吳宗圃

吳宗圃 , Ph.D.
單位: 長庚大學
職稱: 長庚大學醫學院生理暨藥理學科 助理教授
聯絡地址: 桃園市龜山區文化一路259號長庚大學醫學院生理暨藥理學科
電話: 03-2118800 轉3754
E-mail: wuchung@mail.cgu.edu.tw

研究領域:

• 癌症
• 藥物學

工作經歷:
美國國家衛生院 癌症研究中心 (NCI , NIH, USA) 博士後研究員
台灣國家衛生研究院 生物技術與藥物研究組 (NHRI, TW) 博士後研究員

學歷:
英國劍橋大學 (University of Cambridge, UK) 藥理學 博士

代表論文:

1. C-P Wu*, S-H Hsiao, C-Y Su, S-Y Luo, Y-Q Li, Y-H Huang, C-H Hsieh and C-W Huang. Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2. Biochemical Pharmacology (2014) Nov, 92: 567-576.
2. C-P Wu*, S-H Hsiao, S-Y Luo, W-C Tuo, C-Y Su, Y-Q Li, Y-H Huang and C-H Hsieh. Overexpression of human ABCB1 in cancer cells leads to reduced activity of GSK461364, a specific inhibitor of polo-like kinase 1. Molecular Pharmaceutics. (2014) Oct, 11(10): 3727-36.
3. C-P Wu*, S-H Hsiao, H-M Sim, S-Y Luo, W-C Tuo, H-W Cheng, Y-Q Li, Y-H Huang and SV Ambudkar. Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of polo-like kinase 1. Biochemical Pharmacology (2013) Oct, 86(7): 904-913
4. C-P Wu*, H-M Sim, Y-H Huang, Y-C Liu, S-H Hsiao, H-W Cheng, Y-Q Li, SV Ambudkar and S-C Hsu. Overexpression of ATP-Binding Cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells. Biochemical Pharmacology (2013) Feb, 85(3): 325-334.

5. C-H Hsieh, C-P Wu, H-T Lee, J-A Liang, C-Y Yu and Y-J Lin. NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in Glioblastoma multiforme. Free Radical Biology and Medicine (2012) Aug, 53(4): 649-658.

所有論文著作一覽表

學會與認證：
American Association for Cancer Research
The Pharmacological Society in Taiwan 台灣藥理學會

目前進行中研究計畫：
2014/01/01-2016/12/31 快速識別與鑑定多重抗藥性相關ATP-binding cassette 蛋白ABCB1和ABCG2 對新開發藥物的相互關係與影響