吳清源
吳佩昌
楊宜倩
林坤成
杜元佑
蔡佳玲
高常發
莊蕙青
陳國書
陳志平
吳旻憲
李亦淇
林素珍
張國友
黃幸宜
郭敏玲
趙 玫
白麗美
陳君侃
歐陽品
梅雅俊
中野敏明
石宗憲
康宏佑
蕭長春
蘇中慧
吳佩昌
楊宜倩
林坤成
杜元佑
蔡佳玲
高常發
莊蕙青
陳國書
陳志平
吳旻憲
李亦淇
林素珍
張國友
黃幸宜
郭敏玲
趙 玫
白麗美
陳君侃
歐陽品
梅雅俊
中野敏明
石宗憲
康宏佑
蕭長春
蘇中慧
游正博
陳鈴津
洪榮堂
梁毓津
何銘益
葉龍坤
鄭明輝
張毓翰
曹中侃
黃嫆茹
謝森永
林蔚然
王燕玲
林秀娜
張國軒
賴彬卿
李宗海
褚柏顯
林彥辰
詹昆明
林柏宏
陳宏吉
江東和
蔡宗廷
鄭運聰
陳建宗
蔡嘉軒
何偉民
林彥斌
吳孟晃
陳鈴津
洪榮堂
梁毓津
何銘益
葉龍坤
鄭明輝
張毓翰
曹中侃
黃嫆茹
謝森永
林蔚然
王燕玲
林秀娜
張國軒
賴彬卿
李宗海
褚柏顯
林彥辰
詹昆明
林柏宏
陳宏吉
江東和
蔡宗廷
鄭運聰
陳建宗
蔡嘉軒
何偉民
林彥斌
吳孟晃
洪榮堂, Ph.D.
單位: 林口長庚醫院 幹細胞與轉譯癌症研究所
職稱: 助理研究員
連絡地址: 333 桃園市龜山區復興街五號 幹細胞與轉譯癌症研究所
電話: 03-328-1200, 分機: 8067
E-mail: felixhjt@gmail.com
研究領域:
Alpha-galactosyl ceramide analogs and their use as immunotherapies. Application number: 12/218,082. Publication number: US 2010/0008954 A1. Filing date: 11 Jul 2008. Issued patent: US7928077 (Issue date 19 Apr 2011)
Alpha-galactosyl ceramide analogs and their use as immunotherapies, adjuvants, and antibiral, antibacterial, and anticancer. Publication number, EP2320947 A2. Filing date, Jul 10, 2009.
代表論文:
1.Sytwu, H. K., Lin, W. D., Roffler, S. R., Hung, J. T., Sung, H. S., Wang, C. H., Cheng, T. L., Tsou, S. C., Hsi, S. C. & Shen, K. L. (2003) Anti-4-1BB-based immunotherapy for autoimmune diabetes: lessons from a transgenic non-obese diabetic (NOD) model, J Autoimmun, 21, 247-54.
2. Sung, H. H., Juang, J. H., Lin, Y. C., Kuo, C. H., Hung, J. T., Chen, A., Chang, D. M., Chang, S. Y., Hsieh, S. L. & Sytwu, H. K. (2004) Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice, J Exp Med, 199, 1143-51.
3. Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., Mcdevitt, H. & Sytwu, H. K. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model, J Autoimmun, 25, 181-92.
4. Chang, Y. J., Huang, J. R., Tsai, Y. C., Hung, J.T., Wu, D., Fujio, M., Wong, C. H. & Yu, A. L. (2007) Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids, Proc Natl Acad Sci U S A, 104, 10299-304.
5. Chang, W. W., Lee, C. H., Lee, P., Lin, J., Hsu, C. W., Hung, J.T., Lin, J. J., Yu, J. C., Shao, L. E., Yu, J., Wong, C. H. & Yu, A. L. (2008) Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis, Proc Natl Acad Sci U S A, 105, 11667-72.
6. Wang, C. C., Huang, Y. L., Ren, C. T., Lin, C. W., Hung, J.T., Yu, J. C., Yu, A. L., Wu, C. Y. & Wong, C. H. (2008) Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer, Proc Natl Acad Sci U S A, 105, 11661-6.
7. Lai, C. Y., Hung, J.T., Lin, H. H., Yu, A. L., Chen, S. H., Tsai, Y. C., Shao, L. E., Yang, W. B. & Yu, J. (2010) Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro, Vaccine, 28, 4945-54.
8.*Hsieh, M. H., *Hung, J.T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L. & Liang, P. H. (2012) Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation, Chembiochem, 13, 1689-97.
9.*Huang, Y. L., *Hung, J.T., *Cheung, S. K., Lee, H. Y., Chu, K. C., Li, S. T., Lin, Y. C., Ren, C. T., Cheng, T. J., Hsu, T. L., Yu, A. L., Wu, C. Y. & Wong, C. H. (2013) Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer, Proc Natl Acad Sci U S A, 110, 2517-22.
10.Tsai Y. C., Huang J. R., Cheng J. Y., Lin J. J., Hung J. T., Wu Y. Y., Yeh K. T. and Yu A. L. (2013) A Prevalent Cancer Associated Glycan, Globo H Ceramide, Induces Immunosuppression by Reducing Notch1 Signaling. J Cancer Sci Ther, 5(7), 264-270
* co-first author
所有論文著作一覽表
單位: 林口長庚醫院 幹細胞與轉譯癌症研究所
職稱: 助理研究員
連絡地址: 333 桃園市龜山區復興街五號 幹細胞與轉譯癌症研究所
電話: 03-328-1200, 分機: 8067
E-mail: felixhjt@gmail.com
研究領域:
- Molecular mechanisms of tumor associated carbohydrate antigen during tumorigenesis.
- Carbohydrate-based cancer vaccine development.
- Immunotherapeutic effects of iNKT cells on hepatocellular carcinoma.
2006/1 ~ 2013/5 Postdoctoral fellows, Genomics research center, Academia Sinica
2013/6 ~ Present Assistant Research Fellow, Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital
1993/9 ~ 1997/7 BS, Department of Medical Sciences and Technology, Chung-Shan Medical University
1997/9 ~ 1999/7 MS, Institute of Microbiology and Immunology, National Defense Medical Center
1999/9 ~ 2005/10 Ph. D, Institute of Life Sciences, National Defense Medical Center
- 2007 Academia Sinica Regular Postdoctoral Fellow
- 2009 Travel scholarship for 5th International Symposium on CD1/NKT Cells
- 2009 Academia Sinica Regular Postdoctoral Fellow
- 2010 Outstanding Post-Doctor Researchers Conference Travel Grant from Foundation for the Advancement of Outstanding Scholarship
代表論文:
1.Sytwu, H. K., Lin, W. D., Roffler, S. R., Hung, J. T., Sung, H. S., Wang, C. H., Cheng, T. L., Tsou, S. C., Hsi, S. C. & Shen, K. L. (2003) Anti-4-1BB-based immunotherapy for autoimmune diabetes: lessons from a transgenic non-obese diabetic (NOD) model, J Autoimmun, 21, 247-54.
2. Sung, H. H., Juang, J. H., Lin, Y. C., Kuo, C. H., Hung, J. T., Chen, A., Chang, D. M., Chang, S. Y., Hsieh, S. L. & Sytwu, H. K. (2004) Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice, J Exp Med, 199, 1143-51.
3. Hung, J. T., Liao, J. H., Lin, Y. C., Chang, H. Y., Wu, S. F., Chang, T. H., Kung, J. T., Hsieh, S. L., Mcdevitt, H. & Sytwu, H. K. (2005) Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model, J Autoimmun, 25, 181-92.
4. Chang, Y. J., Huang, J. R., Tsai, Y. C., Hung, J.T., Wu, D., Fujio, M., Wong, C. H. & Yu, A. L. (2007) Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids, Proc Natl Acad Sci U S A, 104, 10299-304.
5. Chang, W. W., Lee, C. H., Lee, P., Lin, J., Hsu, C. W., Hung, J.T., Lin, J. J., Yu, J. C., Shao, L. E., Yu, J., Wong, C. H. & Yu, A. L. (2008) Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis, Proc Natl Acad Sci U S A, 105, 11667-72.
6. Wang, C. C., Huang, Y. L., Ren, C. T., Lin, C. W., Hung, J.T., Yu, J. C., Yu, A. L., Wu, C. Y. & Wong, C. H. (2008) Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer, Proc Natl Acad Sci U S A, 105, 11661-6.
7. Lai, C. Y., Hung, J.T., Lin, H. H., Yu, A. L., Chen, S. H., Tsai, Y. C., Shao, L. E., Yang, W. B. & Yu, J. (2010) Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro, Vaccine, 28, 4945-54.
8.*Hsieh, M. H., *Hung, J.T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L. & Liang, P. H. (2012) Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation, Chembiochem, 13, 1689-97.
9.*Huang, Y. L., *Hung, J.T., *Cheung, S. K., Lee, H. Y., Chu, K. C., Li, S. T., Lin, Y. C., Ren, C. T., Cheng, T. J., Hsu, T. L., Yu, A. L., Wu, C. Y. & Wong, C. H. (2013) Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer, Proc Natl Acad Sci U S A, 110, 2517-22.
10.Tsai Y. C., Huang J. R., Cheng J. Y., Lin J. J., Hung J. T., Wu Y. Y., Yeh K. T. and Yu A. L. (2013) A Prevalent Cancer Associated Glycan, Globo H Ceramide, Induces Immunosuppression by Reducing Notch1 Signaling. J Cancer Sci Ther, 5(7), 264-270
* co-first author
所有論文著作一覽表