503; Chemistry, Medicinal 13/60)

23. Chen NF#, Chen WF#, Sung CS, Lu CH, Chen CL Hung HC, Feng CW, Chen CH, Tsui KH, Ku HM, Wang HM, Wen ZH*, Huang SY*. Contributions of p38 and ERK to the antinociceptive effects of TGF-â1 in chronic constriction injury-induced neuropathic rats. The Journal of Headache and Pain. 2016 Aug; 17:72. (SCI; IF=3.580; Clinical Neurology 48/194)

24. Chen CH, Sung CS, Huang SY, Feng CW, Hung HC, Yang SN, Chen NF, Tai MH, Wen ZH*, Chen WF*. The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury. Exp Neurol. 2016 Apr; 278:27-41. (SCI; IF=4.706; Neurosciences 52/258) (* co-corresponding author)

25. Chen WF*, Chen CH, Chen NF, Sung CS, Wen ZH. Neuroprotective effects of direct intrathecal administration of granulocyte colony-stimulating factor in rats with spinal cord injury. CNS Neuroscience & Therapeutics. 2015 Sep; 21:698-707. (SCI; IF=3.919; Pharmacology & Pharmacy 47/256)

26. Chen WF, Huang SY, Liao CY, Sung CS, Chen JY, Wen ZH*. The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials. 2015 Jun; 53:1-11. (SCI; IF=8.402; Engineering, Biomedical 2/77) ( first author)

27. Chen NF, Huang SY, Lu CH, Chen CL, Feng CW, Chen CH, Hung HC, Lin YY, Sung PJ, Sung CS, Yang SN, Wang HM, Chang YC, Sheu JH, Chen WF*, Wen ZH*. Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-â1 in neuropathic rats. Marine drugs. 2014 Jun; 12: 3792-3817. (SCI; IF=3.503; Chemistry Medicinal 13/60)

28. Feng CW, Wen ZH, Huang SY, Hung HC, Chen CH, Yang SN, Chen NF, Wang HM, Hsiao CD, Chen WF*. Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae. Zebrafish. 2014 Jun; 11(3): 227-239. (SCI; IF=2.242; Zoology 23/162) (* corresponding author)

29. Chen CH, Huang SY, Chen NF, Feng CW, Hung HC, Sung CS, Jean YH, Wen ZH*, Chen WF*. Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia. Neuroscience. 2013 Jul; 242:39-52. (SCI; IF=3.277; Neuroscience 100/258) (* corresponding author)

30. Huang YH, Yang TM, Lee TC, Chen WF, Yang KY*. Acute autologous bone flap infection after cranioplasty for postinjury decompressive craniectomy. Injury. 2013 Jan; 44(1): 44-7. (SCI; IF=1.894; Emergency Medicine 9/24)

陳武福副院長		1963出生於台南縣
		教育訓練　國防醫學院醫學科學研究所醫學博士(Ph.D.) 國防醫學院醫學系醫學士 (M.D.)
		現職　高雄長庚醫院副院長高雄長庚醫院神經外科教授長庚大學醫學院外科教授
		經歷　 2020-2021高雄市立鳳山醫院副院長 2019-2021台灣立體定位功能性神經外科及放射手術學會理事長 2015-2020高雄長庚醫院國際醫療中心主任 2009-2015高雄長庚醫院神經外科主任
		專長巴金森氏症(Parkinson’s disease) 深腦部刺激術(Deep Brain Stimulation) 腦瘤(Brain Tumor) 脊椎手術(Spine Surgery)
		論文及研究　迄今共發表論文113篇，代表論文：　 1. Chen YF, Chang YP, Chen WF, Lin WC, Chang YY, Lin HC, Shih FY. Effect of Intraoperative Computed Tomography in Microelectrode Recording during Frameless Stereotactic Deep Brain Stimulation for Parkinson's Disease. World Neurosurg. 2021 Oct;154:e1-e6. 2. Wen ZH, Huang SY, Kuo HM, Chen CT, Chen NF, Chen WF, Tsui KH. Liu HT, Sung CS. Fumagillin attenuates spinal angiogenesis, neuroinflammation, and pain in neuropathic rats after chronic constriction injury. Biomedicines 2021 Sep 10;9(9):1187. (IF=6.081; Pharmacology & Pharmacy ; Biochemistry & Molecular Biology 65/297) 3. Hung SY, Chen WF, Lee YC, Su JH, Juan YS, Lin IP, Zhang YH, Chang MK, Lin MY, Chen CY, Lee CH. Rhopaloic acid A induces apoptosis, autophagy and MAPK activation through ROS-mediated signaling in bladder cancer. Phytomedicine. 2021 Aug 17;92:153720. 4. Wen ZH, Huang JS, Lin YY, Yao ZK, Lai YC, Chen WF, Liu HT, Lin SC, Tsai YC, Tsai TC, Jean YH. Chondroprotective Effects of a Histone Deacetylase Inhibitor, Panobinostat, on Pain Behavior and Cartilage Degradation in Anterior Cruciate Ligament Transection-Induced Experimental Osteoarthritic Rats. Int J Mol Sci. 2021 Jul 7;22(14):7290. 5. Cheng SY, Chen NF, Wen ZH, Yao ZK, Tsui KH, Kuo HM, Chen WF. Glutathione S-transferase M3 Is Associated with Glycolysis in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells. International Journal of Molecular Science 2021; 22(13):7080. (IF=5.923; Biochemistry & Molecular Biology 67/298. (corresponding author) 6. Feng CW, Chen NF, Chan TF, Chen WF. Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo. Parkinsons Dis. 2020 Dec 29;2020:8814236 (corresponding author) 7. Chen YF, Shih PC, Kuo HM, Yang SN, Lin YY, Chen WF, Tzou SJ, Liu HT, Chen NF. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma cells via modulating the tumor microenvironment. Cancer Med. 2020 Jun;9(11):3918-3931. 8. Wang HC, Chen KY, Lin YT, Chen WF, Liaw MY, Lin YJ, Shih FY, Hsu SY, Tsai NW, Lin MC, Lu CH. Factors Associated With Prolonged Mechanical Ventilation and Reventilation in Acute Cervical Spinal Cord Injury Patients. Spine (Phila Pa 1976). 2020 May 1; 45(9): E515-E524. 9. Cheng MH, Pan CY, Chen NF, Yang SN, Hsieh S, Wen ZH, Chen WF, Wang JW, Lu WH, Kuo HM. Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells. Sci Rep. 2020 Mar 19;10(1):5045. 10. Cheng MH, Pan CY, Chen NF, Yang SN, Hsieh S, Wen ZH, Chen WF, Wang JW, Lu WH, Kuo HM. Piscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells. Sci Rep. 2020 Mar 19;10(1):5045. 11. Chen KH, Shao PL, Li YC, Chiang JY, Sung PH, Chien HW, Shih FY, Lee MS, Chen WF, Yip HK. Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Effectively Protected the Brain Architecture and Neurological Function in Rat After Acute Traumatic Brain Injury. Cell Transplant. 2020 Jan-Dec;29:963689720929313. 12. Wen ZH, Lin YY, Chang YC, Tang CC, Hsieh SP, Lee HP, Sung CS, Chen WF, Lee CH, Hsuan Jean Y. The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-β1 and NGF expressions in chondrocytes. Eur J Pain. 2020 Jan;24(1):209-222. 13. Feng CW, Chen NF, Sung CS, Kuo HM, Yang SN, Chen CL, Hung HC, Chen BH, Wen ZH, Chen WF. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci. 2019 Aug 2;13:769. (corresponding author) 14. Lin CC, Su JH, Chen WF, Wen ZH, Peng BR, Huang LC, Hwang TL, Sung PJ. New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae). Molecules. 2019 Jul 7;24(13):2487. 15. Feng CW, Chen NF, Wen ZH, Yang WY, Kuo HM, Sung PJ, Su JH, Cheng SY, Chen WF. In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway. Mar Drugs. 2019 May 29;17(6):315. (corresponding author) 16. Shih FY, Lin CC, Wang HC, Ho JT, Lin CH, Lu YT, Chen WF, Tsai MH. Risk factors for seizures after cranioplasty. Seizure. 2019 Mar;66: 15-21. 17. Cheng SY, Chen NF, Lin PY, Su JH, Chen BH, Kuo HM, Sung CS, Sung PJ, Wen ZH, Chen WF. Anti-invasion and antiangiogenic effects of stellettin B through inhibition of the Akt/Girdin signaling pathway and VEGF in glioblastoma cells. Cancers (Basel). 2019 Feb 14;11(2). (IF=5.326; Oncology 45/223) (* co-corresponding author) 18. Chen NF, Sung CS, Wen ZH, Chen CH, Feng CW, Hung HC, Yang SN, Tsui KH, Chen WF. Therapeutic Effect of Platelet-Rich Plasma in Rat Spinal Cord Injuries. Front Neurosci. 2018 Apr 23;12:252. (SCI;IF= 3.566, Neuroscience, 83/259=32%) 19. Cheng SY, Chen NF, Kuo HM, Yang SN, Sung CS, Sung PJ, Wen ZH, Chen WF. Prodigiosin stimulates endoplasmic reticulum stress and induces autophagic cell death in glioblastoma cells. Apoptosis. 2018 Jun;23(5-6):314-328. (SCI;IF=3.967, Pharmaceutical Science 11/205=5.4%) 20. Kao CJ#, Chen WF#, Guo BL, Feng CW, Huang HC, Yang WY, Sung CS, Tsui KH, Chu H, Chen NF, Wen ZH. The 1-tosylpentan-3-one protects against 6-hydroxydopamine-induced neurotoxicity. International Journal of Molecular Sciences 2017 May;18: 1096 (SCI; IF=3.226; Chemistry, Multidisciplinary 54/166) 21. Feng CW, Hung HC, Huang SY, Chen CH, Chen YR, Chen CY, Yang SN, Wang HM, Sung PJ, Sheu JH, Tsui KH, Chen WF, and Wen ZH. Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway In Vitro and In Vivo Models of Parkinson’s Disease. Marine Drugs 2016 Oct; 14 (10). pii: E187. (SCI; IF=3.503; Chemistry, Medicinal 13/60) 22. Chen CH, Chen NF, Feng CW, Chen SY, Hung HC, Tsui KH, Hsu CH, Sung PJ, Chen WF, Wen ZH. A coral-derived compound improves functional recovery after spinal cord injury through its antiapoptotic and anti-inflammatory effects. Marine Drugs 2016 Sep 2; 14(9). pii: E160 (IF=3.503; Chemistry, Medicinal 13/60) 23. Chen NF#, Chen WF#, Sung CS, Lu CH, Chen CL Hung HC, Feng CW, Chen CH, Tsui KH, Ku HM, Wang HM, Wen ZH, Huang SY. Contributions of p38 and ERK to the antinociceptive effects of TGF-â1 in chronic constriction injury-induced neuropathic rats. The Journal of Headache and Pain. 2016 Aug; 17:72. (SCI; IF=3.580; Clinical Neurology 48/194) 24. Chen CH, Sung CS, Huang SY, Feng CW, Hung HC, Yang SN, Chen NF, Tai MH, Wen ZH, Chen WF. The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury. Exp Neurol. 2016 Apr; 278:27-41. (SCI; IF=4.706; Neurosciences 52/258) ( co-corresponding author) 25. Chen WF, Chen CH, Chen NF, Sung CS, Wen ZH. Neuroprotective effects of direct intrathecal administration of granulocyte colony-stimulating factor in rats with spinal cord injury. CNS Neuroscience & Therapeutics. 2015 Sep; 21:698-707. (SCI; IF=3.919; Pharmacology & Pharmacy 47/256) 26. Chen WF, Huang SY, Liao CY, Sung CS, Chen JY, Wen ZH. The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials. 2015 Jun; 53:1-11. (SCI; IF=8.402; Engineering, Biomedical 2/77) ( first author) 27. Chen NF, Huang SY, Lu CH, Chen CL, Feng CW, Chen CH, Hung HC, Lin YY, Sung PJ, Sung CS, Yang SN, Wang HM, Chang YC, Sheu JH, Chen WF, Wen ZH. Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-â1 in neuropathic rats. Marine drugs. 2014 Jun; 12: 3792-3817. (SCI; IF=3.503; Chemistry Medicinal 13/60) 28. Feng CW, Wen ZH, Huang SY, Hung HC, Chen CH, Yang SN, Chen NF, Wang HM, Hsiao CD, Chen WF. Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae. Zebrafish. 2014 Jun; 11(3): 227-239. (SCI; IF=2.242; Zoology 23/162) ( corresponding author) 29. Chen CH, Huang SY, Chen NF, Feng CW, Hung HC, Sung CS, Jean YH, Wen ZH, Chen WF. Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia. Neuroscience. 2013 Jul; 242:39-52. (SCI; IF=3.277; Neuroscience 100/258) (* corresponding author) 30. Huang YH, Yang TM, Lee TC, Chen WF, Yang KY*. Acute autologous bone flap infection after cranioplasty for postinjury decompressive craniectomy. Injury. 2013 Jan; 44(1): 44-7. (SCI; IF=1.894; Emergency Medicine 9/24)